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Kathleen Carter currently works in the Department of Chemistry at Georgia State University. Kathleen does research in Computational Biophysical Chemistry. Current project is 'DNA microstructure'.
Regulation of gene-expression by specific targeting of protein-nucleic acid interactions has been a long-standing goal in medicinal chemistry. Transcription factors are considered “undruggable” because they lack binding sites well suited for binding small-molecules. In order to overcome this obstacle, we are interested in designing small molecules...
Specific targeting of protein–nucleic acid interactions is an area of current interest, for example, in the regulation of gene-expression. Most transcription factor proteins bind in the DNA major groove; however, we are interested in an approach using small molecules to target the minor groove to control expression by an allosteric mechanism. In an...