Katrin Schaak

Katrin Schaak
University of Wuerzburg | JMU · Department of Dermatology, Venereology and Allergology

PhD tumor immunology

About

9
Publications
5,006
Reads
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525
Citations
Research Experience
June 2014 - October 2015
The University of Edinburgh
Position
  • PostDoc Position
May 2010 - April 2013
Ludwig-Maximilians-University of Munich
Position
  • PostDoc Position
May 2005 - December 2009
University of Tuebingen
Position
  • PhD Student

Publications

Publications (9)
Article
Full-text available
Strict regulation of stem cell metabolism is essential for tissue functions and tumor suppression. In this study, we investigated the role of fumarate hydratase (Fh1), a key component of the mitochondrial tricarboxylic acid (TCA) cycle and cytosolic fumarate metabolism, in normal and leukemic hematopoiesis. Hematopoiesis-specific Fh1 deletion (resu...
Article
Full-text available
Leukemogenesis occurs under hypoxic conditions within the bone marrow (BM). Knockdown of key mediators of cellular responses to hypoxia with shRNA, namely hypoxia-inducible factor-1α (HIF-1α) or HIF-2α, in human acute myeloid leukemia (AML) samples results in their apoptosis and inability to engraft, implicating HIF-1α or HIF-2α as therapeutic targ...
Article
Corticotropin-independent Cushing's syndrome may be caused by tumors or hyperplasia of the adrenal cortex. Until now genetic alterations explain only a small fraction of cases. The observation that a subset of adrenal adenomas is characterized by abnormal PKA activity despite the absence of mutations in candidate genes suggested as yet unknown alte...
Article
Full-text available
Background: Corticotropin-independent Cushing's syndrome is caused by tumors or hyperplasia of the adrenal cortex. The molecular pathogenesis of cortisol-producing adrenal adenomas is not well understood. Methods: We performed exome sequencing of tumor-tissue specimens from 10 patients with cortisol-producing adrenal adenomas and evaluated recur...
Article
Immune responses may arrest tumor growth by inducing tumor dormancy. The mechanisms leading to either tumor dormancy or promotion of multistage carcinogenesis by adaptive immunity are poorly characterized. Analyzing T antigen (Tag)-induced multistage carcinogenesis in pancreatic islets, we show that Tag-specific CD4+ T cells home selectively into t...

Questions

Question (1)
Question
I am looking for Harding-Passey melanoma cells transplantable into BALB/c mice. This has been done until the 1971s quite frequently to my knowledge, but I do not find these cells with ATCC nor elsewhere..
At ATCC they just offer B16 (C57BL/6), YUMM1-5 (C57BL/6J) and
Cloudman S91 melanoma cells ( DBA).
But we need to use the BALB/c background as knock-out mice we are planning to work with are generated in BALB/c.
Could anybody spare a vial of frozen Harding-Passey melanoma cells or know somebody who might do so?
Thanks a lot in advance!

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Projects

Project (1)
Project
Investigate alterations in described and not yet described monocyte subpopulations, evaluate prognostic values