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Katharina V. Wellstein

Katharina V. Wellstein
ETH Zurich | ETH Zürich · Institute for Biomedical Engineering

Master of Science
currently analysing data using auricular percutaneous vagus nerve stimulation

About

18
Publications
5,003
Reads
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166
Citations
Introduction
I am currently employed as a Doctoral Student at the Institute for Biomedical Engineering, ETH Zurich. I am interested in social learning processes in individuals with persecutory ideation in the general and at risk mental state population. As of recently I also started working on additional projects on hierarchical models of interoception and how interoceptive processes are linked to Psychosis and to affective disorders.
Additional affiliations
March 2016 - present
wellstein reden.ch
Position
  • Public Speaking Coach
Description
  • Teaching public speaking in seminars for middle management professionals, pastor's in training, and nurses in training. Private coachings.
Education
January 2018 - January 2023
ETH Zurich
Field of study

Publications

Publications (18)
Article
Full-text available
The auditory mismatch negativity (MMN) has been proposed as a biomarker of NMDA receptor (NMDAR) dysfunction in schizophrenia. Such dysfunction may be caused by aberrant interactions of different neuromodulators with NMDARs, which could explain clinical heterogeneity among patients. In two studies ( N =81 each), we used a double-blind placebo-contr...
Preprint
Full-text available
The auditory mismatch negativity (MMN) has been proposed as a biomarker of NMDA receptor (NMDAR) dysfunction in schizophrenia. Pathophysiological theories suggest that such dysfunction might be partially caused by aberrant interactions of different modulatory neurotransmitters with NMDARs, which could explain heterogeneity among patients with schiz...
Article
While persecutory delusions (PDs) have been linked to fallacies of reasoning and social inference, computational characterizations of delusional tendencies are rare. Here, we examined 151 individuals from the general population on opposite ends of the PD spectrum (Paranoia Checklist [PCL]). Participants made trial-wise predictions in a probabilisti...
Article
Full-text available
Background Persecutory delusions (PD) are a prominent symptom in first episode psychosis and psychosis patients. PD have been linked to abnormalities in probabilistic reasoning and social inference (e.g., attribution styles). Predictive Coding theories of delusion formation suggest that rigid delusional beliefs could be formalized as precise (i.e....
Article
Full-text available
It has been suspected that abnormalities in social inference (e.g., learning others' intentions) play a key role in the formation of persecutory delusions (PD). In this study, we examined the association between subclinical PD and social inference, testing the prediction that proneness to PD is related to altered social inference and beliefs about...
Poster
Full-text available
While persecutory delusions (PD) have been linked to fallacies of reasoning (1-4) and social inference (5-7), computational characterisations of delusional tendencies are rare. In this study, we examined individuals from the general population on opposite ends of the PD spectrum (Paranoia Checklist, PCL, 7) employing hierarchical Bayesian models of...
Preprint
It has long been suspected that abnormalities in social inference (e.g., learning others’ intentions) play a key role in the formation of persecutory delusions (PD). In this study, we examined the association between subclinical PD and social inference, testing the prediction that proneness to PD is related to altered social inference and beliefs a...
Article
Full-text available
Theoretical frameworks such as predictive coding suggest that the perception of the body and world – interoception and exteroception – involve intertwined processes of inference, learning, and prediction. In this framework, attention is thought to gate the influence of sensory information on perception. In contrast to exteroception, there is limite...
Preprint
Full-text available
Theoretical frameworks such as predictive coding suggest that the perception of the body and world, interoception and exteroception, involve intertwined processes of inference, learning, and prediction. In this framework, attention is thought to gate the influence of sensory information on perception. In contrast to exteroception, there is limited...
Article
Full-text available
Background Persecutory delusions (PD) constitute core symptoms in psychosis that may emerge from aberrant learning and inference about others’ intentions. Computational assays that use generative models of electrophysiological data to probe this learning process and its underlying neuronal mechanisms, in particular the effects of dopamine (DA) on s...
Article
Full-text available
Background It has long been suspected that abnormalities in social inference (e.g., about the intentions of others) play a key role for persecutory delusions. In this study, we examined the association between subclinical persecutory delusions (PD) and social inference, testing the prediction that proneness to PD is related to altered social infere...
Article
Recently developed methods for functional MRI at the resolution of cortical layers (laminar fMRI) offer a novel window into neurophysiological mechanisms of cortical activity. Beyond physiology, laminar fMRI also offers an unprecedented opportunity to test influential theories of brain function. Specifically, hierarchical Bayesian theories of brain...
Poster
Full-text available
Experimental investigation of social inference in sublinical persecutory delusion with a neurobiologically implemented probabilistic advice taking paradigm.
Poster
Action optimization relies on learning about the success of past decisions and on accumulated knowledge about the (in)stability of the environment [1]. In Bayesian models of learning and decision-making, belief updating is informed by multiple prediction errors (PEs) that are related hierarchically [2]. Recent work has examined these computational...
Poster
In reward learning, action optimization relies on the success of past decisions and on accumulated knowledge about the (in)stability of the environment. Consequently, belief updating is informed by multiple prediction errors (PEs) that are related hierarchically. Recent work linked these computational quantities to fMRI data, implying that hierarch...

Questions

Questions (2)
Question
I am looking for validated voice databases, where voices are recorded speaking different statements with their voice also expressing different emotions. Specifically, speaking in an angry and a warm/loving voice would be interesting. Does anyone know anything?
Question
We would like to investigate interoception in the respiratory domain and the interaction of cardiac and respiratory signalling. We'd like to combine autonomic measurements with EEG.
I have been looking at many blood pressure measurement tools, they all have their pro's and con's as anything in life I guess. The normal blood pressure cuff for example is not as sensitive as a finger cuff. But tools using finger cuffs are a lot more expensive and I am not sure how much better they really are. That is why I thought it would be best to direct my question to the community and get some expert insight from a physiological perspective and an experimental perspective. What is the best blood pressure measurement tool you know and why? And the same for respiration (CO2, O2, etc.). Hope to find some interesting suggestions here :)

Network

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Projects

Projects (3)
Project
Identifying Computational Assays Related to Dopaminergic and Cholinergic Receptor Function in Psychosis With a Series of Learningtasks.
Project
Investigating social inference processes in subclinical persecutory delusions
Project
(1) Providing evidence of interoceptive prediction errors (2) Establishing a causal link between perception of body states and psychiatric disorders (3) Probing different intervention techniques to improve interoception