Kazuhisa Konishi

• Brigham and Women's Hospital

Background Pulmonary fibrosis is a life-threatening disease characterized by progressive dyspnea and worsening pulmonary function. Atrial natriuretic peptide (ANP), a heart-derived secretory peptide used clinically in Japan for the treatment of acute heart failure, exerts a wide range of protective effects on various organs, including the heart, bl...

Background: MicroRNAs (miRNAs) have been reported to be involved in multiple diseases, including chronic obstructive pulmonary disease (COPD), a progressive disease in which alveolar apoptosis may play a role. We hypothesized that miRNAs are associated with the response to injury. induced by high mobility group box 1 (HMGB1), a cytokine crucial fo...

Background: Mesenchymal stromal cells (MSCs) have been intensively investigated in regenerative medicine. Since among the different types of MSCs adipose tissue-derived stromal cells (ASCs) can be obtained with relatively less invasive techniques, ASC administration is a candidate strategy for the treatment of pulmonary fibrosis. Aims: We investiga...

Background: Chronic obstructive pulmonary disease (COPD) is described with its clear association with cigarette smoke and other environmental aspects, but the biological elements of COPD are not fully understood. Animal models have implicated interleukin 13 (IL-13) as a critical cytokine in the development of COPD through Th type 2 immune response....

Lung fibrosis is the final result of a large number of disorders and is usually considered an irreversible process. However, some evidence suggests that fibrosis could eventually be reversible. In this study we aimed to document the time-related reversibility of bleomycin-induced lung fibrosis, and to examine the gene expression profile associated...

Primary human distal lung/parenchymal fibroblasts (DLFs) exhibit a different phenotype from airway fibroblasts (AFs), including the expression of high levels of α-smooth muscle actin (α-SMA). The scope of the differences between these anatomically differentiated fibroblasts, or the mechanisms driving them, has remained unknown. To determine whether...

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and usually lethal fibrotic lung disease characterized by profound changes in epithelial cell phenotype and fibroblast proliferation. To determine changes in expression and role of microRNAs in IPF. RNA from 10 control and 10 IPF tissues was hybridized on Agilent microRNA microarrays an...

Idiopathic pulmonary arterial hypertension (PAH) is a life-threatening condition characterized by pulmonary arteriolar remodeling. This investigation aimed to identify genes involved specifically in the pathogenesis of PAH and not other forms of pulmonary hypertension (PH). Using genomewide microarray analysis, we generated the largest data set to...

The molecular mechanisms underlying acute exacerbations of idiopathic pulmonary fibrosis (IPF) are poorly understood. We studied the global gene expression signature of acute exacerbations of IPF. To understand the gene expression patterns of acute exacerbations of IPF. RNA was extracted from 23 stable IPF lungs, 8 IPF lungs with acute exacerbation...

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease associated with substantial morbidity and mortality. The objective of this study was to determine whether there is a peripheral blood protein signature in IPF and whether components of this signature may serve as biomarkers for disease presence and progression. We an...

Spanish Translation of the Abstract by Moises Selman (42 KB DOC)

Japanese Translation of the Abstract by Kazuhisa Konishi (22 KB DOC)

Chinese Translation of the Abstract (38 KB DOC)

Russian Translation of the Abstract by Anna E. Lokshin (24 KB DOC)

Hebrew Translation of the Abstract (69 KB DOC)

Supplementary Methods (148 KB DOC)