Katharina Schmidt

Katharina Schmidt
University Hospital Essen | UK Essen · Clinic for Neurology

PhD, M.Sc. Psychology and M.A. Higher Education

About

26
Publications
2,355
Reads
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238
Citations
Introduction
I am investigating pain cognition interactions, specifically placebo analgesia and treatment expectation effects as well as pain-related learning mechanisms using behavioral, physiological and fMRI data in chronic clinical as well as experimental pain. I am working as a postdoctoral researcher and scientific coordinator of a collaborative research center (www.treatmentexpectation.de)
Additional affiliations
April 2018 - present
University Hospital Essen
Position
  • Lecturer
Description
  • Pain, Placebo & Nocebo Effect
April 2016 - present
University of Hamburg
Position
  • Lecturer
Description
  • Psychology, Pain, and Perception
January 2014 - present
University Hospital Essen
Position
  • Researcher
Education
April 2018 - August 2020
University of Hamburg
Field of study
  • Higher Education
September 2012 - December 2016
University Medical Center Hamburg - Eppendorf
Field of study
  • Pain research, Neuroscience
October 2010 - August 2012
University of Hamburg
Field of study
  • Psychology

Publications

Publications (26)
Article
Chronic low back pain is prevalent, highly disabling and a relevant socioeconomic health concern. Although allocated to placebo groups, patients in randomized controlled trials show significant pain relief, pointing to the relevance of placebo effects. Overcoming ethical and legal concerns related to deceptive placebos, recent studies have demonstr...
Article
Full-text available
Background Risk literacy, i.e., the ability to calculate and apply risk parameters, represents a key competence for risk communication and medical decision making. However, risk literacy is reportedly low in medical students. The successful acquisition of statistical competencies is often difficult, and can be hampered by emotional learning obstacl...
Article
Full-text available
Appetitive and aversive learning are both key building blocks of adaptive behavior, yet knowledge regarding their differences is sparse. Using a capsaicin heat pain model in 36 healthy participants, this study directly compared the acquisition and extinction of conditioned stimuli (CS) predicting pain exacerbation and relief. Valence ratings show s...
Article
Full-text available
Pain-related learning mechanisms likely play a key role in the development and maintenance of chronic pain. Previous smaller-scale studies have suggested impaired pain-related learning in patients with chronic pain, but results are mixed, and chronic back pain (CBP) particularly has been poorly studied. In a differential conditioning paradigm with...
Article
Full-text available
Acute pain captures attentional resources and interferes with ongoing cognitive processes, including memory encoding. Despite broad clinical implications of this interruptive function of pain for the pathophysiology and treatment of chronic pain conditions, existing knowledge exclusively relies on studies using somatic pain models. Visceral pain is...
Article
Full-text available
Introduction Migraine is the most common neurological disorder and one of the major causes of years lived with disability. Its treatment (especially of chronic forms) is often challenging and accompanied with adverse effects. Although new therapeutic approaches have recently emerged (eg, calcitonin gene-related peptide antibodies), these are linked...
Article
Migraine is one of the leading causes of years lived with disability and considered to be a major global health concern. Pharmacological preventive treatment often causes side effects that limit the adherence to longer-term treatment regiments. Both experimental and clinical evidence suggests that positive expectations can modulate pain and analges...
Article
Full-text available
The cold pressor test (CPT) is widely implemented and offers a simple, experimental acute pain model utilizing cold pain. Previous trials have frequently paired the CPT with opioids in order to investigate the mechanisms underlying pharmacological analgesia, due to their known analgesic efficacy. However, opioid side effects may lead to unblinding...
Preprint
Full-text available
We aimed to develop a screening tool that allows for the general assessment and quantification of patients’ treatment expectations and their effects on clinical outcomes, irrespective of the clinical condition. In addition to patients’ treatment related expectations, it assesses both prior treatment experiences and current experiences of treatment...
Article
Full-text available
Psychological distress is prevalent in students and can predispose to psychiatric disorders. Recent findings indicate that distress might be linked to impaired cognitive performance in students. Experimental findings in healthy participants suggest that placebo interventions can improve cognition. However, whether non-deceptive (i.e., open-label, O...
Article
Full-text available
Pain is evolutionarily hardwired to signal potential danger and threat. It has been proposed that altered pain-related associative learning processes, i.e., emotional or fear conditioning, might contribute to the development and maintenance of chronic pain. Pain in or near the face plays a special role in pain perception and processing, especially...
Article
Full-text available
Background: Pain is highly prevalent in patients with Parkinson's disease (PD), but underlying pathophysiological mechanisms are largely unclear. In many chronic pain syndromes deficits in endogenous pain inhibition have been detected that can be assessed using conditioned pain modulation paradigms. Previous studies employing this approach in medi...
Article
Chronic back pain is a major global health problem, while its treatment is hampered by a lack of efficacy and restricted safety profile of common front-line therapies. The present trial aims to determine whether a 3-week open-label placebo treatment reduces pain intensity, and subjective and objective functional disability in chronic back pain pati...
Article
Memory retrieval is accompanied by a reactivation of cortical and subcortical areas that have been active during encoding. This neural reinstatement is stronger during retrieval of pain-associated material compared with other unpleasant events. In this functional magnetic resonance imaging study, we investigated the differences in neural reinstatem...
Article
Background: Pain is highly prevalent in patients with Parkinson's disease (PD), but underlying pathophysiological mechanisms are largely unclear. Alterations in somatosensory processing might contribute to sensory abnormalities in PD. Objective: This study investigated sensory processing in PD patients. Methods: We used the standardized "Quant...
Article
Because of its unique evolutionary relevance, it is understood that pain automatically attracts attention. So far, such attentional bias has mainly been shown for pain-related stimuli whereas little is known about shifts in attentional focus after actual painful stimulation. This study investigated attentional shifts by assessing eye movements into...
Article
Pain is a frequent but still neglected non-motor symptom of Parkinson's disease (PD). However, neural mechanisms underlying pain in PD are poorly understood. Here we explored whether the high prevalence of pain in PD might be related to dysfunctional descending pain control. Using fMRI we explored neural responses during the anticipation and proces...
Presentation
This instructional video was shown to all participating patients (group-independently) of the Essen OLP CBP trial.
Article
Background Expectations can dramatically influence the perception of pain, as has been shown in placebo analgesia or nocebo hyperalgesia. Here, we investigated the role of expectation on the interruptive function of pain - the negative consequences of pain on cognitive task performance - in 42 healthy human subjects. Methods Verbal and written inst...
Article
Compared to peripheral pain, trigeminal pain elicits higher levels of fear, which is assumed to enhance the interruptive effects of pain on concomitant cognitive processes. In this fMRI study we examined the behavioral and neural effects of trigeminal (forehead) and peripheral (hand) pain on visual processing and memory encoding. Cerebral activity...
Article
Over the recent years, neuroimaging studies have investigated the neural mechanisms underlying the influence of expectations on perception. However, it seems equally reasonable to assume that expectations impact cognitive functions. Here we used fMRI to explore the role of expectations on task performance and its underlying neural mechanisms. 43 he...
Article
Background: Pain is hardwired to signal threat and tissue damage and therefore automatically attracts attention to initiate withdrawal or defensive behaviour. This well-known interruptive function of pain interferes with cognitive functioning and is modulated by bottom-up and top-down variables. Here, we applied predictable or unpredictable painfu...
Article
Unlabelled: Habituation and sensitization are important features of individual sensitivity to repetitive noxious stimulation and have been investigated in numerous studies. However, it is unclear whether these phenomena vary depending on the site of stimulation. Here we compared short-term and long-term effects of painful heat stimulation on the f...
Article
Full-text available
The interruptive effect of painful experimental stimulation on cognitive processes is a well-known phenomenon. This study investigated the influence of pain duration on the negative effects of pain on cognition. Thirty-four healthy volunteers performed a rapid serial visual presentation task (RSVP) in which subjects had to detect (visual detection...

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Projects (2)
Project
We suspect that OLP may increase cognitive functions and have a positive influence on different mood parameters.