Kenneth Liegner

Kenneth Liegner
Private Practice of Medicine

About

21
Publications
5,445
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353
Citations
Introduction

Publications

Publications (21)
Article
Full-text available
A total of 71 patients with Lyme disease were identified for analysis in whom treatment with disulfiram was initiated between 15 March 2017 and 15 March 2020. Four patients were lost to follow-up, leaving 67 evaluable patients. Our retrospective review found patients to fall into a “high-dose” group (≥4 mg/kg/day) and a “low-dose” group (<4 mg/kg/d...
Article
Full-text available
Objective: Chronic Lyme disease has been a poorly defined term and often dismissed as a fictitious entity. In this paper, the International Lyme and Associated Diseases Society (ILADS) provides its evidence-based definition of chronic Lyme disease. Definition: ILADS defines chronic Lyme disease (CLD) as a multisystem illness with a wide range of sy...
Article
Full-text available
Whether Borrelia burgdorferi, the causative agent of Lyme disease, can persist for long periods in the human body has been a controversial question. The objective of this study was to see if we could find B. burgdorferi in a Lyme disease patient after a long clinical course and after long-term antibiotic treatment. Therefore, we investigated the po...
Article
Full-text available
Three patients, each of whom had required intensive open-ended antimicrobial therapy for control of the symptoms of chronic relapsing neurological Lyme disease and relapsing babesiosis, were able to discontinue treatment and remain clinically well for periods of observation of 6–23 months following the completion of a finite course of treatment sol...
Chapter
Lyme disease is a vector-borne illness rapidly advancing in response to human activities, particularly climate change. In the US alone, there are as many as 440,000 cases of commercial laboratory evidence of Lyme borreliosis (Lyme disease) and a conservatively estimated 30,000 new cases reported annually, making it one of the most common infectious...
Article
Patients with chronic Lyme disease who experience persistent cognitive deficits despite having received the recommended antibiotic treatment pose a therapeutic dilemma. This pilot study was designed to assess whether additional antibiotic therapy is beneficial. Enrolled in the study were 23 patients with complaints of persistent memory problems who...
Article
Full-text available
Differentiating neuropsychiatric Lyme disease from a primary psychiatric disorder can be a daunting task. This article describes how functional brain imaging and neuropsychological testing can be particularly valuable in helping to make diagnostic distinctions. In addition to a review of the relevance of functional imaging to neuropsychiatry in gen...
Article
Modulation of cellular immune responses by the spirochaete Borrelia burgdorferi, the bacteria that causes Lyme disease, was demonstrated. When cultured in the presence of sonicated Borrelia preparation (Bb), the mitogen- or antigen-stimulated proliferative responses of normal lymphocytes were consistently lowered. Bb caused the greatest reduction i...
Article
Erythema migrans recurred in a patient 6 months after a course of treatment with minocycline for Lyme disease. Polymerase chain reaction on heparinized peripheral blood at that time demonstrated the presence of Borrelia burgdorferi-specific DNA. The patient was seronegative by Lyme enzyme-linked immunosorbent assay but showed suspicious bands on We...
Article
Full-text available
Lyme borreliosis (Lyme disease), a tick-borne spirochetal illness, has multisystemic involvement and is rapidly increasing in certain areas of the United States. Although its neurologic manifestations are becoming increasingly well recognized, its psychiatric presentations are not well known. The first section of this paper will provide an overview...
Article
The disclosure is of a tracheostomy tube for partial insertion into the trachea of a human, for the purpose of providing an airway from outside of the human's body directly into the trachea. The tracheostomy tube of the invention provides a controlled air leak to the upper trachea, whereby the patient may speak during mechanical ventilation.
Article
PROPONENTS of laetrile claim it is beneficial and safe. Opponents point to the lack of proof of its efficacy, the delay in seeking more effective therapy its use may entail, and the risk of death or illness from cyanide poisoning resulting from its use. We report the case of a patient in whom agranulocytosis developed, apparently due to laetrile.Re...

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