Kartik Janardan Salwe

Mahatma Gandhi Medical College and Research Institute | MGMCRI · Department of Pharmacology

Due to the widespread use of antimicrobial agents, many Microorganisms have developed drug resistance to many available antimicrobials today. Essential oils from different plants are being explored for their ability to treat various human diseases, including infectious diseases. Earlier, we have found that the essential oil from the leaves of Ocimu...

Background: Drug utilization pattern helps to understand the current trend of the drug used in various conditions by healthcare providers. It also helps in rationalizing budget expenditure on the medication cost. The Chief Minister Arogya Arunachal Yojana/Pradhan Mantri Jan Arogya Yojana (CMAAY/PMJAY) is a cashless scheme run by Govt of Arunachal P...

Objective: This study focused on the prescriptions audit of indoor patients treated under Pradhan Mantri Jan Arogya Yojana (PMJAY) and Chief Minister Arogya Arunachal Yojana (CMAAY) insurance schemes as per the World Health Organization (WHO) prescribing indicators. Materials and Methods: Retrospective cross-sectional study was conducted and the pr...

Objective: To evaluate the Hypolipidemic& Antioxidant effect of Garcinia gummi-gutta barks on Atherogenic Diet-Induced Hyperlipidemic Rats. Materials and methods: Bark extract was prepared using a Soxhlet apparatus. 30 Wistar albino rats of either sex was divided into 5 groups (n=6). Atherogenic diet (AD) was administered to all the rats except gro...

Extraction is the first most important step for preparing herbal drug formulations. It serves as an alternate method to identify the lead compound by isolating the active compounds from the crude drug using various extraction techniques by adding suitable solvent. Selection of solvent is the most important step as the success rate depends on it. Th...

Objective: The objective of the study was to evaluate the hypolipidemic activity of fruit rind extracts of Garcinia gummi-gutta in diet-induced hyperlipidemic rats. Methods: Hydroalcoholic extract of fruit rinds of G. gummi-gutta was prepared using Soxhlet apparatus. 30 Wistar albino rats were divided into five groups (n=6). Except for Group 1, all...

Objective: The objective of the study was to investigate the analgesic activity of hydroalcoholic extract of Murraya koenigii and Coriandrum sativum leaves and compared it with standard drug in an animal model.Methods: Hydroalcoholic extracts of M. koenigii and C. sativum leaves were obtained using Soxhlet apparatus. The central analgesic property...

Background: Many pharmacological substances are known to cause hepatic injuries and paracetamol is one out of them. This study was carried out to investigate the hepatoprotective and antioxidant activity of hydroalcoholic extract of Murraya koenigii leaves in paracetamol induced hepatotoxicity in Rats.Methods: Experimental animal used in this study...

Background Atherosclerosis is one of the major causes of morbidity and mortality in the world. Antioxidants play a major role in prophylaxis and prevention of progression and complications of atherosclerosis. Objective In this study, we are evaluating the antiatherosclerotic effect of two antioxidants such as astaxanthin and lycopene. Materials a...

Objective: This study was done to evaluate the current prescribing and usage pattern of antimicrobial agents (AMAs) in the neonatal intensive care unit (NICU). Methods: A prospective, hospital-based, cross-sectional study (prescription audit) was carried out between May and August 2012 in the NICU of a Teaching Hospital. Data were collected by revi...

Introduction: The proportion of elderly population has been constantly increasing over last few years. Polypharmacy is unavoidable in the elderly as they often suffer from multiple comorbidities. Potential drug-drug interaction due to polypharmacy and potential inappropriate medication among the elderly must be carefully assessed. Aim: To find out...

We investigated anti-diabetic, hypolipedimic and antioxidant activity of hydroalcoholic extract from leaves and fruit peel of Punica granatum. Streptozotocin induced diabetic Wister rats were used in this study consisting of seven groups of six animals each. Groups (1) normal control, (2) diabetic control, (3) leaves extract 100 mg/kg b.w. of P. gr...

Introduction: Several studies have reported that commonly used antiepileptic drugs like phenytoin, and carbamazepine increase serum High Density Lipoproteins Cholesterol (HDL-C) levels, while some others documented no such effect. Further, some researchers also observed that valproic acid and other newer antiepileptic drugs like lamotrigine and lev...

Objective: We investigated antinociceptive, acute and chronic anti-inflammatory activity of hydroalcoholic extracts of leaves and fruit peel of P. granatum and compared it with standard drug Ibuprofen. Materials and Methods: Hydroalcoholic extracts of leaves and fruit peel of P. granatum was prepared using Soxhlet apparatus. Swiss albino mice weigh...

The concept of "pre-emptive analgesia" is becoming popular and the use of clonidine along with regional techniques is one of the important milestones in post-operative pain management. The aim of our study is to assess the effects of oral clonidine premedication on the duration of analgesia by bupivacaine subarachnoid block. Its a randomized contro...

Evaluation of the drug utilisation has become a onetime potential tool to assess appropriateness of drug therapy. General Practitioners are more easily approachable doctors by the society. So this study planned to assess quantitative type of prescription pattern by general practitioners in identifying commonly utilized drugs by the rural and sub ur...

Evaluation of the drug utilisation has become a onetime potential tool to assess appropriateness of drug therapy. General Practitioners are more easily approachable doctors by the society. So this study planned to assess quantitative type of prescription pattern by general practitioners in identifying commonly utilized drugs by the rural and sub ur...

The objective of this study is to evaluate the anti-scorpion venom (ASV) property of Andrographis paniculata in comparison with anti-redscorpion venom serum and this study aimed to determine its combined effect with anti-redscorpion venom serum. Ethanolic extract of the plant AP was obtained using soxhlet apparatus. Swiss albino mice weighing 20-30...

AR. HDL/LDL ratio as a risk factor in type 2 diabetes mellitus. Adv Lab Med Int. 2012; 2(1): 9 -18. ABSTRACT Diabetes mellitus (DM) is characterized by hyperglycemia, due to deficiency or diminished effectiveness of insulin. Patients with Type 2 Diabetes mellitus are at an increased risk for cardiovascular morbidity and mortality. The present study...

This study was carried out to find out the antidiabetic effect of Ocimum Sanctum (O. sanctum) in type 2 diabetes patients as so many studies have showed its antidiabetic effect experimentally but very few studies are performed to investigate the efficacy in humans. The study was performed in two different groups for a period of 90 days. One group r...

The study was undertaken to investigate the neutralizing effect of the alcoholic extract of Andrographis paniculata against the Indian Cobra (Naja naja) and Russell’s viper venom. The lethal dose 99 (LD99) value of snake venom was calculated and then the venom-neutralizing ability of the plant extract at doses of 1 and 2 g/kg was determined using i...

The effect of Gomutra ark (GoA) on experimental alloxan-induced diabetes in rats was studied. For this purpose, Wistar albino rats of either sex weighing 200-250 g were used. The biochemical parameters like blood sugar, vitamin C, and malondialdehyde release were measured. The safety profile of GoA was evaluated using acute and chronic toxicity stu...

Background: The study was undertaken to investigate the neutralizing effect of the alcoholic extract of Andrographis paniculata against the Russell's viper venom. Materials and Methods: The lethal dose 99 (LD 99 ) value of snake venom was calculated and then the venom-neutralizing ability of the plant extract at doses of 1 and 2 g/kg was determined...

Introduction In Sushrita Samhita Gomutra (Cow urine) has been described as the most effective substance / secretion of animal origin with innumerable therapeutic values. In India, drinking of cow urine has been practiced for thousands of years. All the five products such as urine, milk, ghee, curd and dung obtained from cow possess medicinal proper...

Background: The ethanolic extract of Delonix elata was studied for its effect on the acute inflammation and comparison of its ulcerogenic potential with ibuprofen. Materials and Methods: The ethanolic extract of the leaves of D. elata was obtained using the Soxhlet apparatus. Swiss albino mice weighing 20–30 g and Wistar albino rats weighing 120–13...

To investigate the anti-cobra venom effect of alcoholic extract of Andrographis paniculata. After calculating the LD(99) of snake venom, the venom-neutralizing ability of plant extract at the dose 1 g/kg and 2 g/kg was determined using in vitro and in vivo methods. The alleviation in the mean survival time of the animals were used to infer the anti...

Antinociceptive property of ethanolic extract of plant Delonix Elata was screened by acetic acid induced writhing in mice while the anti-inflammatory property against chronic inflammation was studied using cotton pellet granuloma in rats. The gastric irritant action was tested by administering the drug orally and screening the gastric mucosa macros...

Red scorpion (Mesobuthus tamulus) is the most lethal among all poisonous species of scorpions. Envenoming by Mesobuthus tamulus is quite common along the western coast of India, without any established therapy. Andrographis paniculata is one of the plants that has long been used in traditional herbal medicine for the treatment of poisoning by anima...

Objective: Red scorpion (Mesobuthus tamulus) is the most lethal among all poisonous species of scorpion. Envenoming by Mesobuthus tamulus is quite common along the western coast of India, without any established therapy. Andrographis paniculata is one of the plants which have long been used in traditional herbal medicine for the treatment of poison...

To study the effect of calcium channel blockers (CCBs) cinnarizine and nifedipine on maximal electroshock (MES)-induced and pentylenetetrazole (PTZ)-induced convulsions and also their effect in combination with conventional antiepileptic drugs (CAED). For this study, Swiss albino mice were used. Effects of cinnarizine (30 mg/kg), nifedipine (5 mg/k...

Drug isomerism has opened a new era of research in pharmacology and it helps in understanding the mechanisms behind adverse effects and drug actions. Knowledge of isomerism can help in introducing safer and effective drug alternatives of the new as well as existing drugs. Many existing drugs have gone chiral switch i.e. switching from racemate mixt...

This study was carried out to find out the antidiabetic effect of Ocimum Sanctum (O. sanctum) in type 2 diabetes patients as so many studies have showed its antidiabetic effect experimentally but very few studies are performed to investigate the efficacy in humans. The study was performed in two different groups for a period of 90 days. One group r...