Katrina P Nguyen

Katrina P Nguyen
Carnegie Mellon University | CMU · Department of Biomedical Engineering

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32
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172
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Publications

Publications (32)
Preprint
Optogenetic stimulation of Adora2a receptor expressing spiny projection neurons (A2A-SPN) in the striatum drives locomotor suppression and negative reinforcement, results attributed to activation of the indirect pathway. The sole long-range projection target of A2A-SPNs is the external globus pallidus (GPe). Unexpectedly, we found that inhibition o...
Article
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Robust locomotion is critical to many species’ survival, yet the mechanisms by which efficient locomotion is learned and maintained are poorly understood. In mice, a common paradigm for assaying locomotor learning is the rotarod task, in which mice learn to maintain balance atop of an accelerating rod. However, the standard metric for learning in t...
Article
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Feeding is critical for survival and disruption in the mechanisms that govern food intake underlie disorders such as obesity and anorexia nervosa. It is important to understand both food intake and food motivation to reveal mechanisms underlying feeding disorders. Operant behavioral testing can be used to measure the motivational component to feedi...
Preprint
Full-text available
Feeding is critical for survival and disruption in the mechanisms that govern food intake underlie disorders such as obesity and anorexia nervosa. It is important to understand both food intake and food motivation to reveal mechanisms underlying feeding disorders. Operant behavioral testing can be used to measure the motivational component to feedi...
Article
Full-text available
The dorsal striatum has been linked to decision-making under conflict, but the mechanism by which striatal neurons contribute to approach-avoidance conflicts remains unclear. We hypothesized that striatopallidal dopamine D2 receptor (D2R)-expressing neurons promote avoidance, and tested this hypothesis in two exploratory approach-avoidance conflict...
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A correction to this paper has been published and can be accessed via a link at the top of the paper.
Article
Extensive computational and neurobiological work has focused on how the training schedule, i.e. the duration and rate at which an environmental disturbance is presented, shapes the formation of motor memories. If long-lasting benefits are to be derived from motor training, however, retention of the performance improvements gained during practice is...
Article
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Objective Ad libitum high‐fat diets (HFDs) spontaneously increase caloric intake in rodents, which correlates positively with weight gain. However, it remains unclear why rodents overeat HFDs. This paper investigated how changing the proportion of diet that came from HFDs might alter daily caloric intake in mice. Methods Mice were given 25%, 50%,...
Article
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Motor adaptation paradigms provide a quantitative method to study short-term modification of motor commands. Despite the growing understanding of the role motion states (e.g., velocity) play in this form of motor learning, there is little information on the relative stability of memories based on these movement characteristics, especially in compar...
Data
Exponential fits to motion-based components of vFF and pFF adaptation decay. (A) A standard exponential model with rate and offset parameters was fit to the decay of the goal-aligned component for vFF and pFF training (data presented in Fig 3C and 3D). A time constant of 10.4 ± 2.2 trials was estimated for pFF training and a constant of 7.9 ± 0.9 t...
Data
The influence of the covariance matrix on simulated learning trajectories. The simulation of the asymmetric model for the learning (colored traces) and decay trajectories (black traces) in primitive gain space for different correlations between position and velocity primitives: symmetric distributions (A) (αK = αB = 0.98, σK = σB = 0.5, η = 1.5 x 1...
Data
Simulation of decay for vFF and pFF training for the symmetric and asymmetric viscoelastic primitive models. (A) Decay of adaptation for both pFF and vFF training depicted in the primitive gain-space. The abscissa represents the goal-aligned component of learning and the ordinate represents the goal-misaligned component. The gain-space trajectories...
Data
Simulation of the asymmetric viscoelastic primitive model based on separated data sets. Simulations of the learning and decay for adaptation to ucFF and pcFF perturbations when the asymmetric model was separately fit to the (A) pFF (αK = 0.951, αB = 0.971, σK = σB = 0.40, η = 1.5 x 10−4, ρ = 0.45) and (B) vFF data (αK = 0.885, αB = 0.936, σK = σB =...
Data
Exponential fits to vFF and pFF adaptation and decay. (A) A standard exponential model with rate and offset parameters was fit to the trial-by-trial increase in the adaptation coefficient during vFF and pFF training (data presented in Fig 2A). A time constant of 7.2 ± 0.8 was determined for pFF training, and a time constant of 12.3 ± 5.5 trials was...
Data
Simulation of the asymmetric viscoelastic primitive model for adaptation to a velocity biased force-field perturbation. (A) Adaptation (orange trace) and decay (black trace) to a velocity biased force-field (vcFF, a greater velocity and smaller position dependence). This learning goal is represented by the point [0.53, 0.85] in gain space. The para...
Data
Exponential fits to position and velocity-based learning for ucFF and pcFF adaptation decay. (A) A standard exponential model with rate and offset parameters fit to the decay of the velocity- and position-based learning for ucFF training (data presented in Fig 5C). A time constant of 9.4 ± 1.8 was estimated for position-based adaptation and 12.1 ±...
Data
The influence of the retention rates on simulated learning decay trajectories. The simulation of the asymmetric model for the learning (colored traces) and decay trajectories (black traces) in primitive gain space for different retention rates for position- and velocity-based learning: symmetric rates (A) (αK = αB = 0.96, σK = σB = 0.5, η = 1.5 x 1...
Article
Full-text available
Food intake measurements are essential for many research studies. Here, we provide a detailed description of a novel solution for measuring food intake in mice: the Feeding Experimentation Device (FED). FED is an open-source system that was designed to facilitate flexibility in food intake studies. Due to its compact and battery powered design, FED...
Article
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The operant conditioning chamber is a cornerstone of animal behavioral research. Operant boxes are used to assess learning and motivational behavior in animals, particularly for food and drug reinforcers. However, commercial operant chambers cost several thousands of dollars. We have constructed the Rodent Operant Bucket (ROBucket), an inexpensive...

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