Kathiresan Sathasivam

Kathiresan Sathasivam
AIMST University | AIMST

B.App.Sc;MSc; PhD

About

84
Publications
36,373
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
2,782
Citations

Publications

Publications (84)
Article
Full-text available
The rate of breast cancer is rapidly increasing and discovering medications with therapeutic effects play a significant role in women’s health. Drugs derived from marine sponges have recently received FDA approval for the treatment of malignant tumors, including metastatic breast cancer. Spirastrella pachyspira (marine sponge) is mainly obtained fr...
Article
Full-text available
Viniferin is a resveratrol derivative. Resveratrol is the most prominent stilbenoid synthesized by plants as a defense mechanism in response to microbial attack, toxins, infections or UV radiation. Different forms of viniferin exist, including alpha-viniferin (α-viniferin), beta-viniferin (β-viniferin), delta-viniferin (δ-viniferin), epsilon-vinife...
Article
Full-text available
Urinary tract infections (UTIs) are becoming more common, requiring extensive protection from antimicrobials. The global expansion of multi-drug resistance uropathogens in the past decade emphasizes the necessity of newer antibiotic treatments and prevention strategies for UTIs. Medicinal plants have wide therapeutic applications in both the preven...
Article
Full-text available
Fermented foods have been an important component of the human diet from the time immemorial. It contains a high amount of probiotics that have been associated to a wide range of health benefits, including improved digestion and immunity. This review focuses on the indigenously prepared prebiotic-and probiotic-containing functional fermented rice (n...
Article
Full-text available
The rise of the COVID-19 outbreak has made handling plastic waste much more difficult. Our superior, hyper-hygienic way of life has changed our behavioural patterns, such as the use of PPE (Personal Protective Equipment), the increased desire for plastic-packaged food and commodities, and the use of disposable utensils, as a result of the fear of t...
Article
Full-text available
Bisphenol A (BPA), a well-known xenoestrogen, is commonly utilised in the production of polycarbonate plastics. Based on the existing evidence, BPA is known to induce neurotoxicity and behavioural issues. Flavonoids such as silibinin and naringenin have been shown to have biological activity against a variety of illnesses. The current research eval...
Article
Full-text available
Sarsasapogenin is a natural steroidal sapogenin molecule obtained mainly from Anemarrhena asphodeloides Bunge. Among the various phytosteroids present, sarsasapogenin has emerged as a promising molecule due to the fact of its diverse pharmacological activities. In this review, the chemistry, biosynthesis and pharmacological potentials of sarsasapog...
Article
Full-text available
Plants are the natural source for the antioxidants from plants source is boon for the investigators. Present study was aimed to study the antioxidant activity and phytochemical screening of Cananga odorata (Lam.) Hook. f. & Thomson extract. Study involved preparation hydroalcoholic extract of Cananga odorata leaves (HECOL) using maceration method,...
Article
Full-text available
Kirenol, a potential natural diterpenoid molecule, is mainly found in Sigesbeckia species. Kirenol has received a lot of interest in recent years due to its wide range of pharmacological actions. In particular, it has a significant ability to interact with a wide range of molecular targets associated with inflammation. In this review, we summarise...
Article
Full-text available
Genistein is a naturally occurring polyphenolic molecule in the isoflavones group which is well known for its neuroprotection. In this review, we summarize the efficacy of genistein in attenuating the effects of memory impairment (MI) in animals. Scopus, PubMed, and Web of Science databases were used to find the relevant articles and discuss the ef...
Article
Technological advancement to enhance tumor cells (TC) has allowed discovery of various cellular bio-markers: cancer stem cells (CSC), circulating tumor cells (CTC), and endothelial progenitor cells (EPC). These are responsible for resistance, metastasis, and premetastatic conditions of cancer. Detection of CSC, CTC, and EPC assists in early diagnos...
Article
Full-text available
Transdermal drug delivery is important to maintain plasma drug concentrations for therapeutic efficacy. The current study reports the design, formulation, and evaluation of tizanidine transdermal patches formulated using chitosan and thiolated chitosan, ethyl cellulose (EC), polyvi-nylpyrrolidone (PVP), and Eudragit RL100 in different ratios. The t...
Article
Epithelial growth factor receptor (EGFR) is a cell surface transmembrane receptor that mediates the tyrosine signaling pathway to carry the extracellular messages inside the cell and thereby alter the function of nucleus. This leads to the generation of various protein products to up or downregulate the cellular function. It is encoded by cell eryt...
Article
Hylocereus costaricensis more popularly known as the purplish-red pitaya or dragon fruit belongs to the Cactaceae family. The present study analyzes the effect of amino acids, elicitors, and light quality to improve callus proliferation, enhance betalain content and antioxidant profiles through elicitation and amino acid supplementation. The treatm...
Article
Full-text available
In an emergency, drug repurposing is the best alternative option against newly emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, several bioac-tive natural products have shown potential against SARS-CoV-2 in recent studies. The present study selected sixty-eight broad-spectrum antiviral marine terpenoids and p...
Article
Full-text available
In the current pandemic, COVID-19 patients with predisposing factors are at an increased risk of mucormycosis, an uncommon angioinvasive infection that is caused by fungi with Mucor genus which is mainly found in plants and soil. Mucormycosis development in COVID-19 patient is related to various factors, such as diabetes, immunocompromise and neutr...
Article
Full-text available
Natural fibers have proven to be excellent reinforcing agents in composite materials. However , a critical disadvantage of natural fibers is their hydrophilic nature. In this study, banana trunk fibers were mechanically damaged using a high-speed blender, and the resulting fibers (MDBTF) were treated with (i) stearic acid (SAMDBTF) and (ii) calcium...
Article
Full-text available
The present study was intended to review antibiotic use in dental infections or diseases and its implications. This study was based on literature from Google Scholar, Google, Scihub, PubMed, and a link provided by AIMST and MAHSA Universities, Malaysia. Antimicrobials are extensively applied as therapeutic and prophylactic agents in dental infectio...
Article
Full-text available
Transdermal drug delivery is used to deliver a drug by eliminating the first-pass metabolism , which increases the bioavailability of the drug. The present study aims to formulate the chi-tosan-tamarind seed polysaccharide composite films and evaluate for the delivery of protein/pep-tide molecules. Nine formulations were prepared and evaluated by u...
Article
Transdermal drug delivery is used to deliver a drug by eliminating the first-pass metabolism , which increases the bio availability of the drug. The present study aims to formulate the chitosan-tamarind seed polysaccharide composite films and evaluate for the delivery of protein/pep-tide molecules. Nine formulations were prepared and evaluated by u...
Article
Full-text available
Proteus mirabilis, a gram-negative bacterium of the family Enterobacteriaceae, is a leading cause of urinary tract infection (UTI) with rapid development of multi-drug resistance. Identification of small regulatory RNAs (sRNAs), which belongs to a class of RNAs that do not translate into a protein, could permit the comprehension of the regulatory r...
Article
Full-text available
Antimicrobial resistance (AMR), one of the greatest issues for humankind, draws special attention to the scientists formulating new drugs to prevent it. Great emphasis on the biological synthesis of silver nanoparticles (AgNPs) for utilization in single or combinatorial therapy will open up new avenues to the discovery of new antimicrobial drugs. T...
Article
Full-text available
Purpose The present study was intended to fabricate chitosan (Ch)-tamarind gum polysaccharide (TGP) polyelectrolyte complex stabilized cubic nanoparticles of simvastatin and evaluate their potential against human breast cancer cell lines. Materials and Methods The antisolvent precipitation method was used for formulation of nanoparticles. Factoria...
Article
Full-text available
Compost is considered a soil-amending product that can be used for soil improvement and to increase the productivity of organic vegetable crops. Composting can be an alternative solution for solid waste management. In this research, the efficacy of various bakery wastes and bulking agents, such as cow dung, to produce compost were studied. The bin...
Article
Full-text available
Evidence suggests that stem cells exert regenerative potential via the release of extracellular vesicles. Mesenchymal stem cell extracellular vesicles (MSCEVs) offer therapeutic benefits for various pathophysiological ailments by restoring tissues. Facts suggest that MSCEV action can be potentiated by modifying the mesenchymal stem cells culturing...
Article
Full-text available
The rheological properties of tamarind seed polymer are characterized for its possible commercialization in the food and pharmaceutical industry. Seed polymer was extracted using water as a solvent and ethyl alcohol as a precipitating agent. The temperature’s effect on the rheological behavior of the polymeric solution was studied. In addition to t...
Article
Full-text available
Evidence suggests that reactive oxygen species (ROS) mediate tissue homeostasis, cellular signaling, differentiation, and survival. ROS and antioxidants exert both beneficial and harmful effects on cancer. ROS at different concentrations exhibit different functions. This creates necessity to understand the relation between ROS, antioxidants, and ca...
Article
Full-text available
Continuous oxidation of carbohydrates, lipids, and amino acids generate extremely reactive carbonyl species (RCS). Human body comprises some important RCS namely hexanal, acrolein, 4-hydroxy-2-nonenal, methylglyoxal, malondialdehyde, isolevuglandins, and 4-oxo-2-nonenal etc. These RCS damage important cellular components including proteins, nucleic...
Article
Hylocereus costaricensis, commonly known as red-purple dragon fruit or pitaya, is a climbing vine cactus that is currently widely grown as a fruit crop and has gained popularity as a potential source of both natural colourants and antioxidants contributed by betalain compounds. Betalains comprised of red-purple betacyanins and yellow betaxanthins....
Article
Biogenic zinc oxide nanoparticles (BZnONPs) as a nano medicine attain high importance in the treatment of Peri Implantitis (PI). Present study was aimed to biosynthesize, optimize, characterize and evaluate the response of BZnONPs against PI triggering non periodontal pathogen. The BZnONPs synthesis, characterization, optimization and stability wer...
Article
Present study was intended to synthesize and evaluate the Dimocarpus longan leaves aqueous extract (DLLAE) based chitosan nanoparticles (CSNPs) against periodontitis triggering bacteria. In present study the DLLAE was prepared by extracting D. Longan leaves in distilled water using decoction method. The prepared DLLAE was subjected to phytochemical...
Article
Full-text available
Objective: To investigate the antimicrobial activities of various solvent extracts of the bark of Cinnamomum cassia and Cinnamomum zeylanicum. Methods: The powdered barks of C. cassia and C. zeylanicum were extracted using methanol, ethanol and acetone. The antimicrobial activity of methanolic, ethanolic and acetone extracts of barks of C. cassia a...
Article
Full-text available
Present study was intended to synthesize silver nanoparticles (AgNPs) using corn silk aqueous extract (CSAE) and evaluate for antimicrobial and antiurolithiatic potential. The aqueous decoction of corn silk offered light yellow CSAE. Treatment of AgNO3 with CSAE offered AgNPs with absorbance 430 nm. Optimization study established 5 mM silver nitrat...
Article
Evidences over periodontitis predominance by human microbiota, inhibitory response of Citrus hystrix against periodontitis triggering bacteria and potentiation of antimicrobial response by silver nanoparticles (SNPs) were the stimulus to perform green synthesis of SNPs blended with Citrus hystrix and evaluation against periodontitis triggering micr...
Article
Full-text available
Present study was intended to explore the biosorption of Cu(II) and Pb(II) ions in aqueous solution using activated carbon biosynthesized from macro-algae Kappaphycus alvarezii under different experimental parameters. Activated carbon was produced via zinc chloride chemical activation method. The effect of parameters such as pH, temperature over bi...
Article
Full-text available
Secondary bioactive compounds of endophytes are inevitable biomolecules of therapeutical importance. In the present study, secondary metabolites profiling of an endophytic bacterial strain, Acinetobacter baumannii, were explored using GC-MS study. Presence of antioxidant substances and antioxidant properties in chloroform (CHL), diethyl ether (DEE)...
Article
Full-text available
In the present study, we have developed a green approach for the synthesis of silver nanoparticles (DSAgNPs) using aqueous extract of Durio zibethinus seed and determined its antibacterial, photocatalytic and cytotoxic effects. Surface plasmon resonance confirmed the formation of DSAgNPs with a maximum absorbance (λmax) of 420 nm. SEM and TEM image...
Article
Full-text available
Antibiotic resistance is one of the most important global problems currently confronting the world. Different biomedical applications of silver nanoparticles (AgNPs) have indicated them to be promising antimicrobial agents. In the present study, extracellular extract of an endophytic bacterium, Pantoea ananatis, was used for synthesis of AgNPs. The...
Article
Full-text available
Proteus mirabilis, a gram-negative bacterium of the family Enterobacteriaceae, is a leading cause of urinary tract infection (UTI) with rapid development of multi-drug resistance. Identification of small regulatory RNAs (sRNAs), which belongs to a class of RNAs that do not translate into a protein, could permit the comprehension of the regulatory r...
Article
Background: Cinnamomum cassia or Chinese cinnamon is one of the fundamental herbs in traditional Chinese medicine. C. cassia is used as astringent, antiseptic, and used for the treatment of metabolic disorders. The antioxidant and antidiabetic effects of its extracts are unclear. Hence, the present study is planned to investigate the antioxidant an...
Article
An accurate measurement of intrinsic hand muscle strength (IHMS) is required by clinicians for effective clinical decision-making, diagnosis of certain diseases, and evaluation of the outcome of treatment. In practice, the clinicians use Intrins-o-meter and Rotterdam Intrinsic Hand Myometer for IHMS measurement. These are quite bulky, expensive, an...
Article
Full-text available
An accurate measurement of intrinsic hand muscle strength (IHMS) is required by clinicians for effective clinical decision-making, diagnosis of certain diseases, and evaluation of the outcome of treatment. In practice, the clinicians use Intrins-o-meter and Rotterdam Intrinsic Hand Myometer for IHMS measurement. These are quite bulky, expensive, an...
Article
Full-text available
Piezoresistive behavior of 6 to 9 wt % Ketjenblack reinforced deproteinized natural rubber (KB/DPNR) nanocomposite developed by two-roll mill was studied under compressive pressure (0 to 12.54 MPa). The 6 wt % KB/DPNR exhibited monotonic piezoresistivity, the highest electrical resistance change (485%), remarkable reversibility and minimal hysteres...
Article
Chloroxylenol and oxadiazoles are the potent antibacterial and antifungal agents. 2-(4-Chloro-3,5-dimethylphenoxy)acetohydrazide (3), prepared from ethyl 2-(4-chloro-3,5-dimethylphenoxy)acetate (2), when cyclized with aromatic acids offered 2-{(4-chloro-3,5-dimethylphenoxy)methyl}-5-(aryl)-1,3,4-oxadiazole derivatives (4a-f). The novel compounds we...
Article
Azetidinones and PCMX are potent antimicrobial entities. The cyclocondensation of N-substituted benzylidene-2-(4-chloro-3,5-dimethylphenoxy)acetamide (2a-e), with TEA and CAC resulted in formation of N-{3-chloro-2-(aryl)-4-oxoazetidin-1-yl}-2-(4-chloro-3,5-dimethylphenoxy)acetamide (3a-e). The synthesized compounds were characterized by elemental a...
Article
Full-text available
2-Phenylpropanoic acid and oxadiazoles are known to possess antimicrobial potential. 2- phenylpropanehydrazide (2), a derivative of methyl 2-phenylpropionate, on cyclization with aromatic acids offered new 2-aryl-5-(1-phenylethyl)-1,3,4-oxadiazole derivatives (3a-e). The new oxadiazole derivatives were characterized by elemental analysis and spectr...
Article
Full-text available
Chloroxylenol and imines are the known potent antimicrobial entities. 2-(4-Chloro-3,5-dimethylphenoxy)acetohydrazide (2), prepared from ethyl 2-(4-chloro-3,5-dimethylphenoxy)acetate (1), on treatment with aromatic aldehydes offered N-substituted benzylidene-2-(4-chloro-3,5-dimethylphenoxy)acetamides (3a-e). The 1 structures of new compounds were ch...
Article
Biosorption is a promising technology for the removal of heavy metals from industrial wastes and effluents. In the present study, biosorption of Pb2+, Cu2+, Fe2+ and Zn2+ onto the dried biomass of Eucheuma denticulatum (Rhodophyte) was investigated as a function of solution pH, contact time, temperature and initial metal ion concentration. The expe...
Article
Full-text available
The purpose of this study is to determine the impact properties, chemical resistance and morphology of TPU/PVC blend in order to be used as potential material to fabricate bedpan. TPU and incorporation of PVC in TPU was done by melt-mixing method. The blends of TPU/PVC from melt mixing were then undergoing hot press compression moulding to produce...
Conference Paper
Background: Biodiesel derived from renewable lipid feedstocks is largely used in diesel engine. Third generation biodiesel is known to produce from oil of algal biomass and is considered as a very promising fuel. The objective of the present study was to evaluate some physico-chemical properties of biodiesel produced from a Malaysian Rhodophyte, Ka...
Article
Full-text available
Biosorption process is a promising technology for the removal of heavy metals from industrial wastes and effluents using low-cost and effective biosorbents. In the present study, adsorption of Pb2+, Cu2+, Fe2+, and Zn2+ onto dried biomass of red seaweed Kappaphycus sp. was investigated as a function of pH, contact time, initial metal ion concentrat...
Article
Full-text available
The inflatable bedpan is designed to provide comfortable, convenient, safe, hygienic, efficient and easy to use to the patients and their caretakers. In order to investigate the suitability thickness of inflatable bedpan for the pressure inflow in bedpan tube, the analysis is done using Catia analysis. The static analysis work is carried out to inf...
Article
Full-text available
2013): Effect of three different cooking methods on proximate and mineral composition of Asian Sea bass (Lates calcarifer Bloch Disclaimer: This is a version of an unedited manuscript that has been accepted for publication. As a service to authors and researchers we are providing this version of the accepted manuscript (AM). Copyediting, typesettin...
Article
Full-text available
Objective The aim of this study was to identify the presence of antimicrobial activity in different organs/tissues (gills, blood, skin, liver, intestine, kidney, tissue and ovary) extract of snakehead fish Channa striatus.MethodsA total of 48 fractions from the organs and tissue extracts were obtained by solid-phase extraction and the fractions wer...
Article
Microorganisms have been shown to have an adaptive ability for efficiently breaking down oxidized polymers. In the present study, we have developed a rapid and sensitive analytical technique using Fourier Transform Infrared coupled Attenuated Total Reflectance (FTIR-ATR) spectroscopy to quantify low density polyethylene (LDPE) biodegradation by mic...
Article
Sustainable crop production is largely depended on the efficient crop protection measures. Use of synthetic chemicals though seemed to be effective; in long run it proved to be detrimental to the biosphere. Rice being the major stable food of Asians received much attention on improving the productivity. In the present investigation, native Bacillus...
Article
Full-text available
The effects of different cooking methods (boiling, baking, frying and grilling) on proximate and mineral composition of snakehead fish were investigated. The mean content of moisture, protein, fat and ash of raw fish was found to be 77.2 ± 2.39, 13.9 ± 2.89, 5.9 ± 0.45 and 0.77 ± 0.12% respectively. The changes in the amount of protein and fat were...
Article
Full-text available
The present investigation aims to assess the phytochemical content, antioxdative activity and antimicrobial activity of the methanolic leaf extract of locally available Mentha piperita, the mint plant. The methanolic leaf extract of mint leaves was analyzed qualitatively for the phytochemical contents as previously described. The 1,1-diphenyl-2-pic...
Article
Full-text available
To isolate Salmonella from curry samples and to evaluate the drug sensitivity of the food-borne Salmonella and its susceptibility to specific plant extracts. Salmonella was isolated from the curry samples by standard microbiological methods and was confirmed by biochemical tests. The antibiotic susceptibility test was conducted by disc diffusion me...
Article
In aquaculture feeding rate is an important factor affecting the growth of fish, and thus determining the optimal feeding rate is important to the success of any aquaculture operation. In the present study aimed to investigate the effect of different feeding rate on the growth, survival, cannibalism and body composition of African catfish, Clarias...
Article
Thermal decomposition of an agrowaste, namely banana trunk fibers (BTF) were investigated by thermogravimetry (TG) and derivative thermogravimetry (DTG) up to 900 °C at different heating rates (from 5 to 100 °C/min). The BTF was subjected to modification by means of various known chemical methods (mercerization, acetylation, peroxide treatment, est...
Article
Full-text available
To evaluate the mosquito larvicidal potential of the native Bacillus thuringiensis isolate BtReXO2, which was isolated from a tropical rain forest ecosystem in Malaysia. This study also aimed at determining the phenotypic and biochemical characteristics of the isolate. The phenotypic characterization was carried out by growing the isolate in nutrie...
Article
Full-text available
This work describes the removal of Cd(II) ions in aqueous solution by unmodified and base-modified rice husk (RH) as compared to that by activated carbon (AC). Mercerization of RH was carried out by using dilute solutions (0.013 M) of NaOH, KOH, and Ca(OH) 2 . The experiments were conducted in duplicate under 1-batch and 2-batch treatments. In the...
Article
Oil spill leaves detrimental effects to environment, living organisms, and economy. As such, it is of considerable interest to find an effective, simple, and inexpensive method to treat this calamity. This work reports the use of banana trunk fibers (BTF) modified with oleic acid, stearic acid, castor oil, and palm oil for oil spill recovery. The m...
Article
This work aims to investigate the removal of methyl orange, a mutagenic azodye from various aqueous solutions using ground yam leaf fibers of the size 212-350 microns. The parameters studied were the effect of pH, amount of adsorbent, contact time and concentration of adsorbate. Equilibrium data were fitted to the Langmuir, Freundlich and Temkin -...
Article
Full-text available
Objective To evaluate the antibacterial activity of the methanolic extract of mango (Mangifera indica L.) seed kernel.Methods Chokanan mango seed kernel and seed kernels from assorted mango varieties were collected, cleaned, dried and powered. Crude methanolic extracts of mango seed kernel were analyzed for the phytochemical constituents. The free...
Article
Polymer composite using natural fiber as reinforcement material is getting attention due to easy availability and its low cost. In this work, poly(vinyl alcohol) (PVA)/fatty acid esterified banana trunk fibers (FAGBTF) of various compositions were produced by a solution casting method. The characteristic properties of PVA/ FAGBTF composite films we...
Article
Scitation is the online home of leading journals and conference proceedings from AIP Publishing and AIP Member Societies
Article
Fourier transform infrared spectra of cis -1,4-polychloroprene was recorded in the region of 400-4000cm-1 and its Raman spectra was also recorded in the wave number range of 100-4000cm-1. The spectra were completely analyzed. Probable assignments to observe bands were made with the aid of intensities and normal coordinate analysis by assuming Cs sy...
Article
Full-text available
The biosorption of Cd(II), Cu(II), Fe(II) and Zn(II) from aqueous solutions by an agrowaste, namely banana trunk fibers (BTF), was investigated. The effect of pH, contact time, metal ions concentration, adsorbent dose and change in [M2+]/biomass were studied at ambient temperature (25 °C). The equilibrium process was described well by the Freundlic...
Article
Full-text available
Objective: To compare the antioxidative effects of the methanolic leaf extracts of Ficus religiosa (F. religiosa), Chromolaena odorata (C. odorata), Cynodon dactylon (C. dactylon) and Tridax procumbens (T. procumbens) as well as the contents of antioxidants in the extracts. Methods: Total phenol and total flavanoid contents were measured according...
Article
Full-text available
Poly methyl methacrylate (PMMA) is a widely used polymer with various applications. Fourier transform infrared and Raman spectra of PMMA were recorded in range of 4000 – 400 cm -1 and 4000 – 100 cm -1 , respectively. In the present investigation, detailed assignments of the observed fundamental bands of PMMA have been analyzed in terms of peak posi...