Katrien Wijndaele

Katrien Wijndaele
Medical Research Council (UK) | mrc · MRC Epidemiology Unit

About

153
Publications
25,606
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6,841
Citations
Citations since 2017
67 Research Items
3973 Citations
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20172018201920202021202220230200400600800
20172018201920202021202220230200400600800

Publications

Publications (153)
Article
OBJECTIVE To investigate the association between accelerometer-derived physical activity energy expenditure (PAEE) and incident type 2 diabetes (T2D) in a cohort of middle-aged adults and within subgroups. RESEARCH DESIGN AND METHODS Data were from 90,096 UK Biobank participants without prevalent diabetes (mean 62 years of age; 57% women) who wore...
Article
Aims: The interplay between physical activity (PA) volume and intensity is poorly understood in relation to cardiovascular disease (CVD) risk. This study aimed to investigate the role of PA intensity, over and above volume, in relation to incident CVD. Methods and results: Data were from 88,412 UK Biobank middle-aged adults (58% women) without p...
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Unlabelled: To develop healthy ageing interventions, longitudinal associations between objectively assessed physical behaviours and physical function need to be better understood. We assessed associations between accelerometer-assessed total physical activity (PA), moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), seden...
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Purpose: Descriptive studies of objectively measured physical activity behaviours in African populations are rare. We developed a method of combining hip and thigh accelerometery signals to quantify and describe physical behaviours in middle-aged South African men and women. Methods: We integrated signals from two triaxial accelerometers worn sim...
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Background Existing sedentary behaviour guidelines for children and youth target overall sedentary behaviour and recreational screen time, without any specific recommendations regarding school-related sedentary behaviours (i.e., sedentary behaviours performed during the school day, or within the influence of school). The purpose of this paper is to...
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Background The purpose of this systematic review was to examine the associations between school-related sedentary behaviours and indicators of health and well-being in children and youth (~ 5–18 years) attending school. Methods This review was conducted to inform the development of School-Related Sedentary Behaviour Recommendations. Peer-reviewed,...
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Background Emerging evidence suggests accruing sedentary behavior (SB) in relatively more prolonged periods may convey additional cardiometabolic risks, but few studies have examined prospective outcomes. We examined the association of SB accumulation patterns with incident cardiovascular disease (CVD), cancer, and all‐cause mortality (ACM). Metho...
Preprint
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Objective To estimate dose-response associations between non-occupational physical activity and multiple chronic disease outcomes in the general adult population. Eligibility criteria Prospective cohort studies with (a) general population samples >10,000 adults, (b) ≥3 exposure categories, and (c) risk measures and confidence intervals for all-cau...
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As smartphone and wearable device ownership increase, interest in their utility to monitor physical activity has risen concurrently. Numerous examples of the application of wearables in clinical and epidemiological research settings already exist. However, whether these devices are all suitable for physical activity surveillance is open for debate....
Article
Accelerometers provide detailed data about physical activity (PA) across the full intensity spectrum. However, when examining associations with health, results are often aggregated to only a few summary measures [e.g. time spent “sedentary” or “moderate-to-vigorous” intensity PA]. Using multivariate pattern analysis, which can handle collinear expo...
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Background Cardiorespiratory fitness is rarely measured in population studies. Most studies of fitness do not examine differences by population subgroups or seasonal trends. Methods We used a validated submaximal exercise test to measure fitness in 5976 women and 5316 men, residing in England. We expressed fitness as maximal oxygen consumption per...
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Background Although the cardiovascular disease (CVD) benefits of both overall volume and intensity of physical activity (PA) are known, the role of PA intensity, over and above volume, is poorly understood. We aimed to investigate the interplay between PA volume and intensity in relation to incident CVD. Methods Data were from 88,412 UK Biobank pa...
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Background/Objectives Physical activity energy expenditure (PAEE) represents the total volume of all physical activity. This can be accumulated as different underlying intensity profiles. Although volume and intensity have been studied in isolation, less is known about their joint association with health. We examined this association with body fatn...
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Background To limit the spread of COVID-19 in March 2020, the population of England was instructed to stay home, leaving only for essential shopping, health-care, work, or exercise. The impact on population activity behaviours is not clear. We describe changes in duration and types of activity undertaken by adults ≥16 years in England between March...
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Background The joint associations of total and intensity-specific physical activity with obesity in relation to all-cause mortality risk are unclear. Methods We included 34 492 adults (72% women, median age 62.1 years, 2034 deaths during follow-up) in a harmonised meta-analysis of eight population-based prospective cohort studies with mean follow-...
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Background Physical activity and sedentary behaviour are central to public health recommendations and highlight the need for precise measurement. Descriptive studies of objectively measured physical activity behaviours in African populations are rare. We aimed to develop a method of combining the signals from hip and thigh accelerometers to quantif...
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Background: Current physical activity guidelines do not distinguish between activity accumulated in different behavioural domains but some studies suggest that occupational physical activity (OPA) may not confer health benefits and could even be detrimental. The purpose of this study was to investigate associations between OPA and mortality outcom...
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Background/Objectives: Physical activity energy expenditure (PAEE) represents the total volume of all physical activity. This can be accumulated as different underlying intensity profiles. Although volume and intensity have been studied in isolation, less is known about their joint association with health. We examined this association with body-fat...
Article
Background: Development of effective strategies to reduce sedentary time among older adults necessitates understanding of its determinants but longitudinal studies of this utilising objective measures are scarce. Methods: Among 1536 older adults (≥60 years) in the EPIC-Norfolk study, sedentary time was assessed for seven days at two time-points...
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Objectives To investigate associations between occupational physical activity (OPA) and all-cause mortality. Methods From baseline (2006-2010), 452,884 UK Biobank participants (aged 40-69 years) were followed for a median 11.1 (IQR: 10.4-11.8) years. OPA was categorised by cross-tabulating degree of manual work and walking/standing work amongst th...
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Objective To compare the country-level absolute and relative contributions of physical activity at work and in the household, for travel, and during leisure-time to total moderate-to-vigorous physical activity (MVPA). Methods We used data collected between 2002 and 2019 from 327 789 participants across 104 countries and territories (n=24 low, n=34...
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Objectives To examine the joint associations of accelerometer-measured physical activity and sedentary time with all-cause mortality. Methods We conducted a harmonised meta-analysis including nine prospective cohort studies from four countries. 44 370 men and women were followed for 4.0 to 14.5 years during which 3451 participants died (7.8% morta...
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Background: Sedentary behaviour is associated with cardiometabolic diseases amongst office-bound workers, mostly through extended sitting and engaging in low-energy-demanding activities during work hours. The aim of this study is to assess the effectiveness of standing desks and healthy messages on cardiovascular parameters in a cohort of office-b...
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Background: Prolonged sitting time is a risk factor for chronic disease, yet recent global surveillance is not well described. The aims were to clarify: (i) the countries that have collected country-level data on self-reported sitting time; (ii) the single-item tools used to collect these data; and (iii) the duration of sitting time reported acros...
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Use of wearable devices that monitor physical activity is projected to increase more than fivefold per half-decade¹. We investigated how device-based physical activity energy expenditure (PAEE) and different intensity profiles were associated with all-cause mortality. We used a network harmonization approach to map dominant-wrist acceleration to PA...
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Background: Multi-country studies examining trends in sedentary behaviors among adolescents have mainly focused on high-income or Western countries, and almost no data exists for the rest of the world. Thus, this study aims to examine temporal trends in adolescents' leisure time sedentary behavior (LTSB) employing nationally representative dataset...
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Aims Resting heart rate (RHR) is inversely associated with cardiorespiratory fitness (CRF) but few studies have investigated the nature of this relationship in large population samples. We examined the association between RHR and CRF in UK adults and explored factors that may influence this relationship. Methods and Results In a population-based sa...
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Background: To gain more understanding of the potential health effects of sedentary time, knowledge is required about the accumulation and longitudinal development of young people's sedentary time. This study examined tracking of young peoples' total and prolonged sedentary time as well as their day-to-day variation using the International Childre...
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Background: Little is known about population levels of energy expenditure, as national surveillance systems typically employ only crude measures. The National Diet and Nutrition Survey (NDNS) in the UK measured energy expenditure in a 10% subsample by gold-standard doubly labelled water (DLW). Methods: DLW-subsample participants from the NDNS (3...
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Background: UK Biobank is a large prospective cohort study containing accelerometer-based physical activity data with strong validity collected from 100,000 participants approximately 5 years after baseline. In contrast, the main cohort has multiple self-reported physical behaviours from > 500,000 participants with longer follow-up time, offering...
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Background: Physical activity (PA) plays a role in the prevention of a range of diseases including obesity and cardiometabolic disorders. Large population-based descriptive studies of PA, incorporating precise measurement, are needed to understand the relative burden of insufficient PA levels and to inform the tailoring of interventions. Combined...
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Background: Evidence on the association between sitting for extended periods (i.e. prolonged sedentary time (PST)) and cardio-metabolic health is inconsistent in children. We aimed to estimate the differences in cardio-metabolic health associated with substituting PST with non-prolonged sedentary time (non-PST), light (LIPA) or moderate-to-vigorou...
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An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Background: The advent of very large cohort studies (n > 500 000) has given rise to prospective analyses of health outcomes being undertaken after short (<4 years) follow-up periods. However, these studies are potentially at risk of reverse causality bias. We investigated differences in the associations between self-reported physical activity and...
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Introduction Compensatory behaviours may be one of the reasons for the limited success of sedentary time interventions in older adults, but this possibility remains unexplored. Activity compensation is the idea that if we change activity levels at one time we compensate for them at a later time to maintain a set point. We aimed to assess, among adu...
Preprint
Background: Physical activity (PA) plays a role in the prevention of a range of diseases including obesity and cardiometabolic disorders. Large population-based descriptive studies of PA, incorporating precise measurement, are needed to understand the relative burden of insufficient PA levels and to inform the tailoring of interventions. Combined h...
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Background: Active living approaches seek to promote physical activity and reduce sedentary time across different domains, including through active travel. However, there is little information on how movement behaviours in different domains relate to each other. We used compositional data analysis to explore associations between active commuting a...
Poster
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The SBC-GoPA! Sedentary Behaviour Council Global Monitoring Initiative is collating global data on sedentary behaviour prevalence, surveillance, research and policy activity.
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There are few valid instruments to assess domain-specific sedentary behaviours (SB) among Spanish-speaking populations. This study validated the original English version of the last 7 days SB questionnaire (SIT-Q-7d) into Spanish (Castilian). A total of 151 undergraduates (52% male, 21.19±2.57 yrs.) wore an activPAL3M (AP3M) for 7 days and subseque...
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Background The evidence for the prospective relationships between specific physical activities (PA), sedentary behaviours (SB) and sleep on subsequent total PA levels is scarce. The purpose of this study was to examine prospective associations of self-reported PA, SB and sleep, and changes in these with subsequent accelerometer-measured PA. Method...
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Background: Associations between driving and physical-activity (PA) intensities are unclear, particularly among older adults. We estimated prospective associations of travel modes with total PA, sedentary time (ST), light-intensity PA (LPA), and moderate-to-vigorous intensity PA (MVPA) among adults aged 39-70 years. Methods: We studied 90 810 UK...
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Background: Wrist-worn accelerometry is the commonest objective method for measuring physical activity in large-scale epidemiological studies. Research-grade devices capture raw triaxial acceleration which, in addition to quantifying movement, facilitates assessment of orientation relative to gravity. No population-based study has yet described the...
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Objective: Evidence on the impact of leisure time physical activity (LTPA) in pregnancy on birth size is inconsistent. We aimed to examine the association between LTPA during early and late pregnancy and newborn anthropometric outcomes. Design: Individual level meta-analysis, which reduces heterogeneity across studies. Setting: A consortium of...
Preprint
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Background: Little is known about population levels of energy expenditure as national surveillance systems typically employ only crude measures. The National Diet and Nutrition Survey (NDNS) in the UK measures energy expenditure in a 10% subsample by gold-standard doubly-labelled water (DLW). Methods: DLW-subsample participants from the NDNS (383 m...
Article
Background Smartphones and wearable activity trackers present opportunities for large-scale physical activity (PA) surveillance that overcome some limitations of questionnaires or researcher-administered devices. However, it remains unknown whether current users of such technologies are representative of the UK population. Objective The objective o...
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Full-text available
Background : Wrist-worn accelerometry is the commonest objective method for measuring physical activity in large-scale epidemiological studies. Research-grade devices capture raw triaxial acceleration which, in addition to quantifying movement, facilitates assessment of orientation relative to gravity. No population-based study has yet described th...
Poster
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Driven by significant and sustained growth in research activity over the last twenty years, sedentary behaviour has risen in prominence as a potential risk factor for chronic disease morbidity and mortality, capturing the attention of policy-makers and mainstream media. Surveillance of sedentary behaviour is required to establish the scale of the b...
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Little is known about the combined associations of cardiorespiratory fitness (CRF) and hand grip strength (GS) with mortality in general adult populations. The purpose of this study was to compare the relative risk of mortality for CRF, GS, and their combination. In UK Biobank, a prospective cohort of > 0.5 million adults aged 40–69 years, CRF was...
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Purpose: To estimate the strength and shape of the dose-response relationship between sedentary behaviour and all-cause, cardiovascular disease (CVD) and cancer mortality, and incident type 2 diabetes (T2D), adjusted for physical activity (PA). Data Sources: Pubmed, Web of Knowledge, Medline, Embase, Cochrane Library and Google Scholar (through Se...
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Objectives: To determine the role of physical activity intensity and bout-duration in modulating associations between physical activity and cardiometabolic risk markers. Methods: A cross-sectional study using the International Children's Accelerometry Database (ICAD) including 38,306 observations (in 29,734 individuals aged 4-18 years). Accelero...
Preprint
BACKGROUND Smartphones and wearable activity trackers present opportunties for large-scale physical activity surveillance that overcome some limitations of questionnaires or researcher-owned devices. However, it is unknown whether the current users of such technologies are representative of the UK population. OBJECTIVE To investigate potential soc...
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Objective To investigate the associations between using alternatives to the car which are more active for commuting and non-commuting purposes, and morbidity and mortality. Methods We conducted a prospective study using data from 3 58 799 participants, aged 37–73 years, from UK Biobank. Commute and non-commute travel were assessed at baseline in 2...
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Background: Higher grip strength (GS) is associated with lower mortality risk. However, whether this association is independent of adiposity is uncertain.Objective: The purpose of this study was to examine the associations between GS, adiposity, and mortality.Design: The UK Biobank study is an ongoing prospective cohort of >0.5 million UK adults ag...
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Objective The objective of this study was to pool, harmonise and re-analyse national accelerometer data from adults in four European countries in order to describe population levels of sedentary time and physical inactivity. Methods Five cross-sectional studies were included from England, Portugal, Norway and Sweden. ActiGraph accelerometer count d...
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Background: The minimum intensity of physical activity (PA) that is associated with favourable body composition and cardiorespiratory fitness (CRF) remains unknown. Objective: To investigate cross-sectional associations of PA and sedentary time (ST) with body composition and CRF in mid-childhood. Methods: PA, ST, body composition and CRF were...
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Purpose: Leisure-screen-time, including TV viewing, is associated with increased mortality risk. We estimated the all-cause mortality risk reductions associated with substituting leisure-screen-time with different discretionary physical activity types, and the change in mortality incidence associated with different substitution scenarios. Methods...
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Background We aimed to study the independent associations of 10-year change in sedentary behaviour (SB), moderate-to-vigorous physical activity (MVPA) and objectively measured cardiorespiratory fitness (CRF), with concurrent change in clustered cardiometabolic risk and its individual components (waist circumference, fasting glucose, high-density li...
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Background: Prolonged sitting, an independent risk factor for disease development and premature mortality, is increasing in prevalence in high- and middle-income countries, with no signs of abating. Adults in such countries spend the largest proportion of their day in sedentary behaviour, most of which is accumulated at work. One promising method...
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Introduction: Fitness is an important determinant of cardiovascular health in adults. Arterial stiffness has been shown to be a useful prognostic index of cardiovascular events. However, little is known about the relationships of muscular strength with arterial stiffness. Hypothesis: Muscular strength is inversely related to arterial stiffness inde...
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KW is supported by a British Heart Foundation Intermediate Basic Science Research Fellowship (grant number FS/12/58/29709) and the UK Medical Research Council (grant number MC_UU_12015/3). GNH is supported by an Australian National Health and Medical Research Council Career Development Fellowship (grant number 108029).