Katim Alaoui

Mohammed V University of Rabat | um5a · Faculty of Medicine and Pharmacy

We evaluate the analgesic activity of the ethanolic and Alkaloidic extracts obtained from Delphinium staphisagria seeds, using chemical and the Tail flick models which will induce acute pain in mice and rats. This study was carried out by using sex Swiss mice (20-30g) and Wistar male rats (180-200g). The ethanolic extract was prepared by using mace...

Throughout history, honey has been used to treat various diseases. The present work examined and assessed the in vivo anti-inflammatory potential of Moroccan thyme honey and its association with essential oils from three selected plants: Origanum vulgare L.; Mentha spicata L.; Eucalyptus globulus L. The chemical composition of the essential oils wa...

Hydantoins comprise an important class of compounds which have long attracted attention due to their remarkable biological and pharmacological properties including antitumor and antiviral activities. As a continuation of our studies on hydantoins derivatives we report the successful synthesis of hydantoins derivatives. These synthesized compounds w...

Recognized for its nutritional and therapeutic use, extra-virgin Argan Oil (EVAO) is frequently adulterated. Selected-Ion Flow-Tube Mass Spectrometry (SIFT-MS) spectra were applied to quantify adulterants (i.e., Argan oil of lower quality (LQAO), olive oil (OO), and sunflower oil (SO)) in EVAO. Four data sets, i.e., using H3O⁺, NO⁺, O2+• reagent io...

Wound healing consists of several continuous phases involving various cells and chemical intermediates. As a rich source of nutrition elements, honey has proved to have potential benefits in the treatment of various diseases. The present study was designed to investigate the healing effect of a honey mixture with selected essential oils on chemical...

Introduction: Albuca amoena is a Moroccan-Algerian endemic medicinal plant with various implications. The aim of this study is to identify phytochemical compounds of the plant, check its acute toxicity, and test its anti-depressive, anxiolytic, and analgesic effects on the central nervous system (CNS). Methods: The estimation of chemical compounds...

Objective This review intended to evaluate the in vitro antibacterial effect of natural plant extracts against periodontal pathogens responsible for periodontal disease. Methods The research was conducted in five English databases (PubMed, Cochrane Library, Scopus, EBSCO, web of science) from January 2000 to June 2019. Only articles in English and...

The Argan tree (Argania spinosa. L) is an evergreen tree endemic of southwestern Morocco. For centuries, various formulations have been used to treat several illnesses including diabetes. However, scientific results supporting these actions are needed. Hence, Argan fruit products (i.e., cake byproducts (saponins extract) and hand pressed Argan oil)...

The hydantoin scaffold is of substantial importance and it is commonly used in drug discovery. Herein, we report the synthesis of a novel phenytoine (a hydantoin derivative) with high yield by the reaction of phenytoin with 1-bromodecyl agent. Namely, 3-decyl-5,5- diphenylimidazolidine-2,4-dione (3DDID). The optimized geometry of the compound was c...

The characterization of Argan oils to classify them in three categories (‘Extra Virgin’, ‘Virgin’ and ‘Lower quality’) was evaluated. A total of 120 Moroccan Argan oils samples from the Taroudant Argan forest was investigated. The free acidity, peroxide value, spectrophotometric indices (K232 and K270), fatty acids, sterols, and tocopherol contents...

In order to achieve a better understanding of the shelf-life behavior of extra virgin Argan oils (EVAO) during storage, the influences of storage periods, roasting process and packaging materials were studied. Those oils were extracted from roasted and unroasted kernels. The EVAO shelf life assessment was made by determining chemical properties (ac...

[This corrects the article DOI: 10.1155/2012/270824.].

Thymus leptobotrys is a medicinal plant belonging to the Lamiaceae family, endemic in Morocco, and used in traditional medicine. The present work aims to study the phenolic compounds, the antioxidant activity, the anti-inflammatory effect, and the toxicity of two ethanolic and methanolic extracts of Thymus leptobotrys aerial part. The yield of the...

The present work examined and assessed the in vivo anti‐inflammatory effect of polyphenolic extracts from Moroccan edible Argan oils (Argania spinosa L.), extracted by two extraction processes: Hand pressing and mechanical pressing. Chemical properties, such as acidity, peroxide index, ultraviolet indices, total polyphenols composition, fatty acid...

The aim of the present study is to synthesize cationic salts from a relatively toxic compound named 2-mercaptobenzimidazole and to evaluate some of their pharmacological properties. The acute toxicity of these salts is evaluated according to OECD 423 Guidelines at the doses of 300 and 2000 mg/kg; their peripheral analgesic effect is studied using t...

The aim of this work is to evaluate the acute toxicity and to study the anti-inflammatory effect of the leaves, fruits, and roots of Asphodelus microcarpus. Extraction by cold maceration with methanol was carried out on the different parts of the Am (leaves, fruits, and roots). The extracts obtained were subjected to an acute toxicity study to ensu...

Nepeta amethystina is a plant used in traditional Moroccan medicine as an analgesic, as a sedative, and on the abscess to accelerate healing. Our goal is to study the psychotropic activity of the essential oil (EO) of Nepeta amethystina in view of the dose-dependent, sedative action found in studies of acute toxicity and analgesic action of EO of N...

The aim of this work is to deepen the pharmacological effect of 4-phenyl-1,5-benzodiazepin-2-one derivatives which have a similar structure to nonionic surfactants: 4-phenyl-1,5-benzodiazepin-2-one is the hydrophilic head, and the carbon chain is hydrophobic tail. The antinociceptive activity of 4-phenyl-1,5-benzodiazepin-2-one derivatives was dete...

e aim of this work is to deepen the pharmacological effect of 4-phenyl-1,5-benzodiazepin-2-one derivatives which have a similar structure to nonionic surfactants: 4-phenyl-1,5-benzodiazepin-2-one is the hydrophilic head, and the carbon chain is hydrophobic tail. e antinociceptive activity of 4-phenyl-1,5-benzodiazepin-2-one derivatives was determin...

Asphodelus microcarpus (A.m.) est une plante largement utilisée en médecine traditionnelle marocaine pour ses propriétés médicinales qui restent variées et générales. Une extraction des principes actifs contenus dans les feuilles d’A.m. a été réalisée par macération à froid au méthanol. L’extrait obtenu a fait l’objet d’une étude in vitro de cytoto...

L’huile d’argan se distingue par un profil biochimique particulier, riche en acides gras oléique et linoléique, en tocophérols, en stérols, en polyphénols et en alcools triterpéniques, lui conférant des propriétés nutritionnelles, thérapeutiques et préventives contre certaines affections dermatologiques, métaboliques et prolifératives. L’objectif d...

Our study aims to investigate the existence of the analgesic activity on methanolic extract from leaves of Asphodelus microcarpus(A.m.). It's parts in the context valuation the traditional pharmacopoeia. The peripheral and central analgesic activities had evaluated by the Koster and Tail Flick tests respectively. The methanolic extract of leaves fr...

Ormenis mixta L. is traditionally used for central nervous system (CNS)-related diseases. Its anti-stress properties have received attention in Moroccan traditional medicine and aromatherapy. However, no pharmacological studies have yet been undertaken on this plant in Morocco. The present study provides a preliminary phytochemical screening and ps...

Fatty-acid profiling vs UV-Visible fingerprinting in combination with chemometric tools were applied to classify edible Extra Virgin Argan Oils (EVAO) with protected geographic indication according to their geographical origins. Secondly three EVAO categories classification were classified according to their extraction process (mechanical or tradit...

Fatty-acid profiling vs UV-Visible fingerprinting in combination with chemometric tools were applied to classify edible Extra Virgin Argan Oils (EVAO) with protected geographic indication according to their geographical origins. Secondly three EVAO categories classification were classified according to their extraction process (mechanical or tradit...

The hydro-distilled essential oil from the leaves of Juniperus thurifera L. (JTEO) was analyzed by GC-MS and examined for its insecticidal, antifungal and antioxidant activities. A total of 51 compounds were identified. The major components were sabinene (22.4%), followed by terpinen-4-ol (11.0%) and α-pinene (5.9%). JTEO exhibited interesting inse...

This study investigated the effectiveness of SIFT-MS versus chemical profiling, both coupled to multivariate data analysis, to classify 95 Extra Virgin Argan Oils (EVAO), originating from five Moroccan Argan forest locations. The full scan option of SIFT-MS, is suitable to indicate the geographic origin of EVAO based on the fingerprints obtained us...

This study investigated the effectiveness of SIFT-MS versus chemical profiling, both coupled to multivariate data analysis, to classify 95 Extra Virgin Argan Oils (EVAO), originating from five Moroccan Argan forest locations. The full scan option of SIFT-MS, is suitable to indicate the geographic origin of EVAO based on the fingerprints obtained us...

Calendula arvensis (CA) had been reported in traditional Moroccan medicine to exhibit its extensive use to treat pain and inflammation. Therefore, the objective of this study was to evaluate the anti‐inflammatory activity of CA flowers. The methanol, aqueous, and hexane extracts (ME, AE, and HE) were investigated for inflammatory effects by using t...

Introduction Au Maroc, l’enquête nationale en population générale sur les troubles mentaux et la toxicomanie avait estimé la prévalence de consommation de toxique était de 4,1 %, avec un taux d’abus de 3 % et un taux de dépendance de l’ordre de 2,8 %. Notre étude visait à étudier le comportement tabagique des étudiants en médecine, leur degré de dé...

Nepeta amethystina est une plante utilisée en médecine traditionnelle marocaine comme analgésique, sédative et sur les abcès pour accélérer la cicatrisation. Notre objectif est d’étudier l’activité psychotrope de l’huile essentielle (HE) de Nepeta amethystina à la vue de l’action sédative dose-dépendante constatée lors des études de la toxicité aig...

Zizyphus lotus (L.) Desf. ou le jujubier est une plante médicinale utilisée traditionnellement comme antiinflammatoire, antidiabétique, antimicrobienne, antipyrétique et antivirale. Le présent travail a pour objectif d’évaluer l’effet anti-inflammatoire d’huile des graines de Zizyphus lotus afin de valoriser son utilisation en médecine traditionnel...

The present study was designed to study anxiolytic property of aqueous extracts of Mercurialis annua, an important and commonly used medicinal plant for its medicinal properties. The anxiolytic activity was evaluated in adult mice by hole board test and light/dark box test and motor coordination by rotarod test. The efficacy of the plant extract (1...

Background: The most widely prescribed medications for anxiety disorders are the Benzodiazepines; however, they have prominent side effects. Thus, interest in alternative medicine that affects the 'mind' is growing. In Morocco folk medicine, the use of Mercurialis annua is commonly recommended for relief of anxiety, although no scientific informati...

Hydro-distilled essential oil (EO) from the leaves of the western Mediterranean and Moroccan endemic plant Tetraclinis articulata was analyzed by GC/MS and examined for its acute toxicity on mice, in order to establish the safe doses. Furthermore, the anti-Inflammatory activity was evaluated based on carra-geenan and trauma induced rats paw edema a...

Current therapeutic for the treatment of anxiety is associated with a wild variety of prominent side effects. The traditional use of plant extract to health care can indicate an important source of new pharmaceuticals. In Morocco traditional medicine, the use of Mercurialis annua is commonly recommended for relief of anxiety. Nevertheless, despite...

Ceratonia siliqua L. has been used in Moroccan traditional medicine as antidiarrheal and diuretic. The infusion of carob leaves is used as an emetic for acute poisoning. The present investigation was designed to determine the antiinflammatory potential of methanolic barks extract of Ceratonia siliqua in rodents using female Swiss mice (20-30 g) and...

Objective.The aim of this work is to study and compare the antioxidant properties and phenolic contents of aqueous leaf extracts of Juniperus thurifera, Juniperus oxycedrus, Juniperus Phoenicea, and Tetraclinis articulata from Morocco. Methods. Antioxidant activities of the extracts were evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radica...

In our work, we evaluate the potential antioxidant activity of phenolic extract of argan oil derived from two different methods of extraction (hand pressed (HP) and mechanical cold-pressed (MP)) using in vitro methods including DPPH radical scavenging assay, Trolox equivalent antioxidant capacity (TEAC) and Ferric reducing antioxidant power assay (...

The most widely prescribed medications for anxiety disorders are the Benzodiazepines; however, they have prominent side effects. Thus, interest in alternative medicine that affects the ‘mind’ is growing. Among medicinal plants, Urtica urens has been recommended for relief of anxiety in Morocco folk medicine. Nevertheless, no pharmacological studies...

Nepeta amethystina est une plante utilisée en médecine traditionnelle marocaine comme analgésique, sédative et en application sur les « abcès » pour accélérer la cicatrisation. Notre objectif est d’étudier la toxicité aiguë et l’action analgésique de l’extrait global (EG) de N.amethystina, en comparaison avec les résultats antérieurement publiés, a...

Notre travail a pour objectif d’extraire l’huile essentielle (HE) de la partie aérienne de la verveine odorante, d’identifier la composition de l’HE de cette dernière par chromatographie en phase gazeuse couplée à un spectromètre de masse et d’étudier l’activité psychotrope de l’huile essentielle (HE) grâce à une batterie de tests comportementaux u...

The present study was designed to study anxiolytic property of methanolic extracts of Urtica urens; an important and commonly used for its medicinal properties belongs to urticaceae family. The anxiolytic activity was evaluated with the adult mice by hole board test, and the light-dark box test, and motor coordination with the rota rod test. The ef...

Une étude ethnobotanique a été menée au Maroc en vue de recenser à l’échelle nationale les plantes médicinales utilisées en médecine traditionnelle marocaine dans le traitement de l’anxiété. 70 herboristes ont été interrogés individuellement et ont livré chacun les espèces végétales utilisées pour combattre les troubles anxieux. 77 espèces médicina...

The methanolic extract of Nepeta granatensis, were evaluated for the acute toxicity and peripheral and central analgesic activity. Female mice (Iops Offa) were treated with the methanolic extract and had shown a LD50 as 1000 mg/kg Effects of the methanolic extract, on nociception were assessed, by Tail Flick test in rats, as well, acetic acid induc...

Evaluate the rate of breastfeeding at hospital discharge and then at 3 and 6 months in a population of premature infants. Analyze demographic and neonatal characteristics that may influence breastfeeding.

Evaluate the rate of breastfeeding at hospital discharge and then at 3 and 6 months in a population of premature infants. Analyze demographic and neonatal characteristics that may influence breastfeeding. Prospective study in children born before 37 weeks of gestation from 1 June 2011 to 31 December 2011 hospitalized in the neonatology department a...

Les graines de Delphinium staphysagria (DS) contiennent une fraction d’alcaloïdes relativement importante. La combinaison d’extraction, de gradient de pH et les conditions chromatographiques ont permis l’identification de plusieurs types d’alcaloïdes diterpénoïdes MDL (méthylène dioxylycoctonine) connus pour leur activité anti-inflammatoire. La pur...

Le genre Nepeta appartient à la famille des Lamiacées. Notre objectif est de définir la composition chimique des huiles essentielles (HE) de ces quatre espèces marocaines du genre Nepeta: Nepeta tuberosa ssp reticulata, Nepeta granatensis, Nepeta cataria et Nepeta atlantica, puis de tester leur activité antifongique potentielle sur les champignons...

Aloe perryi Baker est une plante endémique du Yémen utilisée traditionnellement pour le traitement de diverses pathologies comme l’inflammation et la douleur. La DL50 de cet extrait de jus de feuille d’Aloe perryi est évaluée à 3 067 mg/kg v.o., avec des limites de confiance à 95 %, ce qui lui confère une absence de toxicité par voie orale. L’effet...

Rosemary (Rosmarinus officinalis L., family Lamiaceae) had been reported in traditional medicine, to exhibit antimicrobial properties. Therefore, this study is aimed at determining the antibacterial activity of R. officinalis leaves against pathogenic microorganisms by determination the minimal inhibitory concentration and to serve as criteria to r...

Rumex nervosus Vahl est une plante utilisée traditionnellement au Yémen comme anti-inflammatoire et en traitement de la douleur. Notre étude se propose d'évaluer la toxicité aiguë et le pouvoir analgésique et central de l'extrait méthanolique de ses feuilles. La DL50 a été évaluée à 1028 mg/kg VO, avec des limites de confiance à 95 % (723,6<DL50<14...

Dracaena Cinnabari balf is species plant in agavaceae family. It is tree endemic to the Island Socotra (Yemen). The resin of this tree, dragon's blood is known in Arabia as « dammalachawin » or Cinnabari. It has been used in traditional medicine for the treatment of gastric sores diarrhea, dysentery, as haemostatic and as anti ulcer remedy, and ant...

Zygophylle or Zygophyllum gaetulum Emberger and. Maire is a Moroccan medicinal plant which has been used as an anti-inflammatory, antidiabetic, antispasmodic and antidiarrheic. The present study was carried out to study and compare the anti-inflammatory effect of ethanolic extract with aqueous extract of Z. gaetulum. Organic extract of Z. gaetulum...

We evaluate the analgesic and anti-inflammatory activities of leaves of Boswellia elongata balf methanolic extract an experimentally induced acute inflammation in rats. This study was carried out by using male and female Swiss mice (20–30 g) and Wister male rats (180–220 g). The methanolic extracts were prepared by using maceration at room temperat...

Background: The most widely prescribed medications for anxiety disorders are the Benzodiazepines; however, they have prominent side effects. Thus, interest in alternative medicine that affects the mind is growing. In Morocco folk medicine, the use of Mercurialis annua is commonly recommended for relief of anxiety, although no scientific information...

We evaluate the sedative and hypnotic activities of the methanolic and aqueous extract of Lavandula officinalis L. on central nervous system (CNS). In this study, the effect of the methanolic and aqueous extracts of this plant was investigated in a battery of behavioural models in mice. Stems and flowers of Lavandula officinalis L. have several the...

Leaves of Rosmarinus officinalis and the flowers of Lavandula officinalis have been used as medicine for treatment of nervous disorders, in traditional Moroccan medicine. We evaluate the central nervous system psychotropic effects of the essential oil from the leaves of R. officinalis and the flowers of L. officinalis using a battery of comportamen...

In the present study, we evaluate the analgesic activity of methanolic extract obtained from Jatropha unicostata balf leaves, using chemical and thermal models which will induce acute pain in mice and rats. This study was carried out by using sex Swiss mice (20-30gm) and wistar male rats (200-250gm).The methanolic extract was prepared by using mace...

We evaluated the in vitro antioxidant property and phytochemical constituents of the crude ethyl acetate and methanol extract of the three genders of carob tree barks (spontaneous male, spontaneous female, and grafted female). The scavenging activity on DPPH (1,1-diphenyl-2-pic-rylhydrazyl) was determined, as well as the phenolic contents (Folin-Ci...

The in vitro antioxidant activity and the total phenolic content (Folin−Ciocalteu method) of three successive extracts of three varieties of Ceratonia siliqua L. leaves ( grafted female, spontaneous female, spontaneous male) grown in Morocco were investigated by using in-vitro antioxidant models including 1,1-diphenyl-2-picrylhydrazyl (DPPH) scaven...

We evaluated the in vitro antioxidant property and phytochemical constituents of the crude ethyl acetate and methanol extract of the three genders of carob tree barks (spontaneous male, spontaneous female, and grafted female). The scavenging activity on DPPH (1,1-diphenyl-2-pic-rylhydrazyl) was determined, as well as the phenolic contents (Folin–Ci...

L’arganier, Argania spinosa (L.) Skeels, Sapotacée du sud-ouest marocain, est un arbre endémique, patrimoine national et mondial á la fois. Arbre forestier á rôle écologique, luttant contre l’érosion des sols et fourrager, alimentant les troupeaux de caprins, il est également fruitier. On extrait de son amandon l’huile d’argan, réputée internationa...

Stem bark of Allanblackia monticola has been used in association with others plant in the Cameroonian folk medicine for the treatment of various diseases such amoebic dysentery, diarrhoea, lung infections, and skin diseases. The methylene chloride fraction, its isolated compounds like alpha-mangostin, lupeol and acid betulinic were screened for ant...

Saponins from Argania spinosa at a non-haemolytic concentration diminish by 53.2% erythrocyte haemolysis induced by free radicals. 2 mM aspirin and acetaminophen diminish by 75% and 68% , respectively, erythrocyte haemolysis induced by free radicals, while 0.3 microM vitamin E shows no significant antioxidant activity. Interestingly, a combination...

Résumé Les différents extraits de Nepeta atlantica Ball et Nepeta tuberosa L. ssp. reticulata (Desf.) Maire sont riches en métabolites secondaires du type iridoïde lactonique et glucosidique et en triterpènes de type lupane. La partie aérienne de chaque espèce est broyée, puis extraite par macération à froid dans le méthanol produisant ce qui est n...

Résumé Introduction La prise en charge médicamenteuse des maladies chroniques au Maroc, notamment l’hypertension artérielle, reste problématique. Objectifs Évaluer la consommation, la segmentation et la part du marché des génériques, des antihypertenseurs au cours de la période 1991-2005 au Maroc. Méthodes utilisées Les données ont été extraites...

La diarrhée représente un problème de santé publique dont la fréquence de la mortalitéet de la morbidité est très élevée, spécialement chez les enfants dans les pays en voie de développement. Au Maroc, la médecine traditionnelle décrit plusieurs plantes, dans le traitement des troubles digestifs comme la diarrhée, dont Zygophyllum gaetulum. Cette p...

The medical assumption of responsibility of the chronic diseases in Morocco, in particular arterial hypertension, remains problematic. To evaluate the consumption, segmentation and the share of the market of generic antihypertensive drugs during the period: 1991-2005. The data were elaborate starting from the declarations of IMS health (Intercontin...