Kavitha Dhandapani

Avinashilingam University · Department of Bio-chemistry/ Bio-technology/ Bio-informatics

Acinetobacter baumannii is an ESKAPE pathogen and threatens human health by generating infections with high fatality rates. A. baumannii leads to a spectrum of infections such as skin and wound infections, endocarditis, meningitis pneumonia, septicaemia and urinary tract infections. Recently, strains of A. baumannii have emerged as multidrug-resist...

Listeria monocytogenes, the third most deleterious zoonotic pathogen, is a major causative agent of animal and human listeriosis, an infection related to the consumption of contaminated food products. Even though, this pathogen has been responsible for the outbreaks of foodborne infections in the early 1980s, the major outbreaks have been reported...

The quorum sensing network of Pseudomonas aeruginosa mediates the regulation of genes controlling biofilm formation and virulence factors. The rise of drug resistance to Pseudomonas aeruginosa infections has made quorum sensing–regulated biofilm formation in clinical settings a major issue. In the present study, LasR inhibitors identified in our pr...

Host–guest complexation of decamethoxypillar[5]arene and difunctionalized pillar[4]arene[1]quinone with isatin were demonstrated by ¹H NMR titration experiments. The antibacterial potentials of isatin, decamethoxypillar[5]arene, difunctionalized pillar[4]arene[1]quinone and their isatin inclusion complexes were evaluated against both Gram-positive...

Several medicinal plants have the potential to be a promising alternative pharmacological therapy for a variety of human illnesses. Many insects, including mosquitoes, are important vectors of deadly pathogens and parasites, which in the world’s growing human and animal populations can cause serious epidemics and pandemics. Medicinal plants continu...

Aspergillosis is a dreadful fungal infection and are more predominant in clinical fields. Due to the limitation of antifungal drugs, there is an emergence to develop efficient antifungal compounds from natural sources. Hence, the present study deals with the validation of active compounds from Aspergillus giganteus against aspergillosis causing Asp...

Occurrence and intensity of systemic invasive fungal infections have significantly risen in recent decades with large amount of mortality and morbidity rates at global level. Treatment therapy lies on the current antifungal interventions and are often limited due to the emergence of resistance to antifungal agents. Chemosensitization of fungal stra...

The present study is aimed at evaluating the antioxidant and antimicrobial properties of aqueous extracts of the plants Moringa olifera (drumstick tree or murungai), Sesbania grandiflora (vegetable hummingbird or agati), Basella alba (malabar spinach or pasalai), and then developing herbal hydrogel with gelatin to improve its pharmacological proper...

Aspergillus flavus is a fungal pathogen which infects maize crops and produces aflatoxin thus bringing about huge losses in crop production. Developing biocontrol agents against Aspergillus flavus has been the best strategy for the control of contamination in the fields. The aim of this study was to evaluate the biocontrol potential of Aspergillus...

Objective: Many of the plants are used for medicinal purposes in human health needs. Trianthema portulacastrum has got many medicinal values and also a dietary plant, being used in Ayurveda. It exhibits nephroprotective, diuretic, anti-cancerous, antihelmintic, antipyretic, analgesic properties, anti-inflammatory activity, and also antibacterial ac...

Objective: To evaluate the leaves of Trianthema portulacastrum for its antibacterial activity, antifungal activity and also to identify the nature of the phytochemicals in the selected plant. Materials and Methods: The leaves of the selected plant were extracted in varying solvents of different polarity and tested against the clinical isolates of b...

Plants have formed the basis of traditional systems of medicine that have been in existence for thousands of years and continue to provide mankind with new remedies. The use of natural products with therapeutic properties is as ancient as human civilization and for a long time, mineral, plant and animal products were the main source of drugs. In th...

Medicinal plants are sources of important therapeutic aids for alleviating human ailments. Medicinal herbs are known to contain a variety of antioxidants. Herbal medicine is the use of medicinal plants for the prevention and treatment of diseases, it ranges from traditional and popular medicines of every country to the use of standardized herbal ex...

The present study focuses on the antibacterial and antifungal activity of the medicinal plant Aristolochia bracteolata. Aqueous, methanol and chloroform extracts of this plant were evaluated against the bacterial strains Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas fluorescens, Shigella flexneri, Pr...

The effect of automobile wastewater (25,50,75 and 100%) was studied on seed germination and seedling growth of black gram (Vigna mungo). The biometric attributes showed a decrease with increased concentration of the effluent. The best germination and seedling growth was observed in 25% concentration. Undiluted effluent had an inhibitory effect wher...

Galinsoga ciliata is a small annual herb, which has a wide traditional use. The leaves and inflorescence in dressing the fresh wounds or cuts as well as saddle sores and rawness of the skin to faster quick healing. Petroleum ether, benzene, ethyl acetate and acetone extracts of the leaves were found to be completely active against the bacteria test...

The floras of Indian medicinal plants are potent source of bioactive principles. Antibacterial activity of Gymnema sylvestre, Couroupita guianesis and Withania somnifera were studied against Bacillus subtilis, Staphylocovvus aureus, Klebsiella pneumoniane, Pseudomonas aeruginosa, Escherichia coli and Salmonella typhi. The maximum inhibitory zone of...