Kesorn Suwanprasert

Thammasat University · Department of Physiology

Reduced cerebrovascular reactivity (CVR) was found in patients with recent lacunar infarct. However, its mechanisms were controversial. The breath holding maneuver as vasodilatory stimulus is clinically useful for an estimation of cerebrovasomotor reactivity in well co-operative patients. Patients with lacunar infarct have no higher cortical dysfun...

Background: Acute stroke can disturb autonomic regulation and promoting oxidative stress. Prolongation of QT interval is very common in stroke and related with stroke recurrent and sudden death. In this study, we hypothesize that neurovascular oxidative stress and autonomic modulation contribute to QT interval variation.

Lacunar stroke (LS) is known as lacunar infarction, which presents minor deficit in neurological finding but it actually causes stroke recurrent and death. High risk of stroke such as chronic hypertension is closely associated with LS. In this study, vasodilatory stimulus through cerebrovascular technique (30 sec breath-holding) was used to activat...

Background: Soluble LOX-1 (sLOX-1) and nitric oxide (NO) are potential biomarkers for vascular oxidative stress that affect to atherosclerotic plaque. Atherosclerotic narrowing of the internal carotid artery is a well-known cause of acute ischemic stroke (AIS). Objective: To measure serums LOX-1and NO levels in acute ischemic stroke patients wit...

Thomsen et al. reported in their retrospective study including comatose survivors of out-of-hospital cardiac arrest (OHCA) with presumed cardiac etiology that sinus bradycardia (HR < 50/min) during maintenance phase of therapeutic hypothermia is independently associated with a lower 180-day mortality rate. They proposed that sinus bradycardia shoul...

Sudden death caused by abnormal QTc and atrial fibrillation (AF) has been reported in stroke. Heart rate variability (HRV) is reduced with missing beats of RRI during arrhythmic episode and abnormal QTc variation during acute stroke. In this study, we develop a hybrid signal processing by Pan Tompkins QRS detection and Kalman filter estimator for m...

Design For Sustainability (DFS) refers to the design which links the relationship among the development of people's well-being, the environment, and the search for change and innovation. Obviously, DFS is not only helping the elderly persons overcome physiological factors and various obstacles in the society with specific approaches, but also promo...

This speech aims to describe the novel role of brain-heart axis and how important it is. We propose the new assessment of Sample Entropy for cardiac entropy and cariac autonomic function via ANS through HRV. We use nitric oxide, hydrogen peroxide, flow, neuro-glia enzymes for neurovascular glia interaction. In conclusion, we show the changes of Sam...

Objectives : Abnormal QTc , tachycardia and arrhythmia with high risks for sudden cardiac death have been reported in stroke patients. Brain-heart axis is shifted affecting autonomic modulation in AF patient with stroke (1). An effective improvement of HRV analysis is needed to verify the complexity of autonomic modulation during acute stroke. More...

Autonomic modulation involves in brain-heart axis have reported in AF stroke and hypothermia treated patients. Predominant activity of parasympathetic nerve and significant increase in mean cerebral blood flow velocity during cerebrovascular reactivity (CVR) in healthy was evident. Cerebrovascular reactivity by breath holding induces vasodilation....

Export Date: 1 December 2014, Correspondence Address: Sungnoon, R.; Thammasat University (Rangsit Campus)Thailand, References: Bollmann, A., Husser, D., Mainardi, L., Analysis of surface electrocardiograms in atrial fibrillation: Techniques, research, and clinical applications (2006) Europace, 8 (11), pp. 911-926;

Background & Objective: Atrial fibrillation (AF) is the most common cardiac arrhythmia associated with risk of ischemic stroke. Atrial electrophysiological properties are influenced by alteration of cardiac autonomic tone. Cardiac autonomic derangement was reported in acute ischemic stroke patients. Atrial activity analysis with sample entropy (Sam...

Complexity of autonomic regulation affects the systemic vascular, but little is known about its influence on cerebrovascular regulation. In this study, we examine the complexity of neuromodulation by frequency and nonlinear heart rate variability (HRV) to cerebral reserve function during cerebrovascular reactivity (CVR) by breath holding induced -h...

Introduction: Therapeutic hypothermia is recommended as a cardiac arrest treatment for neuroprotection. During time course, nonlinear and close loop model are proposed. In this study, we aim to explore nonlinear HRV with other domains to clearify and setting up the significant index for survival. Method: All patients were divided into two groups by...

Nitric oxide (NO) is a key oxidative stress marker. Real time NO measurement in nM/ml by electrochemistry is the powerful tool explores pathophysiological process of many disease including stroke subtypes, especially, lacunar stroke. In this study, we investigate the performance of classification models by hybrid nonlinear kernel function of NO obt...

Background: Cardiac arrest is a cause of death from systemic through global brain injuries. Therapeutic hypothermia is recommended as a guideline for cardiac arrest treatment in order to reduce injury. Until now, many studies have reported controversial data concerning predictors of survival outcome. In this study, we investigate neuronal-glia inte...

To determine whether NO, not H 2 O 2 , plays a vital role for neurovascular coupling activated by cerebrovascular reactivity as neuromodulator which is closely associated with an increase in cerebral blood flow velocity and intact autonomic regulation. Method: 16 healthy volunteers (5 men, 11 women, age 27.33 +3.85) were recruited. All healthy subj...

Enhanced oxidized Low Density Lipoprotein (oxLDL) uptake by Angiotensin II(Ang II) mediated reactive oxygen species (ROS) through eNOS uncoupling and direct activation of Low Density Lipoprotein-1 Receptor (LOX-1) K. Suwanprasert * and C. Tarasub** *, Division of Physiology ; **, Division of Anatomy Faculty of Medicine Thammasat University. Introdu...

Neurovascular Coupling assessed by Heart Rate Variability (HRV), Cerebral Blood Flow Velocity, Circulating Nitric Oxide and Hydrogen Peroxide during Cerebrovascular Reactivity K. Intharakham* and K. Suwanprasert ** * Medical Engineering program Joint Program between Faculty of Medicine and Faculty of Engineering, Thammasat University ** Division of...

Brain-Heart Axis Modulation through Vascular Oxidative Stress during Mild Hypothermia induces Decreased Global Ischemia in Therapeutic Hypothermia after Cardiac Arrest A. Jantanukul*, S. Muengtaweepongsa**, K. Suwanprasert*** *Medical Engineering Program, Joint Program between Faculty of Medicine and Faculty of Engineering, **Division of Neurolo...

Neurovascular oxidative stress in acute stroke may be a potential marker of advancing ischemic brain injury. We investigate neurovascular oxidative stress during the first 72 hours onset of acute stroke patients in order to determine changes of sLOX-1 and circulating NO levels. Changes of decreased NO and elevated sLOX-1 levels in significant steno...

Summary : Impaired cerebral autoregulation and endothelial dysfunctions leading to reduced cerebral reserve function are thought to play an important role in small artery ischemic stroke. In this study, we investigated the relation between endothelial dysfunction through circulating nitric oxide (NO) and autonomic modulation by heart rate variabili...

Summary : Therapeutic hypothermia is widely used to protect cellular injury but during rewarming to recovery phases are still critical periods for survival. In this study, we examined the changes of nitric oxide (NO) in circulation associated with LF/HF ratio of HRV analysis. Advancing greater levels of NO and LF/HF ratio were evident from mild hyp...

This presentation was given on 6th March 2013 for second year medical students in their study of Brain Block and it was integrated preclinical sciences to clinical sciences and aimed to open view of our students .

ABSTRACT Background: LOX-1, major receptor of oxLDL at endothelium is dynamically regulated by various stimuli such as angiotensin II, TNF-�, shear stress, hypoxia, hypertension, diabetes mellitus etc and found in atheroma derived cells of atherosclerosis. In the present study, we investigate the potential role of vascular LOX-1 activated by variou...

EC injury by oxLDL in various oxidation and treated with either Desfersamin, EDTA and BHT for vascular protection during radical chain process

Abstract—Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia associated with an increased risk of left atrial thrombosis as well as ischemic stroke. In this study, we have evaluated the characteristics of paroxysmal AF (PAF) and persistent AF using sample entropy (SampEn), a new biosignal parameter for determining degree of...

Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia associated with an increased risk of left atrial thrombosis as well as ischemic stroke. In this study, we have evaluated the characteristics of paroxysmal AF (PAF) and persistent AF using sample entropy (SampEn), a new biosignal parameter for determining degree of AF signa...

Atherosclerosis is an inflammatory disease that cytokines such as Tumor necrosis factor- (TNF-) plays a critical role in acute phase response and is expressed in the intima of lesion. The activation of TNF- in endothelial dysfunction leading to an initial step of atherosclerosis is obscure. In this study, we hypothesize that endothelial dysfunct...

This quasi experimental research aimed to examine the effectiveness of foot exercise on lower blood supply and leg muscle strength among type II diabetes mellitus in-patients at the Medial Department, Thammasat University Hospital. A sample was purposively selected. Data were collected by using a questionnaire which was approved by the experts for...

Objectives: Vascular inflammation caused by oxidative stress was an initial step in atherosclerosis. We hypothesized that eNOS uncoupling was induced by activated LOX-1 through ROS/RNS. Design and Methods: Human umbilical artery was cut into small rings and cultured as organ model study. mRNA LOX-1 expression was activated by ROS through 40 ng/ml T...

Objective: We investigate neurovascular oxidative stress during 24 hours of acute stroke patients in order to determine a significant role of sLOX-1 and vascular endothelial dysfunction mediated through nitric oxide release. Design and Method: Changes of plasma nitric oxide and sLOX-1 were studied during 3,6,12,18 and 24 hrs in 65 acute stroke pati...

Renal hemodynamics and autoregulation of blood flow were investigated following intravenous injection of Russell's viper venom (0.1 mg/kg) in dogs anesthetized with sodium pentobarbital. After venom injection, the glomerular filtration rate fell significantly throughout the experimental period of three hr. Urine flow rate and renal blood flow also...