Kentaro Ueno

Kentaro Ueno
Kagoshima University | Kadai · Faculty of Medicine

Doctor of Medicine

About

51
Publications
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317
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Introduction
Kentaro Ueno Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan E-mail: ukenta@m3.kufm.kagoshima-u.ac.jp Tel: +81-99-275-5354; Fax: +81-99-265-7196 Current research interests are as follows 1) Kawasaki disease 2) Pediatric cardiology 3) Acute kidney injury 4) Clinical Immunology
Skills and Expertise

Publications

Publications (51)
Article
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Although the number of pediatric patients with long-term survival following cardiac surgery is increasing, concerns regarding chronic kidney disease (CKD) after surgery are growing. We examined the frequency of and risk factors for pediatric CKD development in patients with congenital heart disease (CHD) at least 2 years after cardiac surgery. This...
Article
We herein describe the first pediatric case of an internal mammary artery (IMA) aneurysm caused by a median sternotomy. He was a 2-year-old with tricuspid atresia who underwent an extracardiac conduit Fontan procedure. On the 36th postoperative day, an asymptomatic left IMA aneurysm was detected via contrast computed tomography, which was successfu...
Article
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We report the first early infantile case with paroxysmal atrioventricular block (PAVB). He was born at 33 weeks of gestation and, from 23 days of age, he had paroxysmal bradycardia repeatedly. His heart rate at rest was 150 to 170/minute and there was often some paroxysmal sinus bradycardia. Paroxysmal complete atrioventricular block was observed t...
Article
Background:The usefulness of electrocardiographic (ECG) voltage criteria for diagnosing hypertrophic cardiomyopathy (HCM) in pediatric patients is poorly defined. Methods and Results:ECGs at the 1st grade (mean [±SD] age 6.6±0.3 years) were available for 11 patients diagnosed with HCM at around the 7th grade (13.2±0.3 years). ECGs were available fo...
Preprint
Background: Patients with strong pulmonary vascular occlusive lesions are at risk of developing postoperative pulmonary hypertension (PH). We aimed to evaluate preoperative right ventricular (RV) function in patients with ventricular septal defect (VSD) who required cardiac surgery during infancy and consequently developed postoperative PH and to d...
Article
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Neonatal Marfan syndrome is a rare condition with poor prognosis because of severe mitral and/or tricuspid valve insufficiency. Mitral valve replacement is sometimes required in early infancy, while tricuspid valve replacement is rarely done. We report the first infant neonatal Marfan syndrome case with a missense variant of c.3706T>C in the fibril...
Preprint
Full-text available
Purpose: Patients with strong pulmonary vascular occlusive lesions are at risk of developing postoperative pulmonary hypertension (PH). We aimed to evaluate preoperative right ventricular (RV) function in patients with ventricular septal defect (VSD) who required cardiac surgery during infancy and consequently developed postoperative PH and to dete...
Article
Full-text available
Background: A school-based cardiovascular (CV) screening in Kagoshima City is characterized by a group discussion system. Pediatric cardiologists discuss whether electrocardiograms (ECGs), screened by a cardiologist, should be referred for the second examination. Here, we examined the accuracy of the screening system in Kagoshima City. Methods: Sub...
Article
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Innate immune activity plays an essential role in the development of Kawasaki disease (KD) vasculitis. Extracellular release of high mobility group box-1 (HMGB-1), an endogenous damage-associated molecular pattern protein that can activate the innate immune system and drive host inflammatory responses, may contribute to the development of coronary...
Article
Patients who have undergone cardiac surgery using prosthetic devices have an increased risk of developing prosthetic device-related infection and mediastinitis. However, accurate diagnosis of prosthetic device-related infection can be difficult to evaluate and treat with antibiotic therapy alone. In recent years, 18F-fluorodeoxyglucose positron emi...
Article
This is the first study reported in which a combination of PDE5 inhibitors and ERA have been safe and effective in improving hemodynamics and reducing mean pulmonary artery pressure and pulmonary artery resistance without serious side effects during a 7-year follow-up duration in the pediatric patient. Pharmacological treatment for unilateral absce...
Article
First, serum creatinine (sCr) level has limited usability as a surrogate for the assessment and interpretation of renal function in neonates; however, it remains a standard criterion for the diagnosis of neonatal acute kidney injury (AKI). Second and third, regarding clinical and laboratory confounders, there are many other risk factors for CS-AKI...
Article
Here, we report the case of an infant with interrupted aortic arch (IAA) after the Norwood procedure with the right ventricle to pulmonary artery (RV-PA) conduit complicated by infantile spasms. After ACTH therapy, acute circulatory failure developed due to severe stenosis of the RV- PA conduit following myocardial hypertrophy. With extracorporeal...
Article
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Background: We examined risk factors for development of ventricular tachycardia (VT) in pediatric patients with ventricular premature contractions (VPCs) and a structurally normal heart. Methods: The subjects were 81 844 first graders and 88 244 seventh graders of Kagoshima City School-based cardiovascular screening (SCV-screening) between 2001...
Article
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Background Acute kidney injury (AKI) after cardiac surgery (CS-AKI) in children with congenital heart disease is a serious complication closely associated with high morbidity and mortality. Kidney Disease: Improving Global Outcomes (KDIGO) AKI staging demonstrates high sensitivity for detecting AKI and predicting associated in-hospital mortality. H...
Article
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Background: While the prevalence of short QT syndrome (SQTS) in children and adolescents is low, early detection is important because SQTS can cause life-threatening arrhythmia. The aim of this study was to determine the tentative screening criteria for short QT interval in children and adolescents.Methods and Results:A total of 75,040 digitally s...
Article
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A 14-year-old boy was diagnosed with an anomalous left coronary artery coursing between the ascending aorta and the main pulmonary artery and associated with a single coronary ostium. Owing to the high risk of sudden cardiac death, surgery was performed although he was asymptomatic with no sign of myocardial ischemia. Reimplantation of an anomalous...
Article
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Aim: We aimed to validate the incidence of, risk factors for, and postoperative outcomes of acute kidney injury (AKI) according to the modified Kidney Disease Improving Global Outcomes (m-KDIGO) criteria and compare this criteria with both the pediatric Risk, Injury, Failure, Loss, End-stage disease (pRIFLE) and Acute Kidney Injury Network (AKIN)...
Article
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Disruption of endothelial cell homeostasis may be associated with the pathogenesis of coronary artery abnormalities (CAA) in Kawasaki disease (KD). We sought to clarify the poorly understood pathogenic role of endothelial cell survival and death in KD vasculitis. Human umbilical vein endothelial cells (HUVECs) stimulated with sera from KD patients,...
Article
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This study aimed to evaluate adverse cardiac events using dexmedetomidine in infants with trisomy 21 and those without (controls) and examined potential risk factors in infants after cardiovascular surgery. We conducted a single-center retrospective cohort study. The medical records of 124 consecutive infants who had undergone cardiovascular surger...
Article
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Purpose: Few studies are available on withdrawal seizures about dexmedetomidine (DEX). Thus, we retrospectively evaluated the incidence of withdrawal seizures after discontinuation of DEX and examined potential risk factors in infants after cardiovascular surgery. Methods: The medical records of 142 infants who had undergone cardiovascular surge...
Article
Objective: Circulating platelet-neutrophil aggregates play a crucial role in amplifying acute inflammation and could promote adverse effects involving vascular injury. The aim of this study was to clarify the role of platelet-neutrophil aggregates in patients with Kawasaki disease (KD). Methods: We analyzed 40 patients with KD (30 intravenous immun...
Article
Vascular permeability is one of the characteristics of vasculitis in Kawasaki disease (KD) and is closely related to indurative edema. Evaluating indurative edema may be useful for estimating the severity of KD. Indurative edema is correlated with resistance values in the limbs. Therefore, we evaluated the efficacy of resistance values in the limbs...
Article
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Circulating platelet-neutrophil aggregates play a crucial role in amplifying acute inflammation and could promote adverse effects involving vascular injury. The aim of this study was to evaluate the role of platelet-neutrophil aggregates in Kawasaki disease (KD).Methods and Results:Forty patients with KD (30 intravenous immunoglobulin [IVIG] respon...
Article
Background: Low levels of serum immunoglobulin G (IgG) before intravenous immunoglobulin (IVIG) therapy for Kawasaki disease (KD) have been reported as one of the risk factors for coronary artery abnormalities (CAAs). This risk factor needs to be re-evaluated because the dosage of IVIG has changed from 0.2-0.4 g/kg/day for 5 days to a single high...
Article
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Chromosomal abnormalities involving 19p13.3 have rarely been described in the published literature. Here, we report on a girl with a pure terminal duplication of 6.1 Mb on 19p13.3, caused by an unbalanced translocation der(19)t(10;19)(qter;p13.3)dn. Her phenotype included severe psychomotor developmental delay, skeletal malformations, and a distinc...
Article
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We present a case of a 9-year-old boy with nemaline myopathy and dilated cardiomyopathy. The combination of nemaline myopathy and cardiomyopathy is rare, and this is the first reported case of dilated cardiomyopathy associated with childhood-onset nemaline myopathy. A novel mutation, p.W358C, in ACTA1 was detected in this patient. An unusual featur...
Article
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Transcatheter closure of atrial septal defects (ASDs) has become an alternative to open surgical procedures. The Amplatzer septal occluder (ASO) has been approved since 2005 in Japan, but there are still many concerns about adverse events, and information about outcomes and complications is limited. The objective of this study was to assess the imm...
Article
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抄録 感染を契機に蛋白漏出性胃腸症(protein-losing enteropathy:PLE)を発症し, その主因が心原性と判断できない症例で, 病態と治療について, 血清サイトカイン測定, flow cytometry(FCM)を用いた免疫学的検査, および病変部周囲の組織生検を行い検討した. 症例は6歳男児で無脾症, 房室中隔欠損(左室低形成)の診断でフォンタン術が施行された. フォンタン術後2年でPLEを発症し, 血清アルブミン(Alb)値は2.0~2.5 g/dlで推移し, 各種の治療に抵抗性であった. FCMでリンパ球減少, CD4陽性T細胞の著明な減少(CD4/CD8比 0.14)を認めた. 治療経過中の病理組織像では慢性腸炎の組織像を呈しており, 炎症細胞の浸潤を認め, 軽...
Article
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抄録 背景:川崎病急性期の治療は2g/kgの免疫グロブリン静注 (intravenous immunoglobulin;IVIG) 療法が推奨されているが, 体重の大きい症例ではIVIG量が多くなり単回投与に躊躇する場合もある. 本研究の目的は, 体重の大きい川崎病患児の特徴やIVIG量とその効果を調査し検討することである. 対象および方法:体重25kg以上の川崎病患児 (25KD) 13例と体重15kg未満の川崎病患児 (15KD) 326例の臨床検査値や治療およびその効果について比較した. 結果:25KDの年齢は8±2歳, 体重は30±6kg (25~44) であった. 25KDは15KDと比較して好中球の割合およびCRP値が有意に高値で, 血小板数は有意に低値, 群馬スコアは有意に高点...
Article
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Background: Electrocardiographic and molecular studies have clarified an association between sudden infant death syndrome (SIDS) and long QT syndrome (LQTS), and few data are available for the QT interval in infancy from birth to 1 year of age. Appropriate time of electrocardiographic screening is not clarified. Medical examinations during infancy...
Article
We measured serum procalcitonin concentrations in 160 patients suffering from Kawasaki disease. Serum procalcitonin was significantly higher in nonresponders to an initial intravenous immunoglobulin treatment than in responders. A cutoff value of procalcitonin (0.5 ng/mL) for nonresponders showed that the sensitivity was 85% and the accuracy was 64...
Article
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A diagnosis of Kawasaki disease (KD) is established using six principal symptoms. Because the principal symptoms are deeply connected with KD, it is thus important to investigate the usefulness of the principal symptoms for evaluating the disease severity of KD. Patients with definite KD or suspicion of KD were retrospectively examined. Blood test...
Article
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Neutropenia associated with Kawasaki Syndrome (KS) has been rarely reported, and the detailed mechanisms responsible for this state are not yet elucidated. The aim of this study was to clarify the mechanisms of neutropenia in KS. We examined antibodies to known neutrophil antigens (HNA1a, HNA1b, HNA null, HNA2, HNA3, HNA4 and non-HLA antigen 9a) in...
Article
Full-text available
Kawasaki syndrome (KS) is an acute febrile illness with systemic vasculitis, which may cause coronary artery abnormalities (CAA). Laboratory findings show an increased white blood cell (WBC) count, a shift to the left with segmented neutrophils and increased C-reactive protein (CRP) levels in the acute phase of the disease. Pathological histology a...
Article
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To examine the characteristics of patients with Kawasaki disease (KD) presenting with only fever and cervical lymphadenopathy at admission. The laboratory and clinical findings of patients with definite KD presenting with only fever and cervical lymphadenopathy at admission (KDiL) were compared with those of all other patients with KD. Sixteen pati...
Article
Full-text available
Kawasaki disease (KD) is an acute febrile vasculitis in childhood. Currently, treatment with 2 g/kg of intravenous immunoglobulin (IVIG) is recommended. Previously we had encountered a patient with KD who showed persistent fever and a severe eruption after IVIG treatment. Using a drug-induced lymphocyte stimulation test (DLST), he was positive for...
Article
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Despite the effectiveness of the Hib vaccine, multiple amplification of the capb locus contributes to vaccine failure. However, there has been no report on the effect of Hib locus amplification in Japan. We examined 24 Hib strains from Japanese children with invasive diseases due to Hib. Although all strains showed the same capb sequence, Southern...
Article
Full-text available
Kawasaki syndrome (KS) is an acute febrile vasculitis of childhood. Coronary artery abnormalities (CAA) are a significant problem in KS patients. High dose intravenous immunoglobulin (IVIG) is effective for reducing the occurrence of CAA. Clinical and histopathological findings suggest that vascular endothelial growth factor (VEGF) is involved in C...
Article
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We examined the serum values of high mobility group box 1 (HMGB1) in 36 patients with Kawasaki syndrome (KS) (29 responders and 7 poor-responders to initial intravenous immunoglobulin treatment). A mean value of HMGB1 of poor-responders was significantly elevated compared with those of responders (P = 0.0042). Among the 6 factors showing significan...

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