Kerem Okutur

• M.D.
• Medical Doctor at Medical Park Hospitals

Objectives: Most research in this field has highlighted the significance of the fibrinolytic system in essential hypertension, revealing anomalies within the coagulation and fibrinolytic pathways that contribute to a hypercoagulable condition. We aim to investigate thrombin-activatable fibrinolysis inhibitor (TAFI) levels in individuals diagnosed w...

The studies evaluating the impact of Her2 levels in neoadjuvant setting have conflicting data. The aim of the study was to evaluate the prognostic impact of Her2 status in early triple negative breast cancer(TNBC). In the study TNBC patients who were treated with neoadjuvant chemotherapy (NAC) and surgery were analyzed retrospectively. The primary...

Background There is no standard treatment recommended at category 1 level in international guidelines for subsequent therapy after cyclin-dependent kinase 4/6 inhibitor (CDK4/6) based therapy. We aimed to evaluate which subsequent treatment oncologists prefer in patients with disease progression under CDKi. In addition, we aimed to show the effecti...

Aim: The aim of this study is to evaluate the efficacy and toxicity of trastuzumab emtansine (T-DM1) in cases with metastatic breast cancer (mBC) in different lines of treatment. Method: Retrospective analysis of T-DM1 results of human epidermal growth factor receptor 2 (Her2) positive 414 cases with mBC from 31 centers in Turkey. Findings: Except...

Angiogenesis plays an essential role in tumor development, invasion, and metastasis. In preclinical models, agents that block the vascular endothelial growth factor (VEGF) pathway have been shown to effectively inhibit tumor angiogenesis and growth. Although antiangiogenic therapies, including anti-VEGF antibodies and tyrosine kinase inhibitors, ha...

Altmış yedi yaşında kadın hasta bir aydır halsizlik, nefes darlığı ve öksürük yakınması ile başvurdu. Hasta 2007 yılında sağ memede invaziv duktal karsinom nedeniyle cerrahi ve radyoterapi tedavisi gördüğünü ve dört ay önce de akciğerde multipl metastatik lezyonların saptanması üzerine everolimus tedavisine (10 mg/gün) başlanmış. Tedaviden sonra ha...

Angiogenesis plays an essential role in tumor development, invasion, and metastasis. In preclinical models, agents that block the vascular endothelial growth factor (VEGF) pathway have been shown to effectively inhibit tumor angiogenesis and growth. Although antiangiogenic therapies, including anti-VEGF antibodies and tyrosine kinase inhibitors, ha...

Purpose: This study aimed to reveal the habits of using internet by cancer patients and their relatives to access health-related information and services in Turkey. Methods: An 18-item questionnaire survey was applied in cancer patients and their relatives. Results: A total of 1106 patients (male, 37.3%, and female, 62.7%) and their relatives...

Although signet-ring cell (SRC) adenocarcinoma is commonly seen in the stomach, it is a very rarely seen histologic entity in the bladder. It is difficult to distinguish primary SRC adenocarcinoma of the bladder from bladder metastasis of SRC carcinoma of the stomach only based on histological findings. In such cases, clinical findings and immunohi...

Trichomegaly is a rare side effect of epidermal growth factor receptor inhibitors. We present here 4 patients who treated with cetuximab (an epidermal growth factor receptor inhibitor) for metastatic colorectal cancer. All of the cases were treated with cetuximab 500 mg/m biweekly in combination protocol. The mean period from the start of the treat...

Although involvement of pancreas is a common finding in small cell lung cancer (SCLC), metastasis-induced acute pancreatitis (MIAP) is very rare. A 50-year-old female with SCLC who had limited disease and achieved full response after treatment presented with acute pancreatitis during her follow-up. The radiologic studies revealed a small area causi...

Oxaliplatin is used to treat advanced colorectal cancer. Platinum-containing chemotherapeutic agents are known to be ototoxic. However, ototoxicity is rare with newer generation platinum-derived agents, such as oxaliplatin. This case report presents a rare case of sudden unilateral sensorineural hearing loss following intravenous (IV) infusion of o...

Background: The phosphatidylinositol 3'-kinase/Akt (PI3K/Akt) pathway is a key regulator for HER2- overexpressing breast cancer, but data about whether activation of PI3K/Akt is associated with poor prognosis and resistance to trastuzumab therapy is controversial. In this study we investigated predictive and prognostic significance of expression o...

Neurological involvement is observed in 5%-25% of patients with lymphoma being either the first presentation of the disease or emerging during its course. However, Guillain-Barr? syndrome is rarely reported. In this article, we present a case with intestinal lymphoma developing Guillain-Barr? syndrome during the course of the disease. A 66-year-old...

Sunitinib has become a standard treatment agent for metastatic renal cell carcinoma (RCC) for several years. However, various adverse events have been reported. We present a rare adverse effect of hyperammonemic encephalopathy induced by sunitinib. A 66-year-old woman with metastatic RCC referred to the emergency department with confusion that deve...

Refractory malignant ascites (MA) is a common complication in cancer patients. Renal cell carcinoma (RCC) is rarely present with peritoneal ascites, which is commonly associated with carcinomas of the gastrointestinal and female reproductive tracts; including especially ovarian high-grade serous carcinoma. Currently, chemotherapy and paracentesis r...

The expression of epidermal growth factor receptor (EGFR) has been linked to clinical outcome in several solid tumors. However, the clinical significance of EGFR (c-erbB1) in gastric cancer remains unclear. The present study was designed to detect the clinical implications of EGFR in the Turkish population. Paraffin-embedded tissue microarrays cont...

Megestrol acetate (MA) is a steroid origin medicine often used for control of cachexia in oncologic palliative care. Thrombosis is a common problem in oncology patients. One question is whether MA can cause thrombosis. This retrospective, registry-based analysis was therefore conducted to assess thrombotic processes in oncology patients using MA co...

In many cancer patients, various symptoms and signs not due to invasion or compression of tumor and its metastases are observed. These “remote” effects which can perta into various organs or systems are associated with the presence of tumor and examined under the title of “paraneoplasia” or “paraneoplastic syndrome”. Paraneoplasias are usually deve...

Approximately 10%-20% of all systemic lymphomas have central nervous system (CNS) involvement, which has been correlated to a worsened prognosis. It is well known that secondary involvement of the adrenal glands may occur in up to 25% of patients during the course of diffuse lymphoma. Primary adrenal lymphoma (PAL), however, is a different entity,...

Context: TK1 found to be elevated biomarker in many solid cancers. Objectives: The study aimed to assess the prognostic significance of a serum TK1 in patients with metastatic NSCLC. Methods: The study included 48 consecutive patients, newly diagnosed with metastatic NSCLC, and 10 healthy volunteers. Serum TK1 activity determined by ELISA meth...

Purpose: To determine the clinical features of bevacizumab-associated toxicities in metastatic colorectal cancer (MCRC) patients. Methods: The medical records of 60 patients with MCRC who were treated with chemotherapy including bevacizumab in the first-line setting were retrospectively evaluated. Results: Bevacizumab was administered along wi...

Aim:Serum thymidine kinase 1 (TK1) is a sensitive marker of tumor cell proliferation.In this study we aimed to investigate the prognostic significance of serum TK1 activity in metastatic colorectal cancer (MCRC) patients receiving palliative chemotherapy.Materials and Methods:We prospectively measured serum TK1 activity immediately before the first...

A 56-year-old male patient with locally advanced mucinous rectal cancer underwent neoadjuvant chemoradiotherapy. Follow-up imaging with positron emission tomography-computed tomography (PET-CT) revealed a local response to chemoradiotherapy, whereas diffusion-weighted magnetic resonance imaging (DW-MRI) showed newly presented sacral bone metastasis...

e14698 Background: Expression of EGFR, Her-2 and mTOR have been linked to clinical outcomes in several solid tumors. However clinical significance of these biomarkers in gastric cancer remain unclear. This study was designed to detect the clinical implications of these three biomarkers in Turkish population. Methods: Paraffin-embedded tissue microa...

We report a case of fulminant abdominal gas gangrene in a patient with metastatic colon cancer. A 39-year-old patient with descending colon, high-grade adenocarcinoma and coexisting liver and lymph node metastases received two courses of chemotherapy. The patient developed sudden acute abdominal symptoms accompanied by septic shock parameters. The...

Although gynecomastia is a well-defined paraneoplastic syndrome in patients with non-small cell lung cancer, the association with pleomorphic carcinoma has not been reported. A 50-yr-old man presented with bilateral gynecomastia and elevated serum beta-human chorionic gonadotropin (βhCG) level. Chest tomography showed a mass in the right middle lob...

Pheochromocytoma is a tumor of the chromaffin cells which secretes catecholamines and 90% of it originates from adrenal medulla. The main symptoms and signs are hypertension, tachycardia, sweating and headache. Rarely, acute abdomen may occur as a result of the rupture of tumoral mass or bleeding inside the mass. Here we present a 43 year old male...

A 50-year-old woman with a 30 years history of diabetes mellitus and has been diagnosed with diabetic nephropathy for the last 4 years presented with abdominal pain, nausea and vomiting. Abdominal ultrasonography revealed a hyperechogenic air image at right kidney and with the aid of subsequently performed abdominal tomography type 2 emphysematous...

To determine the beliefs of Turkish cancer patients about the etiology of carcinogenesis. The study was carried out at Istanbul Bilim University, European Florence Nightingale Hospital, Department of Medical Oncology. The data were collected during April-June 2008 from 39 women and 23 men. Sociodemographic data form and beliefs on the reasons of ca...

Familial Mediterranean fever is an autosomal recessive disease largely restricted to certain ethnic groups and presenting with recurrent febrile serositis attacks. Peritonitis, pleuritis, and synovitis are common manifestations; however, the pericardium is rarely affected. In this case report, we describe a 25-year-old Turkish woman who presented w...

Magnetic resonance imaging and computed tomography features of extensive intracranial calcifications due to postoperative hypoparathyroidism are rarely reported in the literature. We presented the cranial computed tomography and magnetic resonance imaging aspects and clinical features of a patient with postoperative hypoparathyroidism who had intra...

Isoniazid is one of the most commonly used antituberculous drugs. Acute intoxication is characterized by repetitious convulsions, high anion gap metabolic acidosis and coma. The basis of therapy consists of parenteral pyridoxine administration in a dose equivalent to that of isoniazid ingested. Here we present a case of acute isoniazid intoxication...

Tiroid cerrahisi sonras› geliflen hipoparatiroidizme bal› intrakraniyal kalsifikasyonlar›n manyetik rezonans ve bilgisayarl› tomografi görüntüleme bulgular› literatürde nadiren bildirilmifltir. Bu yaz›da tiroidektomi ameliyat›ndan y›llar sonra intrakraniyal kalsifikasyonlar geliflen postoperatif hipoparatiroidizmli bir olgunun klinik özellikleri, b...