Kathleen Pajer

Kathleen Pajer
University of Ottawa · Department of Psychiatry

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31
Publications
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306
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Publications

Publications (31)
Article
Full-text available
Background Major depressive disorder is common, debilitating, and affects feelings, thoughts, mood, and behaviors. Childhood and adolescence are critical periods for the development of depression and adolescence is marked by an increased incidence of mental health disorders. This protocol outlines the planned scope and methods for a systematic revi...
Article
Full-text available
Exogenous melatonin can be used to treat sleep disturbance in adults, children, and adolescents. While its short-term use is considered safe, there are some concerns that long-term use might delay children's sexual maturation, possibly by disrupting the decline in nocturnal melatonin levels that occur at the onset of puberty. This narrative review...
Article
Full-text available
Objectives The aim of this review is to evaluate the effectiveness of shared/collaborative care between mental health-care providers and primary care providers (PCPs) on the outcomes of children and adolescents with attention-deficit/hyperactivity disorder (ADHD). This evaluation will be very helpful in the allocation of ADHD resources for models w...
Article
Hysteria is a term that has historically described a syndrome of multiple somatic complaints and dramatic physical dysfunction without any documented anatomic or physiological abnormalities. The term is no longer used. Symptoms once included are now categorized as one of two diagnoses in the somatoform disorders section of the American Psychiatric...
Article
The broad term antisocial disorders describes several groups of behaviors, all of which are illegal, irresponsible, or harmful to others. In the field of psychiatry, children and adolescents with antisocial behaviors are said to have conduct disorder (CD), and adults who display consistently antisocial behavior are diagnosed with antisocial persona...
Article
PurposeThe prescription of psychotropic medications to children and adolescents has increased dramatically over the last decade. However, the development of disparities in prescribing is poorly understood. We examined whether clustering of utilization is a common phenomenon among early adopters of medications described the characteristics of cluste...
Article
The purpose of this chapter is to present a developmental perspective on the relationship between biological substances and processes and aggressive and antisocial behavior in girls. The term "antisocial behavior" refers to externalizing behavior problems, conduct disorder symptoms, delinquency, and violence. We propose that the best way to underst...
Article
Two chlorpromazine analogs, 7,8-diOH- and 7,8-dioxo-didesmethyl-chlorpromazine were compared to chlorpromazine (CPZ) with regard to inhibition of three parameters of enzyme activity in rat striatum: 1) dopamine + GTP-sensitive adenylate cyclase in homogenates; 2) dopamine, GTP, calmodulin and Ca++-sensitive adenylate cyclase in washed particulate f...
Article
Described in this paper is a rapid, isocratic assay for serum indole-3-acetic acid (IAA). The sample preparation involves only protein precipitation using sulfosalicylic acid, and the sensitivity of amperometric detection is in the picogram range. The chromatographic analysis time is approximately 4 min. The devised method was used for a longitudin...
Article
A rapid, isocratic assay for the determination of all major tryptophan metabolites in serum samples from control non-alcoholic subjects, recovered alcoholics and newly abstinent alcoholics is described. The sample preparation involves only precipitation of protein with sulfosalicylic acid. The complete liquid chromatographic analysis is short (25 m...
Article
Six weeks following complete unilateral surgical isolation of the rat caudate nucleus, activation of adenylate cyclase was reduced in response to dopamine (DA), norepinephrine (NE), 5' -guanylyl-imidodiphosphate [Gpp(NH)p], DA + Gpp(NH)p, and NaF. The low Km form of cyclic AMP phosphodiesterase was elevated in the isolated side when compared to the...
Article
Chlorpromazine and five metabolites were evaluated with respect to their influence upon soluble and particulate guanylate cyclases from mouse cerebral cortex. The 8-hydroxy derivative of chlorpromazine was the only compound to consistently block basal, Ca2+ activation (particulate) and sodium azide or hydroxylamine stimulation (soluble) of the enzy...
Article
Thesis (M.P.H.)--Yale University, 1988. Includes bibliographical references (leaves 74-79).

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