Katy Diallo

University of Glasgow | UofG · Institute of Infection, Immunity and Inflammation

Factors governing the coagulopathy and pneumonitis associated with severe viral infections remain unresolved. We previously found that the expression of protein S (PROS1) is increased in lung epithelium of patients with mild COVID-19 as compared to severe COVID-19. We hypothesised that PROS1 may exert a local effect that protects the upper airway a...

Protein S (PROS1) is a ligand for MERTK receptor that plays a key role in inhibiting pro-inflammatory activation of macrophages ,and inducing uptake of apoptotic cells and production of mediators of tissue repair. Recently, we have reported an increase in PROS1 mRNA in epithelial cells in lungs of patients with mild Covid but not in those with seve...

Introduction Les maladies auto-immunes granulomateuses répondent inconstamment aux anti-TNF. Cette réponse thérapeutique semble dépendre du type d’anti-TNF : les anticorps monoclonaux anti-TNF semblent efficaces contrairement au récepteur soluble du TNF. L’action des anti-TNF repose sur la neutralisation du TNF soluble, ainsi que sur leur liaison a...

In order to ascertain the significance of tmTNF reverse signaling in vivo, we generated a triple transgenic mouse model (3TG, TNFR1-/-, TNFR2-/- and tmTNFKI/KI) in which all canonical TNF signaling was abolished. In bone marrow derived macrophages harvested from these mice, various anti-TNF biologics induced the expression of genes characteristic o...

Increased osteoclastogenesis is a common feature of bone erosion, notably in osteoporosis but also in inflammatory diseases such as rheumatoid arthritis (RA) and osteoarticular infections. Human cytomegalovirus (HCMV) infection has been described to impair monocyte differentiation into macrophages and dendritic cells. However, its effect on monocyt...

[This corrects the article DOI: 10.3389/fimmu.2019.01482.].

Introduction: Adipose-derived mesenchymal stem cells (ADSC) have been shown to have remarkable immune-modulating effects. However, their efficacy in clinical trials has yet to be fully demonstrated. This could be due to a lack of a proper inflammatory environment in vivo that primes ADSC. Here, we define how the articular microenvironment of rheuma...

Career situation of first and presenting author Post-doctoral fellow. Introduction Anti-TNF agents are widely used in rheumatoid arthritis (RA). Their effect on inflammation results from the neutralization of soluble TNF (sTNF), but also supposedly from the induction of reverse signaling through their binding to membrane TNF (tmTNF). Despite possi...