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Citations since 2017
3 Research Items
Balanced Ca2+ homeostasis is essential for cellular functions. STIM2 mediated Store-Operated Ca2+ Entry (SOCE) regulates cytosolic and ER Ca2+ concentrations, stabilizes dendritic spine formation and drives presynaptic spontaneous transmission and ER stress in neurons. Recently identified alternative spliced variants expand the STIM protein reperto...
Alternative splicing is a potent modifier of protein function. Stromal interaction molecule 1 (Stim1) is the essential activator of store-operated Ca2+ entry (SOCE) triggering activation of transcription factors. Here, we characterize Stim1A, a splice variant with an additional 31 amino acid domain inserted in frame within its cytosolic domain. Pro...
Alternative splicing is a potent modifier of protein function. Stromal interaction molecule 1 (Stim1) is the essential activator molecule of store-operated Ca ²⁺ entry (SOCE) and a sorting regulator of certain ER proteins such as Stimulator of interferon genes (STING). Here, we characterize a conserved new variant, Stim1A, where splice-insertion tr...