Katarzyna Makyła-Juzak

Katarzyna Makyła-Juzak
Jagiellonian University | UJ · Department of General Chemistry

Dr

About

19
Publications
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Introduction
Of my particular interest is experimental modeling of bi-dimensional biological membranes (with the Langmuir monolayer technique) and studying the influence of bioactive substances on their biophysical properties. Recently my research activities have been also focused on drug/biomolecules carriers as well as preparation of highly ordered thin films based on functional materials of well-defined thickness and desired quality.

Publications

Publications (19)
Article
DNA complexes with cetyltrimethylammonium chloride (CTMA), benzyldimethylhexadecylammonium chloride (BAC) and hexadecylpyridinium chloride (HDP) surfactants as powder samples were studied by Fourier-Transform Middle Infrared spectroscopy, X-ray diffraction and dielectric spectroscopy methods. Complexation as electrostatic interactions was confirmed...
Article
Full-text available
The complex consisting of DNA and cetyltrimethylammonium chloride (DNA-CTMA) is extensively exploited in organic electronics in form of thin films with submicron or nanometer thickness. In this work, using the Langmuir-Blodgett technique, the surface films were prepared from complexes based on different types of chromosomal and plasmid DNA. The res...
Article
Recently, solid forms of deoxyrybonucleic acid (DNA) and its lipoplex with hexadecyltrimethylammonium chloride (CTMA) have been studied with great interest, because of potential applications outside life sciences. In the present work we report on spontaneous formation of characteristic self-assembled linear patterns formed with DNA-CTMA on solid su...
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Glycosaminoglycans (GAGs) are essential components of the extracellular matrices (ECMs) located on the outer surface of cellular membranes. They belong to the group of polysaccharides involved in diverse biological processes acting on the surface and across natural lipid membranes. Recently, particular attention has been focused on possible role of...
Article
Cyclosporin A (CsA), a hydrophobic peptide, mainly known for its immunosuppressant properties, has shown a broad range of biological activities, including antimalarial action. Since CsA was found to be active on membrane level, it was subjected for investigations involving membrane models. Our former studies on interactions between CsA and differen...
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Oxysterols are products of cholesterol oxidation. They can be formed endogenously (in both enzymatic and non-enzymatic reactions) as well as exogenously (delivered with food). Recent studies clearly demonstrate cytotoxic properties of these compounds, being mainly due to their incorporation into natural lipid bilayers. This process can influence me...
Article
Deoxyribonucleic acid (DNA) has been extensively exploited for the past decade as the matrix material in organic electronics and nonlinear optics. In this work thermal stability of DNA in solid form was thoroughly studied, mainly by optical methods. Solid samples of low molecular mass DNA were subjected to heating according to different protocols a...
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Symmetrical triblock semifluorinated n-alkane, di(perfluorohexyl)hexane of the formula F(CF2)6(CH2)6(CF2)6F (abbreviated F6H6F6), has been synthesised and investigated at the air/water interface. Our results show for the first time that this unusual film-forming material, completely hydrophobic in nature and possessing no polar group, is capable of...
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Outer layer of cellular membrane contains ordered domains enriched in cholesterol and sphingolipids, called 'lipid rafts', which play various biological roles, i.e., are involved in the induction of cell death by apoptosis. Recent studies have shown that these domains may constitute binding sites for selected drugs. For example alkylphosphocholines...
Article
A series of triblock semifluorinated n-alkanes of the general formula: F(CF2)m(CH2)n(CF2)mF, (in short FmHnFm), where m = 10, 12, and n = 6, 8, and 12 have been synthesized and employed for liquid crystalline studies and Langmuir monolayer characterization. Differential scanning calorimetry (DSC) measurements together with texture observation with...
Article
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Cyclosporin A (CsA), a hydrophobic cyclic peptide produced by the fungus Tolypocladium inflatum, is well known for its high efficiency as an immunosuppressor for transplanted organs and anti-inflammatory properties; however, it is also active as antiparasitic (antimalarial) drug. Antimalarial mechanism of CsA action lacks a detailed understanding a...
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Full-text available
Carbon-fibre-reinforced polymer composites with an enhanced yellow fluorescent protein (eYFP) at the interface of fibres and resin were prepared. The protein was immobilized on the carbon fibres by physisorption and by covalent conjugation, respectively. The immobilized eYFP fluoresced on the carbon fibres, in contrast to non-protein fluorophores t...
Article
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Proteins are macromolecules with a great diversity of functions. By combining these biomolecules with polymers, exciting opportunities for new concepts in polymer sciences arise. This highlight exemplifies the aforementioned with current research results of our group. We review our discovery that the proteins horseradish peroxidase and hemoglobin p...
Article
Yellow fluorescent protein (YFP) is used as a mechanoresponsive layer at the fiber-resin interface in glass-fiber-reinforced composites. The protein loses its fluorescence when subjected to mechanical stress. Within the material, it reports interfacial shear debonding and barely visible impact damage by a transition from a fluorescent to a non-fluo...
Article
A fluorescent protein is implemented by Nico Bruns and co-workers on page 2701 as a force-responsive molecular sensor at the fiber-resin interface in glass-fiber reinforced composites. Micrometer-scale damage, such as fiber fractures and fiber matrix debonding, is reported by loss of yellow fluorescence in the damaged areas due to a force-induced u...
Article
The present work explores the properties for binary (LA/DPPC), (cholesterol/DPPC) and also ternary (LA/cholesterol/DPPC) mixed Langmuir monolayers, at the air-water interface, treated as the simplest models of a half of the biological membranes. In ternary monolayers both cholesterol and DPPC were mixed at constant molar ratios that correspond to t...
Article
The present work explores the interactions between chloroplast membrane lipids in model experiments. Chloroplast membrane is characterized by a high proportion of galactolipids: MGDG — monogalactosyldiacylglycerol and DGDG — digalactosyldiacylglycerol. Since cadmium is known to be one of the most toxic heavy metal causing plant stress appearing e.g...
Article
The aim of presented researches was to investigate the physicochemical properties of Langmuir monolayer of galactolipids extracted from two different kinds of plastids: immature embryos and inflorescences. Differences between the physicochemical properties of the plastid membranes may help to explain different physiological processes, such as plant...

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