Kelsey Pinkham

Kelsey Pinkham
Graduate School of Systemic Neurosciences (GSN-LMU) | GSN-LMU · Biology

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17
Publications
1,154
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81
Citations

Publications

Publications (17)
Article
Full-text available
Tracking DNA double strand break (DSB) repair is paramount for the understanding and therapeutic development of various diseases including cancers. Herein, we describe a multiplexed bioluminescent repair reporter (BLRR) for non-invasive monitoring of DSB repair pathways in living cells and animals. The BLRR approach employs secreted Gaussia and Var...
Preprint
Full-text available
Tracking DNA double strand break (DSB) repair is paramount for the understanding and therapeutic development of various diseases including cancers. Herein, we describe a multiplexed bioluminescent repair reporter (BLRR) for non-invasive monitoring of DSB repair pathways in living cells and animals. The BLRR approach employs secreted Gaussia and Var...
Article
Full-text available
Abstract Glioblastoma is an incurable and highly aggressive brain tumor. Understanding therapeutic resistance and survival mechanisms driving this tumor type is key to finding effective therapies. Smac mimetics (SM) emerged as attractive cancer therapeutics particularly for tumor populations that are highly resistant to conventional apoptosis-induc...
Article
Full-text available
After publication of this article, the authors realized that the Supplementary Figure S5B had an error in it. Specifically, the labels for BIR and AXD1480 on the x-axis were in the wrong place. All text referring to the figure, including the legend, are correct and this does not impact the findings of the study. This error has not been corrected in...
Article
Full-text available
Inherent plasticity and various survival cues allow glioblastoma stem-like cells (GSCs) to survive and proliferate under intrinsic and extrinsic stress conditions. Here, we report that GSCs depend on the adaptive activation of ER stress and subsequent activation of lipogenesis and particularly stearoyl CoA desaturase (SCD1), which promotes ER homeo...
Article
Full-text available
The malignant primary brain tumor, glioblastoma (GBM) is generally incurable. New approaches are desperately needed. Adeno-associated virus (AAV) vector-mediated delivery of anti-tumor transgenes is a promising strategy, however direct injection leads to focal transgene spread in tumor and rapid tumor division dilutes out the extra-chromosomal AAV...
Article
Full-text available
Glioblastoma (GBM) is the most malignant and common form of brain tumors with high mortality and resistance to therapy. The presence of glioma stem cells (GSCs) that drive tumor growth and promote recurrence exacerbates GBM prognosis. Because of its implication in cancer, and its role in regulating several proteins with oncogenic or tumor suppresso...

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