Karthik Tappa

Karthik Tappa
Washington University in St. Louis | WUSTL , Wash U · Department of Radiology

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28
Publications
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1,070
Citations

Publications

Publications (28)
Article
Full-text available
Previous studies have established halloysite nanotubes (HNTs) as viable nanocontainers capable of sustained release of a variety of antibiotics, corrosion agents, chemotherapeutics and growth factors either from their lumen or in outer surface coatings. Accordingly, halloysite nanotubes (HNTs) hold great promise as drug delivery carriers in the fie...
Conference Paper
Full-text available
Calcium Phosphate Cements (CPCs) with osteoconductive properties are limited in their applications because of their poor mechanical properties. This study investigated the additive effect of dexamethasone-doped halloysite nanotubes (HNTs) on the mechanical properties of CPCs. HNTs are nanosized tubes with aluminosilicate composition. Physicochemica...
Conference Paper
Full-text available
Post-operative complications due to infections are the most common problems that occur following dental and orthopedic implant surgeries and bone repair procedures. Preventing post-surgical infections is therefore a critical need that current Poly(methyl methacrylate) (PMMA) bone cement fail to address. Calcium phosphate cements (CPCs) are unique i...
Article
Full-text available
Three-dimensional (3D) printing and additive manufacturing holds potential for highly personalized medicine, and its introduction into clinical medicine will have many implications for patient care. This paper demonstrates the first application of 3D printing as a method for the potential sustained delivery of antibiotic and chemotherapeutic drugs...
Article
Full-text available
The use of nanomaterials for improving drug delivery methods has been shown to be advantageous technically and viable economically. This study employed the use of halloysite nanotubes (HNTs) as nanocontainers, as well as enhancers of structural integrity in electrospun poly-e-caprolactone (PCL) scaffolds. HNTs were loaded with amoxicillin, Brillian...
Article
Full-text available
Rationale and Objective: 3D printing allows innovative solutions for personal protective equipment, particularly in times of crisis. Our goal was to generate an N95-alternative 3D printed respirator that passed the Occupational Safety and Health Administration (OSHA)-certified quantitative fit testing during the COVID-19 pandemic. Materials and Me...
Article
Full-text available
3D printing is an additive manufacturing technology, which permits innovative approaches for incorporating antibiotics into 3D printed constructs. Antibiotic-incorporating applications in medicine have included medical implants, prostheses, along with procedural and surgical instruments. 3D-printed antibiotic-impregnated devices offer the advantage...
Article
Full-text available
Additive manufacturing has great potential for personalized medicine in osseous fixation surgery, including maxillofacial and orthopedic applications. The purpose of this study was to demonstrate 3D printing methods for the fabrication of patient-specific fixation implants that allow for localized drug delivery. 3D printing was used to fabricate ge...
Article
Full-text available
Background: Selected medical implants and other 3D printed constructs could potentially benefit by the ability to incorporate contrast agents into their structure. The purpose of the present study is to create 3D printed surgical meshes impregnated with iodinated, gadolinium, and barium contrast agents and characterize their computed tomography (CT...
Article
Full-text available
Rationale and Objectives: Additive manufacturing may be used as a form of personalized medicine in interventional radiology by allowing for the creation of customized bioactive constructs such as catheters that can act as a form of localized drug delivery. The purpose of the present in vitro study was to use three-dimensional (3D) printing to const...
Article
Full-text available
Three-dimensional printing has significant potential as a fabrication method in creating scaffolds for tissue engineering. The applications of 3D printing in the field of regenerative medicine and tissue engineering are limited by the variety of biomaterials that can be used in this technology. Many researchers have developed novel biomaterials and...
Article
Full-text available
Three-dimensional (3D) printing holds tremendous potential as a tool for patient-specific devices. This proof-of- concept study demonstrated the feasibility, antimicrobial properties, and computed tomography (CT) imaging characteristics of iodine/polyvinyl alcohol (PVA) 3D meshes and stents. Under scanning electron microscopy, cross-linked PVA disp...
Article
Full-text available
Nanogels are hydrogels formed by connecting nanoscopic micelles dispersed in an aqueous medium, which give an opportunity for incorporating hydrophilic payloads to the exterior of the micellar networks and hydrophobic payloads in the core of the micelles. Biomedical and pharmaceutical applications of nanogels have been explored for tissue regenerat...
Article
Full-text available
The success of an implant depends on the type of biomaterial used for its fabrication. An ideal implant material should be biocompatible, inert, mechanically durable, and easily moldable. The ability to build patient specific implants incorporated with bioactive drugs, cells, and proteins has made 3D printing technology revolutionary in medical and...
Article
Full-text available
Osteomyelitis is typically a bacterial infection (usually from Staphylococcus) or, more rarely, a fungal infection of the bone. It can occur in any bone in the body, but it most often affects the long bones (leg and arm), vertebral (spine), and bones of the foot. Microbial success in osteomyelitis is due to their ability to form biofilms which inhi...
Article
Full-text available
Nasoalveolar molding of the cleft lip, nose, and alveolar palate has been a successful strategy for the restoration of oronasal function and appearance, but it has some drawbacks. The temporary implant that is inserted before surgical reconstruction is a large appliance requiring numerous adjustments, it can irritate delicate soft tissues, and inte...
Article
Full-text available
3D printing has the potential to deliver personalized implants and devices for obstetric and gynecologic applications. The aim of this study is to engineer customizable and biodegradable 3D printed implant materials that can elute estrogen and/or progesterone. All 3D constructs were printed using polycaprolactone (PCL) biodegradable polymer laden w...
Article
Full-text available
Halloysite nanotubes (HNTs) were investigated as a platform for tunable nanoparticle composition and enhanced opacity in poly(methyl methacrylate) (PMMA) bone cement. Hal-loysite has been widely used to increase the mechanical properties of various polymer matrices, in stark contrast to other fillers such as barium sulfate that provide opacity but...
Chapter
Full-text available
Post-operative complications due to infections are the most common problems that occur following dental and orthopedic implant surgeries and bone repair procedures. Blood samples randomly collected from postmortem donors showed a 26% bacterial contamination rate. Preventing post-surgical infections is therefore a critical need that current polymeth...
Article
Full-text available
Background: 3D printing of surgical meshes represents potential for advancement in hernia repair. The purpose of this proof of concept study was to develop 3D printed surgical meshes with the ability to elute bioactive compounds in an in vitro model. Methods: Using 3D printing, gentamicin coated polylactic acid (PLA) pellets were used to fabricate...
Article
Full-text available
A major factor contributing to the failure of orthopedic and orthodontic implants is post-surgical infection. Coating metallic implant surfaces with anti-microbial agents has shown promise but does not always prevent the formation of bacterial biofilms. Furthermore, breakdown of these coatings within the human body can cause release of the anti-mic...
Conference Paper
Calcium phosphate cements (CPCs) with osteoconductive properties are limited in their applications because of their poor mechanical properties. This study investigated the additive effect of Dexamethasone-doped Halloysite Nanotubes (HNTs on the mechanical properties of CPCs. HNTs are nanosized tubes with alumino-silicate composition. Physico-chemic...
Article
Full-text available
Stability studies were performed on various formulations of aceclofenac tablets prepared by wet granulation method and solid dispersions using Eudragit RS 100 as a rate controlling polymer. The in vitro drug release was found to be 89% for aceclofenac from solid dispersion formulation (B7) compared with 83% from wet granulation formulation (B1). Se...

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