Kei Kamide

Kei Kamide
Osaka University | Handai · Division of Health Science

MD, PhD
Dean, Professor, Division of Health Sciences, Osaka Univ. Graduate School of Medicine

About

380
Publications
33,270
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8,001
Citations
Citations since 2017
144 Research Items
3789 Citations
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20172018201920202021202220230200400600800
20172018201920202021202220230200400600800

Publications

Publications (380)
Article
Background: Frailty increases the risk of negative health-related events, such as falls, disability, hospitalizations, and death. Although the association between oral health and physical frailty is well established, the relationship between oral health and psychological frailty has not yet been investigated. Therefore, we conducted a cross-sectio...
Article
We investigated the associations of visit-to-visit variability(VVV) of blood pressure (BP) with clinical events (death, hospitalization, falling) in older patient around 85 years old receiving home medical care. This study was performed in OHCARE (Osaka Home CAre REgistry), which is a prospective cohort study targeted old patients receiving home-ba...
Article
It is well known that excessive salt intake is associated with hypertension (HT) and salt intake reduction lowers blood pressure. However, the knowledge of salt intake and blood pressure in the older people is not sufficient. This study aimed to clarify the relationship between salt intake and blood pressure among community-dwelling Japanese older...
Article
Hypertension, dyslipidemia, and those combinations are very common in older adults. However, the association between cognitive decline and the combination of hypertension and dyslipidemia in older adults is still controversial. Therefore, we investigate the association between cognitive decline and hypertension, dyslipidemia, and their combination...
Article
We clarify the status of home blood pressure (HBP) measurement during the first 90 days after recommendation of self-measurement and recording among community residents and factors associated with everyday-measurement. The study subjects were 677 participants from the intervention group of NOSE study, a intervention study of HBP measurement in comm...
Article
Preventing illness and promoting health is important for prolonging healthy life expectancy, and it also leads to the reduction of medical and long-term care costs. As Japan has entered a super-aged society, prevention of CVD, which causes stroke and dementia, the main causative diseases of the need for long-term care, is becoming more important. I...
Article
Short sleep duration and poor sleep quality in middle age have been reported to affect blood pressure(BP) control. However, the association between sleep duration, sleep quality and BP control is controversial in older adults with hypertension taking antihypertensive drugs. The aim of this study was to investigate this association in 70–80-year-old...
Article
This study examined participants’ health-related awareness, changes in health consciousness, and their spillover effects observed through community-wide home blood pressure (BP) monitoring intervention. This study was based on an ongoing community-based intervention study in Nose, Osaka, which was designed to assess the effect of home BP measuremen...
Article
The purpose of this study was to assess the association between blood pressure (BP) related indicators and physical frailty among the Japanese community-dwelling elderly. The present cross-sectional analysis was based on an ongoing community-based intervention study in Nose, Osaka, which was designed to assess the effect of home BP measurement on p...
Article
Few studies have investigated weekly variations in long-term home blood pressure (BP) measurement. The aim of this study was to examine the intra-week variability and the difference in the day of the week on long-term home BP with or without antihypertensive medication. This study was based on an ongoing community-based intervention study in Nose,...
Article
To determine the association between skeletal muscle mass and systolic blood pressure decline over a 5-year period in older adults over 75 years old. Of those who got health checkups at private A clinic from May 2020 to March 2021, 118 subjects for whom data on systolic blood pressure (SBP) levels consequently collected for five years were included...
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Background Chronic kidney disease (CKD) has few objective symptoms, and it is difficult to make an early diagnosis by using existing methods. Therefore, new biomarkers enabling diagnosis of renal dysfunction at an early stage need to be developed. Here, we searched for new biomarkers of CKD by focusing on kidney-derived proteins that could sensitiv...
Preprint
Full-text available
Background: Factors associated with weight loss in community-dwelling older people have been reported in several studies, but few studies have examined factors associated with weight loss by age groups. The purpose of this study was to clarify factors associated with weight loss by age in community-dwelling older people through a longitudinal study...
Article
Aim: This cross-sectional study aimed to investigate the associations between salivary testosterone concentrations and cognitive function in 70-year-old Japanese elderly people without dementia and stroke. Methods: Participants were 197 Japanese community-dwelling people aged 69-71 years. Their salivary samples were collected, and their cognitiv...
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Background: The oldest old, defined as those aged 90 or over, is now the fastest-growing population sector. This study aimed to determine reference values for several physical performance measures (PPMs) among 90-year-olds using internationally standardized measurements and to clarify the characteristics of these indices by comparing their results...
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The Japanese government has implemented a new screening program to promote measures to avoid worsening lifestyle-related diseases and frailty among the older population. In this effort, the government formulated a new health assessment questionnaire for the screening program of old-old adults aged ≥75 years. The questionnaire comprises 15 items, of...
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Background Proteinuria is an important predictor of cardiovascular disease and mortality. Several studies reported the association between skipping breakfast and the prevalence of proteinuria. Furthermore, skipping breakfast was associated with an increased risk of obesity. Although proteinuria is highly prevalent in obese individuals, the associat...
Article
Objective Tuberculosis (TB) patients are discharged after confirming their non-infective status. However, elder-care facilities often refuse to admit discharged TB patients. As no study has investigated anxiety among elder-care facility employees, we aimed to identify anxiety-associated factors among elder-care facility employees regarding the post...
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Older adults face the concern of developing frailty and sarcopenia due to an inactive lifestyle during the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to reveal the preventive behaviors taken by older adults who perceived a decline in physical fitness during COVID-19 and analyze the background factors which promoted such behavior...
Article
Background Previous studies have shown the social support-mental health associations varied in different bonding social networks. However, a further study is needed to determine these network-specific associations for mutually supportive interaction in a wider social network include bridging relationship members. Method We conducted a self-reporte...
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Full-text available
Some studies reported that home blood pressure (HBP) monitoring was conducted by community-dwelling older people themselves, but there have been few studies on HBP including very old populations aged over 90 years old. Thus, the aim of the present study was to clarify the current situation of white-coat and masked phenomena defined by on-site and h...
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Background Polypharmacy is a serious concern among older adults and is frequently related to adverse outcomes, including health problems, reduced quality of life, and increased medical expenses. Although personality traits are associated with health behaviors and diseases, the effect of polypharmacy on personality traits is unclear. Therefore, we e...
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Background To answer whether older adults' cognitive function benefits from ICT use, we (1) examined the relationship between ICT use and cognitive decline during the COVID-19 pandemic and (2) explored the potential role of ICT use in mitigating the relationship between loneliness, social isolation, and cognitive decline among community-dwelling ol...
Article
Aims: The purpose of this study was to objectively quantify the sleep of elderly patients with dementia at home using a device and to investigate the factors associated with its identification. Methods: Sixteen patients (6 males [37.5%], 84.1±4.7 years old; and 10 patients with mild dementia [62.5%]) and their family caregivers who were using ou...
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Background Older adults were expected to experience a decline in physical activities and an increase in social isolation during the COVID-19 pandemic. Methods We investigated the changes in living conditions of 508 older adults (79.70 years ± 0.88) before (from July to December 2019) and during (in August 2020) the pandemic. We compared the mean s...
Preprint
Full-text available
Background The oldest old, defined as those aged 90 or over, are now the fastest-growing population sector. This study aimed to determine reference values for a number of physical performance measures (PPMs) among 90-year-olds using internationally standardized measurements and to clarify the characteristics of these indices by comparing their resu...
Article
Objectives The aim of this cohort study among community-dwelling older adults aged over 70 years was to investigate the influence of occlusal support on tooth loss, and to determine predictive factors for tooth loss for each occlusal support category using multilevel analyses. Methods Participants were 812 older adults who completed the baseline s...
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Background The relationship between moderate alcohol drinking or other alcohol drinking patterns such as frequency, beverage type, and situation of drinking and cognitive function is not sufficiently clear in older people. The purpose of this study was to investigate the association between alcohol drinking patterns and cognitive function in commun...
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Aim: We carried out a randomized controlled trial using ipragliflozin. We analyzed changes in diastolic function using echocardiography in patients with type 2 diabetes and heart failure with preserved ejection fraction. Methods: We carried out an open-label, multicenter, randomized, two-arm interventional trial. A total of eligible 68 participa...
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Aim: The aim of this study was to clarify the association between dietary protein intake and decline in the estimated glomerular filtration rate (eGFR) among Japanese older adults. Methods: We used the data of the Septuagenarians, Octogenarians and Nonagenarians Investigation with Centenarians (SONIC) study, an ongoing narrow-age range cohort st...
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Background Adipokine dysregulation is a key feature of insulin resistance and a metabolic syndrome associated with obesity. Low adiponectin levels are associated with higher risks of cardiovascular diseases (CVD). However, high adiponectin levels have also been associated with increased all-cause and cardiovascular mortality in the elderly. This ad...
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Global migration has greatly affected intergenerational family support beyond national borders, in particular adult children’s transnational family caregiving for elderly parents. Specifically, the COVID-19 pandemic has largely influenced transnational caregiving due to the travel restrictions. Transnational caregiving for older adults includes adu...
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Grip strength and walking speed are considered to be important indicators of physical frailty. However, no study has contemporaneously examined any association of multiple oral functions with grip strength and walking speed. The purpose of this study was to examine which oral functions are associated with muscle strength (grip strength), physical p...
Article
Background: Many physical functions decline with aging, but it is not known whether oral functions vary according to sex or decline with aging, as it occurs with physical functions. The present study aimed to examine the association of sex, age, and elapsed years with occlusal force and tongue pressure using a generalized linear mixed-effect model...
Article
Aim: To prevent the transmission of the novel coronavirus [COVID-19] and stop its spread, a state of emergency was declared from April to May 2020. People were encouraged to refrain from outings and reduce their contact with people. The purpose of this study was to examine the subjective changes in the amount of activity under COVID-19 crisis among...
Article
Aim: We investigated seasonal variations in blood pressure (BP) and factors related to these variations among older patients receiving home medical care. Method: A total 57 patients ≥ 65 years old receiving home medical care who participated in the Osaka Home Care REgistry study (OHCARE), a prospective cohort study, were included. We investigated t...
Article
Japan will face a super-aged society in the near future, in which 40% of the population will be over 65 years of age. However, prolongation of life expectancy is inevitably associated with greater numbers of frail old people who need help or assistance in their daily activities. The percentage of the old-old population in 2020, comprising more frai...
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Background Considering the increased numbers of Chinese nurses in Japan, we hypothesized that Chinese nurses in Japan are confronted with many difficulties, although few studies have been performed. Therefore, in-depth analyses of their experience to explore significant factors and aspects are required. Objectives To clarify the problems and diffi...
Article
Aim: We examined the effect of "IkiIki Hyakusai Taiso" as way to prevent the physical decline in community-dwelling elderly in Nose Town, Osaka Prefecture. Methods: Participants were community-dwelling elderly who participated in the Preventive Care program "IkiIki Hyakusai Taiso" from October 2015 to June 2019 in Nose Town, Osaka Prefecture, Japan...
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Periodontal disease is a chronic inflammatory condition that affects various peripheral organs. The periodontal inflamed surface area (PISA) quantifies periodontitis severity and the spread of inflammatory wounds. This study aimed to investigate the association between PISA and high-sensitivity C-reactive protein (hs-CRP), a systemic inflammation m...
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The G allele of FOXO3 gene (Single nucleotide polymorphism – SNP; rs2802292) is strongly associated with human longevity. However, knowledge of the effect of FOXO3 in older populations, men or women, with heart disease is limited. This cross-sectional study in Japan included 1836 older adults in the 70 and 80-year-old groups. DNA samples isolated f...
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Objective To evaluate the effectiveness of the nurse-led alcohol guidance to control home blood pressure in the morning (HBP) among male patients with hypertension during outpatient visits. Method We enrolled 53 male patients with an HBP of ≥ 135/85 mmHg with excessive drinking (alcohol ≥210 g/week or ≥60 g/day habitually) among outpatients in a r...
Article
Objectives: To determine any independent influence of occlusal force and of number of natural teeth on decline in body mass index (BMI) among older Japanese adults. Design: Longitudinal study over a 3- to 6-year period. Setting: Urban and rural area in Japan. Participants: Independently living Japanese adults aged 69-71 years and 79-81 years...
Preprint
Full-text available
Background and Objectives: To deepen the understanding of processes underlying older adults’ behavior during the COVID-19 pandemic, we investigated associations among affective (anxiety about the coronavirus), cognitive (perceived risk of infection and fatality), and behavioral (engagement in preventive behaviors) variables. We also examined how th...
Article
Background: Physical function is a strong predictor of the adverse outcomes of cardiovascular disease in older populations. However, studies of healthy older people on the prevention of coronary heart disease (CHD) are very limited. Objectives; We prospectively examined the association of walking speed and handgrip strength with CHD in the communit...
Article
Age-related changes in affect have been described in developmental sciences, and the majority of these studies have focused on long-term intraindividual changes over years. However, evidence on short-term intraindividual variations over days remains limited. Using a daily diary method, we examined age differences in intraindividual variability in e...
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Background: Although early detection of cognitive decline has a significant relation to improving the quality of life of dementia patients, this early detection has been difficult due to requires of neuropsychological tests which people generally take when they notice their cognitive impairment. The timing of patients’ notice was reported to be wor...
Article
Full-text available
Objective: An ecological study using secondary open data from Japanese government statistics was conducted. The study aimed to verify differences in three measures of healthy life expectancy (HLE); namely, disability-free life expectancy without activity limitation (DFLE-AL), life expectancy with self-perceived health (LE-SH), and disability-free...
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The Montreal Cognitive Assessment (MoCA) is a test assessing global cognition in older adults which is often used by researchers and clinicians worldwide, although some of its psychometric properties have yet to be established. We focus on three fundamental aspects: the factorial structure of the MoCA, its general factor saturation, and the measure...
Article
Aim The association between serum uric acid (UA) and atherosclerosis in old people is controversial. Therefore, in this study, we clarified this association by assessing serum UA and common carotid atherosclerosis examined by carotid ultrasound in community‐dwelling older people in their 70s, 80s and 90s in the SONIC study. Methods A cross‐section...
Article
Periodontal disease and arteriosclerotic disease are greatly affected by aging. In this study, the association of conventional risk factors and periodontal disease with atherosclerosis was longitudinally examined in Japanese older adults. Subjects in this study were 490 community-dwelling septuagenarians (69–71 years) randomly recruited from the Ba...
Article
Some studies reported that excessive blood pressure (BP) control was not appropriate for older people, especially from the viewpoint of quality of life and maintaining sufficient blood flow for tissue perfusion. However, the lower limit of the target BP is still unclear, and there has not yet been a sufficient consensus. Therefore, we investigated...
Article
Full-text available
Background: Preventing the need for long-term care (LTC) by identifying physical function risk factors are important to decrease the LTC burden. The objective of this study was to investigate whether grip strength and/or walking speed, which are components of the frailty definition, are associated with LTC in community-dwelling older and oldest pe...
Article
Aim: Heart diseases and social factors are associated with physical frailty, but there are few studies of older people living in the community. Consequently, the aim of this study was to examine the association between heart diseases, social factors and physical frailty in community-dwelling older populations including the oldest-old people. Meth...
Preprint
Full-text available
Objective: Physical function is a strong predictor of the adverse outcomes in older populations. We prospectively examined the association of walking speed and handgrip strength with CHD in the community-dwelling older populations. The study cohort in Japan included 1272 older people free from heart disease at the baseline. Physical function was id...
Article
Despite the clinical usefulness of self-measured home blood pressure (BP), reports on the characteristics of home BP have not been sufficient and have varied due to the measurement conditions in each study. We constructed a database on self-measured home BP, which included five Japanese general populations as subdivided aggregate data that were clu...
Article
Full-text available
We investigated the association of systolic blood pressure (SBP) level with physical frailty and cognitive function in community-dwelling older Japanese. Using the ‘Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians’ survey as the baseline, we performed a cross-sectional analysis of people aged 70 ± 1 (n = 1000), 80 ± 1 (...
Preprint
Full-text available
Background The association of social support with mental health for the older adults has been well documented; however, object-specific support was rarely discussed. This study examined the relationships of multiple aspects of social support, especially focusing on objects of social support, across different aging stages. Methods We conducted a sel...
Article
Aim The incidence of anemia increases with aging, and it is considered to affect mortality through complex pathophysiological outcomes. Although it has been suggested that self‐rated health may also contribute to the prognosis of anemia in older people, the relationship between anemia and self‐rated health is not well understood. This study thus ex...
Preprint
Full-text available
Objective Ecological study using open data collected, compiled, and published in government statistics in Japan was conducted. The study aimed to verify the differences in these three measures of healthy life expectancy (HLE), namely disability-free life expectancy without activity limitation (DFLE-AL), life expectancy with self-perceived health (L...
Preprint
Full-text available
Objective: An Ecological study using open data collected, compiled, and published in government statistics in Japan was conducted. The study aimed to verify the differences in these three measures of healthy life expectancy (HLE), namely disability-free life expectancy without activity limitation (DFLE-AL), life expectancy with self-perceived healt...
Preprint
Full-text available
Objective: An ecological study using secondary open data from Japanese government statistics was conducted. The study aimed to verify differences in three measures of healthy life expectancy (HLE); namely, disability-free life expectancy without activity limitation (DFLE-AL), life expectancy with self-perceived health (LE-SH), and disability-free l...
Preprint
Full-text available
Objective: An ecological study using secondary open data from Japanese government statistics was conducted. The study aimed to verify differences in three measures of healthy life expectancy (HLE); namely, disability-free life expectancy without activity limitation (DFLE-AL), life expectancy with self-perceived health (LE-SH), and disability-free l...
Preprint
Full-text available
Objective: An ecological study using secondary open data from Japanese government statistics was conducted. The study aimed to verify differences in three measures of healthy life expectancy (HLE); namely, disability-free life expectancy without activity limitation (DFLE-AL), life expectancy with self-perceived health (LE-SH), and disability-free l...
Article
Background: We investigated the effects of percutaneous transluminal renal angioplasty on left ventricular (LV) mass, and the impact of LV mass reduction on outcomes. Methods: A total of 144 hypertensive patients with renal artery stenosis (RAS) (mean age 69 years; 22.2% fibromuscular dysplasia [FMD]) who underwent angioplasty were included. Ech...
Preprint
Full-text available
Objectives Physical frailty is geriatric syndrome and can increase the risk of adverse outcome in the older population. Heart diseases are associated with physical frailty but a few studies in community-dwelling old population. Therefore the aim of this study was to examine the association between heart diseases, social factors, and physical frailt...
Article
Full-text available
Objectives: We examined the associations of weight loss and low serum albumin level with death in community-dwelling elderly, as well as related factors by a systematic review with a meta-analysis. Methods: We searched MEDLINE, Cochrane Library (CENTRAL), Web of Science, and CHINAL for articles on cohort studies investigating the association of wei...
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Aim: Several studies have reported a negative correlation between depressive symptoms and family caregivers' (FCs) subjective sleep status. However, there is a paucity of information on the association between objective/subjective sleep status, care burden, and related factors. Methods: Participants were 23 pairs of care receivers (CRs; Mage = 8...
Article
Full-text available
Background: Cognitive impairment is a major health concern among older and oldest people. Moreover, stroke is a relevant contributor for cognitive decline and development of dementia. The study of cognitive decline focused on stroke as the important risk factor by recruiting older and oldest is still lagging behind. Therefore, the aim of this stud...
Preprint
Full-text available
Background: Cognitive impairment is a major health concern among older and oldest people.Moreover, stroke is a relevant contributor for cognitive decline and development of dementia. The study of cognitive decline focused on stroke as the important risk factor by recruiting older and oldest is still lagging behind. Therefore, the aim of this study...