Keith Robison

Keith Robison
Ginkgo Bioworks · NGS

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8
Publications
655
Reads
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2,481
Citations

Publications

Publications (8)
Article
Full-text available
The vast majority of intracellular protein targets are refractory toward small-molecule therapeutic engagement, and additional therapeutic modalities are needed to overcome this deficiency. Here, the identification and characterization of a natural product, WDB002, reveals a therapeutic modality that dramatically expands the currently accepted limi...
Chapter
Protein kinases are key mediators of intracellular signal transduction cascades and are an important target class for pharmaceutical development. Two key challenges to fully understanding the role of individual kinases in cellular biology have been the difficulty in identifying the direct protein substrates phosphorylated by these enzymes and monit...
Article
ACE2, the first known human homologue of angiotensin-converting enzyme (ACE), was identified from 5' sequencing of a human heart failure ventricle cDNA library. ACE2 has an apparent signal peptide, a single metalloprotease active site, and a transmembrane domain. The metalloprotease catalytic domains of ACE2 and ACE are 42% identical, and compariso...
Article
Full-text available
Genes encoding triose-phosphate isomerase (TPI) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) are fused and form a single transcriptional unit (tigA) in Phytophthora species, members of the order Pythiales in the phylum Oomycota. This is the first demonstration of glycolytic gene fusion in eukaryotes and the first case of a TPI-GAPDH fusion...
Data
On Feb 24, 1994 this sequence version replaced gi:405950. This portion of E.coli K12 BHB2600 was sequenced as part of a chimaeric cosmid clone. While we believe the sequence to be accurate, care should be taken in interpreting the sequence, especially near the ends. All of the sequence in this contig was sequenced at least twice on one strand and o...
Data
pIB8 was derived from pHomerI by insertion of a BamHI site at a completely filled-in EcoRI site (Ish-Horowicz and Burke, 1982). pHomerI was derived from pAT153 (Twigg and Sherratt, 1980) by insertion of the cos region of Charon 4 into a BstI site (Chia et al, 1982).

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