Ken Furudate

Ken Furudate
University of Texas MD Anderson Cancer Center | MD Anderson · Department of Leukemia

Ph.D. DMD

About

46
Publications
3,310
Reads
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392
Citations
Citations since 2016
36 Research Items
389 Citations
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
Introduction
Assistant professor, Department of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX

Publications

Publications (46)
Article
Full-text available
Isocitrate dehydrogenase 1 or 2 (IDH1 or IDH2) mutations occur frequently in newly diagnosed (ND) acute myeloid leukemia (AML) often with co‐occurring NPM1 mutations, which may influence treatment outcomes. Detailed analysis of IDH‐mutated AML treated with venetoclax and influence of co‐occurring NPM1 mutations remains unclear. This retrospective s...
Article
Full-text available
T-cell acute lymphoblastic leukemia (T-ALL) is commonly driven by activating mutations in NOTCH1 that facilitate glutamine oxidation. Here we identify oxidative phosphorylation (OxPhos) as a critical pathway for leukemia cell survival and demonstrate a direct relationship between NOTCH1, elevated OxPhos gene expression, and acquired chemoresistance...
Article
Full-text available
There is a growing body of evidence that therapy-related myeloid neoplasms (t-MNs) with driver gene mutations arise in the background of clonal hematopoiesis (CH) under the positive selective pressure of chemo- and radiation therapies (CRT). Uncovering the exposure relationships that provide selective advantage to specific CH mutations is critical...
Article
Full-text available
Recurring genetic abnormalities have been identified in Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL). Among them, IKZF1 deletion was associated with poor prognosis in patients treated with imatinib-based or dasatinib-based regimens. However, the molecular determinants for clinical outcomes in ponatinib-treated patients r...
Article
Background Venetoclax combined with intensive chemotherapy has been shown to be safe with promising activity in fit patients with newly diagnosed acute myeloid leukaemia. The aim of this study was to compare the activity of venetoclax plus intensive chemotherapy with intensive chemotherapy alone. Methods This was a post-hoc propensity score matche...
Article
Full-text available
Purpose This study aimed to evaluate the utility of inflammation-based prognostic scores (IBPS) and systemic immune-inflammation index (SII) in the treatment of oral cancer patients. Methods For the 183 patients enrolled in this study, IBPS and SII were calculated from peripheral blood samples obtained before and after treatment and at the time of...
Article
Full-text available
The role of WT1 protein in hematopoiesis and leukemogenesisis incompletely elucidated. WT1 overexpression is common in acute myeloid leukemia (AML); however, WT1 mutations occur in only about 10% of cases, with increasing incidence in the setting of relapse. In this study, we investigated the clinical and molecular characteristics of WT1 mutations...
Article
Background: Hypomethylating agents (HMA) are well established standard of care for patients (pts) with higher-risk MDS (HR-MDS). However, approximately half of the pts do not respond to HMA therapy and most of the responders eventually lose response (HMA failure). There is no standard of care for pts after HMA failure and median overall survival (O...
Article
Background: NPM1 mutations (NPM1 +) occur in ~30% of acute myeloid leukemia (AML), often with co-occurring mutations including isocitrate dehydrogenase mutations (IDH +). Previous studies suggest early acquisition and expansion of IDH1/2 mutations (IDH1 +/IDH2 +) prior to NPM1 + development increase relapse risk. Yet the clonal hierarchy of NPM1 +...
Article
Rheumatoid arthritis (RA) is associated with temporomandibular joint (TMJ) symptoms in the middle to late phases of the disease. There have been no reports of the initial development of RA in the unilateral TMJ as the only site. Here, we described a case of early RA initially developing in the unilateral TMJ as the only site. A 28-year-old woman wa...
Article
Background: TP53 mutation (TP53mut ) confers an adverse prognosis in acute myeloid leukemia (AML). Venetoclax with hypomethylating agents is a current standard for older patients; however, recent reports suggest that TP53mut confers resistance to venetoclax. The authors investigated the outcomes of patients with TP53mut AML who were treated with a...
Article
While clonal hematopoiesis (CH) can precede the development of acute myeloid leukemia (AML), it can also persist after achieving remission. Long-term clonal dynamics and clinical implications of persistent CH are not well understood. Here, we studied the prevalence, dynamics and clinical implications of post-remission CH in 164 AML patients who att...
Article
Full-text available
Allosteric inhibitors of mutant IDH1 or IDH2 induce terminal differentiation of the mutant leukemic blasts and provide durable clinical responses in approximately 40% of acute myeloid leukemia (AML) patients with the mutations. However, primary resistance and acquired resistance to the drugs are major clinical issues. To understand the molecular un...
Article
Spliceosome mutations (SRSF2, SF3B1, U2AF1, ZRSR2), are encountered in ∼50% of secondary acute myeloid leukemia cases (sAML) and define a molecular subgroup with outcomes similar to sAML in de novo AML patients treated with intensive chemotherapy. Outcomes in patients with spliceosome mutations treated with hypomethylating agents in combination wit...
Article
Clonal haematopoiesis (CH) in patients with acute myeloid leukaemia (AML) may persist beyond attaining complete remission. From a consecutive cohort of 67 patients with nucleophosmin 1-mutated (NPM1mut ) AML, we identified 50 who achieved NPM1mut clearance and had parallel multicolour flow cytometry (MFC) and next generation sequencing (NGS). In to...
Article
Full-text available
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-19902-7
Article
INTRODUCTION: NPM1 mutations (NPM1mut) occur in ∼30% of acute myeloid leukemia (AML) and frequently co-occur with mutations in other genes including those attributed to clonal hematopoiesis (CH) including DNMT3A and TET2, among others. CH mutations may persist beyond attaining NPM1mut-negative remission. Persistent CH may be associated with immunop...
Article
Introduction: Clinical outcomes of patients with Philadelphia chromosome positive (Ph+) B-ALL have been significantly improved with the addition of tyrosine kinase inhibitors (TKIs). The treatments with a TKI alone or a TKI with chemotherapy result in morphological complete response in nearly all patients with Ph+ B-ALL. However, persistence of mea...
Conference Paper
The inferior cure rate of T-cell acute lymphoblastic leukemia (T-ALL) is associated with inherent drug resistance. The activating NOTCH1 gene mutations have been reported to cause chemoresistance at the stem cell level1. Direct NOTCH1 inhibition has failed in clinical trials due to a narrow therapeutic window but targeting key oncogenic and metabol...
Preprint
Allosteric inhibitors of mutant IDH1 or IDH2 induce terminal differentiation of the mutant leukemic blasts and provide durable clinical responses in approximately 40% of acute myeloid leukemia (AML) patients with the mutations. However, primary resistance and acquired resistance to the drugs are major clinical issues. To understand the molecular un...
Article
Full-text available
Clonal diversity is a consequence of cancer cell evolution driven by Darwinian selection. Precise characterization of clonal architecture is essential to understand the evolutionary history of tumor development and its association with treatment resistance. Here, using a single-cell DNA sequencing, we report the clonal architecture and mutational h...
Article
7529 Background: Clonal Hematopoiesis may persist following complete remission (CR) in patients with acute myeloid leukemia (AML) but does not necessarily indicate residual AML and may represent persistence of pre-leukemic stem cells. Post-remission CH identified by NGS has not been systemically studied in parallel with measurable residual disease...
Article
Purpose: Falls are a common cause of the maxillofacial fractures, and falls associated with loss of consciousness might have special characteristics. The purpose of the present study was to measure the association between the types of falls and maxillofacial injury severity. Patients and methods: The present retrospective cross-sectional study f...
Article
Numerous Cochrane Reviews (CRs) in the field of physiotherapy have been published, but their conclusiveness has not been investigated. The purpose of this study was to provide an overview and describe the conclusiveness of evidence from CRs regarding physiotherapy. We conducted a systematic search using the Cochrane Database of Systematic Reviews i...
Article
The aim of this review was to determine the utility of home visits by occupational therapists before and after a patient is discharged from an acute care hospital. All relevant published studies were identified by searching the CENTRAL, MEDLINE, EMBASE, Occupational Therapy Systematic Evaluation of Evidence, and WHO International Clinical Trials Re...
Article
Full-text available
Essential thrombocythemia (ET) is a rare chronic myeloproliferative neoplasm that shows thrombosis and bleeding symptoms with an increase in the platelet count. JAK2 mutation is suggested to be involved in its pathogenesis. We report a case of ET with the JAK2 gene mutation that presented with postextraction bleeding. The patient was a 68-year-old...
Article
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Patients who are immunodeficient or immunosuppressed are at risk of developing a lymphoproliferative disorder (LPD). Methotrexate (MTX) is an iatrogenic cause of LPD, which in up to 50% cases occurs in extranodal sites. The occurrence of MTX-related LPD with osteonecrosis of the jaw (ONJ) has rarely been reported. However, clear diagnostic criteria...
Article
Full-text available
Patients who are immunodeficient or immunosuppressed are at risk of developing lymphoproliferative disorder (LPD). Methotrexate (MTX) is an iatrogenic cause of LPD. However, the occurrence of MTX-related LPD causing osteonecrosis of the jaw (ONJ) has rarely been reported. We report a series of three cases of MTX-related LPD in patients with longst...
Article
Here we report a case of localized AL amyloidosis of the tongue that caused discomfort and tissue mass in the mid-dorsal surface of the tongue. A 70-year-old woman became aware of discomfort and tissue mass in the mid-dorsal surface of the tongue. Biopsy of the lesion was performed in 2010, and pathological examination suggested amyloidosis. A grad...
Article
The trends and features of oral-maxillofacial trauma differ among various generations. The aim of this study was to investigate these trends and features in different age groups. Records of 690 patients who were treated for oral-maxillofacial trauma at the Department of Oral and Maxillofacial Surgery, Hirosaki University, from January 2000 to Decem...
Article
A penetrating injury by a foreign body is comparatively common in the oral and maxillofacial region. On the other hand, injury to the temporomandibular joint (TMJ) by a foreign object is very rare. The TMJ is an anatomically narrow space surrounded by hard bony processes. An unusual case of trauma with severe trismus caused by a foreign body that i...
Article
Full-text available
Tumor microenvironment is related to growth, survival, invasion, and metastasis of tumor cells. Several studies have proved that stromal fibroblasts play an important role in the tumor microenvironment to convert cancer-associated fibroblast (CAFs). Clock genes are known to regulate circadian rhythms, angiogenesis, and immunoreaction. In addition,...
Article
Upon viral infection, the cytoplasmic viral sensor retinoic acid-inducible gene-I (RIG-I) recognizes viral RNA to activate antiviral signaling to induce type I interferon (IFN). RIG-I-like receptors (RLRs) activate antiviral signaling in a tissue-specific manner. The molecular mechanism underlying antiviral signaling in the respiratory system remai...
Article
Full-text available
We experienced a case of refracture during implant treatment after open reduction of mandibular fracture followed by distraction osteogenesis. A male in his thirties who had a craniofacial fracture and fracture in the symphyseal region of the mandible was treated with osteosynthesis plates by a neurosurgeon, plastic surgeon and oral and maxillofaci...
Article
Full-text available
Oral mucositis (OM) is a painful complication of radiation therapy (RT) for head and neck cancer. OM can compromise nutrition, require opioid analgesics and hospitalization for pain control, and lead to interruption of treatment. Severe oral mucositis appears inevitable in superselective intra-arterial chemotherapy concurrent with radiotherapy (SSI...
Article
Although iron is essential in physiological processes, accumulation of iron in central nervous system is associated with various neurological diseases including Alzheimer's disease and Parkinson's disease. Innate immune reactions are involved in the pathogenesis of those diseases, but roles of iron in innate immunity are not known well. In the pres...
Article
Sjögren's syndrome (SS) is commonly observed in Japan, and oral surgeons perform lip biopsy and other examinations for definite diagnosis. Oral and maxillofacilal region are not the site of predilection for localized AL amyloidosis. In addition to that, SS related to localized AL amyloidosis is extremely rare.Here we report a rare case of SS associ...
Article
Cherubism is a rare genetic disorder and the majority of patients with cherubism are children. The aim of this study was to determine if analysis of mutations in the SH3BP2 gene using collected blood could distinguish cherubism from other similar diseases and might therefore replace the current extensive and invasive methods of diagnosis of cherubi...
Article
We report the case of a 3-month-old female infant who presented with a cystic swelling in the left side of the oral floor (i.e., a congenital ranula). Observation was initially carried out because of the patient's poor general condition. A puncture was performed twice because the ranula enlarged gradually and caused difficulty with sucking during f...
Article
Full-text available
Background. Distant metastasis is considerably more frequent in superselective intra-arterial chemoradiotherapy than other radical treatments for advanced oral cancers. However, there is no evidence supporting such claim. The purpose of this study was to report our experience in superselective intra-arterial chemoradiotherapy and conventional surgi...
Article
The CXC chemokine growth-related oncogene protein-α (GRO-α) has a wide variety of biological activities including as neutrophil trafficking or migration of vascular endothelial cells. In addition, studies have shown a crosstalk between tumor cells and vascular endothelial cells; GRO-α released by endothelial cells induces invasion of tumor cells to...

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