Kelly S Swanson

Kelly S Swanson
University of Illinois, Urbana-Champaign | UIUC · Department of Animal Sciences

PhD

About

342
Publications
68,368
Reads
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10,442
Citations
Citations since 2016
128 Research Items
8074 Citations
201620172018201920202021202205001,0001,500
201620172018201920202021202205001,0001,500
201620172018201920202021202205001,0001,500
201620172018201920202021202205001,0001,500
Additional affiliations
January 2017 - present
University of Illinois, Urbana-Champaign
Position
  • Professor
August 2014 - present
University of Illinois, Urbana-Champaign
Position
  • Professor (Full)
August 2009 - August 2014
University of Illinois, Urbana-Champaign
Position
  • Professor (Associate)

Publications

Publications (342)
Article
Full-text available
In our published randomized, double-blind, placebo-controlled, 3-period crossover trial, healthy adult men (n = 21) consumed bars containing no supplemental fiber (placebo; NFC), polydextrose (21 g/d), and soluble corn fiber (SCF; 21 g/d) for 21 d each. Fecal specimens were collected between days 16 and 21 for fermentative end-product analysis and...
Article
High-throughput DNA sequencing techniques allow for the identification and characterisation of microbes and their genes (microbiome). Using these new techniques, microbial populations in several niches of the human body, including the oral and nasal cavities, skin, urogenital tract and gastrointestinal tract, have been described recently. Very litt...
Article
Full-text available
Background: Previously, we demonstrated that dietary protein:carbohydrate ratio dramatically affects the fecal microbial taxonomic structure of kittens using targeted 16S gene sequencing. The present study, using the same fecal samples, applied deep Illumina shotgun sequencing to identify the diet-associated functional potential and analyze taxono...
Article
Full-text available
Inclusion of fermentable fibres in the diet can have an impact on the hindgut microbiome and provide numerous health benefits to the host. Potato fibre (PF), a co-product of potato starch isolation, has a favourable chemical composition of pectins, resistant and digestible starch, cellulose, and hemicelluloses. The objective of the present study wa...
Article
Full-text available
Sustainable practices meet the needs of the present without compromising the ability of future generations to meet their needs. Applying these concepts to food and feed production, nutritional sustainability is the ability of a food system to provide sufficient energy and essential nutrients required to maintain good health in a population without...
Presentation
The worldwide prevalence of obesity has risen tremendously over the past four decades, and 42% of Americans now live with obesity (body mass index >30 kg/m2). Obesity is linked to a shortened lifespan and an increased risk for cardiovascular diseases, type 2 diabetes, and cancer. Current clinical strategies to treat obesity give priority to pharmac...
Article
Full-text available
Background Diet has a large influence on gut microbiota diversity and function. Although previous studies have investigated the effect of dietary interventions on the gut microbiome, longitudinal changes in the gut microbiome, microbial functions, and metabolite profiles post dietary interventions have been underexplored. How long these outcomes re...
Article
Full-text available
Feline obesity elicits a plethora of metabolic responses leading to comorbidities, with potential reversal during weight loss. The specific metabolic alterations and biomarkers of organ dysfunction are not entirely understood. Untargeted, high-throughput metabolomic technologies may allow the identification of biological components that change with...
Article
Full-text available
Kefirs are fermented beverages containing yeast and bacteria produced by the fermentation of water or milk with kefir grains. Because microorganism density may influence a product's health benefits, label accuracy regarding viable bacterial density and taxonomy of fermented foods is important. In this study, the microbiota of 5 commercial kefir pro...
Article
Full-text available
Oligosaccharides are important components of milk, serving as substrates for the intestinal microbiota, acting as antimicrobials that prevent pathogen colonization, and supporting the developing gastrointestinal immune system of neonates. Nutrient composition of canine and feline milk samples has been described previously, but little is known about...
Article
The ‘buzz’ in society around insects has resulted in the appearance of insect-based pet food products on the market and more products are under development. This contribution aimed to provide background information on pet foods and the sector and to provide an overview of the current state of knowledge regarding naturalness, palatability, nutrition...
Article
Obesity is associated with systemic inflammation due to macrophage accumulation in adipose tissue (AT). AT macrophages are, therefore, a target for therapeutics to modulate inflammation and prevent comorbidities. Because inflammatory processes have pleiotropic effects throughout the body and are intertwined with metabolic axes, systemic anti-inflam...
Article
Full-text available
When owners decide to change their pet's food, a rapid transition may cause gastrointestinal distress. Yeast products may help with digestive upset during diet transition due to the bioactive compounds they possess, which may lead to improved intestinal morphology and integrity, modified gut microbiota, and modulated immune responses. The objective...
Article
Full-text available
Background: Oral microorganisms contribute to oral health and disease, but few have studied how infant feeding methods affect their establishment. Methods: Infant (n = 12) feeding records and tongue and cheek swabs were collected within 48 h of birth, and after 2, 4, and 6 mo. DNA was extracted from samples, bacterial and fungal amplicons were gene...
Article
Full-text available
Introduction To date, there has been little effort to develop standards for metabolome-based gut microbiome measurements despite the significant efforts toward standard development for DNA-based microbiome measurements. Objectives The National Institute of Standards and Technology (NIST), The BioCollective (TBC), and the North America Branch of th...
Conference Paper
A variety of ingredients are added to pet foods to support gastrointestinal and immune health. This study was conducted to evaluate the effects of diets containing a blend of fibers, prebiotics, probiotics, and/or immune mediators on stool quality and fecal microbiota, metabolites and immune markers of adult dogs. Twelve healthy adult dogs were use...
Conference Paper
High-protein, grain-free (HPGF) extruded dog diets (>32% protein) are increasing in popularity, but few have compared the digestibilities of these diets to others. The objective of this experiment was to determine the standardized nutrient and amino acid (AA) digestibilities of commercial extruded dog foods using the precision-fed cecectomized roos...
Article
Kefir is a fermented beverage containing yeast and bacteria produced by the fermentation of water or milk with kefir grains. Lack of regulation for probiotic-containing fermented food sold for companion dogs and cats creates the potential for misreporting on viable microbial counts, taxonomy, and label claims. In this study, the microbiota of 6 com...
Article
Milk oligosaccharides (MO) confer multiple potential physiological benefits, such as the selective growth promotion of beneficial microbiota, inhibition of enteric pathogen growth and adhesion to enterocytes, maturation of the gut mucosal barrier, and modulation of the gastrointestinal immune system. This study was conducted to determine the fermen...
Article
Periodontal disease is the most common clinical condition occurring in adult dogs. The objective of this study was to evaluate the benefits of daily dental chew administration on oral health outcomes in adult dogs. Twelve adult (mean age = 5.31 ± 1.08 yr; mean BW = 13.12 ± 1.39 kg) female beagle dogs were used in a replicated 4x4 Latin square desig...
Article
Full-text available
Similar to humans, the fecal microbiome of dogs may be useful in diagnosing diseases or assessing dietary interventions. The accuracy and reproducibility of microbiome data depend on sample integrity, which can be affected by storage methods. Here, we evaluated the ability of a stabilization device to preserve canine fecal samples under various sto...
Article
Full-text available
In May 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of nutritionists, physiologists and microbiologists to review the definition and scope of synbiotics. The panel updated the definition of a synbiotic to “a mixture comprising live microorganisms and substrate(s) selectively utilized by host...
Article
Full-text available
Grain-free diets tend to have greater inclusions of pulses in contrast to grain-based diets. In 2018 the Food and Drug Administration (FDA) released a statement that grain-free diets may be related to the development of canine dilated cardiomyopathy (DCM). However, all dog foods met regulatory minimums for nutrient inclusion recommended by the Asso...
Article
Full-text available
Objectives The beneficial effects of supplementing yeast products in terms of promoting gut health have been demonstrated in several animal species. These benefits include promoting gut integrity, modulating gut microbiota, and positively affecting immune responses. With these benefits, yeast products may be a strategy to relieve clinical signs ass...
Article
Full-text available
Exercise improves the health of dogs; however, the extreme exertion experienced by sled dogs may lead to variable metabolic and fecal characteristics. Nutritional interventions, such as dietary tryptophan (Trp), may reduce the prevalence of these exercise-induced disturbances. Sporting diets tend to have high crude protein concentrations in contras...
Article
Neutering is a risk factor for pet obesity, which reduces the quality and length of life. Dietary interventions may serve as preventive and therapeutic options for pet obesity. The objective of this study was to evaluate the effects of specially formulated diets on body weight (BW), body composition, and blood hormones and metabolites of adult fema...
Conference Paper
Full-text available
Pet obesity is a growing problem, with 58% of cats and 45% of dogs classified as overweight or obese. The gut microbiome is altered in obese vs lean animals, but little research has been done in pets. The objective of this study was to identify key microbial species/strains associated with feline leanness or obesity. All experimental procedures wer...
Conference Paper
Full-text available
Periodontal disease is the most common clinical condition occurring in adult dogs and cats, but is preventable. The objective of this study was to evaluate the benefits of daily dental chew administration in adult dogs. Twelve adult (mean age = 5.2 years) female beagles were used in a replicated 4 × 4 Latin square design consisting of 28‐day period...
Article
Full-text available
This study evaluated the effects of a grain-based (GB) and grain-free (GF) diet on protein utilization and taurine status in healthy Beagle dogs. Two practical dog diets sufficient in crude protein, sulfur amino acids, and taurine content were formulated with the same ingredients with exception of the carbohydrate sources. The GB contained sorghum,...
Article
Absolute measurements of biodistribution are essential for understanding and optimizing the function of nanomaterials for in vivo diagnostic and therapeutic uses. Biodistribution analysis by optical imaging is desirable due to its low cost, wide accessibility, and high throughput nature, but it is substantially less accurate than isotopic and chemi...
Article
Full-text available
An experiment was conducted to test the hypothesis that inclusion of the direct fed microbial Clostridium butyricum in diets for weanling pigs will improve growth performance, systemic immune function, microbiota composition, and gut morphology in weaned pigs. A total of 275 newly weaned pigs (20 ± 2 d of age) with an average initial BW of 6.4 ± 0....
Article
Full-text available
For a pet diet to be labeled as human-grade, every ingredient and the finished food must be stored, handled, processed, and transported according to the current good manufacturing practices for human edible foods. Human-grade dog foods are now available and increasing in popularity, but little research has been conducted to test the digestibility o...
Conference Paper
Exposing ingredients to high temperatures may result in chemical reactions between amino acids and sugars, leading to the formation of Maillard reaction products (MRPs). These products may result in altered palatability, protein quality, and digestibility. This experiment quantified key MRPs in commercial pet foods, estimated daily intake of MRPs o...
Article
Black soldier fly larvae (BSFL) is an alternative protein source for animals, including dogs and cats. The larval diet may affect their nutrient composition and overall nutritional value. Calcium carbonate (CaCO3) and calcium chloride (CaCl2) are common Ca sources, but differ in solubility (CaCO3 is insoluble; CaCl2 is soluble), so their intestinal...
Article
Obesity is the most prevalent disease in companion animals. Feline pets have access to palatable and nutrient dense foods and often live a sedentary lifestyle leading to a positive energetic balance. Obese companion cats are more predisposed to suffer from insulin resistance and diabetes. This study examined changes in abdominal subcutaneous adipos...
Article
Full-text available
Spay and neuter surgeries are common procedures to control the pet population, but have been associated with increased risk for obesity due to changes in appetite, decreased metabolic rate, and decreased energy expenditure. Dietary management post-spay could help decrease obesity risk, but few research studies have been conducted on cats following...
Article
Diet is one of the greatest influences on gut microbiota number and activity, and one that can rapidly alter conditions. However, limited information about the longitudinal effects of diet on canine fecal microbiota is available. The objective of this study was to determine the effects of dietary macronutrient content on fecal microbiota population...
Article
Obesity reduces the quality and length of life of companion animals. Spaying increases risk, but dietary modification may attenuate obesity and related co-morbidities. The objective of this study was to determine the effects of specially formulated diets on apparent total tract macronutrient digestibility (ATTD) and fecal metabolites of female dogs...
Article
Edible insects such as black soldier fly larvae (BSFL) are alternative protein sources for animal feeds due to their high protein content and low environmental footprint. However, protein quality and amino acid (AA) content may vary across insect species and life stage. Our objective was to determine the effects of life stage on true nutrient and A...
Conference Paper
Pork-based dog foods are increasing in popularity, but there has been a lack of research conducted on these diets, including information about their digestibility. Therefore, the objective of this experiment was to determine the true nutrient and amino acid (AA) digestibilities of commercial pork-based extruded dog foods using the precision-fed cec...
Article
Research in various animal species has demonstrated the effectiveness of yeast products to improve health and performance. However, little research on yeast products are available for dogs. The objective of this study was to investigate the effects of a yeast product on apparent total tract macronutrient digestibility (ATTD), fecal characteristics,...
Article
Dietary fiber and protein concentrations can impact large intestinal fermentation and metabolite concentrations, consequently affecting gastrointestinal health and fecal characteristics. The objective of this study was to evaluate the effects of dietary intervention on fecal characteristics and metabolite concentrations of cats after spay surgery....
Conference Paper
Human-grade dog foods are now available and increasing in popularity, but little research has been conducted to test the digestibility of these foods. The objective of this experiment was to determine the true nutrient and amino acid (AA) digestibilities of human-grade ingredient-based dog foods using the precision-fed cecectomized rooster assay. S...
Article
Consumption of grain-free (GF) diets has recently been linked to canine dilated cardiomyopathy in selected dog breeds. Soluble fiber present in GF carbohydrate sources may be contributing to taurine depletion, thus affecting heart health. The objective of this study was to evaluate the effects of different carbohydrate sources on taurine status in...
Article
Edible insects such as black soldier fly larvae (BSFL) are alternative protein sources for animal feeds due to their high-protein content and potential low environmental footprint. However, protein quality and AA content may vary across insect species and age. Our objective was to determine the effects of age on nutrient and AA digestibility of BSF...
Article
Oats are uniquely nutritious, owing to their composition of bioactive compounds, lipids, and β-glucan. Scientific research has established that oats can improve diet quality, reduce cholesterol, regulate satiety, and protect against carcinogenesis in the colon; however, determining the effects of oats on gastrointestinal health and the gut microbio...
Article
Objective: To evaluate selected effects of midazolam or lidocaine administered prior to etomidate for co-induction of anesthesia in healthy dogs. Study design: Prospective crossover experimental study. Animals: A group of 12 healthy adult female Beagle dogs. Methods: Dogs were premedicated with intravenous (IV) butorphanol (0.3 mg kg-1), and...
Article
Objectives: Cholecystectomy (XGB), removal of the gallbladder, is the most common abdominal surgery performed in the United States. Individuals can survive without a gallbladder, but have an increased prevalence of gastrointestinal (GI) cancers and small intestinal bacterial overgrowth. However, little is known about the impact of XGB on the compo...
Article
Cholecystectomy (XGB), the removal of the gallbladder, is the most common abdominal surgery performed in the United States. Individuals can survive without a gallbladder, but have an increased prevalence of metabolic syndrome, hepatic steatosis, and small intestinal bacterial overgrowth. However, little is known about the underlying mechanisms lead...
Article
Full-text available
In recent years, it has become increasingly obvious that dietary fiber or nondigestible carbohydrate (NDC) consumption is critical for maintaining optimal health and managing symptoms of metabolic disease. In accordance with this, the US FDA released its first official definition of dietary fiber in 2016 for regulation of Nutrition and Supplement F...
Article
The gut microbiota has been implicated in the pathogenesis and progression of kidney disease. However, little is known about the gut microbiota in hemodialysis (HD) patients. We assessed the gut microbiota and its relationship with clinical variables in 10 HD patients. We found that the Firmicutes-to-Bacteroidetes ratio was positively associated wi...
Article
Yeast products may serve as functional ingredients due to their benefits on host health, but vary greatly in source, composition, and functionality, justifying research in host species of interest. In this study, a Saccharomyces cerevisiae fermentation product (SCFP) was investigated as a dietary supplement for adult dogs. Adult female beagles (n =...
Article
Full-text available
Chicken-based ingredients are commonly used in pet food products, but vary greatly in nutrient composition and processing conditions that may affect their protein quality and digestibility. Testing the quality of protein sources undergoing different processing conditions provides important information to pet food producers. The objective of this st...
Article
The objective of this study was to investigate the effects of a yeast fermentation product on diet palatability, apparent total tract macronutrient digestibility, and fecal characteristics of adult dogs. Twelve adult female beagles (age: 3.3 ± 0.8 yr, BW: 10.3 ± 0.68 kg) were fed the same diet, but supplemented with a yeast fermentation product at...
Article
Full-text available
Abstract Phytoestrogens are plant-derived compounds found in a variety of foods, most notably, soy. These compounds have been shown to improve immuno-metabolic health, yet mechanisms remain uncertain. We demonstrated previously that dietary phytoestrogen-rich soy (SOY) rescued metabolic dysfunction/inflammation following ovariectomy (OVX) in female...
Article
Absorption of dietary lipids in the small intestine is dependent on the emulsification by bile acids (BA) and the formation of chylomicrons. Cholestyramine is a common drug used in humans – and potentially dogs – to treat BA malabsorption associated with chronic diarrhea. It is known to bind BA to form insoluble complexes, preventing their reabsorp...
Article
Recent data has supported a role for the gut microbiota in improving cognition and shaping behavior. Here, we assessed whether pectin, a soluble, fermentable fiber, could enhance learning and memory in mice. Two cohorts of young male C57Bl/6 J mice, C1 (n = 20) and C2 (n = 20), were obtained from Jackson Laboratory and randomized to semi-purified A...