Katalin Nagy

Katalin Nagy
University of Szeged · Faculty of Dentistry

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150
Publications
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Publications

Publications (150)
Article
Full-text available
Submerging roots for ridge preservation was the earliest partial extraction therapy and has been described since the 1970s. Despite the approximately 47 animal and human studies published since, an updated and contemporary step-by-step protocol has not yet been provided. This technique report describes in detail how to manage submerged roots at sin...
Article
Full-text available
Statement of problem. As socket grafting with commercially available biomaterials has become popular reports of the root submergence technique for ridge preservation have decreased. A systematic review of this partial extraction therapy is lacking. Purpose. The purpose of this systematic review was to review the root submergence technique as well a...
Article
Purpose: To compare the trueness and precision of 3D-printed versus milled monolithic zirconia crowns (MZCs). Methods: A model of a maxilla with a prepared premolar was scanned with an industrial scanner (ATOSQ®, Gom) and an MZC was designed in computer-assisted-design (CAD) software (DentalCad®, Exocad). From that standard tessellation language...
Article
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Purpose: To investigate and compare the production tolerances of six different commercially available implant scan bodies (SBs), with the null hypothesis that there would be no tolerances in the production or significant differences between the different SBs. Materials and methods: Six different implant SBs (IO 6A-B and IO 2B-B, Nobel Biocare; R...
Article
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The potential mechanical impact of different rotary systems used for root canal preparation has been a matter of debate for long. The aim of this study was to explore the incidence of dentinal cracks after root canal instrumentation with various rotary systems, in vitro. One hundred and eighty intact lower central incisors were selected and randoml...
Article
Full-text available
Ten years have passed since Hürzeler and coworkers first introduced the socket-shield technique. Much has developed and evolved with regard to partial extraction therapy, a collective concept of utilizing the patient's own tooth root to preserve the periodontium and peri-implant tissue. The specifications, steps, instrumentation, and procedures dis...
Article
Bevezetés: Kutatásunkban különböző üvegszálas anyagokkal és eltérő direkt technikákkal II. osztályú mezio-okkluzo-disztális (MOD) üregekbe elkészített direkt restaurátumokat hasonlítottunk össze statikus törési ellenállási teszt segítségével.Anyag és módszer: 72 alsó moláris fogat 6 csoportba osztottunk (n = 12). A kontrollként szolgáló csoporton k...
Article
Full-text available
Partial extraction therapies, such as the socket-shield technique, use the patient's tooth tissues and periodontium to preserve the alveolar ridge and limit postextraction resorption. Internal exposure through the overlying peri-implant mucosa has been reported as the most common complication, suggesting that the preparation technique requires modi...
Article
Dental amalgam has been used for more than 150 years due to its beneficial mechanical properties and durability in dentistry. In the past and to date, many questions about amalgam restorations have arisen, especially regarding the mercury content, which has been the subject of global disputes. By presenting the past and present of the 'amalgam issu...
Article
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The socket-shield technique for avoiding postextraction tissue alteration was first described in 2010. The technique was developed for hopeless teeth in anterior esthetic sites but has not yet been described for molar sites. Managing postextractive ridge changes in the posterior region by prevention or regeneration remains a challenge. The socket s...
Article
Introduction: In a clinicopathological retrospective epidemiological study we investigated benign tumors and tumor-like lesions located in the orofacial region, diagnosed at the Universiy of Szeged, Department of Oral Medicine. Method: During a 54-year period (1960-2014), 14 661 biopsies were taken. The included subjects were 7491 patients diagn...
Article
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Oral carcinogenesis often leads to the alteration of the microbiota at the site of the tumor, but data are scarce regarding the microbial communities of oral potentially malignant disorders (OPMDs). Punch biopsies were taken from healthy and non-healthy mucosa of OPMD patients to analyze the microbiome using metagenome sequencing. In healthy oral m...
Article
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The aim of the present review is to provide an up-to-date picture of what we know about the connection between odontogenic foci and non-oral diseases. After a brief historical summary, we give an overview on how the odontogenic focus causes disease in distant areas of the body in general, and then we start the discussion of the particular condition...
Article
In addition to traditional risk factors such as smoking, alcohol consumption and betel nut use, human papillomavirus (HPV) infection also plays a role in the development of head and neck squamous cell carcinomas (HNSCCs). Although among European countries the highest incidence and mortality rates of head and neck cancer types were recorded in Hunga...
Article
Introduction: It is known that the quality of life (QoL) of patients surgically treated for head and neck cancer (HNC) is significantly enhanced by rehabilitation. It is also known that some of these patients will not quit smoking. Aim: To assess if smoking hampers rehabilitation-related QoL enhancement after surgery. Method: Applying the H&N...
Article
Therapeutic stem cell transplantation bears the promise of new directions in organ and tissue replacement, but a number of its difficulties and perils are also well known. Our goal was to develop a method of transplantation by which the transplanted cells remain confined to the transplantation site and induce favorable processes. With the help of m...
Article
Full-text available
Objectives: Because torque teno virus (TTV) has been implicated in tumorigenesis as a cocarcinogen, we studied TTV prevalence in saliva and biopsy samples from head and neck cancer (HNCC) patients, patients with premalignant lesions of oral cancer, and controls. We also wished to determine the TTV genotypes in HNCC patients. Methods: A semineste...
Article
In the literature both smoking and psoriasis are discussed as predisposing factors for chronic periodontal disease. It is also known that smoking leads to deterioration in both psoriasis and periodontal disease. However, up to now, the only study to address the question what effect the co-occurrence of psoriasis and smoking has on the periodontal s...
Article
Background: Head and neck cancers comprise the sixth most common cancer type worldwide. One of the most remarkable malignancies of the head and neck is the cancer of the nasopharynx, with a strong metastatic tendency already in the early stage. Besides the conventional pathways of metastasis formation, the information content of exosomes produced...
Article
The Department of Oral Medicine at the University of Szeged was responsible for the stomato-oncological care of the population of three counties (with a population of 1,7 M at an average) in the period 1960-201 4. The present report summarizes the incidence of oral medicine diseases during this period. The overall number of new out-patients at the...
Article
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Background Oral squamous cell carcinoma (OSCC) is the most common form of oral cancer, in this study, the association between OSCC and oral yeast carriage was investigated. Findings20 patients having OSCC as well as 40 healthy controls were tested for the presence of yeasts in the oral cavity. Fungal burdens were examined by colony forming unit det...
Article
Full-text available
The purpose of this study was to evaluate the reinforcing effect of fibre-reinforced composites (FRC) applied in premolar teeth with different techniques and minimally invasive post space preparation. Fifty extracted and endodontically treated premolar teeth were used. The teeth were divided into five groups (n = 10) depending on the restorative te...
Book
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Preface This book represents the vast esthetic dentistry experience accumulated by leading women dentists from around the world. The idea of a multidisciplinary book on esthetic dentistry arose from my realization that esthetics is a subject that engages all the dental disciplines, and not merely prosthetics or surgery. In many cases, the key to ex...
Article
This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal) This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's ab...
Article
In addition to traditional risk factors such as smoking habits and alcohol consumption, certain microbes also play an important role in the generation of head and neck carcinomas. Infection with high-risk human papillomavirus types is strongly associated with the development of oropharyngeal carcinoma, and Epstein-Barr virus appears to be indispens...
Article
Papillon-Lefévre syndrome (PLS; OMIM 245000) and Haim-Munk syndromes (HMS; OMIM 245010) are phenotypic variants of the same rare disease caused by mutations of the cathepsin C (CTSC) gene, and they exhibit autosomal recessive inheritance. To identify diseases caused by mutations of the CTSC gene in two Hungarian patients and to perform haplotype an...
Article
Acidic pH and high fluoride (F) concentration impair the corrosion resistance of titanium (Ti). Caries-preventive products contain high amounts of F and are applied at low pH. The purpose of this study was to evaluate whether fluoride applied in different forms has different short-, mid-, and long-term effects on the growth of the bacteria Streptoc...
Article
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The growing concern regarding the use of agricultural land for the production of biomass for food/feed or energy is dictating the search for alternative biomass sources. Photosynthetic microorganisms grown on marginal or deserted land present a promising alternative to the cultivation of energy plants and thereby may dampen the 'food or fuel' dispu...
Article
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The rate-limiting nature of the hydrogen concentration prevailing in the anaerobic digester has been recognized, but the associated alterations in the microbial community are unknown. In response to the addition of Enterobacter cloacae cells in laboratory anaerobic digesters, the level of biogas production was augmented. Terminal restriction fragme...
Article
The instrumental measurement of volatile sulphur compounds is a common practice to assess halitosis. One of the most widespread devices for that purpose is OralChroma(TM), a combination of a semiconductor gas sensor and a compact gas chromatograph (GC) system. Several lines of evidence indicate that although the hardware of OralChroma(TM) is fit fo...
Article
Full-text available
Following our previous works of in-vitro tests, the biocompatibility of photopolymer scaffolds was tested against immune responses in vivo. Neither relevant immune reactions nor the rejection of implanted scaffolds was detected, being an essential step for in vivo implantation of excimer laser-prepared scaffolds. The scaffolds were fabricated by UV...
Article
The aim of the study was to evaluate the knowledge of dental trauma management in the southern part of Hungary among parents, teachers, medical doctors and dentists. A cross-sectional study was performed among the mentioned groups, with a structured questionnaire aire--questionnaire. The participants consisted of 275 people, most of them were paren...
Article
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This study demonstrates that appropriate adaptation of the microbial community to protein-rich biomass can lead to sustainable biogas production. The process of acclimation to these unusual mono-substrates was controlled by the protease activity of the microbial community. Meat extract (C/N = 3.32) and kitchen waste (C/N = 12.43) were used as bioga...
Conference Paper
Objectives: Dental pulp stem cells (DPSCs) and periodontal ligament stem cells (PDLSCs) possess extensive regeneration potential. Their therapeutic application demands a scaffold with appropriate properties. HydroMatrix (HydM, Sigma) is an injectable peptide nanofiber hydrogel developed recently for cell culture but it was applied only once for thi...
Article
Full-text available
Papillon-Lefèvre syndrome, a rare disease with autosomal recessive inheritance, is characterized by aggressive periodontitis and palmoplantar hyperkeratosis. Mutations of the cathepsin C gene are responsible for the development of the disease. In this study, we aimed to describe in details the clinical symptoms and to determine the underlying genet...
Article
Full-text available
Papillon–Lefèvre syndrome (PLS; OMIM 245000) is an autosomal recessive condition characterized by palmoplantar hyperkeratosis and periodontitis. In 1997, the gene locus for PLS was mapped to 11q14-21, and in 1999, variants in the cathepsin C gene (CTSC) were identified as causing PLS. To date, a total of 75 different disease-causing mutations have...
Article
Full-text available
Population-based studies have identified smoking as a pathogenetic factor in chronic periodontitis. At the same time, chronic periodontal disease has also been found to occur more often in persons suffering from psoriasis than in controls with no psoriasis. It is known that smoking aggravates both periodontal disease and psoriasis, but so far it ha...
Article
ABO blood group antigen (ABGA) secretion into the saliva and other body fluids is a well-known phenomenon, and there is evidence to suggest a link between secretor status and the appearance of caries. It has been proposed that secretion of these antigens into the saliva might be caries-preventive, however, this proposition is still a matter of deba...
Article
The high incidence of oral carcinoma in Hungary is attributed primarily to tobacco and alcohol use. Recently, however, a series of publications suggested a role for humán papillomavirus in the development of oral carcinoma. For this reason we reviewed the literature regarding the associations of human papillomavirus with oral carcinoma and its preb...
Article
Full-text available
Pathoepigenetics is a new discipline describing how disturbances in epigenetic regulation alter the epigenotype and gene expression pattern of human, animal or plant cells. Such 'epigenetic reprogramming' may play an important role in the initiation and progression of a wide variety of diseases. Infectious diseases also belong to this category: rec...
Article
A röntgenfelvétel alapján megfelelőnek ítélt, az endodonciai ellátás ellenére is perzisztáló apikális elváltozással érintettfogak megmentésére utolsó lehetőségként áll rendelkezésre az endodonciai sebészet. Az endodonciai sebészeti beavatkozáselsődlegesen azokban az esetekben javasolt, amikor nem sebészi terápia kivitelezése nem lehetséges, a hagyo...
Article
Health condition of the gingival tissues contacting the surfaces of fixed prostheses is a result of multiple etiologic factors. The aim of the investigation discussed here was to evaluate the attachment and proliferation rate of cultured human epithelial cells on three commonly used restorative materials under in vitro conditions. Morphological and...
Conference Paper
Objective: Tobacco use is a public health burden worldwide and smoking has a definitively negative effect on the health status of the oral cavity. Dental professionals have proven to be in an exceptional situation to assist cessation. Several publications have described the methods of cessation in the dental office, but only few did examine its a...
Conference Paper
Objective: Priodontal ligament stem cells (PDLSC) and dental follicle stem cells (DFSC) were discovered in 2004 and 2005, respectively. There are several data about their potential for tissue regeneration, but the precise cell biological characterization of the different stages during their osteogenic differentiation is still unclear. To our knowle...
Conference Paper
Objectives: The prevention of peri-implant inflammation by materials with an antibacterial effect can be necessary when the normal healing process is slowed down and the competition between bacteria and cells is not balanced. The purpose of our experiments was to establish an antibacterial coating which is effective against typical colonizers of...
Article
Full-text available
The investigation of the antifungal activities of drugs whose primary activities are not related to their antimicrobial potential is in the current forefront of research. Statin compounds, which are routinely used as cholesterol-lowering drugs, may also exert direct antimicrobial effects. In this study, the in vitro antifungal activities of various...
Article
In the last 2 decades, several studies have questioned the application of the rule of golden proportion in dentistry. The purpose of this study was to test the rule of golden proportion for the maxillary anterior region in a population of young, healthy people with excellent oral hygiene at the Faculty of Dentistry of the University of Szeged. One...
Article
Full-text available
Purpose The retentive strength of two self-adhesive resin cements used for the cementation of fiber posts into root canals filled with methacrylate-based sealer and core material (Resilon) was evaluated using the thin-slices push-out test on human molars. Materials and methods RelyX Fiber Posts #3 (3M ESPE, Seefeld, Germany) were luted with RelyX...
Article
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Objectives: The role was studied of multiple single nucleotide polymorphisms in tooth agenesis in the Hungarian population using a complex approach. Methods: Eight SNPs, PAX9 -912 C/T, PAX9 -1031 A/G, MSX1 3755 A/G, FGFR1 T/C rs881301, IRF6 T/C rs764093, AXIN2-8150 A/G, AXIN2-8434 A/G and AXIN2-30224 C/T, were studied in 192 hypodontia and 17 ol...
Article
Full-text available
Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis are human fungal pathogens with clinical importance. The recently reclassified three closely related species have significant variation in virulence, clinical prevalence and susceptibility characteristics to different antifungal compounds. The aim of this study was t...
Article
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The aims of this double-blind, controlled, crossover study were to assess the influence of food preservatives on in situ dental biofilm growth and vitality, and to evaluate their influence on the ability of dental biofilm to demineralize underlying enamel over a period of 14 days. Twenty volunteers wore appliances with six specimens each of bovine...
Data
MicroRNAs (miRNAs) are posttranscriptional regulators fine-tuning the level of most messenger RNAs (mRNAs) and proteins in mammalian cells. Their expression is dysregulated in neoplastic cells and upregulated or downregulated miRNAs play an important role in tumorigenesis. Changes in the miRNA transcriptome appear to be suitable markers for the dif...
Article
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The pancreas and salivary glands have similar anatomical structures and physiological functions producing bicarbonate-rich fluid containing digestive enzymes and other components to be delivered into the gut. Despite these similarities, the two organs are also different in numerous respects, especially regarding the inflammatory diseases affecting...
Article
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Purpose: The aim of the study was to evaluate patient-reported quality of life effects of post-treatment intraoral and extraoral rehabilitation in head and neck cancer by repeated measures. Methods: Fifty-nine patients were involved. Basic socio-demographic, oncological and epidemiological data were gathered, and the type of rehabilitation was r...
Article
Full-text available
The purpose of this in vitro study was to compare the antimicrobial efficacy of five different irrigating solutions against complex polymicrobial bacterial biofilms harvested from root canals to model actual endodontic irrigation as closely as possible, and to test the efficacy of these irrigants in these conditions. Two multi-species in vitro biof...
Conference Paper
Objective: The aim of this double-blind, controlled, cross-over study was to evaluate the effect of a zinc containing glass-ionomer cement on the in situ biofilm formation and to compare it to enamel and a glass ionomer cement without zinc ions Method: Fifteen volunteers wore individual acrylic appliances in which six sterilised discs were insert...