Katrin Vogel

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Verified

Katrin verified their affiliation via an institutional email.

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• Dr. rer. medic.
• PostDoc Position at Otto-von-Guericke University Magdeburg

Background: Myeloproliferative neoplasms (MPNs), a hematological malignancy commonly associated with the JAK2-V617F mutation, exhibit a considerable burden of comorbidities resulting from inflammation-mediated processes. The JAK2-V617F malignant clones instigate systemic inflammation by upregulating various pro-inflammatory cytokines. This leads to...

Microbial infections early in life are challenging for the unexperienced immune system. The SARS-CoV-2 pandemic again has highlighted that neonatal, infant, child, and adult T-helper(Th)-cells respond differently to infections, and requires further understanding. This study investigates anti-bacterial T-cell responses against Staphylococcus aureus...

Newborns are highly susceptible to infections; however, the underlying mechanisms that regulate the anti-microbial T-helper cells shortly after birth remain incompletely understood. To address neonatal antigen-specific human T-cell responses against bacteria, Staphylococcus aureus (S. aureus) was used as a model pathogen and comparatively analyzed...

The emergence of point-of-care (POC) testing has lately been promoted to deliver rapid, reliable medical tests in critical life-threatening situations, especially in resource-limited settings. Recently, POC tests have witnessed further advances due to the technological revolution in smartphones. Smartphones are integrated as reliable readers to the...

After recovery, mild and severe COVID-19 diseases are associated with long-term effects on the host immune system, such as prolonged T-cell activation or accumulation of autoantibodies. In this study, we show that mild SARS-CoV-2 infections, but not SARS-CoV-2 spike mRNA vaccinations, cause durable atopic risk factors such as a systemic Th2- and Th...

Bifidobacterium is the first microbial coloniser of the gut and thus falls into the window of time when tolerance to harmless environmental antigens is implemented. Although Bifidobacterium is thought to have a beneficial effect on health not only early in life, its actual mechanism of action is not well understood. Here, we investigated the mechan...

Einleitung: Infolge der pandemischen Ausbreitung des SARS-CoV-2 wurde eine Induktion von Autoantikörpern bei symptomatischen Verläufen berichtet, die große Mehrheit der Infizierten entwickelt jedoch einen milden COVID-19-Krankheitsverlauf. Gerade über die Langzeitfolgen dieser Patienten ist noch wenig bekannt, insbesondere in Bezug auf die Entstehu...

T cells in neonates, infants, and adults differ dramatically in the initiation, strength, and stability of their responses. In this study, we investigate cellular mechanisms of CD4+ T cells from neonates, infants and adults to show the antigen specific response to Staphylococcus aureus, Staphylococcus epidermids and Bifidobacterium longum. T cells...

Monitoring the immune system’s status has emerged as an urgent demand in critical health conditions. The circulating cytokine levels in the blood reflect a thorough insight into the immune system status. Indeed, measuring one cytokine may deliver more information equivalent to detecting multiple diseases at a time. However, if the reported cytokine...

The variability in resolution of SARS-CoV-2-infections between individuals neither is comprehended, nor are the long-term immunological consequences. To assess the long-term impact of a SARS-CoV-2-infection on the immune system, we conducted a prospective study of 80 acute and former SARS-CoV-2 infected individuals and 39 unexposed donors to evalua...

The monoclonal antibody against CTLA-4, Ipilimumab, is a first-in-class immune-checkpoint inhibitor approved for treatment of advanced melanoma in adults but not extensively studied in children. In light of the fact that the immune response early in life differs from that of adults, we have applied a human in vitro model stimulating CD4⁺ T-cells fr...

Abstract The origin of human T-cell responses against fungal pathogens early in life is not clearly understood. Here, we show that antifungal T-cell responses are vigorously initiated within the first years of life against lysates and peptides of Candida albicans or Aspergillus fumigatus, presented by autologous monocytes. The neonatal responding T...

Neonates and infants are very susceptible to infections. The immune system of neonates and infants is clearly distinct from that of adults. Yet relatively little research effort has focused on neonatal immune development. To redress this situation we investigate cellular mechanisms of CD4+ T cells from neonates, infants and adults to show the antig...

Neugeborene und Kleinkinder sind sehr anfällig für Infektionen. Die Grundlagen hierfür sind bisher nur wenig erforscht. Die adaptive Immunantwort des Neugeborenen und Kleinkindes sind sehr unterschiedlich zu der von Erwachsenen. Sie zeichnen sich durch ein Favorisieren von humoralen T-Helfer(Th)-2-Immunantworten aus. Die zelluläre Immunität (u.a. T...

T cells in human neonates, infants, and adults differ dramatically in the initiation, strength, and stability of their responses. In this study, we investigate cellular mechanisms of CD4 + T cells from neonates, infants and adults to show the antigen specific response to Staphylococcus aureus and Bifidobacterium longum ssp. infantis. CD14 + monocyt...

T cells in human neonates, infants, and adults differ dramatically in the initiation, strength, and stability of their responses. In this study, we investigate cellular mechanisms of CD4+ T cells from neonates, infants and adults to show the antigen specific response to Staphylococcus aureus and Bifidobacterium longum ssp. infantis. T cells from su...

Induction of bacterial and fungal-specific T-cell responses in human adenoids as potential first-line organs of pathogen-defense Background: Infants are in particular susceptible to infections. Adenoids are strategically located representing the first contact point of inhaled bacteria and fungi with the immune system.

Endocarditis and sepsis caused by the gram-positive pathogen Staphylococcus aureus are associated with high morbidity and mortality. Human platelets are susceptible to α-toxin (also denoted as α-hemolysin), one of the most prominent virulence factors of Staphylococcus aureus. The activity of this 34 kDa exotoxin is mediated by formation of transmem...

A major virulence factor in the pathogenesis of Staphylococcus aureus infections is α-toxin, a 34 kDa pore forming exotoxin. Alpha–toxin accelerates platelet-dependent clot formation and induces platelet aggregation by an influx of extracellular calcium ions. These findings raise the question for the major signalling events involved. Human platelet...

A major virulence factor in the pathogenesis of Staphylococcus aureus infections is α-toxin, a 34 kDa pore forming exotoxin. Alpha–toxin accelerates platelet-dependent clot formation and induces platelet aggregation by an influx of extracellular calcium ions. These findings raise the question for the major signalling events involved. Human platelet...

Bacterial infections such as sepsis and endocarditis are associated with high morbidity and mortality. Bacterial secreted products can modulate platelet functions. A major virulence factor in the pathogenesis of staphylococcal infections is α-toxin, a 34 kDa pore forming exotoxin. In platelets, α–toxin-induced influx of extracellular calcium ions i...

Tyrosine phosphorylation and dephosphorylation of proteins are important molecular mechanisms for the regulation of functions of human platelets. Human platelets contain high amounts of non-receptor protein tyrosine kinases of the Src family among them Src itself is the most abundant. In the present paper, by the use of various inhibitors of Src-fa...

Advanced glycation end products (AGEs) are formed by the non-enzymatic glycation of proteins by reducing carbohydrates or alpha-oxo-aldehydes such as glyoxal and methylglyoxal and further rearrangements, eliminations and oxidations. AGE-modifications alter peptide structure, function and stability and accumulate under several pathophysiological con...

Bacterial infections such as sepsis and endocarditis are associcated with high morbidity and mortality. Bacterial secreted products can modulate platelet functions and affect platelet accumulation at sites of vascular injury and inflammation. An important virulence factor in the pathogenesis of staphylococcal infections is α-toxin, a 34 kDa pore fo...