Kayambu Namitharan

• PhD
• PostDoc Position at Nanyang Technological University

Herein, we report a copper/amine catalyzed stereoselective addition of alkynes to ketenimine intermediates generated in situ from the sulfonyl azide-alkyne cycloaddition cascade for the stereoselective synthesis of (Z)-1,3-enynes. Significantly, for the first-time, enamine intermediates generated in the copper-catalyzed sulfonyl azide-alkyne cycloa...

Transition metal and organic catalysts have established their own domains of excellence. It has been expected that merging the two unique domains should provide complimentary or unprecedented opportunities in converting simple raw materials to functional products. N-heterocyclic carbenes alone are excellent organocatalysts. When used with transitio...

A novel synthetic protocol for the one-pot chemo- and stereoselective construction of diversely functionalized pyrido[1,2-a]pyrimidin-4-imines via copper(I)-catalyzed [3+2] cycloaddition/ring-opening rearrangement/[4+2] cycloaddition/aromatization cascade of sulfonyl azides, alkynes and N-arylidenepyridin-2-amines under mild reaction conditions is...

A remarkable role of Lewis acid additives in syntheses of bis-N-sulfonylcyclobutenes via copper(I) catalyzed (3 + 2)/(2 + 2) cycloaddition cascade of sulfonyl azides and terminal alkynes is described. In addition, these cyclobutenes display a unique aggregation-induced emission enhancement (AIEE), reported for the first time, arising predominantly...

A novel one-pot azide-alkyne/ketenimine-nitrone cycloaddition sequence that is induced by copper(I) and allows the transformation of sulfonyl azides, alkynes, and nitrones to highly substituted imidazolidin-4-ones is described. The corresponding heterogeneous version utilizing Cu(I)-modified zeolites as recyclable heterogeneous catalysts shows marg...

A versatile three-component coupling of aldehydes, alkynes and amines has been developed, catalyzed by Ni2+-exchanged Y-zeolite, which acts as an environmentally benign, recyclable, efficient and heterogeneous catalyst. This three-component (A3) coupling (reported for the first time to proceed under nickel catalysis) is carried out under solvent-fr...

A versatile three-component coupling of aldehydes, alkynes and amines has been developed, catalyzed by Ni2+ exchanged Y-zeolite, which acts as all environmentally benign, recyclable, efficient and heterogeneous catalyst This three-component (A(3)) coupling (reported for the first time to proceed under nickel catalysis) is carried out under solvent-...

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

A copper-aluminum hydrotalcite (Cu/Al-HT(3:1) as a new, environmentally benign, recyclable, efficient, and heterogeneous CuII catalyst system for the Huisgen [3+2] cycloaddition of azides and alkynes, was reported. (Cu/Al-HT(3:1) was prepared and characterized by powder x-ray diffraction (XRD). Reactions of benzyl azide with several aliphatic and a...

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.