Kazuhiro Ikumi

MEDICOLAB · Research and Development

TAR DNA-binding protein 43 kDa (TDP-43), encoded by TARDBP, is an RNA-binding protein, the nuclear depletion of which is the histopathological hallmark of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder affecting both upper and lower motor neurons. Besides motor symptoms, patients with ALS often develop nonneuronal signs inc...

We report a case of long-standing overt ventriculomegaly without aqueductal stenosis. A 66-year-old woman developed progressive gait disturbance. Her gait was wide-based, with a difficulty in turning. Prominent macrocephaly was present, which suggests long-standing hydrocephalus since childhood. Cognitive impairments were detected on neuropsycholog...

Fingolimod is an oral, disease-modifying therapy used to treat multiple sclerosis (MS).¹ However, severe viral infections, including disseminated varicella-zoster virus infection,¹ herpes simplex encephalitis,1,2 varicella-zoster virus encephalitis and vasculopathy,³ or progressive multifocal leukoencephalopathy,⁴ have been reported during fingolim...

The patient is a 72-year-old Japanese woman. Seven years prior to admission, multiple nodules in her left lung were found. Bronchoscopic biopsy of the nodules did not provide a confirmative diagnosis, and probable diagnosis of cryptococcosis was made. Follow-up CT scan of the chest revealed reduction in size of the lung nodules. She was admitted to...

The patient is a 68-year-old Japanese woman. She was admitted to our hospital due to continuous hiccups and vomiting episodes for more than one week. On examinations, muscle strength in her right lower limb was slightly decreased, and pyramidal tract signs were positive bilaterally. The fluid attenuated inversion recovery imaging of the brain showe...