Kasper Frederik van der Zwaan

Leiden University Medical Centre | LUMC · Department of Neurology

Background: In biomedicine, machine learning (ML) has proven beneficial for the prognosis and diagnosis of different diseases, including cancer and neurodegenerative disorders. For rare diseases, however, the requirement for large datasets often prevents this approach. Huntington’s disease (HD) is a rare neurodegenerative disorder caused by a CAG r...

Background Machine learning (ML) enables the discovery of patterns and relationships within large-scale datasets and can turn information into valuable actionable knowledge. In biomedicine, ML has proven beneficial for the prognosis and diagnosis of different diseases, including cancer and neurodegenerative disorders. Enroll-HD has become a large,...

Huntington's disease (HD) is an inherited neurodegenerative disease. People at risk for HD can choose to get predictive testing years before the clinical onset. HD is characterized by motor, cognitive and psychiatric symptoms and has a mean age at onset between 30 and 50 years, an age at which people are usually still working. This systematic revie...

Objective To assess the efficacy of triheptanoin, a medium chain triglyceride with an odd number of carbons that targets the Krebs cycle, on key brain imaging and clinical measures in HD. Background We previously showed that energy deficit in HD is associated with increased substrate requirements for the Krebs cycle. Using brain MR spectroscopy, w...

Background Nowadays, chronic work-related stress, also known as burnout, seems to be an ever growing epidemic. Burnout is defined in terms of depersonalization, feelings of incompetence and occupational exhaustion. This syndrome is often reported by Huntington’s Disease (HD) patients, and although we know that 65% of HD patients report work-related...

Background: Huntington's disease (HD) is an inherited neurodegenerative disorder that is characterized by motor, cognitive, and psychiatric symptoms. Although 65%of HD expanded gene carriers report changes in employment as the first functional loss, little is known about the predictors leading to changes of working capacity. Given the impact on qu...

It is remarkable that studies focusing on the prevalence and the burden of pain in patients with Huntington disease (HD) are scarce. This may lead to inadequate recognition of pain and hence lack of treatment, eventually affecting the quality of life. The aim of this review is to investigate the prevalence of pain and its burden in HD by performing...

Objective: In Huntington's disease (HD), a hereditary neurodegenerative disorder, cognitive impairment in early disease stages mainly involves executive dysfunction. However, visual cognitive deficits have additionally been reported and are of clinical relevance given their influence on daily life and overall cognitive performance. This study aime...

Objective Investigating driving competence with a simulator provides a controlled setting and has a high reproducibility. In addition, there is less risk of physical harm compared to on-road tests. A disadvantage of using simulators is the occurrence of simulator sickness, which is comparable to symptoms of motion sickness. The aim of this study wa...