Kaweh Mansouri

Clinique De Montchoisi · Glaucoma Center

Background Measuring and controlling intraocular pressure (IOP) provide the foundation for glaucoma treatment. Self-tonometry has been proposed as an alternative to better measure IOP throughout the entire day. The novel EYEMATE-SC sensor is implanted in the suprachoroidal space to enable contactless continual IOP monitoring. The aim of the present...

Background: The purpose of this study is to evaluate the outcome of deep sclerectomy (DS) as a secondary procedure following failed ab-interno XEN gel stent implantation in patients with open-angle glaucoma. Methods: Prospective, single-center, non-randomized, interventional study. Consecutive eyes that underwent mitomycin C (MMC) augmented XEN...

Objectives: To describe the efficacy and safety of goniotomy with trabecular meshwork excision using the Kahook Dual Blade (KDB, New World Medical Inc., Rancho Cucamonga, CA) in patients with severe or refractory glaucoma. Methods: This retrospective multicentre case series reports on 40 eyes with severe or refractory open-angle glaucoma that un...

Background Patients with glaucoma on topical glaucoma medication are often affected by dry eye symptoms and thus likely to rub or squeeze their eyelids. Here, we telemetrically measure peak intraocular pressure (IOP) during eyelid manoeuvres and eyelid rubbing. Methods Eleven patients with primary open-angle glaucoma (POAG) previously implanted wi...

Purpose To evaluate the association between optical microangiography (OMAG) measurements and progressive ganglion cell-inner plexiform layer (GCIPL) loss in primary open angle glaucoma (POAG). Design Prospective case-series Methods Sixty-three eyes of 38 POAG patients were studied for at least 2 years and with at least 3 optical coherence tomogra...

Aim To investigate the safety and performance of a telemetric suprachoroidal intraocular pressure (IOP) sensor (EYEMATE-SC) and the accuracy of its IOP measurements in open angle glaucoma (OAG) patients undergoing simultaneous non-penetrating glaucoma surgery (NPGS). Methods Prospective, multicentre, open-label, single-arm, interventional clinical...

Purpose : To evaluate the association between optical microangiography (OMAG) measurements and progressive retinal nerve fiber layer (RNFL) loss in primary open angle glaucoma (POAG). Design : Prospective case series Methods : Sixty-four eyes of 40 POAG patients (108 quadrants) with mild to moderate functional damage were longitudinally studied f...

Background/aims: The purpose of this study was to assess the difference in outcome between the first-operated eye and the second-operated eye following non-penetrating deep sclerectomy (DS), and to identify potential success predictors for the second eye. Methods: This single-surgeon, retrospective study analyzed the outcomes of all bilateral no...

Purpose: Intravitreal injections (IVI) may create transient intraocular pressure (IOP) elevation. This report describes continuous IOP fluctuations following multiple IVI measured with a permanent implantable sensor. Patient and methods: We report the case of a 49-year-old Caucasian glaucomatous male with refractory macular edema secondary to ce...

Purpose: To explore the effect of gaze direction and eyelid closure on intraocular pressure (IOP). Methods: Eleven patients with primary open-angle glaucoma previously implanted with a telemetric IOP sensor were instructed to view eight equally-spaced fixation targets each at three eccentricities (10°, 20°, and 25°). Nine patients also performed...

PurposePseudoexfoliation syndrome is common in elderly patients and is associated with intraocular pressure elevation. Goniowash is a novel surgical technique to remove pseudoexfoliation material from the irido-corneal angle to decrease intraocular pressure. We assessed the long-term efficacy of Goniowash on relevant parameters in patients with pse...

The recent advent of continuous intraocular pressure (IOP) telemetry has led to an increased awareness of the importance of IOP fluctuations, and theories have emerged that IOP variations could play as much a role in glaucoma progression as the mean level of IOP. The aim of the present study was to evaluate the direct effect of common daily activit...

Objectives To determine the effect of laser trabeculoplasty on peripapillary retinal nerve fibre layer thickness (RNFL), fovea avascular zone (FAZ), peripapillary and macular vessel density (VD) in glaucoma using with optical coherence tomography angiography (OCT‐A). Methods This was a prospective observational study performed at the Glaucoma Rese...

Purpose: To evaluate in glaucoma patients the feasibility and use of remote monitoring of intraocular pressure (IOP) with an implanted telemetry sensor during the COVID-19 lockdown period. Design: Cross-sectional study. Subjects: Patients previously implanted with a telemetric IOP sensor (eyemate®, Implandata GmbH, Hannover, Germany) were incl...

Precis: Lower whole enface disc (coefficient: 0.02, P=0.03) and macular vessel densities (coefficient: 0.04, P=0.02) on OCT angiography were significantly associated with faster rate of mean deviation decline. Purpose: To evaluate the association between optical coherence tomography angiography (OCTA) features and prior visual field (VF) progres...

Summary Background To contribute to the WHO initiative, VISION 2020: The Right to Sight, an assessment of global vision impairment in 2020 and temporal change is needed. We aimed to extensively update estimates of global vision loss burden, presenting estimates for 2020, temporal change over three decades between 1990–2020, and forecasts for 2050....

Purpose: To determine whether 24-hour recording of intraocular pressure (IOP)-related ocular dimensional changes with a contact lens sensor (CLS, Triggerfish, Sensimed) is associated with the rate of visual field progression in primary open-angle glaucoma (POAG) patients. Design: Retrospective, observational cohort study. Participants: Patient...

Glaucoma management has changed dramatically over the last decades, through clinical advances and technological revolutions. This review discusses the latest innovations and challenges faced in the field around three major axes: minimally-invasive glaucoma surgery (MIGS), implantable sensors and injectable therapeutics. Indeed, the vast number of...

Aim: To compare the repeatability of peripapillary perfusion density and flux index measurements on referenced and non-referenced optical microangiography (OMAG) scans in normal, glaucoma suspect and glaucoma eyes. Methods: In a cross-sectional study, 48 eyes (33 subjects) underwent three repeat, non-referenced peripapillary OMAG scans in the sa...

Purpose: To evaluate the 3-year treatment outcomes of XEN 45 gel stent in open-angle glaucoma patients. Methods: In this prospective, single-centre interventional study, consecutive eyes with uncontrolled intraocular pressure (IOP) or signs of disease progression despite medical treatment underwent XEN implantation either alone or combined with ph...

Aim: To investigate the reliability of anterior chamber angle (ACA) measurements in narrow angles and assess the effect of laser peripheral iridotomy (LPI) on these measurements using novel swept-source optical coherence tomography (SS-OCT) technology. Methods: In this prospective observational study, patients with gonioscopically narrow angles...

PurposeTo evaluate outcomes of XEN-augmented Baerveldt drainage device implantation in refractory glaucoma and factors predicting surgical success.Method All eyes undergoing XEN-augmented Baerveldt for refractory open-angle glaucoma at a tertiary glaucoma centre between January 2016 and November 2017 were retrospectively enrolled. Intraocular press...

Aims (1) To test the feasibility of simultaneous steady-state pattern electroretinogram (ssPERG) and intraocular pressure (IOP) measurements with an implanted IOP sensor. (2) To explore the scope of this approach for detecting PERG changes during IOP manipulation in a model of lateral decubitus positioning (LDP; lateral position). Methods 15 healt...

Purpose To evaluate the short- and long-term variability of intraocular pressure (IOP) in eyes with primary open-angle glaucoma (POAG). Methods Twenty-two patients who had previously been implanted with a sulcus based IOP sensor (EyeMate, Implandata GmbH, Germany) were included. They were requested to obtain at least 4 IOP measurements per day. Da...

Purpose To compare the long‐term safety and efficacy of pattern scanning laser trabeculoplasty (PSLT) and selective laser trabeculoplasty (SLT). Methods This was a retrospective database analysis (Lausanne Laser Trabeculoplasty Registry) of patients having had laser trabeculoplasty (LT) prior to 2017 with a minimum follow‐up of 1 year. Inclusion c...

Background/Aims To better understand seasonal and weekday intraocular pressure (IOP) variations, long-term daily IOP measurements were assessed in patients with glaucoma using an intraocular telemetric sensor. Methods This prospective, open-label, multicentre observational study analysed the IOP variation patterns in 22 eyes of 22 patients with pr...

Purpose: The last decade has witnessed an unprecedented growth in glaucoma treatment options through the introduction of minimally invasive glaucoma surgeries (MIGS). The aim of the present review is to provide an understanding of the currently available MIGS and to examine what data are currently available to guide treatment choice. Design: Met...

Purpose: Scarce data are available on the symmetry of 24-hour intraocular pressure (IOP) variations between fellow eyes of glaucoma patients, and such evidence could have profound consequences on the interpretation of monocular therapeutic trials. The objective is to evaluate the intereye correlation of continuously measured circadian IOP-related...

Purpose: To determine the factors associated with the outcomes of selective laser trabeculoplasty (SLT). Methods: This was a database analysis (Lausanne Laser Trabeculoplasty Registry) of patients who had SLT between 2015 and 2017. Exclusion criteria were age below 40 years and diagnosis other than ocular hypertension and open-angle glaucoma. IO...

Precis: The surgical outcome of iStent inject devices is associated with device protrusion within the anterior chamber. Schlemm canal (SC) dilatation has a prognostic value. iStent inject devices do not move within the first year after implantation. Introduction: The iStent inject is a device designed to be implanted ab-interno through the trabe...

Background/aims: Both eyes of a same person are not completely independent entities. The purpose of this study was to assess the difference in outcome between the first-operated eye and the fellow-operated eye following bilateral XEN surgery, and to identify potential success predictors for the fellow eye. Methods: This single-site, prospective,...

Purpose To evaluate the use of a 24‐hr ocular dimensional profile recorded with a contact lens sensor (CLS) combined with a single tonometric intraocular pressure (IOP) reading to indicate the potential for exceeding the diagnostic threshold for normal tension glaucoma (NTG) in Japanese patients. Methods Intraocular pressure (IOP) of untreated Jap...

Purpose: In recent years, new technologies have emerged to better analyze and interpret IOP fluctuations. Amongst them is the progression report (PR), an algorithm based on continuous contact lens sensor (CLS) readings to estimate the likelihood of fast visual field (VF) glaucomatous progression. The objective of this study is to validate the PR....

Background/Aims This study assessed the feasibility of a novel contact lens device for intraocular pressure (IOP) and ocular pulse amplitude (OPA) continuous measurements over 24 hours. Methods This prospective, open-label, single-centre, non-randomised study included glaucoma and healthy subjects. IOP and OPA values acquired by the pressure-measu...

Hintergrund: Die stressinduzierte Aktivierung des sympathischen Nervensystems löst eine Kaskade metabolischer Reaktionen aus. Emotionaler Stress ist eine spezielle Form von Stress, bei der der Stressor eine psychische Reaktion auf eine Situation ist, die subjektiv als traumatisch empfunden wird. Stresshormone können vielfältige Wirkungen auf den Kö...

Optical coherence tomography angiography (OCTA) is a relatively new, non-invasive, dye-free imaging modality that provides a qualitative and quantitative assessment of the vasculature in the retina and optic nerve head. OCTA also enables visualization of the choriocapillaris, but only in areas of parapapillary atrophy. With OCTA, movement of red bl...

Purpose: To evaluate the outcome of pericardium patch graft (Tutoplast®) as an adjuvant to either bleb repair or bleb reduction after nonpenetrating filtering surgery. Method: Retrospective study, at a tertiary glaucoma center. Bleb revision with Tutoplast® positioning was performed either for bleb repair to treat early leaks or hypotony with ma...

Purpose To test the feasibility of simultaneous steady-state pattern electroretinogram (PERG) and intraocular pressure (IOP) measurements with an IOP sensor and to test a model for IOP manipulation during lateral decubitus positioning (LDP) and its impact on the PERG. Design A prospective, observational study. Methods 15 healthy controls and 15 t...

Optical coherence tomography (OCT) evaluates optic nerve head, peripapillary retinal nerve fiber layer and inner retinal layers at macula for detecting structural abnormalities in glaucoma. The structural abnormalities detected on OCT precede functional loss (detected on standard automated perimetry) enabling early diagnosis of glaucoma. Assessing...

Background: The efficiency and safety of primary open-angle glaucoma with high-frequency deep sclerotomy (HFDS) combined with cataract surgery has to be investigated. Methods: Right after cataract surgery, HFDS was performed ab interno in 205 consecutive patients with open angle glaucoma. HFDS was performed with a custom-made high-frequency disSect...

The most effective way to control glaucoma is by lowering intraocular pressure (IOP) in order to prevent the progression of the disease. Glaucoma drainage devices (GDDs) are a surgical option reserved for refractory cases and have been designed to address known complications of conventional filtering surgery. They are however associated with a high...

Introduction: Corneal integrity has long been a preoccupation of glaucoma surgeons considering glaucoma drainage device (GDD) surgery or antimetabolite-enhanced trabeculectomy. Despite having demonstrated a good safety profile and significant IOP lowering capacities, the impact of XEN gel stents (Allergan, Dublin, CA) on endothelial density was ne...

Aim: Glaucoma drainage device (GDD) failure is usually rectified by the replacement of the entire device or using a tube extender, both of which were associated with postoperative complications. To minimize these risks, we developed a technique to replace the failing section of a tube while keeping the filtration plate in place, and without resort...

Aim: The aim of this report is to explore the risk factors of XEN stent obstruction, suggesting the need for a stricter control of these factors and highlighting areas for further research. Background: Despite its proven effectiveness and safety profile, XEN gel stents (Allergan Plc, Dublin, Ireland) can become obstructed. The causes and predict...

Introduction: The XEN gel stent is currently the only minimally invasive glaucoma surgical device that targets the subconjunctival outflow pathway through an ab interno placement. It has demonstrated a significant intraocular pressure (IOP)-lowering potential and a favorable safety profile compared with traditional filtering surgery. However, desp...

Introduction: If intraocular pressure (IOP) is the sole modifiable risk factor for glaucoma progression, glaucoma management should not rely on a vague estimation of its value measured over seconds, out of the 31,536,000 seconds in a year. A technology that would allow continuous and accurate IOP measurement in any situation could drastically enhan...

Elevated intraocular pressure (IOP) is a major, and currently the only, modifiable risk factor, that has been shown to reduce the risk of glaucoma onset and progression. Diurnal measurements of IOP, usually during office hours, are commonly used for the assessment of IOP variation and the relative success of medical, laser, or surgical IOP-lowering...

Purpose: The aim of this study was to investigate the safety and performance of the second generation of an implantable intraocular pressure (IOP) sensor in patients with primary open angle glaucoma (POAG). Design: prospective, non-comparative, open-label, multicenter clinical investigation METHODS: In this study patients with POAG, regularly sc...

Objectives: To determine the effect of surgical intraocular pressure (IOP) lowering on peripapillary retinal nerve fibre layer thickness (RNFL), fovea avascular zone (FAZ), peripapillary and macular vessel density (VD) in glaucoma using with optical coherence tomography angiography (OCT-A). Methods: This was a prospective observational study per...

Objective To estimate the prevalence and causes of blindness and vision impairment for distance and near in Latin America and the Caribbean (LAC) in 2015 and to forecast trends to 2020. Methods A meta-analysis from a global systematic review of 283 cross-sectional, population-representative studies from published and unpublished sources from 1980 t...

A 29-year-old woman presented with longstanding 1 history of daily headaches. Neurological examination and brain MRI were unremarkable and family history was positive for glaucoma in every known relative on her paternal side. On examination, her intraocular pressure (IOP) was 40 mmHg in the right eye and 15 mmHg in the left eye. Cup-to-disc ratio w...

Purpose To evaluate the 2-year treatment outcomes of the XEN gel stent (Allergan, Inc, Irvine, CA) in glaucoma patients. Design Prospective, single-center interventional study. Participants One hundred forty-nine eyes of 113 patients with open-angle glaucoma. Methods Consecutive eyes with uncontrolled intraocular pressure (IOP) or signs of disea...

Purpose: To compare the prevalence of choroidal microvasculature dropout (CMvD) in pseudoexfoliation glaucoma (PXG) and disease severity-matched primary open-angle glaucoma (POAG) eyes. Methods: In a cross-sectional study, 39 eyes with PXG (33 patients) and 39 glaucoma severity-matched POAG eyes (34 patients) underwent visual fields, optical coh...

Précis: A larger proportion of iStent inject microstents than suggested by gonioscopic examination could be entirely burrowed within the trabeculum (45.7%). The length of device protrusion within the anterior chamber is linked to post-operative intraocular pressure. Introduction: The iStent inject® (Glaukos Corporation, CA, USA) is a relatively ne...

PRéCIS:: This study confirms the safety and efficacy of XEN gel stents in the management of pseudoexfoliative glaucoma 2 years after implantation, with similar success rates to primary open-angle glaucoma regardless of the definition of success. Purpose: To compare the long-term safety and efficacy of XEN gel implant surgery (Allergan Inc., Irvin...

Abstract – Objective: Breast cancer is the most common cancer among women worldwide. This study was conducted to investigate the trend of Age-Standardized Incidence Rate (ASIR) of breast cancer and its relationship with Human Development Index (HDI) in Iran during 2003-2009. Materials and Methods: This cross-sectional study was carried out using...

Background: Stress-induced activation of the sympathetic nervous system leads to a cascade of metabolic reactions. Emotional stress is a more specific form of stress in which the stressor is a psychological response to a situation subjectively perceived as traumatic. Stress hormones can have a wide range of effects on the body, however, it is still...

PRéCIS:: The 24-hour ocular dimensional profile recorded by a contact lens sensor was affected by intraocular pressure lowering interventions. Among different treatments, incisional surgery had the most significant effect. Purpose: We investigated the effect of different intraocular pressure (IOP)-lowering interventions on contact lens sensor (CL...

Purpose: To analyze the dynamics of telemetrically measured intraocular pressure (IOP) during the first year after implantation of a Boston keratoprosthesis type I (BI-KPro) cornea and to compare agreement of telemetric IOP measurements with finger palpations. Design: Prospective, open-label, multicenter, single-arm clinical trial. Methods: In...

Purpose: The purpose of the study was to evaluate the tolerability and functionality of a wireless ocular telemetry sensor in African American patients with glaucoma. Materials and methods: In this prospective, observational cohort study, 20 African American patients with primary open angle glaucoma (POAG) were evaluated at the University of Col...

Introduction: Kabuki syndrome (KS) is a rare congenital and polymalformative condition, traditionally associated with mental retardation, unusual facial features and skeletal abnormalities. We hereby describe a case of bilateral congenital glaucoma associated with MLL2-mutation Kabuki Syndrome. To the best of our knowledge, this is the first associ...

Introduction: While there are several examples of glaucoma drainage devices dislocations in the literature, the movement of XEN gel stents is scarcely documented and the impact of such displacements on the corneal endothelium remains unknown. In light of the recent global market withdrawal of the CyPass micro-stent over concerns regarding endotheli...

Introduction: The iStent inject® (Glaukos Corporation, CA, USA) is a relatively new device designed to be implanted ab-interno through the trabecular meshwork. This is, to the best of our knowledge, the first in-vivo description of a trabecular bypass device visualised with anterior segment optical coherence tomography (AS-OCT), and report of its...

Purpose: To determine the prevalence and factors associated with the presence of choroidal microvascular dropout (CMvD) in primary angle-closure glaucoma (PACG) eyes compared to primary open-angle glaucoma (POAG) eyes. Design: Cross-sectional study. Methods: Thirty-six POAG eyes (36 patients) and 28 PACG eyes (28 patients) underwent optical co...

Purpose: The main purpose of this study was to compare the prevalence of choroidal microvascular dropout (CMvD) in primary open-angle glaucoma (POAG) eyes with and without disc hemorrhage (DH). Methods: In a cross-sectional study, 44 eyes of 44 control subjects, 32 eyes of 32 POAG patients with DH, and 41 eyes of 41 POAG patients without DH unde...