Katsuhiko Miyazaki

Katsuhiko Miyazaki
Okinawa Institute of Science and Technology | OIST · Neural Computation Unit

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24
Publications
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812
Citations

Publications

Publications (24)
Article
Serotonin is a neuromodulator that is implicated in awake-sleep cycle, motor behaviors, reward, motivation, and mood. Recent molecular tools for cell-type-specific activity recording and manipulation with fine temporal and spatial resolutions are providing unprecedentedly detailed data about serotonergic neuromodulation. These newly gained informat...
Article
Full-text available
Optogenetic activation of serotonergic neurons in the dorsal raphe nucleus (DRN) enhances patience when waiting for future rewards, and this effect is maximized by both high probability and high timing uncertainty of reward. Here, we explored which serotonin projection areas contribute to these effects using optogenetic axon terminal stimulation. W...
Article
Full-text available
Recent experiments have shown that optogenetic activation of serotonin neurons in the dorsal raphe nucleus (DRN) in mice enhances patience in waiting for future rewards. Here, we show that serotonin effect in promoting waiting is maximized by both high probability and high timing uncertainty of reward. Optogenetic activation of serotonergic neurons...
Article
Serotonin is a neuromodulator that is involved extensively in behavioral, affective, and cognitive functions in the brain. Previous recording studies of the midbrain dorsal raphe nucleus (DRN) revealed that the activation of putative serotonin neurons correlates with the levels of behavioral arousal [1], rhythmic motor outputs [2], salient sensory...
Article
Full-text available
The forebrain serotonergic system is a crucial component in the control of impulsive behaviors. We previously reported that the activity of serotonin neurons in the midbrain dorsal raphe nucleus increased when rats performed a task that required them to wait for delayed rewards. However, the causal relationship between serotonin neural activity and...
Article
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Classic theories suggest that central serotonergic neurons are involved in the behavioral inhibition that is associated with the prediction of negative rewards or punishment. Failed behavioral inhibition can cause impulsive behaviors. However, the behavioral inhibition that results from predicting punishment is not sufficient to explain some forms...
Article
The serotonergic system plays a key role in the control of impulsive behaviors. Forebrain serotonin depletion leads to premature actions and steepens discounting of delayed rewards. However, there has been no direct evidence for serotonin neuron activity in relation to actions for delayed rewards. Here we show that serotonin neurons increase their...
Article
Full-text available
The forebrain serotonergic system is a crucial component in the control of impulsive behaviours. However, there is no direct evidence for natural serotonin activity during behaviours for delayed rewards as opposed to immediate rewards. Herein we show that serotonin efflux is enhanced while rats perform a task that requires waiting for a delayed rew...
Article
We recorded single units in the rat nucleus accumbens (NAcc) and medial prefrontal cortex (mPFC) to investigate activity related to reward mediation and anticipation during execution of an alternating reward task. NAcc and mPFC neurons showed increased activity differently during an interposed delay preceding reward delivery. Some NAcc neurons incr...
Article
A novel voltammetric method using a new carbon electrode has been developed for simultaneous measurement of any combination of nitrite ion (NO−2), dopamine (DA) and serotonin (5-HT) with ascorbic acid (AA). Both cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used for measurements of the neurotransmitters by means of a GRC (gr...
Article
Single unit recording in rat nucleus accumbens (NAcc) was used to ascertain NAcc neuronal activity in mediating of reward including its anticipation. Of the 103 neurons investigated, 63% showed some response in connection with the task activity. Of these, 20 units responded during delivery of the primary reward (food and/or water) and five responde...
Conference Paper
Brain information processing is supported by the dual architecture of the cortical and limbic systems for the knowledge-based and emotional information, respectively. We hypothesize this dual architecture of the brain contributes to brain learning control. In order to examine the role of emotion in forming memory that is, automatic algorithm acquis...

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