Katia AndradeInstitut de la Mémoire et de la Maladie d'Alzheimer (IM2A) · Hôpital de la Salpêtrière
Katia Andrade
About
16
Publications
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124
Citations
Citations since 2017
Publications
Publications (16)
Although neurocognitive models have been proposed to explain anosognosia (i.e., the lack of awareness of one's own deficits) in Alzheimer's disease (AD), the neural cascade responsible for its origin in the human brain is still unknown. Here, we build on a mechanistic, dual-path hypothesis that brings error-monitoring and emotional processing syste...
Background
Electroencephalography (EEG) is a non-invasive method that records the brain signals with time resolution in the millisecond range, thereby allowing the monitoring of subjects’ mental states in real time. Using appropriate biomarkers extracted from these EEG signals and presenting them back in a neurofeedback loop can foster neural compe...
Unawareness of memory deficits is an early manifestation in patients with Alzheimer’s disease (AD). This intriguing behavior constitutes a form of anosognosia and has neural mechanisms that remain largely unknown. Here, we hypothesized that it may result from a failure in the error-monitoring system, which would prevent AD patients from being aware...
Anosognosia, or the lack of awareness of one's own impairment, is frequent for memory deficits in patients with Alzheimer's disease (AD). Although often related to frontal dysfunctions, the neural mechanisms of anosognosia remain largely unknown. We hypothesized that anosognosia in AD may result from a failure in the error-monitoring system, thus p...
Alzheimer’s disease (AD) patients are often unaware of their memory deficits even at early stage of disease. Anosognosia has been related to frontal dysfunction although its underlying neural mechanism is still unknown. We hypothesized that it may result from an inability to monitor ongoing behavior due to a failure in the error‐monitoring system....
EEG-based passive brain-computer interfaces (BCIs) estimate the subjects’ mental states in real time, using appropriate biomarkers extracted from electroencephalographic signals. These BCIs, when present in a neurofeedback loop, make it possible to apply neurophysiological regulation to foster neural compensation mechanisms by teaching subjects to...
Introduction
Tout apprentissage repose sur la capacité de prendre conscience de l’erreur. Cependant, les mécanismes d’apprentissage peuvent être altérés par une charge cognitive trop élevée. Ce concept fait notamment référence à la capacité limitée de la mémoire de travail.
Objectifs
Nous faisons l’hypothèse qu’une charge cognitive élevée serait s...
EEG based passive brain computer
interfaces (pBCIs) estimate the subjects’ mental states
in real time, using appropriate biomarkers extracted from
the EEG signals (Zander & Kothe, 2011). In particular,
pBCIs, when present in a neurofeedback loop, make it
possible to apply neurophysiological regulation to foster
neural compensation mechanisms by tea...
The idea of using brain computer interfaces (BCI) for
cognitive rehabilitation is based on evidence suggesting
that not only self-regulated brain signals, but also
involuntary brain signals may provide information about
the BCI user. These BCI systems acquire brain waves
from an EEG and then utilize the biomarkers derived
from the brain signal and...
Le neurofeedback est une forme de thérapie cognitive, dont l’efficacité reste controversée en raison de résultats contradictoires. Identifier les variables cachées expliquant ces contradictions est un enjeu majeur. En particulier, le cadre d’application du neurofeedback implique des facteurs psycho-sociaux qui restent à ce jour peu documentés. En c...
To determine the neural substrates of biased spatial orienting in posterior cortical atrophy (PCA) by using a combined structural and functional neuroimaging approach.
Patients with spatial neglect typically bisect horizontal long lines towards their brain lesions but the precise neural substrates of this spatial bias remain controversial and poorl...
We studied visuospatial performance and obtained brain perfusion scintigraphy in 27 patients with posterior cortical atrophy (PCA) and 24 healthy controls, with two aims: (1) to determine inter-hemispheric perfusion imbalances underlying signs of spatial neglect and (2) to establish the functional substrates of patients' performance on distinct vis...
In posterior cortical atrophy (PCA), there is a progressive impairment of high-level visual functions and parietal damage, which might predict the occurrence of visual neglect. However, neglect may pass undetected if not assessed with specific tests, and might therefore be underestimated in PCA. In this prospective study, we aimed at establishing t...
A dysexecutive syndrome is expected in brain disorders that affect any of the different parts of the frontostriatal system. Executive functions should thus be systematically assessed in patients with cognitive, behavioral, or motor disturbances. The chapter explains that the pattern of executive dysfunction in degeneration of primarily frontal and...
Projects
Projects (2)
i) addressing a fundamental scientific question towards a causal understanding on how self-awareness emerges in the human brain;
ii) developing a cognitive BCI-system, which will allow us to validate neurophenomenologically EEG biomarkers in anosognosia,
iii)developing applications for the improvement of self-awareness in early stages of AD and bvFTD
The DORY project was based on the hypothesis that one could use NFB training, targeting distinct EEG biomarkers, in order to promote neuroplasticity in the elderly
