Kenneth Sung Lai Yuen

• University of Hong Kong
• Researcher at Universitätsmedizin der Johannes Gutenberg-Universität Mainz

Depressed patients are advised by clinicians to avoid making critical life decisions because their decision-making process might be influenced by their pathological mood states. In order to provide empirical support for this practice, we examined the influence of different mood states on risk-taking tendencies that govern one's decision during crit...

Directed forgetting (DF) is considered an adaptive mechanism to cope with unwanted memories. Understanding it is crucial to develop treatments for disorders in which thought control is an issue. With an item-method DF paradigm in an auditory form, the underlying neurocognitive processes that support auditory DF were investigated. Subjects were aske...

Motivated by the recent replicability crisis we tested replicability of functional magnetic resonance imaging (fMRI) group activations in two independent samples. An identical behavioral and fMRI test battery for the longitudinal investigation of stress resilience mechanisms was developed for the Mainz Resilience Project (MARP) and conducted in a d...

Data analysis workflows in many scientific domains have become increasingly complex and flexible. To assess the impact of this flexibility on functional magnetic resonance imaging (fMRI) results, the same dataset was independently analyzed by 70 teams, testing nine ex-ante hypotheses. The flexibility of analytic approaches is exemplified by the fac...

Background: While the presence of cognitive performance deficits in bipolar disorder I (BD-I) is well established, there is no consensus about which cognitive abilities are affected. Heterogeneous phenotypes displayed in BD-I further suggest the existence of subgroups among the disorder. The present study sought to identify different cognitive pro...

Background Up to 30% of pregnant individuals experience high levels of stress. At the same time, 15-20% of new mothers develop postpartum depression, and 25-35% experience postpartum anxiety. Mobile applications have the potential to provide an accessible, scalable solution to these mental health challenges. However, previous evidence indicates tha...

The elucidation of the functional neuroanatomy of human fear, or threat, extinction has started in the 2000s by a series of enthusiastically greeted functional magnetic resonance imaging (fMRI) studies that were able to translate findings from rodent research about an involvement of the ventromedial prefrontal cortex (vmPFC) and the hippocampus in...

Background Up to 30% of pregnant individuals experience high levels of stress. At the same time, 15-20% of new mothers develop postpartum depression, and 25-35% experience postpartum anxiety. Mobile applications have the potential to provide an accessible, scalable solution to these mental health challenges. However, previous evidence indicates tha...

Background Up to 30% of pregnant individuals experience high levels of stress. At the same time, 15-20% of new mothers develop postpartum depression, and 25-35% experience postpartum anxiety. Mobile applications have the potential to provide an accessible, scalable solution to these mental health challenges. However, previous evidence indicates tha...

Perceived control is a key mechanism implicated in stress resilience. A tendency to perceive control over stressors may protect individuals against negative outcomes across various situations by increasing active coping and preventing exacerbated stress reactions. Assuming that individual differences in perceived control during an uncontrollable st...

Background: Stress-related disorders present a significant global burden. There is great need for effective, preventive measures. Mobile just-in-time adaptive interventions (JITAI) have the potential to be applied in real time and context-specifically, precisely when individuals need them most. However, they have not been widely implemented in the...

This study investigates the role of positive cognitive reappraisal (PCR) flexibility and variability in mental health in response to real-life stressors among college students. We employed ecological momentary assessment and intervention through ReApp, a mobile app designed to train and promote PCR. We analyzed data from the intervention groups acr...

Stress resilience is the maintenance of mental health despite adversity. We have predicted that a tendency to appraise stressors in a realistic to slightly unrealistically positive fashion (positive appraisal style, PAS) is prospectively associated with more resilient outcomes; that PAS is a proximal and integrative resilience factor, mediating the...

Objective Digital mental health interventions delivered via smartphone-based apps effectively treat various conditions; however, optimizing their efficacy while minimizing participant burden remains a key challenge. In this study, we investigated the potential benefits of a burst delivery design (i.e. interventions delivered only in pre-defined tim...

Appraisal refers to the evaluation of stimuli or situations with respect to an individual’s goals and needs. Stimuli or situations that are appraised as a threat to one’ goals and needs (‘stressors’) induce stress responses (‘stress’). Stressor appraisal occurs on various dimensions, of which the magnitude or cost of a potential adverse outcome, th...

Robust reward sensitivity may help preserve mental well‐being in the face of adversity and has been proposed as a key stress resilience factor. Here, we present a mobile health application, “Imager,” which targets reward sensitivity by training individuals to create mental images of future rewarding experiences. We conducted a two‐arm randomized co...

Background Cross-sectional relationships between psychosocial resilience factors (RFs) and resilience, operationalized as the outcome of low mental health reactivity to stressor exposure (low “stressor reactivity” [SR]), were reported during the first wave of the COVID-19 pandemic in 2020. Objective Extending these findings, we here examined prosp...

Objective: Digital mental health interventions delivered via smartphone-based apps effectively treat various conditions, but optimizing their efficacy while minimizing participant burden remains a key challenge. Here, we investigated the potential benefits of a burst delivery design, i.e., intervention delivered only in pre-defined time intervals,...

Background Stress-related disorders such as anxiety and depression are highly prevalent and cause a tremendous burden for affected individuals and society. In order to improve prevention strategies, knowledge regarding resilience mechanisms and ways to boost them is highly needed. In the Dynamic Modelling of Resilience – interventional multicenter...

Background: Stress-related mental disorders are highly prevalent and pose a substantial burden on individuals and society. Improving strategies for the prevention and treatment of mental disorders requires a better understanding of their risk and resilience factors. This multicenter study aims to contribute to this endeavor by investigating psychol...

BACKGROUND Cross-sectional relationships between psychosocial resilience factors (RFs) and resilience, operationalized as the outcome of low mental health reactivity to stressor exposure (low “stressor reactivity” [SR]), were reported during the first wave of the COVID-19 pandemic in 2020. OBJECTIVE Extending these findings, we here examined prosp...

Greater cortical gyrification (GY) is linked with enhanced cognitive abilities and is also negatively related to cortical thickness (CT). Individuals who are congenitally blind (CB) exhibits remarkable functional brain plasticity which enables them to perform certain non-visual and cognitive tasks with supranormal abilities. For instance, extensive...

The obesity epidemic has crossed social-demographic barriers and is a matter of significant concern. Why do individuals fail to restrain from eating high-calorie foods and fail to follow treatment routines that reduce the risk of health complications? These questions have been addressed through behavioral and brain imaging studies on prefrontal cor...

Intentional forgetting (IF) is an important adaptive mechanism necessary for correct memory functioning, optimal psychological wellbeing, and appropriate daily performance. Due to its complexity, the neuropsychological processes that give birth to successful intentional forgetting are not yet clearly known. In this study, we used two different meta...

BACKGROUND Stress-related mental disorders are highly prevalent and pose a significant burden on individuals and society. Improving strategies of their treatment and prevention requires knowledge about risk and resilience. This multi-center study aims to contribute to this endeavor by investigating psychological resilience in healthy, but vulnerabl...

Background Stress-related mental disorders are highly prevalent and pose a substantial burden on individuals and society. Improving strategies for the prevention and treatment of mental disorders requires a better understanding of their risk and resilience factors. This multicenter study aims to contribute to this endeavor by investigating psycholo...

Recently, cross-sectional relationships between psycho-social resilience factors (RFs) and resilience, operationalized as an outcome of low reactivity of mental health to stressor exposure (low ‘stressor reactivity’) during the first wave of the COVID-19 pandemic, were reported. Extending these findings, we here examine prospective relationships an...

Recently, cross-sectional relationships between psycho-social resilience factors (RFs) and resilience, operationalized as an outcome of low reactivity of mental health to stressor exposure (low ‘stressor reactivity’) during the first wave of the COVID-19 pandemic, were reported. Extending these findings, we here examine prospective relationships an...

Deep learning approaches can uncover complex patterns in data. In particular, variational autoencoders achieve this by a non-linear mapping of data into a low-dimensional latent space. Motivated by an application to psychological resilience in the Mainz Resilience Project, which features intermittent longitudinal measurements of stressors and menta...

Introduction: Robust sensitivity to reward may help preserve positive emotions in the face of adversity and has been proposed as a key resilience factor. We describe the development, feasibility, and efficacy of an mHealth application, Imager, which targets reward sensitivity by training individuals to create mental images of future rewarding exper...

Stress-related mental disorders are highly prevalent and pose a significant burden on individuals and society. Improving strategies of their treatment and prevention requires knowledge about risk and resilience. This multi-center study aims to contribute to this endeavor by investigating psychological resilience in healthy, but vulnerable young adu...

Synaesthesia is a condition in which one sensory dimension triggers another sensation. The exact contribution of genetic and environmental factors in synaesthesia is not yet fully understood. Most synaesthesia phenotypes involve associations in which the synaesthetic inducer constitutes some form of linguistic/conceptual information acquired during...

Background Popular protests have broken out in worldwide, particularly in the last few years. In 2019, numerous demonstrations against an extradition bill occurred in Hong Kong until pandemic restrictions were imposed. The policing response relied heavily on methods such as batons, tear gas and rubber bullets. Given the relevance for other geograph...

Background In a recent cross-sectional study, we highlighted psychosocial resilience factors associated with good mental health during the first COVID-19-lockdown. However, dynamic concepts of resilience suggest that people’s response to adversity can change over time. To better understand the emergence of resilience, we here examined individual dy...

Resilience has been defined as the maintenance or quick recovery of mental health during and after times of adversity. How to operationalize resilience and to determine the factors and processes that lead to good long-term mental health outcomes in stressor-exposed individuals is a matter of ongoing debate and of critical importance for the advance...

Background: Popular protests have broken out in worldwide, particularly in the last few years. In 2019, numerous demonstrations against an extradition bill occurred in Hong Kong until pandemic restrictions were imposed. The policing response relied heavily on methods such as batons, tear gas and rubber bullets. Given the relevance for other geograp...

Abstract The SARS-CoV-2 pandemic is not only a threat to physical health but is also having severe impacts on mental health. Although increases in stress-related symptomatology and other adverse psycho-social outcomes, as well as their most important risk factors have been described, hardly anything is known about potential protective factors. Resi...

Animal studies have shown that the prediction error (PE) signal that drives fear extinction learning is encoded by phasic activity of midbrain dopamine (DA) neurons. Thus, the extinction PE resembles the appetitive PE that drives reward learning. In humans, fear extinction learning is less well understood. Using computational neuroimaging, a previo...

The SARS-CoV-2 pandemic is not only a threat to physical health but is also having severe impacts on mental health. While increases in stress-related symptomatology and other adverse psycho-social outcomes as well as their most important risk factors have been described, hardly anything is known about potential protective factors. Resilience refers...

Hintergrund: Die SARS-CoV-2-Pandemie bringt Belastungen durch Überforderung des Gesundheitssystems, Lockdown der Wirtschaft, Kontakt-und Ausgangsbeschränkungen sowie Quarantänemaßnahmen mit sich. Diese Arbeit gibt einen Überblick über psychische Belastungen in der gegenwärtigen Pandemie und identifiziert protektive und Risikofaktoren. Methode: Ei...

Deep learning approaches can uncover complex patterns in data. In particular, variational autoencoders (VAEs) achieve this by a non-linear mapping of data into a low-dimensional latent space. Motivated by an application to psychological resilience in the Mainz Resilience Project (MARP), which features intermittent longitudinal measurements of stres...

Data analysis workflows in many scientific domains have become increasingly complex and flexible. Here we assess the effect of this flexibility on the results of functional magnetic resonance imaging by asking 70 independent teams to analyse the same dataset, testing the same 9 ex-ante hypotheses¹. The flexibility of analytical approaches is exempl...

Background The current Corona pandemic is not only a threat to physical health. First data from China and Europe indicate that symptoms of anxiety and depression and perceptions of stress rise significantly as a consequence of the pandemic. There are also anecdotal reports of increased domestic violence, divorce, and suicide rates. Hence, the Coron...

Resilience has been defined as the maintenance or quick recovery of mental health during and after times of adversity. Such good longer-term mental health outcomes despite adversity presumably result from complex and dynamic processes of adaptation to stressor exposure (‘resilience processes’), which in many cases include changes in individual prop...

Dopamine dysfunction is associated with a wide range of neuropsychiatric disorders commonly treated pharmacologically or invasively. Recent studies provide evidence for a nonpharmacological and noninvasive alternative that allows similar manipulation of the dopaminergic system: transcranial direct current stimulation (tDCS). In rodents, tDCS has be...

Resilience is the maintenance or rapid recovery of mental health during and after stressor exposure. It is becoming increasingly clear that resilience results from a complex and dynamic process of adaptation to stressors involving the biological, psychological and social levels. Positive appraisal style theory of resilience (PASTOR) claims that the...

Over-learned semantic representations, such as numbers, are strongly associated with space in normal cognition, and in the phenomenon called number-space synaesthesia. In number-space synaesthesia, numbers are linked to spatial locations in an idiosyncratic way. Synaesthetes report numbers as belonging to a specific location, or feelings that a spe...

Enumeration is one of the building blocks of arithmetic and fingers are used as a counting tool in early steps. Subitizing-fast and accurate enumeration of small quantities-has been vastly studied in the visual modality, but less in the tactile modality. We explored tactile enumeration using fingers, and gray matter (GM) changes using voxel-based m...

Anxiety reduction through mere expectation of anxiolytic treatment effects (placebo anxiolysis) has enormous clinical importance. Recent behavioral and electrophysiological data suggest that placebo anxiolysis involves reduced vigilance and enhanced internalization of attention; however, the underlying neurobiological mechanisms are not yet clear....

Learning fear via the experience of contingencies between a conditioned stimulus (CS) and an aversive unconditioned stimulus (US) is often assumed to be fundamentally different from learning fear via instructions. An open question is whether fear-related brain areas respond differently to experienced CS-US contingencies than to merely instructed CS...

A horizontal mental number line (MNL) is used to describe how quantities are represented across space. In humans, the neural correlates associated with such a representation are found in different areas of the posterior parietal cortex, especially, the intraparietal sulcus (IPS). In a phenomenon known as number-space synaesthesia, individuals visua...

Diffuse inflammation in multiple sclerosis (MS) extends beyond focal lesion sites, affecting interconnected regions; however, little is known about the impact of an indi- vidual lesion affecting major white matter (WM) pathways on brain functional connectivity (FC). Here, we longitudinally assessed the effects of acute and chronic lesions on FC in...

Introduction: Historically, emotion regulation problems have been reported as a common consequence of rPFC damage. It has been proposed that the rPFC, particularly the rIFG, has a key role inhibiting prepotent reflexive actions, thus contributing to emotion regulation and self-regulation. This study is the first to directly explore this hypothesis,...

It has been 15 years since Kaplan-Solms and Solms published their Clinical Studies in Neuropsychoanalysis, where they proposed a neuroanatomy of the mental apparatus. One of their main observations was that damage to certain areas of the left PFC, particularly those related to expressive language (Broca’s area), did not generate changes in the ment...

Purpose: Phantoms are often used to assess MR system stability in multicenter studies. Postmortem brain phantoms best replicate human brain anatomy, allowing for a combined assessment of the MR system and software chain for data analysis. However, a wash-out of fixative fluid affecting T1 values and thus T1-weighted sequences such as magnetization...

This study used 3T MRI to elucidate the functional role of supplementary motor area (SMA) in relation to visuo-spatial processing. A localizer task contrasting sequential number subtraction and repetitive button pressing was used to functionally delineate non-motor sequence processing in pre-SMA, and activity in SMA-proper associated with motor seq...

Emotion plays an essential role in the perception of time such that time is perceived to “fly” when events are enjoyable, while unenjoyable moments are perceived to “drag.” Previous studies have reported a time-drag effect when participants are presented with emotional facial expressions, regardless of the emotion presented. This effect can hardly...

The beneficial effects of placebo treatments on fear and anxiety (placebo anxiolysis) are well known from clinical practice, and there is strong evidence indicating a contribution of treatment expectations to the efficacy of anxiolytic drugs. Although clinically highly relevant, the neural mechanisms underlying placebo anxiolysis are poorly underst...

The Internet provides an easily accessible way to meet certain needs. Over-reliance on it leads to problematic use, which studies show can be predicted by psychological distress. Self-determination theory proposes that we all have the basic need for autonomy, competency, and relatedness. This has been shown to explain the motivations behind problem...

Dysexecutive impairment is a common problem after brain injury, particularly after damage to lateral surface of the frontal lobes. There is a large literature describing the cognitive deficits associated to executive impairment after dorsolateral damage, however, little is known about its impact on emotional functioning. This case study describes c...

Neuroimaging biomarkers of depression have potential to aid diagnosis, identify individuals at risk and predict treatment response or course of illness. Nevertheless none have been identified so far, potentially because no single brain parameter captures the complexity of the pathophysiology of depression. Multi-voxel pattern analysis (MVPA) may ov...

This study examines how brain damage can affect the cognitive processes that support the integration of sensory input and prior knowledge during shape perception. It is based on the first detailed study of acquired ventral simultanagnosia, which was found in a patient (M.T.) with posterior occipitotemporal lesions encompassing V4 bilaterally. Despi...

Background: People with Alzheimer disease (AD) are capable of new learning when cognitive support is provided, suggesting that there is plasticity even in a degenerating brain. However, it is unclear how a cognition-focused intervention operates on a neural level. Objective: The present study examined the effects of cognitive rehabilitation (CR)...

Since the successful demonstration of “brain reading” of fMRI BOLD signals using multivoxel pattern classification (MVPA) techniques, the neuroimaging community has made vigorous attempts to exploit the technique in order to identify the signature patterns of brain activities associated with different cognitive processes or mental states. In the cu...

Functional Magnetic Resonance Imaging serves to identify networks and regions in the brain engaged in vari-ous mental activities, represented as a set of voxels in the 3D image. It is important to be able to measure how similar two selected voxel sets are. The major flaw of the currently used correlation-based and overlap-based measures is that the...

Studies on the effect of a low intensity coordination exercise on the elderly with limited mobility are sparse. This prospective study attempted to compare the effectiveness of a customized coordination exercise and a strength exercise in improving the cognitive functioning and physical mobility on the elderly. Participants from two centers for the...

Reappraisal has been defined as a conscious, deliberate change in the way an emotional stimulus is interpreted, initiated in order to change its emotion-eliciting character (Gross, 2002). Reappraisal can be used to down-regulate negative emotions, including anxiety (reviewed in Kalisch, 2009). There is currently a strong interest in identifying the...

Diverse effects of memory training were observed in the literature. One possible factor is the amount of concurrent cognitive training received during the training program. In this pilot study, we recruited 24 elderly adults with or without concurrent cognitive stimulations to attend a memory-training program. Findings suggested that elderly people...

To provide evidence regarding the clinical efficacy of cognitive rehabilitation (CR) in early-stage Alzheimer disease (AD). Single-blind randomized controlled trial comparing CR with relaxation therapy and no treatment. Outpatient, community-based setting. Sixty-nine individuals (41 women, 28 men; mean age 77.78 years, standard deviation 6.32, rang...

Research from Western countries reported that the incidence rate of dementia patients getting lost in the community ranged from 30 to 60%. It had imposed significant burden on the caregivers. In the current study, we investigated the situation on the incidents of getting lost in a densely populated as well as homogenous community environment. Two h...

To understand neural reorganization of response regulation after stroke, a 54-year-old woman with a chronic left thalamic stroke performed a task requiring decisions about the directionality of an arrow during cerebral functional magnetic resonance imaging. Her performance was compared to 13 matched healthy control subjects. Her behavioral response...

This fMRI study studied age-related differences in neural activities during response regulation. Twenty-one male participants from two age groups, a younger group and an older group (mean ages: 29.9 and 65.2 years, respectively), were scanned while performing a task with response compatibility manipulation. They were presented with a sequence of ar...

Previous research has found heroin addicts to be impulsive. This study employed functional magnetic resonance imaging technology to investigate the differences between heroin addicts and normal controls in neural activity associated with cognitive regulation of behavior. Twenty-one Chinese men participated in this study, 11 of whom were newly admit...

Memory difficulty is one of the most common complaints of older people, with or without psychiatric conditions. It is therefore of utmost important to understand how normal ageing process impacts upon prose memory so as to gain insight into ways to differentiate pathological vs normal age-related changes of the recall of prose observed among older...

To examine the effect of gender on the volume and pattern of brain activation during the viewing of alternating sets of faces depicting happy or sad expressions, 24 volunteers, 12 men and 12 women, participated in this functional magnetic resonance imaging study. The experimental stimuli were 12 photographs of Japanese adults selected from Matsumot...

Normative information on neuropsychological measures for Chinese people is scarce. This study addresses this inadequacy by providing norms on several tests, using a sample of 475 Cantonese-speaking Chinese aged from 13 to 46. Included are eight neuropsychological measures of attention, memory, and fluency, which provided an overview of some importa...