Kelsey M Mangano

Kelsey M Mangano
University of Massachusetts Lowell | UML · Biomedical and Nutritional Sciences

PhD, RD

About

52
Publications
6,418
Reads
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1,202
Citations
Citations since 2017
29 Research Items
940 Citations
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2017201820192020202120222023050100150
Introduction
Kelsey M Mangano, PhD, RD currently works in the Department of Biomedical and Nutritional Sciences, University of Massachusetts Lowell. Her research interests include dietary protein, dairy, gut microbiome, musculoskeletal aging.
Additional affiliations
September 2015 - August 2017
University of Massachusetts Lowell
Position
  • Managing Director

Publications

Publications (52)
Article
Full-text available
Objectives We aimed to measure associations between food security status and bone mineral density (BMD) among Puerto Rican adults. Osteoporosis, which is characterized by low BMD and reduced bone strength, increases risk of fracture. Food insecurity is associated with poor dietary quality, which may be associated with poorer BMD. However, few studi...
Article
Full-text available
Objectives To examine associations between empirically derived dietary patterns and osteoporosis among Puerto Rican adults. Methods Participants from the Boston Puerto Rican Osteoporosis Study, an ancillary study to the Boston Puerto Rican Heath Study, were included if they presented with complete bone and dietary data (n = 955, mean age = 59.9 ±...
Article
Background Titanium dioxide (TiO2/E171) is used in foods primarily as a whitening agent. Little is known regarding TiO2 exposure in the U.S. Objective To quantify stool TiO2 content among U.S. adults and evaluate its association with estimated intake. Methods Adults participated in phase 1 (three, 24h dietary recalls (DR) and stool TiO2 measured...
Article
Background Vitamin C may benefit bone as an antioxidant. Objectives This cross-sectional study evaluated associations between dietary, supplemental, and plasma vitamin C with bone mineral density (BMD) among Puerto Rican adults. Methods Diet was assessed by food-frequency questionnaire (n = 902); plasma vitamin C, measured in fasting blood (n = 8...
Article
Objectives Dietary calcium and magnesium have been shown to be beneficial for bone health primarily in non-Hispanic white populations. There are no studies of calcium and magnesium intake among Hispanics of Caribbean origin. A calcium to magnesium ratio (Ca: Mg) may be important due to their competitive nature during absorption. This study examined...
Article
Objectives To evaluate the effect of daily yogurt intake on markers of inflammation and bone turnover in an 8wk RCT among Caribbean Latino adults with low-grade inflammation, at high-risk for osteoporosis (OP). Methods Eligible adults (n = 39) at-risk for OP (FRAX score) reporting <2 s/wk of yogurt intake, provided written informed consent, and pa...
Article
Objectives Engineered nanomaterials, such as titanium dioxide (TiO2/E171) are used in food primarily as a whitening agent. Over 99% ingested TiO2 passes to the gastrointestinal (GI) tract while 1% is absorbed and shown to bioaccumulate in organs and may cause adverse outcomes. At present, dietary exposure of TiO2 in the US is unknown. The objective...
Article
Objectives There is evidence to suggest that higher serum concentration of carotenoids is protective of osteoporosis, although studies have shown inconsistent findings. The majority of studies on serum carotenoids and bone have been conducted in predominantly non-Hispanic white populations. This study examined the relationship between serum total c...
Article
Background Puerto Rican adults residing in the US mainland experience a high prevalence of metabolic syndrome (MetS). A diet containing healthy protein-rich sources may help control risk factors for MetS. Objective This study aimed to evaluate 2-year longitudinal associations between intake of various protein-rich foods and changes in the six MetS...
Article
Full-text available
Research shows that higher dietary protein of up to 1.2 g/kgbodyweight/day may help prevent sarcopenia and maintain musculoskeletal health in older individuals. Achieving higher daily dietary protein levels is challenging, particularly for older adults with declining appetites and underlying health conditions. The negative impact of these limitatio...
Article
Background The impact of nutrition on the metabolic profile of osteoporosis (OS) is unknown. Objective Identify biochemical factors driving the association of fruit and vegetable (FV) intakes with OS prevalence using an untargeted metabolomics approach. Design Cross-sectional dietary, anthropometric and plasma metabolite data were examined from t...
Article
The link between poor diet and poor health is well-known. Nevertheless, 90% of Americans are not meeting current dietary guidelines, avoiding nutrient dense foods like vegetables, and opting for high-calorie foods. One of the reasons for this behavior is that healthy options are often considered less enjoyable, compared with less healthy options. A...
Article
Background Caribbean Latino adults have disproportionately high prevalence of chronic disease; however, underlying mechanisms are unknown. Unique gut microbiome profiles and relation to dietary quality may underlie health disparities. Objectives To examine the dietary quality of an underrepresented group of Caribbean Latino older adults with high...
Article
Objectives To investigate the prospective associations of DASH and MeDS with self-reported arthritis across three time points [baseline, 2y and 6y follow-up] among Puerto Rican older adults. Methods Data are from the Boston Puerto Rican Health Study, a prospective cohort of Puerto Rican adults aged 45 to 75 y. Individuals were included if they pre...
Article
Background: Conflicting results on associations between dietary quality and bone have been noted across populations, and this has been understudied in Puerto Ricans, a population at higher risk of osteoporosis than previously appreciated. Objective: To compare cross-sectional associations between 3 dietary quality indices [Dietary Approaches to...
Article
Full-text available
Few studies have examined knowledge and perceptions of osteoporosis among Caribbean Latino adults. Confusion regarding the term osteoporosis was noted. Doctors were viewed as trusted sources of health information, although descriptions of a paradoxical relationship emerged. This study can be used to inform culturally tailored interventions for oste...
Preprint
Full-text available
The impact of nutrition on the metabolic profile of osteoporosis is incompletely characterized. The objective of this cross-sectional study was to detangle the association of fruit and vegetable (FV) intakes with osteoporosis prevalence. Dietary, anthropometric and blood plasma metabolite data were examined from the Boston Puerto Rican Osteoporosis...
Article
Objectives: To analyze the impact of different sources of protein (pea, whey or casein) on functional muscle performance in C57BL/6 mice. Methods: A total of 21 mice were randomized to protein intervention groups. Mice were individually caged in a temperature controlled and 12-h light-dark cycle room. Subjects were randomly assigned to casein, w...
Article
Objectives: To examine risk factors for bone mineral density (BMD) and osteoporosis at the femoral neck (FN) and lumbar spine (LS) in a cross-sectional study among Puerto Rican adults, 47- 77 y. Methods: The Boston Puerto Rican Osteoporosis Study (BPROS) is an ancillary study to the Boston Puerto Rican Health Study, a cohort of 1504 Puerto Rican...
Chapter
Whey protein is one of the two major protein types of bovine milk, accounting for 20 percent of milk protein, while casein accounts for the remaining 80 percent. Human breast milk contains less methionine, phenylalanine, and lysine compared to bovine milk and more cysteine and tryptophan. Branched chain amino acids (BCAAs) are highly valued amino a...
Article
Full-text available
Background: Dairy foods have been shown to improve bone mineral density (BMD) in non-Hispanic whites. Puerto Rican adults have a higher prevalence of osteoporosis and vitamin D deficiency than non-Hispanic whites. However, there is little understanding of lifestyle influences on bone in this population. Objective: The aim of this study was to ex...
Article
Full-text available
PurposeThe purpose of this study was to investigate whether a treadmill endurance exercise program would reduce serum testosterone and leptin in male rats and assess the impact of increased dietary cholesterol on serum hormones. Methods Male Sprague-Dawley Rats (n = 20) were randomly assigned to a control group (C) or an exercise training group (EX...
Article
Objective: Colleges should aim to cultivate healthy behaviors among students by addressing alterations in wellness students view as important. The purpose of this study was to determine the self-perceived wellness-related concerns and behaviors of college students. Participants: Thirty-seven undergraduate students participated in this study between...
Chapter
Osteoporosis, or low bone mass, currently affects 48 million adults in the United States. Vegans may be at increased risk for developing low bone mass due to lack of adequate consumption of specific bone-benefiting nutrients found largely in animal products, such as calcium, vitamin D, protein, vitamin B12, zinc, and n-3 fatty acids. Educating the...
Article
Historically, osteoporosis has not been considered a public health priority for the Hispanic population. However, recent data indicate that Mexican Americans are at increased risk for this chronic condition. Although it is well established that there is heterogeneity in social, lifestyle, and health-related factors among Hispanic subgroups, there a...
Article
Background: Previous studies showed beneficial effects of specific dairy foods on bone health in middle-aged adults.Objective:We examined the association of milk, yogurt, cheese, cream, fluid dairy (milk + yogurt), and milk + yogurt + cheese intakes with bone mineral density (BMD) and 4-y percentage of change in BMD [▵%BMD; femoral neck, trochanter...
Article
Background: Above-average dietary protein, as a single nutrient, improves musculoskeletal health. Evaluating the link between dietary protein and musculoskeletal health from a whole-diet perspective is important, as dietary guidelines focus on dietary patterns. Objective: We examined the prospective association of novel dietary protein food cluster...
Chapter
Full-text available
This chapter will provide an overview regarding bone, osteoporosis, musculoskeletal health and dietary protein intakes in adult men and women. A background on evolving thoughts and tested hypotheses on the Acid-base theory will be presented, followed by an overview of the major scientific findings of the effect of dietary protein intake upon bone a...
Article
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Malnutrition is a significant risk factor for poor functional recovery following hip fracture. General undernutrition can be assessed using nutrition assessment screening tools. Identification of nutritionally at risk individuals may prevent complications and poor recovery following a fracture. Simple nutritional supplementation has not resulted in...
Article
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Background: Age-related decline in muscle strength is an important public health issue for older adults. Dietary protein has been associated with maintenance of muscle mass, yet its relation to muscle strength remains unclear. Methods: We determined the association of dietary protein (total, animal, and plant) intake, measured by food frequency...
Article
Full-text available
Osteoporosis is characterized by systemic impairment of bone mass, strength, and microarchitecture, resulting in increased risk for fragility fracture, disability, loss of independence, and even death. Adequate nutrition is important in achieving and maintaining optimal bone mass, as well as preventing this debilitating disease. It is widely accept...
Article
Full-text available
Dietary protein is beneficial to bone health; however, dietary patterns of protein intake and their relationship with bone mineral density (BMD) have not been evaluated. To examine the relationship of dietary protein food clusters with BMD at the femoral neck, trochanter, total femur, and lumbar spine among middle-aged and older men and women. Cros...
Article
Full-text available
The impact of dietary protein intake on lower extremity lean mass and strength in community-dwelling adult Americans is not fully understood. The objective was to determine the association between total protein (TP), animal protein (AP), and plant protein (PP) intake and lean mass of the legs and quadriceps muscle strength. We further examined whet...
Article
Full-text available
Food is always a good topic of conversation and inquiry. Humans require it, the variety of eating patterns spark personal debate, scientific measurement of dietary intakes are fraught with methodical issues, and the often changing (and inconsistent) nutrition messages in the media make for good discussion. The devil is in the detail when it comes t...
Article
Full-text available
It has been assumed that the increase in urine calcium (UCa) that accompanies an increase in dietary protein was due to increased bone resorption. However, studies using stable Ca isotopes have found that dietary protein increases Ca absorption without increasing bone resorption. To investigate the impact of a moderately-high protein diet on bone m...
Article
Full-text available
IMPORTANCEDairy foods are rich in bone beneficial nutrients, yet the role of dairy foods in hip fracture prevention remains controversial.OBJECTIVE To evaluate the association of milk, yogurt, cheese, cream and milk + yogurt intakes with incident hip fracture in the Framingham Original Cohort.DESIGN, SETTING AND PARTICIPANTS830 men and women from t...
Article
High dietary acid load (DAL) may be detrimental to bone mineral density (BMD). The objectives of the study were to: 1) evaluate the cross-sectional relation between DAL and BMD; 2) determine whether calcium intake modifies this association. Men (n = 1218) and women (n = 907) ≥60y were included from the National Health and Nutrition Examination Surv...
Article
Full-text available
Objectives: Objectives Sarcopenia, the involuntary loss of skeletal muscle with age, affects up to onequarter of older adults. Evidence indicates a positive association between dietary protein intake and lean muscle mass and strength among older persons, but information on dietary protein’s effect on physical performance in older adults has receive...
Article
To underscore recent clinical studies, which evaluate the association between dietary protein and bone health. Epidemiologic studies show greater protein intake to be beneficial to bone health in adults. In addition, randomized controlled trials show that protein's positive effect on bone health is augmented by increased calcium intake. The relatio...
Article
Soy foods contain several components, notably, isoflavones and amino acids, that may improve cardiovascular health. We evaluated the long-term effect of soy protein and/or soy isoflavones supplementation on serum lipids and inflammatory markers using a 1-year randomized, double-blind, placebo-control, clinical trial in 131 healthy ambulatory women...
Article
The relation of omega 3 fatty acids (n-3 FA) with bone mineral density (BMD) was assessed among adults >60 years; NHANES data (2005-2008). The association of dietary n-3 FA with measures of hip BMD was equivocal, but n-3 FA supplement use was significantly associated with higher spine BMD-a finding that deserves further study. Associations between...
Article
Full-text available
Age-related bone and muscle loss are major public health problems. Investigational therapies to reduce these losses include anti-inflammatory dietary supplementations, such as polyunsaturated fatty acids (PUFA). Surprisingly, this topic has received little attention in the osteoporosis community. Recent research highlights the role of PUFA in infla...
Article
Adequate lifelong calcium intake is essential in optimizing bone health. Recent National Health and Nutrition Examination Survey data were used to quantify variation in calcium intake across adult age groups and to relate age-associated changes in calcium intake with energy intake. Additional goals were to assess differences in dietary calcium inta...
Article
Full-text available
Soy foods contain several components (isoflavones and amino acids) that potentially affect bone. Few long-term, large clinical trials of soy as a means of improving bone mineral density (BMD) in late postmenopausal women have been conducted. Our goal was to evaluate the long-term effect of dietary soy protein and/or soy isoflavone consumption on sk...

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