Kerim Bora Yilmaz

• Professor
• Prof. at University of Health Sciences, Ankara Gulhane Education and Research HospitalTurkey

Introducing the relationship between the surgical instruments used in modified radical mastectomy and wound complications is important for preventing and decreasing complications. This prospective randomized trial was designed to assess the impact of scalpel, electrocautery, and ultrasonic dissector usage on wound complications and tissue damage. E...

Background: Idiopathic Granulomatous Mastitis (IGM) is a benign chronic inflammatory breast disease that mimics breast cancer, and the etiopathogenesis has not yet been fully evaluated. Autoimmunity has received the most focus as a possible etiology. Our aim in this prospective clinical study was to investigate the possible association between the...

Inflammatory alterations of the extracellular matrix shape the tumor microenvironment and promote all stages of carcinogenesis. This study aims to determine the impact of cellular fibronectin on inflammatory facets of tumor-associated macrophages (TAMs) in breast cancer. Cellular fibronectin (FN) harboring the alternatively spliced extra domain A (...

The parathyroid glands are localized at the back of the thyroid glands in the cervical region and are responsible for regulation of the calcium level in the blood, through specialized cells that sense Ca2+ and secrete parathyroid hormone (PTH) in response to a decline in its serum level. PTH stimulates the skeleton, kidneys and intestines and contr...

While investigating psychosocial factors on resilience and post-traumatic growth draws attention, research on biological correlates is limited. We investigated the relationship between post-traumatic growth, resilience, post-traumatic stress, and potential biomarkers in female patients with breast cancer (n = 71) from the general surgery or oncolog...

Objective: The second consensus study on idiopathic granulomatous mastitis (IGM) aimed to establish treatment options based on the clinical classification proposed in the first consensus, standardize criteria for treatment discontinuation, and develop follow-up protocols. Method: A structured methodology, identical to the first consensus study, was...

Muscle strength, balance, performance, and gait speed of individuals diagnosed with diabetic foot wound are negatively affected. This study aimed to investigate the effects of wound localisation on balance, performance, muscle strength, and gait speed in individuals with diabetic foot wounds. Individuals (n = 48) with a mean age of 59.35 ± 11.28 ye...

Pyoderma gangrenosum (PG) is a rare, chronic, neutrophilic dermatosis characterized by painful ulcers that are often misdiagnosed as wound infections. We report two cases of postsurgical PG following breast surgery: A 46-year-old woman with a non-healing ulcer after a breast biopsy and a 37-year-old woman with wound dehiscence after bilateral reduc...

Necrotizing fasciitis is a rare but potentially lethal infection of the skin and soft tissue, commonly seen in the perianal and gluteal regions. Concomitant diabetes is a predisposing factor. Primary necrotizing fasciitis of the breast is rare in healthy women. In this article, we present a very rare case of breast necrotizing fasciitis in the cont...

Objective: The aim of the Idiopathic Granulomatous Mastitis (IGM) consensus study is to evaluate the etiology, diagnostic steps, differential diagnosis, and propose a widely accepted clinical classification of this mysterious breast disease. Method: The organization of a national IGM consensus was decided by the joint evaluation of the Turkish Fede...

Background: Refractory IGM causes patients to use antibiotics, steroid therapy, immunosuppressive agents for a very long time and even leads to surgical procedures resulting in the loss of breast tissue. Hyperbaric Oxygen Therapy (HBOT) is a frequently used method in the treatment of wounds that are difficult to heal. We thought that HBOT would be...

Our study aims to evaluate the potential of a deep learning (DL) algorithm for differentiating the signal intensity of bone marrow between osteomyelitis (OM), Charcot neuropathic osteoarthropathy (CNO), and trauma (TR). The local ethics committee approved this retrospective study. From 148 patients, segmentation resulted in 679 labeled regions for...

Background: Lower-extremity amputation for a diabetic foot is mainly performed under general or central neuraxial anesthesia. Ultrasound-guided peripheral nerve block (PNB) can be a good alternative, especially for patients who require continuous anticoagulation treatment and patients with additional comorbidities. We evaluated bleeding due to PNB...

Background Functional status of T cells determines the responsiveness of cancer patients to immunotherapeutic interventions. Even though T cell‐mediated immunity is inaugurated in the tumor‐adjacent lymph nodes, peripheral blood has been routinely sampled for testing the immunological assays. The purpose of this study is to determine the immune che...

Background: Diabetic foot is a complex syndrome that is associated with other diabetic complications, such as peripheral arterial disease and peripheral neuropathy. Optimization of plasma glucose and glycated hemoglobin (HbA1c) is one of the main principles of standard care and treatment approach in individuals with diabetes mellitus (DM). In this...

The number of studies on the diabetes health literacy of patients with diabetic foot is very limited. The aim of this study was to determine the diabetes health literacy levels of patients with diabetic foot. The data in this cross-sectional, descriptive study were collected using a sociodemographic data collection form and the Health Literacy Scal...

Objectives: Our study used a radiomics method to differentiate bone marrow signal abnormality (BMSA) between Charcot neuroarthropathy (CN) and osteomyelitis (OM). Methods and materials: The records of 166 patients with diabetic foot suspected CN or OM between January 2020 and March 2022 were retrospectively examined. A total of 41 patients with...

Seroma is the most common wound complication due to dead space remaining after mastectomy and axillary dissection. Seroma formation, which causes pain and tension, together with the limitations of shoulder and arm movements, can cause wound healing problems that can progress to wound dehiscence and flap necrosis. The aim of our study was to investi...

Necrotizing fasciitis (NF) is an aggressive, necrotic, life-threatening infection of the soft tissues. The delay on treatment is generally accompanied by almost 90 % lethality according to the development of septic shock and its associated complications. Primary Necrotizing Fasciitis of the Breast (PNFB) is seen extremely rare. To date, breast necr...

Air density superposed on breast tissue on mammography has never been reported before. As a well-known X-ray rule; intensity of radiographic air is usually a cause of exogenous air or infection of soft tissues. We report a case with air density on mammogram as a sign of a skin ulceration of a young woman who is addicted to heroin and chooses her le...

Introduction: Thyroid ultrasonography (US) is the first-step noninvasive and easily accessible diagnostic method widely used in the detection and characterization of nodular thyroid disease. We aimed to develop a TI-RADS, which is easy to apply and only relies on the counting of suspicious criteria. In order to measure the reliability of the syste...

Purpose To assess the relationship between MP and coexisting non-neoplastic disorders. Methods Consecutive abdominal computed tomography (CT) scans of 4674 patients were evaluated retrospectively for CT features of MP between January 2017 and January 2018. Clinical findings of patients were analyzed. Four control patients were selected from our co...

Myeloid-derived suppressor cells (MDSC) populate the peripheral blood and contribute to immune regulation in cancer. However, there is limited knowledge on the myeloid cell types with proinflammatory capacities that may serve as opponents of MDSC. In the circulation of cancer patients, a monocyte subpopulation was identified with a specific immunop...

PurposeIncisional hernia repair is a frequently performed operation worldwide. In this experimental study, our aim is to present the incisional hernia model after creating midline laparotomy and several type of defects on abdominal wall of the rats. Thereby, the method determined here may be used in future experimental incisional hernia repair stud...

Objective: The clinical importance of nutritional awareness and assessment has become evident over the years. This study aimed to investigate the nutritional attitudes, personal perceptions and behaviors, and basic knowledge levels of physicians working in the General Surgery Clinic, University of Health Sciences. Methods: A total of 37 physicians...

In contrast to the mouse, functional assets of polymorphonuclear myeloid‐derived suppressor cells (PMN‐MDSC) in the human spleen remain to be better elucidated. Here, we report that the spleen in gastric and pancreatic cancer adopts an immune regulatory character, harbors excessive amount of PMN‐MDSC, and anatomically enables their interaction with...

Background Myeloid-derived suppressor cells (MDSC) are a functional myeloid cell subset that includes myeloid cells with immune suppressive properties. The presence of MDSC has been reported in the peripheral blood of patients with several malignant and non-malignant diseases. So far, direct comparison of MDSC across different diseases and Centers...

Background To evaluate the correlation between intraabdominal pressure (IAP) measured via the bladder and renal resistive index (RRI) measured by Doppler ultrasonography (USG). Methods Eighty consecutive surgical patients were included into this study. Before Doppler USG evaluation, IAP was measured by a Foley catheter via the bladder. The left an...

Purpose With this study, we evaluated the perfusion magnetic resonance imaging (MRI) features of benign inflammatory breast lesions for the first time and compared their Ktrans, Kep, Ve values and contrast kinetic curves to benign masses and invasive ductal carcinoma (IDC). Materials and methods Perfusion MRIs of the benign masses (n = 42), inflam...

Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength which is associated with increased risks such as physical disability, poor quality of life and death. The authors aimed to evaluate the effects of sarcopenia on postoperative outcomes for curative surgeries of gastrointestinal malignancie...

Endocrine glands regulate homeostasis of the body with the hormones they secrete. Regeneration and/or replacement of malfunctioning endocrine glands is a global need since the diseases associated with them affect more people year by year. Tissue engineering is an emerging promising field for the patients who suffer organ failure with recent pioneer...

Aim:Splenic infarction is a rare condition successfully treated with medical methods in general. The aim of this study was to evaluate the invasive treatment options in patients with splenic infarction-associated abscess.Methods:Files of thirteen patients, who underwent percutaneous drainage or a surgical procedure due to abscess as a result of spl...

Depending on the microenvironment conditions, macrophages display phenotypic and functional heterogeneity. This study characterizes the programmed cell death‐ligand 2 (PD‐L2)‐expressing macrophage‐like cells drained from surgical wound zones, and investigates their influence on helper T (Th) cell responses. Even though all CD14+ myeloid cells posse...

This study aimed to postoperatively evaluate the effects of intraoperative neural monitoring (IONM) on muscles and nerves in patients who underwent modified radical mastectomy (MRM). In the 11 patients included in the study, nerves were determined and protected by nerve monitoring during the axillary dissection (IONM group). In another 11 patients,...

The assesment of nutritional awareness and basic knowledge levels of physicians working in the surgery clinic

Background/objective: The aim of this study was to evaluate with electromyography (EMG) the effect of lateral pectoral nerve sparing technique (LPNST) and radiotherapy (RT) on the lateral pectoral nerve (LPN) in patients applied with modified radical mastectomy (MRM). Methods: The study included 66 patients who underwent MRM surgery. The patient...

Background/Objective Despite extensive published research, the surgical approach to penetrating abdominal trauma patients is still under debate. Computed tomography-guided tractography (CTT) is an imaging modality in which water soluble iodinated contrast medium is administered into the site of the injury in the CT unit. The aim of this study was t...

Pyometra, the accumulation of purulent material in the uterine cavity, is a rare gynecological condition whose etiology is impaired drainage of the uterine cavity. It is uncommon in premenopausal age and occurs mainly in older and postmenopausal women. Clinical signs of pyometra are vaginal discharge, postmenopausal bleeding, and lower abdominal pa...

ABSTRACT Aim: In this study, we aimed to investigate the patients with colorectal polyps who underwent surgical resection because of failed endoscopic removal. Method: Patients who underwent surgical resection for colorectal polyps in our clinic between January 2014 and August 2017 were included in this study. Demographic information of the patien...

Aim . The aim was to evaluate the clinical Alvarado scoring system and computed tomography (CT) criteria for the diagnosis of acute appendicitis. Material and Methods . 117 patients with acute abdominal pain who underwent abdominal CT were enrolled in this retrospective study. Patient demographics, clinical Alvarado scoring, CT images, and patholog...

Background: The purpose of this study was to evaluate the effect of clinical, laboratory and radiological results on treatment decision and surgical results in patients with blunt abdominal trauma, who were admitted to the emergency department due to traffic accident. Methods: Two hundred and twenty-two patients with blunt abdominal trauma were...

Objective: Colorectal cancer is still one of the most common causes of cancer related deaths in the world despite improvements in diagnosis and treatment modalities, and application of community-based screening methods. Symptoms of colorectal cancer are non-specific and usually manifest following local progression. A number of patients with advanc...

Diffusion-weighted magnetic resonance imaging has emerged as a successful technique in the early diagnosis of acute pancreatitis. An 82-year-old male patient suspected of acute pancreatitis refused to undergo intravenous contrast-enhanced abdominal computed tomography due to a history of previous allergic reactions to contrast medium. He was imaged...

Schwannomas are well capsulated, benign, and slowly growing tumors which originate from Schwann cells of peripheral nerve sheath. The incidence of schwannomanas in the axillary region is not common. This rarity causes misdiagnosis at the radiological evaluation. In this case we present the imaging and histopathological findings of a cystic schwanno...

Ultrasound is as a noninvasive method commonly used in the work-up of thyroid nodules. This study aimed to evaluate the usefulness of sonographic and elastosonographic parameters in the discrimination of malignancy. 150 thyroid nodules were evaluated by gray-scale, Doppler and elastosonography. The cytological analysis revealed that 141 nodules wer...

A 53-year-old female patient who was operated for adenocarcinoma of ascending colon having a recent history of anticoagulation therapy was admitted to hospital with ileus. She was diagnosed with a prominantly cystic pelvic mass in close proximity to iliac arteries on CT. The differential diagnosis included metastatic lesion, organizing hematoma, pr...

Drains and catheters are used for both prophylactic and therapeutic reasons in clinical practice. This study aimed to investigate the factors that affect safety of drains, catheters, nasogastric tube and central venous line in patients who underwent surgery. Two hundred and four consecutive patients who were operated at the general surgery clinics...

In the diagnosis of traumatic and nontraumatic emergencies, computed tomography (CT) is the most frequently performed procedure. The aims of this study were to find out whether CT report results can be used as a reliable tool for the diagnosis and management of patients at an emergency department and to evaluate the appropriateness of the selection...

Background: Ventral incisional hernias are more commonly associated with comorbid diseases when compared to other hernia types. We investigate the hypothesis that unfavourable local factors related to comorbid diseases may lead to incisional hernia development. Materials and methods: The characteristics of incisional hernia (71 patients), primar...

Malignancy is correlated with stiffness which is assessed by real time elastosonography (RTE). RTE is not used in routine practice. We aimed to establish the learning curve of RTE on radiology residents. Forty >/=1 cm solitary thyroid nodules referred to fine needle aspiration cytology were examined with RTE by a radiology specialist and two radiol...

Purpose: This study investigated the surgical gastrostomy and jejunostomy procedures in cancer patients who needed nutritional support and endoscopy was unattainable. Methods: Operation time and procedure, anesthesia and tube types, procedure-specific and surgical complications, and tube replacement at the follow up period were retrospectively a...

Post-laparotomy wound dehiscence, evantration and evisceration are important complications leading to an increase in both morbidity and mortality. Incisional hernias are frequently observed following abdominal surgeries and their occurrence is related to various local and systemic factors. This study aims to analyze the factors affecting wound heal...

Injury due to go-karting accidents is a new kind of surgical emergency in Turkey and may show variations between patients. There are special details as relate to the design of the vehicles and patient characteristics. We report two seriously injured patients as a result of two different go-kart accidents. Severe intraabdominal hemorrhage due to liv...

There is no consensus among surgeons on the indication of putting drains for in groin hernias. In this study we aimed to investigate the factors that are associated with drain usage by comparing the clinical characteristics of patients who had drains with the patients without drains in the repair of groin hernias. The data of all groin hernia repai...

Metaplastic breast carcinoma (MBC) is a rare and heterogeneous group of neoplasms characterized by a mixture of spindle, squamous and/or mesenchymal cells. The purpose of this study was to assess the immunohistochemical features, biological characteristics and myoepithelial differentiation of a series of MBC patients. The archival pathological mate...

In this double-blind prospective randomized trial, our objective was to investigate the effect of antibiotic prophylaxis in patients undergoing elective inguinal hernia surgery with mesh repair in a large-volume tertiary referral trauma center. Eligible patients were assigned randomly to either an antibiotic prophylaxis group or a control group. Pa...

The indications for surgical treatment of multinodular goiter (MNG) are pressure symptoms, suspicion of malignancy, and cosmetic concerns. We report our clinical experience of performing total thyroidectomy (TT) for MNG, focusing on outcome and complications, to evaluate its effectiveness. The medical records of 154 patients who underwent TT for MN...

In this case report, we describe an unusual tuba-ovarian inguinal herniation after percutaneous inguinal lymphocele treatment which is a rare condition after a radiological intervention. Lymphocele and other cystic structures of the groin are reviewed within the differential diagnosis Keywords: Lymphocele, Inguinal Herniation, Percutaneous Drainage

Purpose: To identify the factors that affect the unfavorable clinic outcomes of emergent incarcerated groin hernias in adults. Materials and Methods: Emergent repairs for incarcerated groin hernias were compared with elective repairs (n=109 versus 858) regarding age, gender, type of the hernia, recurrence, surgical repair, resections, type of the a...

A 65-year old male admitted to emergency department due to bloody vomiting and abdominal pain. Radiological examinations showed extensive intraperitoneal free air, prolapsed stomach and free fluid at the abdomen. During laparotomy a perforation measuring 4 cm length, revealing blood and fluid containing a lot of aliment in the abdominal cavity was...

Aim: Seroma is an important complication of breast surgery. This study investigated the effects of fixation of the flaps and obliterating the dead space on seroma formation. Materials and methods: Patients undergoing modified radical mastectomy were separated into 2 random groups of 50 according to wound closure methods: either flap fixation/mechan...

Hernia repairs are a common surgical procedure, and are associated with a significant cost. Despite the acceptance of the advantages of early elective hernia repairs, the incidence of emergency admissions with complicated presentations remains high, and the natural history of an untreated hernia is not obvious. This study aimed to define risk facto...

The aim of the study was to determine the incidence of venous thrombosis in cancer patients with central venous catheters inserted perioperatively. A prospective analysis was performed with 68 patients in whom central venous catheters were placed perioperatively. Cancer patients with planned central venous catheters had prophylaxis with low-molecul...

Epidermodyplasia Verruciformis is a rare genetic disease, which is usually inherited in an automosal recessive manner. Flat, papular and macular skin lesions generally occur at the dorsal side of the hands, extremities and face at childhood due to defect of cell mediated immunity. These macular lesions progress to intraepithelial lesions and skin m...

To evaluate the characteristics of recurrence and examine the clinicopathological factors related to disease- free (DFS) and overall survival (OS) of patients with colorectal cancer (CRC) recurrence. One hundred and sixteen CRC patients with stage II and III disease that had been resected curatively in our clinic between 1999 and 2006 were retrospe...

Objectives: Cutaneous metastases of colorectal cancer are rarely detected in clinical practice. This study aimed to evaluate the patients with cutaneous metastases of colorectal cancer in order to define their clinical presentation, clinical course, and prognosis. Patients and Methods: Patients (7 females, 1 male; mean age 49 years; range 28 to 72...

Purpose: The aim of this study was to analyse the clinical and radiological findings of five patients treated with the diagnosis of hydatid disease of the spleen and discuss their treatment in the view of current literature. The most commonly affected organs are the liver (70%) and the lung (15-20%). But almost every organ of the body can be affect...

Transcutaneous electrical nerve stimulation (TENS) is primarily used for pain reduction and is thought to activate neural fibers modifying vascular resistance and local blood flow influencing flap necrosis. This study aimed to delineate the effects of TENS on the viability of skin flaps created during mastectomy in breast cancer patients. Patients...

Secretory breast carcinoma is a rare form of invasive breast carcinoma constituting less than 1% of all breast cancer cases. Since insufficient data have been compiled about this rare tumor, it is important to report every case of secretory breast carcinoma in an effort to better understand the histopathological and clinical characteristics of this...

Amaç: Bu çalışmada, idiyopatik trombositopenik purpura nedeniyle splenektomi yapılan hastaların tedavi sonuçlarınının değerlendirilmesi amaçlandı. Hastalar ve Yöntem: 1999-2006 yılları arasında idiyopatik trombositopenik purpura tanısıyla splenektomi yapılan hastalar retrospektif olarak değerlendirildi. Hastaların yaşı, cinsiyeti, cerrahi öncesi ve...

Purpose: The treatment results of patients treated with splenectomy for idiopathic thrombocytopenic purpura were evaluated in this study. Patients and Methods: Patients treated with splenectomy for idiopathic trombocytopenic purpura between 1999-2006 were retrospectively evaluated. Patients’ age, gender, preoperative and postoperative medical treat...

Aim: Electrocautery has been postulated as a risk factor for wound complications. This study was conducted to evaluate the effects of electrocautery and scalpel dissections on wound complications and local cytokine levels. Materials and Methods: Patients undergoing modified radical mastectomy were assigned to flap dissection with either electrocaut...

Breast carcinomas represent a heterogenous group of tumors and recent studies have demonstrated several subtypes of breast cancer by gene expression profiles. This study aimed to compare hormon receptor negative (ER-/PR-/ERBB2+) and triple negative (ER-/PR-/ERBB2-) patients in terms of prognosis and to show that molecularly defined subtypes can be...

Purpose: The aim of this study was to evaluate the parameters related to septic complications after curative surgery for rectal cancer. Patients and Methods: Eighty-two patients treated in our clinic with the diagnosis of stage II and III rectal carcinoma have been evaluated retrospectively. The parameters evaluated were age, gender, tumor localisa...

Purpose: To evaluate the patients with classic Kaposi's sarcoma which is frequently encountered in Mediteranean and East European countries.Patients and Methods: Patients diagnosed and treated between 2000 and 2005 were included in this study. Patients were evaluated according to their age, sex, tumor localization, number, size and stage as well as...

A close relationship between autoimmunity and malignant diseases has been supposed for a long time. In clinical practice, anti-SS-B and anti-CENP-B antibodies are used as serologic markers for autoimmune diseases. In this study, anti-SS-B and anti-CENP-B autoantibodies were studied in breast cancer patients and compared to a control group surgicall...