Keisuke Mori

International University of Health and Welfare, Nasushiobara, Japan · Department of Ophthalmology

We conducted a genome-wide association study (GWAS) on the outcome of anti-VEGF treatment for exudative age-related macular degeneration (AMD) in a prospective cohort. Four hundred and sixty-one treatment-naïve AMD patients were recruited at 13 clinical centers and all patients were treated with 3 monthly injections of ranibizumab followed by pro r...

Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. Previous sequencing studies of AMD susceptibility genes have revealed the association of rare coding variants in CFH, CFI, C3 and C9 in European population; however, the impact of rare or low-frequency coding variants on AMD susceptibility in other populations is l...

Polypoidal choroidal vasculopathy (PCV), a subtype of 'wet' age-related macular degeneration (AMD), constitutes up to 55% of cases of wet AMD in Asian patients. In contrast to the choroidal neovascularization (CNV) subtype, the genetic risk factors for PCV are relatively unknown. Exome sequencing analysis of a Han Chinese cohort followed by replica...

To present baseline images of the vitreous, retina, and choroid from the macula to the periphery in normal patients using a novel montaging technique of spectral domain optical coherence tomography. Twenty-six normal eyes of 22 healthy volunteers were enrolled in this study. Montaged images of four radial optical coherence tomography scans through...

To demonstrate the posterior vitreous mobility following eye movements in patients forming macular holes, using an optical coherence tomography (OCT) eye tracking system. Prospective consecutive interventional case series. Twenty four eyes of seventeen consecutive patients with idiopathic macular hole and the remaining fellow eyes were recruited. F...

Age-related macular degeneration (AMD) is a major cause of blindness, but presents differently in Europeans and Asians. Here, we perform a genome-wide and exome-wide association study on 2,119 patients with exudative AMD and 5,691 controls, with independent replication in 4,226 patients and 10,289 controls, all of East Asian descent, as part of The...

There are errors in Tables Tables22 and S2. Please see the corrected tables below. Table 2 SNPs showing associations with diabetic retinopathy (DR) in combined stages 1 and 2 samples with P<10–3 using the allele model.

Age-related macular degeneration (AMD) is a major cause of blindness, but presents differently in Europeans and Asians. Here, we perform a genome-wide and exome-wide association study on 2,119 patients with exudative AMD and 5,691 controls, with independent replication in 4,226 patients and 10,289 controls, all of East Asian descent, as part of The...

Background This study aimed to demonstrate the phenotypic and genotypic factors associated with photodynamic therapy (PDT) for age-related macular degeneration (AMD). Methods The study included 149 patients with exudative AMD treated by PDT. Eight phenotypic factors and ten genotypic factors for three single nucleotide polymorphisms (SNPs; rs80029...

Elucidation of the genetic susceptibility factors for diabetic retinopathy (DR) is important to gain insight into the pathogenesis of DR, and may help to define genetic risk factors for this condition. In the present study, we conducted a three-stage genome-wide association study (GWAS) to identify DR susceptibility loci in Japanese patients, which...

Purpose To evaluate localization and transgene expression from adenoviral vector of serotypes 5, 35, and 28, ± an RGD motif in the fiber following intravitreal or subretinal administration. Methods Ocular transduction by adenoviral vector serotypes ± RGD was studied in the eyes of mice receiving an intravitreous or subretinal injection. Each serot...

Anti-vascular endothelial growth factor (anti-VEGF) therapies including intravitrous bevacizumab injection (IVB) emerged as an effective treatment for various fundus diseases. Reports of adverse reactions derived from bevacizumab itself are rare. We report a case in which corneal subepithelial infiltrates developed following IVB. A sixty-six-year-o...

To describe the treatment outcome of photodynamic therapy (PDT) in Japanese patients with age-related macular degeneration (AMD) followed for 5 years. We retrospectively reviewed clinical charts of 51 patients with AMD. Thirty-one eyes of typical AMD (tAMD) and 20 eyes of polypoidal choroidal vasculopathy (PCV) were evaluated. The mean logarithm of...

Purpose: To describe the morphologic and anatomic relationships at the vitreoretinal interface, from the macula into the periphery, in patients with idiopathic macular hole. Montaged images of posterior and peripheral spectral-domain (SD) optical coherence tomography (OCT) studies were used to describe the anatomic vitreoretinal relationships. De...

7017 Background: We previously reported the superiority of combined chemo-radiotherapy (CRT) over RT alone in elderly pts with locally advanced NSCLC (Atagi et al. ECCO2011). One and a half years follow-up data from last accrual are presented. Methods: Pts older than 70 years with unresectable stage III NSCLC were randomized to either RT alone (RT...

High strength steel and aluminium alloy sheets were joined by mechanical clinching with dies for control of metal flow. Since the sheets undergo plastic deformation for the joining during the mechanical clinching, the high strength steel sheets tend to fracture due to the small ductility. For the upper high strength steel sheet, fracture was caused...

A punching process using local resistance heating of a shearing zone was developed to shear ultra-high strength steel sheets. The shearing zone was heated by passing electric current between the sheet holder and the knockout in order to decrease the flow stress in the shearing, and the heating of the die and punch was prevented by no contact with t...

Recently several press builders developed gap and straight-sided metal forming presses that utilise the mechanical servo-drive technology. The mechanical servo-drive press offers the flexibility of a hydraulic press (infinite slide (ram) speed and position control, availability of press force at any slide position) with the speed, accuracy and reli...

Ground-based gamma-ray astronomy has had a major breakthrough with the impressive results obtained using systems of imaging atmospheric Cherenkov telescopes. Ground-based gamma-ray astronomy has a huge potential in astrophysics, particle physics and cosmology. CTA is an international initiative to build the next generation instrument, with a factor...

To see if there is an association in Japanese between elastin gene (ELN) polymorphisms and neovascular age-related macular degeneration (AMD) or its subtypes, typical AMD (tAMD) and polypoidal choroidal vasculopathy (PCV). The authors genotyped five single nucleotide polymorphisms (SNPs), rs2301995, rs2856728, rs868005, rs884843, and rs13239907, at...

Individualized surgical simulation using three-dimensional (3D) imaging to allow safe performance of clipping surgery for unruptured middle cerebral artery (MCA) aneurysm via pterional keyhole mini-craniotomy was performed in 100 consecutive patients. 3D images were reconstructed of the skin, skull, cerebral arteries and veins, and aneurysm. The si...

Age-related macular degeneration (AMD), the leading cause of irreversible blindness in the world, is a complex disease caused by multiple environmental and genetic risk factors. To identify genetic factors that modify the risk of exudative AMD in the Japanese population, we conducted a genome-wide association study and a replication study using a t...

To prevent a sharp rise in load in compression of plates, a compression process using load pulsation was developed. In this process, the compression load is partially released during the forming to re-lubricate the surfaces of the plate. Gaps on the outer surfaces of the plate were caused in each release of unload by the difference in elastic recov...

To assess modifiable environmental risk factors and protective factors for age-related macular degeneration (AMD) in a native Japanese population. A case-control study. We included 422 case-control samples composed of 279 consecutive AMD cases and 143 controls. Information regarding systemic conditions and lifestyle were documented in each subject...

A mechanical clinching has the advantage of low running costs. However, the joint strength is not high. To improve the maximum load of the joined sheets by a mechanical clinching, square and rectangular mechanical clinching were introduced. In the mechanical clinching, the two sheets are mechanically joined by forming an interlock between the lower...

To determine whether there is an association between complement factor H (CFH), high-temperature requirement A-1 (HTRA1), vascular endothelial growth factor (VEGF), and pigment epithelium-derived factor (PEDF) genotypes and response to treatment with photodynamic therapy (PDT) for age-related macular degeneration (AMD) in a Japanese population. Pro...

The stretch flangeability of an ultra-high strength steel sheet having low ductility was improved by smoothing the sheared edge of the sheet. Since the stretch flangeability of the ultra-high strength steel sheet is strongly influenced by the quality of the sheared edge, the quality was heightened. The stretch flangeability was evaluated from an ex...

Tailor die quenching in the hot stamping of quenchable steel sheets was developed to produce ultra-high strength steel formed parts having strength distribution. Local portions of the heated sheet were quenched by holding grooved tools at the bottom dead centre during the stamping. Non-contact portions were generated in the sheet by grooving the to...

We determined whether there is an association between complement factor H (CFH), high-temperature requirement A-1 (HTRA1), vascular endothelial growth factor (VEGF), and pigment epithelium-derived factor (PEDF) genotypes and the response to treatment with a single intravitreous injection of bevacizumab for age-related macular degeneration (AMD). Ei...

7088 Background: Concurrent chemoradiotherapy is the standard treatment for unresectable stage III non-small cell lung cancer (NSCLC). Few researchers, however, have reported on follow-up data of longer than three years. We investigated the long-term feasibility and efficacy of vinorelbine and cisplatin chemotherapy with concurrent thoracic radioth...

To describe phenotype and genotype characteristics of age-related macular degeneration (AMD) in Japanese patients. A case-control study. A total of 550 case-control samples composed of 408 consecutive AMD cases and 142 controls. Clinical information assessing age, gender, affected eyes, fundus features, and fluorescein/indocyanine green angiograms...

To evaluate visual outcome one year after photodynamic therapy (PDT) in patients with exudative age-related macular degeneration (AMD) showing good visual acuity (VA). One hundred and thirteen patients with AMD who received PDT therapy were recruited for this study. The study subjects were divided into two groups : those having a better visual acui...

To investigate the functional characteristics of the detached retina on a serous retinal detachment (SRD) in eyes with central serous chorioretinopathy (CSC) with spared visual acuity. Multifocal electroretinograms (mfERGs) were recorded with a long recording time of 14 minutes, 34 seconds, to obtain accurate measurement of the second-order kernel...

Oxidation in hot stamping of quenchable steel sheets heated in an electrical furnace was prevented by coating the sheets with oxidation preventive oil. A solid film is generated on the surface of the sheet by drying the coated sheet, and the film changes into a liquefied film having an oxidation barrier at elevated temperatures. Hot hat-shaped bend...

Time-optimal trajectory planning for mechanical systems has been widely studied thus far because of its effectiveness to reduce the time required for many industrial tasks. However, in general, because the time-optimal trajectory is generated based on ideal dynamics of controlled systems, it may be difficult to implement the obtained trajectory to...

To evaluate the effect of photodynamic therapy (PDT) on retinal functions, such as oxygen saturation, blood flow, and electrophysiological function using Fourier transform-based spectral retinal imaging (SRI), Heidelberg retinal flowmeter (HRF), and multifocal electroretinogram (mfERG). This was a prospective interventional case series. Twenty-two...

We have measured and corrected chromatic X-Y coupling at an interaction point to improve the luminosity of KEKB. We have measured the beam position of betatron oscillations induced by the kicker using turn-by-turn beam position monitors. A phase space structure reconstructed by the beam position provides us not only the Twiss parameters but also in...

A two-stage cold stamping process for forming magnesium alloy cups having a small corner radius from commercial magnesium alloy sheets was developed. In the 1st stage, a cup having large corner radius was formed by deep drawing using a punch having large corner radius, and the corner radius of the cup was decreased by compressing the side wall in t...

The joinability of hot-dip coated steel sheets using a mechanical clinching was investigated by an experiment. The distributions of the layer thickness of Zn alloy coating of the joined sheets were examined. Although the sheets were joined, the layer of coating on the side wall of the punch was scratched and the layer thickness on the bottom of the...

High tensile strength steel sheets having different strengths were joined with an aluminium alloy sheet by a self-piercing rivet. In the joining, a conventional rivet and die used for aluminium alloy sheets were employed in order to have the versatility for various steel sheets. The effects of the flow stress of the high strength steel sheets and t...

A cosmic dust detector is currently being developed using a piezoelectric lead zirconate titanate (PZT) element. The characteristics of the multilayered detector (MD), which was composed of one hundred PZT disks, were investigated by bombarding it with hypervelocity iron particles supplied by a Van de Graaff accelerator. It was confirmed that there...

The detector characteristics of a pentagonal element were studied by colliding it with hypervelocity micro-particles. A charge-sensitive amplifier was developed for the element of its capacitance ∼10 nF. The output amplitudes were expressed as a linear function of the momentum at collision. Empirical formulas obtained from on-ground experiments cou...

Warm and hot punching using resistance heating was developed to improve the quality of sheared edges of an ultra high strength steel sheet. As the heating temperature increased, the depth of the shiny burnished surface on the sheared edge increased and that of the rough fracture surface decreased. The rollover depth and burr height of the sheared e...

Experience with dissection of the cavernous sinus (CS), one of the most complicated structures in the brain, is essential for understanding its anatomy and training in CS-related skull base surgery, but only a limited number of neurosurgical residents have the opportunity of cadaver dissection. A three-dimensional (3D) skull model is proposed for s...

A cosmic dust detector using piezoelectric lead zirconate titanate (PZT) is currently being developed for use onboard a spacecraft for the BepiColombo mission. The characteristics of the PZT detector were studied by carrying out hypervelocity impact measurements with iron particles supplied by a Van de Graaff accelerator. The measurements with part...

Clipping of an anterior communicating artery (A-com A) aneurysm requires various working angles for safe manipulation and observation. The lateral supraorbital keyhole approach provides a more lateral subfrontal corridor to observe and clip an A-com A aneurysm than the standard Perneczky method. Preoperative planning was individualized in each pati...

A cosmic dust detector for use onboard a satellite is currently being constructed from piezoelectric lead zirconate titanate (PZT). The characteristics of the PZT detector were studied by bombarding it with hypervelocity iron particles, which were supplied by a Van de Graaff accelerator. There was a linear relationship between the rise time of the...

To quantify the effects of oxidant challenge on the redox state of adult human retinal pigment epithelial cells using microscopic autofluorescence spectroscopy and to determine whether treatment with the isothiocyanate sulforaphane protects these cells against oxidative stress. Oxidative stress was evoked in ARPE-19 cells by H2O2 and tert-butyl hyd...

A two-stage forming process of tailor blanks having local thickening for controlling the distribution of wall thickness of stamped parts was developed. In the 1st stage, the target portion of the sheet for the local thickening is drawn into the die cavity, and then the bulging ring is compressed with the flat die under the clamping of the flange po...

The joinability of the self-pierce riveting process of three high strength steel and aluminium alloy sheets was investigated. The effects of the sheet strength and sheet combination on the deforming behaviour were examined under the fixture of the lower aluminium alloy sheet. Although the joining of three aluminium alloy and mild steel sheets is co...

We have previously identified a neuroprotective effect associated with empty (E1(-), E3(-), E4(-)) adenovirus vector delivery in a model of light-induced, photoreceptor cell death. In this study, we further characterize this protective effect in light-injured retina and investigate its molecular basis. Dark-adapted BALB/c mice, aged 6-8 weeks, were...

Patients with previously untreated extensive-disease small-cell lung cancer were treated with irinotecan 60 mg m(-2) on days 1 and 8 and cisplatin 60 mg m(-2) on day 1 with (n=55) or without (n=54) etoposide 50 mg m(-2) on days 1-3 with granulocyte colony-stimulating factor support repeated every 3 weeks for four cycles. The triplet regimen was too...

Retinal pigment epithelium (RPE) cells play important roles in the visual system that supports neurosensory retina homeostasis. Connexin (Cx) 43-mediated gap-junctional intercellular communication (GJIC) participates in the regulation of retinal organogenesis, but much of the function of Cx43 on the differentiation of RPE cells is unclear. Here, we...

The beam-abort system is an important element of KEKB for the protection of sensitive components of the Belle detectors and the accelerator components from dam- ages due to intense beams. A new beam position monitor (BPM) was installed in front of a beam dump to observe the positions of dumped beams. The BPM measures the transverse position of each...

A noninvasive imaging technique was used for serial assessment of gene expression after intraocular gene transfer. Bioluminescence after intravitreous administration of an adenovirus vector containing the firefly luciferase gene was measured serially and noninvasively. The optical signal was then used as a bioassay to determine whether periocular i...

Two patients with glossopharyngeal neuralgia associated with cardiac syncope were treated with temporary cardiac pacemakers for cardiac syncope and then microvascular decompression. The offending arteries were the posterior inferior cerebellar artery in one patient and the anterior inferior cerebellar artery in the other. The offending arteries wer...

Ethnic variation has been reported in age-related macular degeneration (AMD)-associated Y402H polymorphism in complement factor H (CFH). This variation is evident in the Japanese population. Recently a strong association between a novel single-nucleotide polymorphism (SNP; rs1410996) in the CFH gene and AMD has been identified in Caucasian patients...

Pigment epithelium-derived factor (PEDF or SERPINF1), a neuroprotective and anti-angiogenic factor, may play an important role in the pathogenesis of diabetic retinopathy (DR). In 416 patients with type 2 diabetes, four polymorphisms in the PEDF SNPs were identified, rs12150053 and rs12948385 in the promoter region, rs9913583 in the 5'-untranslated...

The supraorbital keyhole approach via an eyebrow skin incision provides a method for the minimally invasive clipping of aneurysms located in the circle of Willis, but has disadvantages for aneurysms located in the lateral Sylvian fissure. The pterional keyhole minicraniotomy via an outer canthal skin incision is proposed for the clipping of unruptu...

Crab cavities have been installed in the KEKB B-factory rings to compensate the crossing angle at the collision point and thus increase luminosity. The beam operation with crab crossing has been done since February 2007. This is the first experience with such cavities in colliders or storage rings. The crab cavities have been working without seriou...

KEKB has been operating with crab cavities for the first time in the world. This paper represents beam operation with the crab crossing.

Crab cavities have been installed in the KEKB B--Factory rings to compensate the crossing angle at the collision point and thus increase luminosity. The beam operation with crab crossing has been done since February 2007. This is the first experience with such cavities in colliders or storage rings. The crab cavities have been working without serio...

The lipid-lowering and anti-atherosclerotic effects of atorvastatin (10 mg/day) were investigated by measuring changes in the levels of oxidized low-density lipoprotein (LDL), serum lipids (total cholesterol [TC], LDL-cholesterol [LDL-C] and triglycerides [TG]), and in the protein adiponectin. This was undertaken in 22 patients with ischaemic heart...

Various high tensile strength steel sheets and an aluminum alloy sheet were joined with a self-piercing rivet. It is not easy to weld the aluminum alloy sheet and high tensile strength sheets by means of conventional resistance welding because of very different melting points. To obtain optimum joining conditions, joining defects were categorized i...

To describe the biodistribution of a hydrophilic sensitizer, mono-L-aspartyl chlorin e6 (NPe6), in a primate model of choroidal neovascularization (CNV). NPe6 (25 mg/kg) and indocyanine green (ICG, 15 mg/kg) were intravenously administered simultaneously in monkeys with laser-induced CNVs. Eyes were enucleated and examined by fluorescence microscop...

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The springback behaviour of ultra-high-strength steel sheets in bending was investigated under controlled conditions using a CNC servo press. Although the ultra-high-strength steel sheets are attractive in reducing weight of cars, the amount of springback of the ultra-high-strength steel sheets in the forming is very large due to high strength. The...

The purpose of this investigation was to determine whether the high-temperature requirement A-1 (HTRA1) gene polymorphism is associated with age-related macular degeneration (AMD) in native, unrelated Japanese patients. A total of 123 patients with AMD and 133 control subjects without AMD were recruited for this study. The single-nucleotide polymor...

To demonstrate the morphological and functional outcomes of intravitreous injection of an expansile gas bubble for the treatment of stage 2 macular holes. Prospective interventional case series. Twenty eyes of 20 consecutive patients with unilateral stage 2 macular holes. The patients underwent intravitreous sulfur hexafluoride injection, followed...

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Alpha-ray detector (ARD) will be on-board SELENE, a Japanese lunar orbiter to be launched around 2006. Primary target is the alpha particles emitted by 222Rn and 210Po. 222Rn is produced by the decay of 238U and emanates from the lunar surface. It is trapped by the lunar gravity and decays with the half-life of 3.8 days emitting 5.490 MeV alpha par...

Ultra high strength steel and aluminium alloy sheets were plastically joined by a self piercing rivet driven through the upper sheet and spread in the lower sheet with a die. The self piercing rivet directly pierces into the sheets without drilling the sheets beforehand unlike the conventional rivets. Insufficient driving though the upper sheet and...