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June 2014 - October 2015
The University of Edinburgh
- PostDoc Position
May 2010 - April 2013
Ludwig-Maximilians-University of Munich
- PostDoc Position
May 2005 - December 2009
University of Tuebingen
- PhD Student
Strict regulation of stem cell metabolism is essential for tissue functions and tumor suppression. In this study, we investigated the role of fumarate hydratase (Fh1), a key component of the mitochondrial tricarboxylic acid (TCA) cycle and cytosolic fumarate metabolism, in normal and leukemic hematopoiesis. Hematopoiesis-specific Fh1 deletion (resu...
Leukemogenesis occurs under hypoxic conditions within the bone marrow (BM). Knockdown of key mediators of cellular responses to hypoxia with shRNA, namely hypoxia-inducible factor-1α (HIF-1α) or HIF-2α, in human acute myeloid leukemia (AML) samples results in their apoptosis and inability to engraft, implicating HIF-1α or HIF-2α as therapeutic targ...
Corticotropin-independent Cushing's syndrome may be caused by tumors or hyperplasia of the adrenal cortex. Until now genetic alterations explain only a small fraction of cases. The observation that a subset of adrenal adenomas is characterized by abnormal PKA activity despite the absence of mutations in candidate genes suggested as yet unknown alte...
Background: Corticotropin-independent Cushing's syndrome is caused by tumors or hyperplasia of the adrenal cortex. The molecular pathogenesis of cortisol-producing adrenal adenomas is not well understood. Methods: We performed exome sequencing of tumor-tissue specimens from 10 patients with cortisol-producing adrenal adenomas and evaluated recur...
Immune responses may arrest tumor growth by inducing tumor dormancy. The mechanisms leading to either tumor dormancy or promotion of multistage carcinogenesis by adaptive immunity are poorly characterized. Analyzing T antigen (Tag)-induced multistage carcinogenesis in pancreatic islets, we show that Tag-specific CD4+ T cells home selectively into t...
I am looking for Harding-Passey melanoma cells transplantable into BALB/c mice. This has been done until the 1971s quite frequently to my knowledge, but I do not find these cells with ATCC nor elsewhere..
At ATCC they just offer B16 (C57BL/6), YUMM1-5 (C57BL/6J) and
Cloudman S91 melanoma cells ( DBA).
But we need to use the BALB/c background as knock-out mice we are planning to work with are generated in BALB/c.
Could anybody spare a vial of frozen Harding-Passey melanoma cells or know somebody who might do so?
Thanks a lot in advance!