Kelsey Sewell

Murdoch University · School of Allied Health

Background Wide evidence suggests that physical activity (PA) confers protection against Alzheimer’s disease (AD). On the other hand, the apolipoprotein E gene (APOE) ε4 allele represents the greatest genetic risk factor for developing AD. Extensive research has been conducted to determine whether frequent PA can mitigate the increased AD risk asso...

Introduction: The current study investigated the association between objectively measured physical activity and cognition in older adults over approximately 8 years. Methods: We utilized data from 199 cognitively unimpaired individuals from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study, aged ≥60. Actigraphy was used to measure ph...

Physical inactivity is one of the greatest modifiable risk factors for dementia and research shows physical activity can delay cognitive decline in older adults. However, much of this research has used subjective physical activity data and a single follow‐up cognitive assessment. Further studies using objectively measured physical activity and comp...

Evidence suggests that physical activity (PA) confers protection against Alzheimer’s disease (AD), while the Apolipoprotein E (APOE) ε4 allele represents the greatest genetic risk factor. Extensive research has thus far failed to establish whether frequent PA can mitigate the increased AD risk associated with APOE ε4. Studies looking at various AD‐...

There is increasing evidence of a bidirectional relationship between suboptimal sleep and brain Aβ‐amyloid (Aβ) accumulation. Suboptimal sleep is suggested to both result from and contribute to the accumulation of brain Aβ. This study tested whether aspects of self‐reported sleep quality predict the longitudinal accumulation of brain Aβ. Linear mix...

Background Lifestyle factors such as physical activity and optimal sleep are associated with better cognition and lower levels of Alzheimer’s disease (AD) biomarkers, including brain beta-amyloid (Aβ) burden. Objective We utilised cross-sectional data from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study to determine whether self-repo...

Background: Wide evidence suggests that physical activity (PA) confers protection against Alzheimer’s disease (AD). On the other hand, the Apolipoprotein E gene (APOE) ε4 allele represents the greatest genetic risk factor for developing AD. Extensive research has been conducted to determine whether frequent PA can mitigate the increased AD risk ass...

Is the field of cognitive aging irretrievably concerned with decline and deficits, or is it shifting to emphasize the hope of preservation and enhancement of cognitive function in late life? A fragment of an answer comes from research attempting to understand the reasons for individual variability in the extent and rate of cognitive decline. This b...

Background Lifestyle factors such as sleep and physical activity influence risk of cognitive decline and dementia. Higher habitual physical activity and optimal sleep are associated with better cognitive function and lower levels of Alzheimer’s disease biomarkers, including beta‐amyloid (Aß). There is currently a poor understanding of how physical...

SEWELL, K.R., K. I. Erickson, S. R. Rainey-Smith, J. Peiffer, H. R. Sohrabi, and B. M. Brown. Relationships Between Physical Activity, Sleep and Cognitive Function: A Narrative Review…NEUROSCI BIOBEHAV REV 125(1) XXX-XXX, 2021. - Physical activity and exercise can improve cognitive function and reduce the risk for dementia. Other lifestyle factors,...