Kenneth Maduabuchi Ezealisiji

Kenneth Maduabuchi Ezealisiji
University of Port Harcourt · Faculty of Pharmaceutical Sciences

M.Pharm, Ph.D Pharmaceutical Chemistry

About

60
Publications
48,931
Reads
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462
Citations
Additional affiliations
April 2011 - August 2019
University of Port Harcourt
Position
  • Lecturer
Description
  • Specialist in Drug analysis and Pharmaceutical nanotechnology as well as drug delivery.
January 2011 - November 2017
University of Port Harcourt
Position
  • Professor (Associate)

Publications

Publications (60)
Article
Full-text available
Silica nanoparticles (SiNPs) have been touted for their role in the management of non-communicable diseases. Their neuroprotective benefits against heavy metal-induced neurotoxicity remain largely unexplored. This is a comparative evaluation of the oxido-inflammatory and neurotrophic effects of Ni, Al, and Ni/Al mixture on the cerebellum of male al...
Article
Full-text available
This study evaluated nickel and aluminium-induced neurotoxicity, as a binary metal mixture. Twenty-eight male Sprague Dawley albino rats were weight-matched and divided into four groups. Group 1 (control) received deionized water. Group 2 and 3 received Aluminium (1 mg/kg) and Nickel (0.2 mg/kg) respectively, while Group 4 received Ni and Al mixtur...
Article
Full-text available
Peptic ulcer disease is a lesion of the gastric or duodenal mucus membrane that causes abdominal discomfort and even death if not well treated. Most drugs used in handling this disease have side effects and are out of reach for the common man. Hence, there is need to search for a better and affordable ulcer agent from medicinal plants. The study wa...
Article
Full-text available
The recent antimicrobial resistant to the present antibacterial agents has been the biggest problem in the treatment of antimicrobial infection. Over the years, various strategies has been implemented to overcome the resistance the resistance to the available antibiotic agents. In regards to this, phytochemical found in plants like Allium cepa, whi...
Article
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The use of herbal medicine has achieved global success as an ethno-medicine, yet there are lots of drawbacks in their commercial value and wide acceptance due to poor regulation and standardization. Present study aims to chemo-metrically characterize the phyto-chemical principles present in the n-hexane seed extracts of Xylopia aethiopica using chr...
Article
Full-text available
In the quest to effectively diagnose and treat the diseases that afflict mankind, the development of a tool capable of simultaneous detection and treatment would provide a significant cornerstone for the survival and control of these diseases. Theranostics denotes a portmanteau of therapeutics and diagnostics which simultaneously detect and treat a...
Article
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The use of chemicals, surfactants, and polymers in improving the property of drilling fluid and enhancing the effectiveness of drilling process and in tertiary oil recovery is costly and ineffective in handling the challenges. Metal and metal oxide nanoparticles (MMO NPs) have gotten attention in recent time on their use in oil drilling processes....
Article
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Objective: Metal based nanomaterials has been implicated in the treatment and healing of antibiotic-resistant bacteria infected wounds such as found in patients with tuberculosis, human immunodeficiency virus (HIV) and diabetes. Current research investigates the wound healing potentiation of green synthesized silver nanoparticles in the presence of...
Article
Full-text available
Metal and metal oxide nanoparticles (MMO NPs) are excellent antimicrobials, anti-biofilm and possess quorum sense quenching and inhibition property. The biocides used to control biocorrosion are expensive, release unwanted by-products into the environment and in most cases not effective against established biofilm. MMO NPs are ecofriendly, less exp...
Article
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Since time immemorial, man utilized herbs for their medicinal and nutritive value. Traditionally, the stem bark extract of Pterocarpus mildbraedii are used in the treatment of Malaria and digestive disorder in some West African countries including Nigeria. They are believed to possess anti-inflammatory and antioxidant as well as anti-microbial prop...
Article
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Background: Foodborne diseases (FBD) caused by resistant pathogens are a global public health problem. One main driver of the increasing FBD incidence is the transfer of pathogenic organisms from animal guts to carcasses during processing and subsequent transfer from meat products to consumers. Methods: In this study, meat samples from abattoirs...
Article
Full-text available
Newbouldia leavis is a shrub found around Nigeria. It is known as fertility plant. This study covers the phyto-chemical evaluation and GC-MS analysis of the methanolic extract of the leaves of Newbouldia leavis. Quantitative phytochemical screening was done using various standard laboratory methods. The result obtained from the phytochemical screen...
Article
Full-text available
Abstract: Background and Objective: Antimicrobial resistance is one of the biggest threats to world health, food security and development. Generally, infections-such as pneumonia, tuberculosis, gonorrhoea and salmonellosis-are becoming harder to treat as the drugs used to treat them become less efficacious. Present research was designed to investig...
Article
Full-text available
The use of Copper oxide nanoparticles (CuONPs) in a wide range of applications such as Optical sensors, Catalytic, Electronics, Superconductors and Biomedical field have attracted lots of interest in recent time [1-6]. The importance of Copper oxide nanoparticles in biomedical fields has also gained significant attention and these include their use...
Article
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Current study reports a simple and one-pot synthesis of zinc oxide nanoparticles (ZnONPs) using an aqueous extract of Solanum torvum and evaluation of its toxicological profile (0.5% w/w and 1.0% w/w) in Wistar albino rats with respect to the biochemical index. The nanoparticles were characterized using ultraviolet–visible spectroscopy, transmissio...
Article
Full-text available
Western dietary lifestyle has gained lots of attention globally with high level of patronage hence generating human health concern. This calls for dietary balance and supplementation with vegetables, fish and nuts which are known to contain Omega-3, Omega-6 and Omega-9 fatty acids. Plant based oils such as Walnut (Tetracarpidium conophorum), are kn...
Article
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Evaluation of antimicrobial and anti-inflammatory properties of leaf extracts of Crateva religiosa
Article
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Penetration enhancers are usually surfactants, and co-surfactants added to dermatological applications (creams) to solubilize lipophilic active principles. They have the potential to alter the lipid integrity within the stratum corneum. Transdermal preparations such as antibiotics are now gaining a lot of interest. The present study evaluates the e...
Article
Full-text available
Present study was aimed at the bio-synthesis and characterization of silver nanoparticles (AgNPs) using bacterial cell free lysate of Bacillus specie isolated from iron-rust contaminated soil sample from the Niger Delta region of Nigeria. This method was cost effective, eco-friendly and an alternative to chemical synthesis which is hazardous and re...
Article
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Azithromycin an antibiotic drug has a half-life of 50-60 hours and a bioavailability of 37-42 %, it undergoes appreciable first pass metabolism, has very poor aqueous solubility with an expected poor skin permeability. The aim of present work was to evaluate the effect of permeability enhancers: Tween 80, Tween 20, Sodium lauryl sulphate, propylene...
Article
Full-text available
Skin permeability of drugs determines the rate and extent these agents cross the tissue and be absorbed into the systemic circulation to reach their sites of action. Praziquantel, is clinically used for the treatment of all types of schistosomiasis. Drug delivery through the skin has become a good alternative to oral or parenteral route of drug adm...
Article
Full-text available
Methanol extracts of the leaf, stem and root barks of Chrysophyllum albidum were analyzed for their total polyphenol contents, flavonoids concentration and in vitro antioxidant activity using ultraviolet (UV) spectrophotometric analysis of the gallic acid equivalent (GAE), quercetin equivalent (QE), and 1,1-diphenyl-2-picrylhydrazyl (DPPH) reductio...
Article
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High rate of both adult and child mortality from waste related diseases have increased tremendously over the past five decades. Soil samples were taken from three different waste dump sites in Port Harcourt and analysed for the presence of viable bacteria as follows: rustingmetal contaminated soil, municipal waste dump soil and mechanic workshop/en...
Article
Full-text available
The aim of this study was to isolate and evaluate the antimicrobial constituent of the leaves of Pterocarpus santalinoides DC (Fabaceae) growing in the tropical rain forest region of Nigeria, Sub Saharan Africa. The powdered leaf materials were defatted with n-hexane and extracted in a soxhlet extractor with 90.0 % methanol. The methanol extract wa...
Article
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Remarkable alteration in bio – therapeutic toxicity may occur as a result of physicochemical deterioration of active pharmaceutical ingredients or drugs hence the need for drug stability studies. The aim of this research was to investigate the stability of mirtazapine in nano-emulsion and to establish the shelf life of mirtazapine in the formulatio...
Article
Full-text available
Multiple Intravenous drug administered in one route cannot be avoided in critical care as the need for various drug is higher than the amount of venous access, therefore this study is aimed at assessing the physicochemical compatibility and stability of fluconazole in infusion fluids over time. Two different brands of fluconazole infusion were reco...
Article
Full-text available
Although the African herbal medicine have achieved unequivocal success as an ethno medicine yet they suffer many setbacks in their commercial value and global acceptance as a result of poor regulation and standardization. This study aims to characterize the phyto- chemical constituents present in the n-hexane and dichloromethane leaf extracts of Te...
Article
Full-text available
ABSTRACT The aim of this study was to carry out a spectrophotometric and other pharmaceutical quality evaluation of different brands of azithromycin dihydrate tablets and capsules from Nigerian markets and to predict their bioequivalence using in vitro dissolution tests. The evaluation was done by carrying out tests such as weight uniformity, friab...
Article
Full-text available
INTRODUCTION Generally, pharmaceutical dosage forms, such as tablets, with same drug content may not give the same therapeutic response as the differences of formulation additives in the tablets, physical form of the drug and variation in manufacturing process might give rise to variation in the observed dissolution profile and therapeutic effect i...
Article
Full-text available
In recent time, various phytosynthetic methods have been employed for the fabrication of silver nanoparticles; these unique metal nanoparticles are used in several applications which include pharmaceuticals and material engineering. The current research reports a rapid and simple synthetic partway for silver nanoparticles (AgNPs) using root bark aq...
Article
Full-text available
Oxidative processes can compromise the immune system. The problem posed by oxidative processes is quite challenging in the field of internal medicine and oncology. This study was aimed at evaluating the phytochemical and in vitro antioxidant activity of different parts of Annona muricata. Methanol extracts of the leaves, root, root bark, and stem b...
Article
Full-text available
The in vitro study of skin permeability plays a vital role in the selection of candidates for the development of transdermal dosage forms. In this work, mirtazapine nanoemulsions were developed, characterized and the pharmacokinetics were studied. Nanoemulsions were prepared using the spontaneous emulsification mechanism. Surfactant (sodium lauryl...
Article
Full-text available
Although the African herbal medicine have achieved unequivocal success as an ethno medicine yet they suffer many setbacks in their commercial value and global acceptance as a result of poor regulation and standardization. This study aims to characterize the phyto-chemical constituents present in the n-hexane and dichloromethane leaf extracts of Ter...
Article
Full-text available
This work assesses the stability and quality of Ciprofloxacin hydrochloride tablets after subjection to accelerated stability conditions of sunlight, temperature of 40±10C, 75% relative humidity, and UV light of 365 nm for 4 hours each day. This study was performed at time zero and at 4-day intervals for a period of 45 days (that is, days 0, 4, 8,...
Article
Full-text available
The use of African walnut, Tetracarpidium conophorum had been in existence for time immemorial among the West African coastal region and sub-saharan Africa. Ethno-medicinal uses of the above nut include remedy for stomach ache, sperm boost as well as treatment of bacterial infection. The aim of the study was to chemo-metrically profile the bio acti...
Article
Full-text available
Background: Although hand sanitizers have been proven to be as effective as soap and water in reducing bacterial load, there is still a need for more effective hand sanitizers to reduce the spread of infections. The antimicrobial potency of Pleurotus ostreatus mushroom extract formulated into an alcohol based liquid hand sanitizer was thus evaluate...
Article
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The main risk factor of atherosclerosis which is directly related to coronary heart disease is Hypercholesterolemia and this is the most common cause of death in the developing world. Ethno-medical claim on Tetracarpidum conophorum is that it is used in the treatment of hypertensive patients. Also, previous studies have shown that the seed of Tetra...
Conference Paper
Full-text available
Background: The in vitro study of skin permeability plays a vital role in the selection of candidates for the development of transdermal dosage forms. Transdermal drug delivery avoids problems associated with gastrointestinal intolerance, first-pass metabolism, inter- subject variability and drug short half-lives etc. Mirtazapine is a tetracyclic a...
Article
Full-text available
Semi-preparative High Liquid Column Chromatographic separation of the ethyl acetate soluble fraction of a methanol extract of the leaves of Loranthus micranthus Linn. parasitic on Hevea brasiliensis (Willd. ex A. Juss.) led to the isolation of two gallic acid derivatives (1-2). The structures of the compounds were solved by using spectroscopic meth...
Article
Full-text available
This study aims to evaluate the efficacyof some antacid brands as it relates to their cost effectiveness. Nineteen (19)commercially available brands of antacid formulations sold in some cities in South Nigerian Pharmacieswere evaluated using the back titration technique. The antacids were mostly white with a few colored pink and yellow. Peppermint...
Article
Full-text available
Esealisiji and Nwoke. Anti-ulcerogenic properties of fixed oil of African walnut in albino Wistar rats. ABSTRACT The anti-ulcerogenic properties of fixed oil of Tetracarpidium conophorium (Mull. Arg.) was investigated in pylorus ligated and ethanol induced model in albino Wistar rats. Parameters such as gastric volume,pH, total and free acidity, an...
Article
Full-text available
The poor aqueous solubility of drugs is a challenging problem faced by pharmaceutical scientists in drug formulation. Cosolvency and micellization techniques have been severally used to enhance the solubility of poorly aqueous soluble drugs. Mirtazapine, a tetracyclic antidepressant used for the treatment of moderate to severe depression and anxiet...
Article
Full-text available
Objective: To determine the anti-ulcer activity of methanol extract of Tetracarpidium conophorum (Mull. Arg.) (METC) nuts in albino Wistar rats. Methods: METC was investigated in pylorus ligation and ethanol induced models in experimental animals. Parameters such as gastric volume, pH, total and free acidity, and ulcer index were used as indicator...
Article
Full-text available
In vitro evaluations of five brands of Chlorpheniramine maleate marketed in Nigeria from companies designated A, B, C, D and E were carried out in order to determine the bioavailability of each brand. The uniformity, hardness, friability, disintegration time and dissolution test were conducted. The BP standard value of the deviation for weight unif...
Article
Full-text available
The leaf of Cnidoscolus aconitifolius (Euphorbiaceae) was reported to be an important food crop and medicinal plant. The aim of the current study was to characterize the bioactive constituents present in methanolic leaf extracts of C. aconitifolius which will be useful for its proper identification. Chemometric profile of methanolic leaf extract of...
Article
Full-text available
The first line drugs in the management of thromboembolic diseases in Nigeria include Urokinase and Streptokinase. These drugs come with their attendant shortcomings. The need to source for cheap and accessible alternative therapy forms the basis of this study. The fibrinolytic potentials of 10 Nigerian medicinal plants: Anona senegalensis, Buchholz...
Article
Full-text available
The African walnut is used in Nigerian folkloric medicine for the treatment of bacterial infections and ailments caused by oxidative stress. The n-hexane and methanol extracts of cooked African walnut Tetracarpidium conophorum (Mull. Arg.) were investigated to evaluate the rate of wound healing in Wistar rats. Treatment of wounds with placebo (5%,...
Article
Full-text available
Dried leaves of Crateva religiosa were extracted with methanol using a soxhlet extractor. The classes of phytocompounds present in the extract were determined and the LD50 estimated in mice intraperitoneally. The extraction gave a yield of 14.6%. Alkaloids, carbohydrates, tannins, flavonoids, resins, proteins, oils, steroids and terpenoids were pre...
Article
Full-text available
Newbouldia leavis is a shrub found around Nigeria. It is known as fertility plant. This study covers the phyto-chemical evaluation and GC-MS analysis of the methanolic extract of the leaves of Newbouldia leavis. Quantitative phytochemical screening was done using various standard laboratory methods. The result obtained from the phytochemical screen...

Questions

Questions (7)
Question
One will like to prove that an observed pharmacological activity is due to nanoparticles and not metal ions.
Question
 Characterization of drug loaded nano emulsions using photon correlation microscope with zeta sizer.

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