Katja Weismüller

• Justus Liebig University Giessen

Background Ischemia of intestinal organs is a main cause of complications in surgical intensive care patients. Changes in the tonus of arteries contributing to vascular resistance play an important role in the determination of blood flow and thus oxygen supply of various abdominal organs. It is generally acknowledged that hypoxia itself is able to...

. Severe traumatization induces a complex pathophysiology, driven by the patient’s own immune system. The initial activation is a result of damage-associated molecular patterns, which are released from disrupted and dying cells and recognized by immune receptors, for example, RAGE. In this study we aimed to evaluate the contribution of the RAGE axi...

Supplementary figure 1 contains figures of routine laboratory parameters of the trauma cohort over time, including leucocytes, C-reactive protein (CRP) and blood glucose.

Als Sepsis wird eine komplexe systemische Entzündungsreaktion auf eine Infektion bezeichnet, welche oft zur Entwicklung eines Multiorganversagens mit hoher Letalität führt. Pathophysiologischer Hintergrund ist oftmals eine dysregulierte Immunantwort auf das eingedrungene Pathogen, was u. a. zu Funktionsstörungen des Metabolismus, der Zellintegrität...

Der Glukosestoffwechsel hat eine zentrale Bedeutung für den Organismus. Er ist fein reguliert und Störungen dieser Regulation können schwerwiegende Folgen haben. Beim Intensivpatienten beeinflussen insbesondere inflammatorische Mechanismen den Glukosemetabolismus und rufen typische Veränderungen desselben hervor. Die therapeutischen Konsequenzen di...

Der Gastrointestinaltrakt ist ein komplexes Organsystem. Störungen in diesem Organsystem können vielfältige Auswirkungen auf den Gesamtorganismus haben und insbesondere die Inflammationsreaktion beeinflussen. In der perioperativen Therapie können Ernährung, Prokinetika, Periduralanästhesie, Katecholamingabe und Volumentherapie dahingehend eingesetz...

The gastrointestinal tract is a complex organ system. Dysfunctions of this organ system may evoke a variety of consequences for the entire organism and influence the inflammatory response in particular. In perioperative medicine, nutrition, prokinetics, peridural anesthesia, catecholamines and volume therapy can be applied in order to improve the g...

Inflammation is the physiological answer of the organism to damage affecting its integrity, such as infection or trauma. In inflammation, cells of the immune system release cytokines and other mediators, which contribute to the destruction of bacteria and tissue repair. We distinguish here between pro-inflammatory cytokines, e.g., interleukin-1 (IL...

Intensive care medicine plays an important role in the medical care of patients as well as the economic success of hospitals. Knowledge and implementation of recent relevant scientific evidence are prerequisites for high quality care in intensive care medicine. The aim of this review is to present an overview of the most important publications in i...

For the first time the immunonutritional role of pyruvate on neutrophils (PMN), free α-keto and amino acid profiles, important reactive oxygen species (ROS) produced [superoxide anion (O(2) (-)), hydrogen peroxide (H(2)O(2))] as well as released myeloperoxidase (MPO) acitivity has been investigated. Exogenous pyruvate significantly increased PMN py...

In this retrospective observational study, we investigated the impact of prior splenectomy on the outcome of patients with complicated peritonitis. Of the 284 subjects with severe sepsis or septic shock due to intra-abdominal infection, 27 (9.5%) had undergone splenectomy before the development of that infection and 257 (90.5%) had not undergone sp...

Various studies have shown that dietary glutamine can modify the course of an immune response, through altering the release of cytokines. Nutritional supplementation of glutamine may therefore be of advantage to patients, particularly those with compromised immunity. Given that polymorphisms in cytokine genes can also affect cytokine levels, we hav...

The immune system and the central nervous system are able to affect each other. Proinflammatory cytokines induce the expression of CRH or AVP in the hypothalamus and ACTH in the pituitary gland. Thus, enhanced adrenal release of cortisol suppresses the activation of NF-κB and activates antiinflammatory cytokines. The cholinergic antiinflammatory pa...

Critical care medicine plays an important role for the medical and economic success of hospitals. Knowledge and implementation of recent relevant studies are prerequisites for high quality intensive care medicine. The aim of the present manuscript is to present an overview of the most important publications in intensive care medicine in 2009 and co...

Critical care medicine plays an important role for the medical and economic success of hospitals. Knowledge and implementation of recent relevant studies are prerequisites for high quality intensive care medicine. The aim of the present manuscript is to present an overview of the most important publications in intensive care medicine in 2009 and co...

The aim of this study was to determine the effects of alpha-ketoglutarate on neutrophil (PMN), free alpha-keto and amino-acid profiles as well as important reactive oxygen species (ROS) produced [superoxide anion (O(2) (-)), hydrogen peroxide (H(2)O(2))] and released myeloperoxidase (MPO) activity. Exogenous alpha-ketoglutarate significantly increa...

Patients encountering severe trauma are at risk of developing sepsis syndrome and subsequent multiple organ failure. This is often associated with fatal outcome despite survival of the initial injury. We postulate that variation of the gene coding for tumor necrosis factor (TNF)-alpha is associated with increased occurrence of sepsis syndrome and m...

Procedures for the analysis of free alpha-keto acids in human fluids (i.e. plasma, cerebrospinal fluid, urine, etc.) as well as for studying the dynamic free alpha-keto acid pools in differentiated tissues and organ cells have been the subject of growing clinical interest in the study of metabolic regulatory and pathophysiological phenomena. Due to...

We examined the effects of beta-alanine (taurine analogue and taurine transport antagonist), taurine (regarding its role in neutrophil (PMN) immunonutrition) and taurine combined either with L-NAME (inhibitor of *NO-synthase), SNAP (*NO donor), DON (glutamine-analogue and inhibitor of glutamine-requiring enzymes), DFMO (inhibitor of ornithine-decar...

http://www.egms.de/de/meetings/gmds2006/06gmds192.shtml

Severe trauma may be followed by an uncontrolled inflammatory response that is associated with high mortality and morbidity and the patient is at high risk of developing MOF [1]. Serial gene expression analysis of peripheral blood obtained from patients with polytrauma should provide a molecular portrait of mechanisms leading to sepsis. Genome-wide...

The development of medical research networks within the framework of translational research has fostered interest in the integration of clinical and biological research data in a common database. The building of one single database integrating clinical data and biological research data requires a concept which enables scientists to retrieve informa...

Type 1 diabetic individuals are known to develop disorders of bone metabolism resulting in osteopenia. Previous studies have suggested an influence of vitamin D receptor alleles on bone metabolism and susceptibility for type 1 diabetes mellitus. The present study was initiated to investigate the distribution of vitamin D receptor alleles in Caucasi...

Es existieren Hinweise auf einen Zusammenhang zwischen der diabetischen Osteopathie bei Typ 1- und Typ 2-Diabetes mellitus und Vitamin-D-Rezeptor-Polymorphismen. Die vorliegende Arbeit hatte zum Ziel, an einem Kollektiv von kaukasischen Patienten mit Typ 1-Diabetes mellitus und einem gesunden Kontrollkollektiv Unterschiede hinsichtlich des Vorkomme...