Katić Vuka

Katić Vuka
University of Niš | NIS · Center of Development, Scientific and Research Work

Prof. Emeritus specialist path

About

113
Publications
26,229
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517
Citations
Citations since 2017
8 Research Items
222 Citations
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201720182019202020212022202301020304050
201720182019202020212022202301020304050

Publications

Publications (113)
Article
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: This study examined the hepatoprotective and anti-inflammatory effects of anthocyanins from Vaccinim myrtillus (bilberry) fruit extract on the acute liver failure caused by carbon tetrachloride-CCl4 (3 mL/kg, i.p.). The preventive treatment of the bilberry extract (200 mg anthocyanins/kg, orally, 7 days) prior to the exposure to the CCl4 resulted...
Article
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Background and objectives: Here we report a rare case of a pancreatic polypeptide-secreting tumour (PPoma) discovered by accident during an autopsy. These PPomas occur in less than 2% of all pancreatic neoplasms and are almost exclusively silent, i.e., they are non-functional. Symptoms arising from PPoma are due to its compression of surrounding ti...
Article
This study examined the nephroprotective effects of 15 different anthocyanins from the bilberry extract on the acute kidney injury caused by CCl4. The acute nephrotoxicity in rats was induced 24 h after the treatment with a single dose of CCl4 (3 mL/kg, i.p.).The nephroprotective effects of the anthocyanins were examined in the animals that had bee...
Article
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Papillary carcinoma of the breast is an extremely rare form of breast carcinoma in males. We report a case of an 83-year-old man who presented with a retroareolar palpable mass, associated with bloody nipple discharge. Cytological characteristics were rare clusters and papillary formations with enlarged hyperchromatic nuclei, surrounded by erythroc...
Article
Plasma Cell Mastitis (PCM) is a benign breast entity that occurs in females in middle age with main histopathological characteristic-infiltration of plasma cells and lymphocytes in breast tissue. The importance of PCM lies in his similarity to the breast cancer in a clinical, microscopical and macroscopical presentation. Different stages of the PCM...
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Peutz-Jeghers syndrome (PJS) is a rare genetic disorder with autosomal-dominant pleiotropic inheritance, variable penetrance and characteristic signs of the disease that predisposes persons to increased risk of developing cancer, particularly in the gastrointestinal tract and the breast. Due to genetic nature of disease, in the familial Peutz-Jeghe...
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Lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of the stomach usually occurs as a consequence of Helicobacter pylori (H. pylori) infection. The aim of this study was to investigate the long-term effect of treatment of low-grade gastric MALT lymphoma with the H. pylori eradication method. In the period 2002-2012 in 20 patients with dy...
Article
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Aim To describe demographic and histomorphological characteristics of 139 patients with epithelial salivary gland tumors in the Southeastern Serbia population. Methods A total number of 139 patients with epithelial tumors arising in major and minor salivary glands in the period 2010-2012 was evaluated. After standard tissue proceeding, the routine...
Article
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Melanomas are malignant neoplasms that originate from melanocytes. The most common are on the skin and mucous membranes. Choroidal melanomas are quite different from cutaneous melanomas with regard to presentation, metastases, and treatment. We report two cases of metastatic gastric malignant melanoma of the eye and skin, with reference to the lite...
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Purpose: To investigate both the clinicopathological and immunohistochemical characteristics of a very rare skin cancer - Merkel cell carcinoma (MCC) - and to review the relevant literature. Methods: The study group was composed of 12 patients, with mean age 53.08±10.26 years. Multiple subcutaneous masses and lymph node metastases were surgicall...
Article
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Peutz-Jeghers (PJ) syndrome is a rare familial disorder with the autosomal transmission characterized by multiple intestinal polyps, mucocutaneous pigmentation and increased incidence of various malignancies. Some clinical manifestations of PJ syndrome may be associated with the serotonin secretion from the enterochromaffin cells (EC). Since no dat...
Article
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SUMMARY Introduction Peutz-Jeghers (PJ) syndrome is a rare familial disorder with the autosomal transmission characterized by multiple intestinal polyps, mucocutaneous pigmentation and increased incidence of various malignancies. Some clinical manifestations of PJ syndrome may be associated with the serotonin secretion from the enterochromaffin cel...
Article
Basal cell carcinoma (BCC) is the most common malignant tumor of the skin. This study was conducted to analyze patients with BCC, their age and sex distribution, occupation, site distribution of tumors, clinical types, and histopathological characteristics of lesions. Based on the data obtained from the Histopathological Registry, a clinical and hi...
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The aim of the study: The aim was to compare the effects of intermittent and continuous inflow occlusion on liver I/R injury in an experimental model. Method: The experiment was done using the Wistar rats that underwent continuous and intermittent inflow liver vascular occlusion. Blood and liver tissue samples were taken and parameters of hepati...
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In order to obtain good cheese quality, the milk has to possess good physical-chemical properties and should originate from healthy cows. Since milk fat and milk protein are the main constituents of cheese, their proportion in milk is of particular importance for the product yield and quality. This paper describes studies on the protein to fat rati...
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Carcinoid tumours are rare lesions that belong to the APUDoma category having the capacity of Amine Precursor Uptake and Decarboxylase. Gastrointestinal system comprises 90% of all carcinoids in the body and they are the most common type of primary malignant lesions of the appendix. New WHO classification of gastrointestinal carcinoids, diagnostic...
Conference Paper
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052 Forgotten organs for metastases V. Katic * , J. Gligorijevic, M. Krstic, Z. Radovanovic, A. Radovanovic, K. Katic * Policlinic of Nis, Dept. of Pathology, Serbia Objective: The ability to migrate and invade into surrounding tissues, blood, and lymphatic vessels is one of the marks of cancer, but underlying mechanisms controlling cell invas...
Article
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Prostatic gland basal cell proliferations exhibit morphological continuum ranging from basal cell hyperplasia to basal cell carcinoma. In the following report, we described clinical features, morphological spectrum, neuroendocrine differentiation and histogenesis of prostatic gland basal cell carcinoma in our patient. Hematoxylin-eosin (HE), Alcian...
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The purpose of the paper was to examine weight loss and correlation between total bacteria count and the somatic cells count and weight loss of semihard naturally dried cheese, product of dairy plant ZZ"Cijevna" in Podgorica. Weigt loss was calculated on the base of difference in mass of cheese at the beginning of ripening and after specified perio...
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Small bowel hemorrhages are rare and account for 2-10% of all gastrointestinal bleedings. In case that surgery is necessary, identification of the bleeding site is the most important problem. We presented here the case of a 65-year old man, admitted for urgent care of massive lower gastrointestinal bleeding. After reanimation and normalization of v...
Article
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Gastrointestinal stromal tumors (GIST) are the most frequent mesenchymal tumors of gastrointestinal system and they are characterised by extreme variability in clinical, hystopathological and genetic features. It is considered that all GISToms have a malignant potential. Ethiological factors which cause GISToms have not been clarified yet, and gene...
Article
The association between celiac disease (CD) and type 1 diabetes mellitus (T1DM) is well known. Up to now, CD prevalence in children and adolescents with T1DM in Serbia has not been reported. The aim of the present study was to determine CD prevalence and its clinical manifestations in patients with T1DM. One hundred and twenty-one patients (70 girl...
Article
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Pancreatic schwannoma is a very uncommon tumor of the pancreas, with only 27 cases reported. Most pancreatic schwannomas are benign, with only four malignant tumors reported. We describe a case of giant malignant schwannoma of the pancreatic body and tail, which involved the transverse colon. The tumor was treated successfully with en bloc distal s...
Article
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Sjögren's syndrome is a chronic autoimmune systemic disease characterized by polyglandular tissue destruction, leading to keratoconjunctivitis sicca and xerostomia. These patients have 44-fold increased risk of developing salivary gland lymphoma, of which 80% are marginal zone (MALT) type. Having in mind that criteria for distinguishing benign lymp...
Article
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Introduction: An inflammatory fibroid polyp is a rare condition with frequent localisation in the antrum of the stomach. Because of the localisation in the bottom parts of the mucosa and submucosa, a histological diagnosis is difficult to establish at endoscopic biopsies. So, a correct diagnosis is histologically possible after surgical excision w...
Article
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Background/Aim. It is a general opinion that the biggest number of colorectal carcinoma (CRC) develops with the malignant alteration of colorectal adenomas (adenoma carcinoma sequence). Malignant potential of adenoma is in the function of its size, histological structure and the grade of dysplasia. An adequate analysis of colorectal adenomas helps...
Article
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Colorectal lymphoma is a rare tumor representing 1.4% of human lymphomas, 10-20% of gastrointestinal lymphomas, namely 0.2-0.6% of all malignancies in the colon. The aim of this study was to review clinical characteristics of primary colorectal lymphoma and overall survival. A detailed analysis of 16 surgically treated patients included patients ag...
Article
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Mammary phyllodes tumors (MPT) are uncommon fibroepithelial (biphasic) neoplasms whose clinical behavior is difficult to predict on the basis of histological criteria only. They are divided into benign, borderline malignant and malignant groups. Sometimes it appears difficult to distinguish these tumors from other types of soft tissue sarcomas. Bec...
Article
The expression of the human Ki-67 protein is strictly associated with cell proliferation. The cell proliferation and kinetics of normal gastrointestinal tract are well known but the cell kinetics of adenoma in gastrointestinal tract is poorly understood. The aim of this study was to provide an immunohistochemical evaluation of the expression of Ki-...
Article
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The aims of this study were to review the clinical presentation of non-Hodgkin's lymphomas of the large bowel, to analyze the prognostic factors using univariate and multivariate methods, as well as the overall survival. We identified 24 cases at our clinic between 1991 and 2005, based on pathohistological analysis and standard diagnostic criteria...
Article
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Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndromes I and II, accounts for about 5-8% of colorectal cancers. Lynch syndrome I is an autosomal dominant inherited disorder characterized by early onset of colorectal cancer, predominance of proximal and multiple tumors, and microsatellite instability. In order to identify H...
Article
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Lymphoma of the colon is a rare tumor accounting for 10-20% of gastrointestinal lymphomas, i.e. 0.2-0.6% of all large bowel malignant tumors. We herein present the case of a young male patient, 17 years of age, admitted for surgery of palpable lymphoma of the cecoascendent portion of the colon 8-10 cm in size, detected during clinical examination a...
Article
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Ceruminous gland tumors are infrequent lesions of the external auditory canal (EAC). Controversy exists regarding several aspects of these tumors. In this report we presented a case of 63 years old woman with an 8-year history of a painless mass in the left EAC. Physical examination showed a skin-covered mass, occupying all its lumen. First superfi...
Article
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A significant increase in colonic carcinoma has been analyzed in numerous clinico-pathological studies and genetics models. The aim of this study was to determinate the differences in clinico-pathological parameters of colonic carcinoma regarding localization and histological type. The study enrolled 124 patients who had undergone surgery for color...
Article
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The aim of this study was to apply computer-assisted methodology in assessment of Ki-67 positivity in "adenoma-like" dysplasia associated lesions or masses (DALMs), and carcinoma in ulcerative colitis (UC), and to determine a new approach to grading of Ki-67 staining intensity. Immunohistochemical slides were quantitatively analyzed for estimation...
Article
This article describes a 4-y-old girl with spontaneous, generalized bruising, abdominal distention, and signs of malnutrition. She had been treated previously with an antibiotic for diarrhea. Laboratory analyses showed the presence of iron-deficiency anemia, mild hypoalbuminemia, and considerably prolonged prothrombin time and activated thromboplas...
Article
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Gastrointestinal (GI) stromal tumors (GIST) are the most common mesenchymal tumors of GI tract. The most frequent localization is gastric (60-70%) followed by intestinal localization (20-30%). The histogenesis, classification, diagnostic criteria and biological behavior of GIST are still discussable. Gastrointestinal stromal tumors are thought to o...
Article
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The vast majority of prostatic tumors developing in adult males are adenocarcinomas (ACP). Histological diagnosis of prostate cancer relies on the infiltrative growth pattern, presence of macronucleoli, and absence of basal cell layer. In the last few years a special attention has been focused on investigation of cancerous glands lumen content. The...
Article
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Autoimmune atrophic fundic gastritis induces the pernicious anemia (PA), as well as the changes in both epithelium and endocrine cells of gastric mucosa. The most important complications are: achlorhydria, hypergastrinemia, gastric cancer and enterochromaffin-like (ECL) carcinoid. The aim of this study was to examine ECL carcinoid histogenesis in A...
Article
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U radu su opisane intestinalne i ekstraintestinalne manifestacije familijarne adenomatozne polipoze koje mogu imati dijagnosticki i prognosticki znacaj. Pojava tumora izvan kolona znacajna je za razvoj ozbiljnih simptoma bolesti (opstrukcija, krvarenje), ali i za malignu alteraciju i razvoj karcinoma, posebno u duodenumu (karcinom duodenuma i dezmo...
Article
A 27-year-old male started to have his ankles swollen during his military service. He was examined at a military hospital where electromyoneurography showed the signs of distal sensory-motor polyneuropathy with axon demyelinization and weak myopathic changes, whereas histopathological examination of gastrocnemius muscle biopsy revealed some mild an...
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Amebiasis is uncommon in developed countries. Its clinical presentation can be variable and non-specific, and the diagnosis can be easily overlooked. Among the wide variety of clinicopathologic manifestations of the intestinal amebiasis, amebomas occur rarely, resulting from the formation of annular colonic granulation tissue, usually in the cecum...
Article
A wide spectrum of glandular epithelial metaplastic changes may be seen in the bladder. Cystitis glandularis (CG) is a well-known metaplastic lesion occurring in the presence of chronic inflammation, but there are a few data about mucin expression in its two subtypes (typical and intestinal). The purpose of the present study was to determine the ex...
Article
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Mucosa-associated lymphoid tissue (MALT) lymphoma was described for the first time in 1983 by Isaacson and Wright. It was classified into extranodal non-Hodkin's lymphomas of B-cell lymphocytes of the marginal zone of reactive lymphe follicles. It is characterized by both hyperplasia and colonization of plasmocytic, centrocytoid and monocytoid cell...
Article
Currently, there is no perfect test for the detection of bladder cancer. Even the gold standard cystoscopy is increasingly being demonstrated to miss both Tis and papillary bladder cancer. The oldest urine-based biomarker, cytology, has high specificity but has low sensitivity and significant variability in performance. Stage and grade of transitio...
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Monosodium glutamate is neurotoxin, potentially toxic to everyone -even to those people who do not respond with adverse reactions such as migraine headache, asthma, nausea and vomiting, fatigue, disorientation, and depression. However, it is used worldwide to improve the food preference. Hypothalamic lesions induced by neonatal treatment with MSG a...
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Breast cancer in elderly women is the major health issue and therapeutic challenge. The aim of the study was to determine specific characteristics of breast cancer biology in elderly patients. Retrospectively, we followed: breast cancer clinical and pathohistological characteristics of patients treated during the 5-year period at the Surgical Clini...
Article
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Sertoli-Leydig cell tumors belong to the group of sex-cord stromal tumors of the ovary. They account for less than 0,5% of all ovarian neoplasms. The majority of these tumors are benign and almost all are localized unilaterally. Herewith, we describe an ovarian Sertoli- Leydig cell tumor (arrhenoblastoma) with virilization, in an 63-year-old woman....
Article
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Introduction: The receptor activator of NF-B ligand (RANKL), expressed on the surface of osteoblasts and stromal cells in the bone marrow, plays an essential role in the formation and differentiation of osteoclasts and bone resorption. RANKL binds to its functional receptor, receptor activator of NF-B (RANK), expressed as a transmembrane heterotri...
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Continual increasing of breast cancer in young women, its rare discovery in the early stage (stage I), as well as high mortality from this disease, are the facts that explain why the breast cancer is a target for many scientists. Thanks to the Greek scientist Papanicolaou and his report (l928), a successful battle with the most frequent carcinoma i...
Article
Introduction: A clinically normal-appearing nipple in patients with breast cancer may contain unsuspected neoplastic cells. Preservation of a nipple containing occult malignancy could potentially increase local recurrence rates and affect disease-free survival. Consequently, patients considered for breast conservation operations with nipple preserv...
Article
Twenty-megahertz ultrasound is a potentially useful noninvasive method for the preoperative determination of tumor dimensions and for defining tumor margins and shape.1 Using 20-MHz ultrasound equipment (Dermascan C; Cortex Technology, Hadsund, Denmark), we examined 35 different types of skin tumors (basal cell carcinoma [n = 12], nevus pigmentosus...
Article
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The fact that cell death is not ultimately a bad thing came as a surprise to many researchers. Physiological cell death has been observed in various multicellular organisms. Apoptosis or programmed cell death is the predominant form of physiological cell death by which the organism eliminates unnecessary or damaged single cells. It is a major compo...
Article
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Kidney morphogenesis is a complex and stepwise process. The formation of mature kidney in mammals is preceded by two primitive embryonic kidneys known as pronephros and mesonephros. Metanephros develops as a result of reciprocal inductive interactions between two primordial mesodermal derivates: ureteric bud, an epithelial outgrowth of the Wolffian...
Article
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Primary pericardial mesothelioma is an extremely rare and lethal cardiac tumor. We report an autopsy case of a primary pericardial mesothelioma in a 52-year-old man. He developed dyspnea, cough, low-grade fever and night sweats approximately 3 months before last admission. Initially, he was evaluated at a hospital in another city, without a firm di...
Article
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Primary bone tumors and cancers that metastasize to bone require osteoclastic activity to release tumor-supportive growth factors from bone tissue. A number of systemic and locally acting factors are known to influence osteoclast formation, fusion, activation, and survival. Recently, two critical extracellular regulators of osteoclast differentiati...
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New data on apocrine carcinoma of the breast, especially on its unusual pathogenesis, are the facts that justify this study. The aim of this study was to describe the morphological features in both benign apocrine lesions and invasive apocrine carcinomas of the breast. The following apocrine lesions were pointed out: cysts, metaplasia, adenosis, ad...
Article
The present study was performed to evaluate the immunohistochemical analysis of estrogen receptor (ER) and progesterone receptor (PR) in invasive breast carcinomas of various histological subtypes and grades. In this paper an attempt was made to establish a correlation between hormone receptor status and histological and nuclear grading of breast c...
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The presence of lymphocytes within the liver parenchyma is related to immunologically mediated liver damage in chronic hepatitis C. The aim of the study was to make histological, histochemical, and immunocytochemical assessment of liver biopsy specimens in patients with chronic hepatitis C virus (HCV) infection. Biopsy specimens of 20 patients with...
Article
Introduction: A number of methods are currently available for the detecion of H. pylori, but histological detection in a gastric biopsy is the commonest and among the most sensitive.Aim: To compare the sensitivity of detecting H. pylori in gastric biopsy and resection specimens using haematoxylin and eosin (HE) stain and modified Giemsa stain.Metho...
Article
Colorectal carcinoma (CRC) is one of the most common malignancies found in Western countries. The inherited gastrointestinal polyposis syndromes account for approximately 1% of all CRC cases. They can be divided into adenomatous and hamartomatous syndromes. Adenomatous polyposis syndrome is familial adenomatous polyposis (FAP) with three phenotypic...
Article
Serum ascites albumin gradient (SAAG) has long been recognized as a reliable biochemical marker that can help in differential diagnosis of ascites. Values under 11 g/L indicate that patient with ascites has portal hypertension and vise versa. Because of poor sensitivity (Se) and specificity (Sp) of SAAG in some of the previous studies and possibili...
Article
The evaluation of UC activity is necessary for the purpose of optimum therapeutic approach and the analysis of the effects. The aim of the study is to direct attention to the importance of clinical, endoscopic and patho-histological evaluation of the ulcerative colitis activity. A prospective study included 117 patients with chronic ulcerative coli...
Article
Barrett's oesophagus refers to an acquired change characterised by replacement of the normal epithelium of the lower oesophagus by a columnar epithelium and occuring in subjects with gastroesophageal reflux disease. The mucosa represents a complex mixture of cell types and architectural patterns found in the stomach and small intestine. Gastric met...
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Dysgerminoma is best known as the ovarian counterpart of seminoma of the testis Relatively uncommon tumors, dysgerminomas account for less than 2% of all ovarian cancer. We report a case of a 14 years old girl with a large and rapidly growing unilaleral ovarian dysgerminoma. Examination of the surgical specimen showed a tumor of 27x17x8 cm in size...
Article
Most of the MALT-lymphoma of the stomach is generated in the antrum and it is macroscopically characterized by unclear boundaries, mucosa thickening or its ulceration. The MALToma generation is a many-phase process and it is a consequence of the chronic infection Helicobacter pylori. At an early stadium, the tumor is limited to the stomach mucosa w...