Karsten Seidl

Karsten Seidl
University of Duisburg-Essen / Fraunhofer IMS · Micro- and Nanosystems

Professor

About

62
Publications
7,277
Reads
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964
Citations
Citations since 2016
27 Research Items
397 Citations
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
Additional affiliations
June 2006 - July 2011
University of Freiburg

Publications

Publications (62)
Conference Paper
Full-text available
Zur Detektion und rechtzeitigen Behandlung von Lungenerkrankungen ist die Messung von Lungenfunktionspara-metern von großer Bedeutung. Die kontaktlose Atemvoluminam-essung kann hierfür zukünftig eine mobile Alternative zur Bo-dyplethysmographie darstellen. In dieser Arbeit vergleichen wir daher drei Methoden zur Berechnung von Atemvolumina über ein...
Article
Full-text available
Exercise therapy is able to reduce symptom burden in advanced cancer patients (ACP). However, ACP daily form differs between days e.g. tumor and therapy induced. We included five ACP to classify individual exercise capacity due to cardiovascular parameters. Features are extracted from the electrocardiogram and then processed with a neural network a...
Article
Full-text available
To overcome limitations of currently used blood pressure measurement devices in accuracy, continuity and comfort, we propose an approach for blood pressure estimation from electrocardiogram (ECG) signals only. Thereby, statistical signal features are extracted from the ECG which, eventually, serve as input to a random forest regression. The method...
Conference Paper
Full-text available
In the context of the development of an implantable embedded system interfacing brain activity and enabling paralyzed patients to interact with devices that are usable on an everyday basis, we designed a real-time-suitable, low-power hardware architecture with an artifact-suppressing analog front-end, connected to a neural signal processing pipelin...
Article
Full-text available
With recent developments, terahertz (THz) technology has attracted great interest in many different fields of research and application. In particular, biosensors that detect a thin film of captured pathogens are in high demand for rapid diagnosis. Based on the interaction between analytes under test and electromagnetic (EM) field, THz resonators ar...
Article
Full-text available
Fast fluorescence lifetime (FL) determination is a major factor for studying dynamic processes. To achieve a required precision and accuracy a certain number of photon counts must be detected. FL methods based on single-photon counting have strongly limited count rates because of the detector’s pile-up issue and are suffering from long measurement...
Article
Full-text available
In recent years terahertz (THz) technology has attracted great interest in biosensing applications. Due to the interaction between analyte and electromagnetic (EM) field, a THz resonator is sensitive to changes in the refractive index of the analyte and can be used as a thin-film sensor for rapid pathogen diagnosis. To achieve high sensitivity and...
Article
The aim of this research is to investigate low-power circuit concepts for the hardware implementation of an adaptively controlled stimulator for future retinal implants. For this specific application purpose, the circuit complexity must be low, while at the same time the functionality is extended. This paper presents the implementation of an analog...
Article
Full-text available
Flexible Multi Electrode Arrays (MEAs) for neural interfacing reduce the mechanical mismatch between the soft brain tissue and the electrode arrays allowing accurate signal recordings and neural stimulation while reducing inflammatory responses. Many standard manufacturing processes of MEAs are designed for planar structures and the production of t...
Article
This study reports on the development of vertical, partially encapsulated nanoelectrodes for electrically contacting the interior of electrogenic cells with microelectronics. Intracellular electrical stimulation and recording with single cell resolution enables new insights into the electrophysiology of cells embedded in a complex multicellular net...
Article
Point-of-care (POC) devices are essential for rapid testing of samples for early diagnosis of diseases. The accuracy and the sensitivity of the POC device depend mainly on the biosensors. The currently used POC devices require specialized operating personnel, long sample preparation time and high equipment costs. We aim to explain a bio-sensing con...
Article
Full-text available
A piezoelectric FPW-sensor has been developed for a point of care device in this work. The Bio- MEMS FPW-sensor consists of an electrode configuration termed as an interdigital transducer (IDT) placed on a membrane. An input IDT excites and an output IDT detects the propagating acoustic waves through a PZT layer. Design optimizations and fabricatio...
Article
Full-text available
The application of artificial intelligence (AI) in the areas of health, care and social participation offers great opportunities but also involves great challenges. Extensive regulatory, ethical and data-security related requirements exist for data recording, storage and processing of respective personalized and patient-related data. “Artificial In...
Conference Paper
t a novel miniaturized multi sensor implant for monitoring hemodynamic parameters in cardiovascular regions. Pressure measurements are performed with a highly accurate capacitive pressure sensor. An additional acceleration and temperature sensor allows compensating the impact of patient's inclination and temperature variations on the pressure measu...
Article
Abstract In this article, we evaluated the electrophysiological performance of a novel, high-complexity silicon probe array. This brain-implantable probe implements a dynamically reconfigurable voltage-recording device, coordinating large numbers of electronically switchable recording sites, referred to as electronic depth control (EDC). Our result...
Article
Full-text available
Abstract Intracortical microprobes allow the precise monitoring of electrical and chemical signaling and are widely used in neuroscience. Microelectromechanical system (MEMS) technologies have greatly enhanced the integration of multifunctional probes by facilitating the combination of multiple recording electrodes and drug delivery channels in a s...
Conference Paper
This paper reports on the design, fabrication and characterization of an innovative silicon-based neural probe with optical functionality. This so-called optrode is intended as an ultracompact tool for optogenetic applications in neuroscientific research. Beside platinum microe-lectrodes for electrical recording applications, bare laser diode (LD)...
Article
This paper reports on the characterization and intracortical recording performance of high-density complementary-metal-oxide-semiconductor (CMOS)-based silicon microprobe arrays. They comprise multiplexing units integrated on the probe shafts being part of the signal transmission path. Their electrical characterization reveals a negligible contribu...
Conference Paper
This paper reports on the design and fabrication of a neural probe for simultaneous recording of neural activity and localized drug delivery. In comparison to common microfluidic probes, additional electrodes facing the fluidic channel are integrated in the polyimide-based membrane covering the microchannels. The novel fabrication process applies t...
Article
Recently developed CMOS-based microprobes contain hundreds of electrodes on a single shaft with inter-electrode distances as small as 30 μm. So far, neuroscientists needed to select electrodes manually from hundreds of electrodes. Here we present an electronic depth control algorithm that allows to select electrodes automatically, hereby allowing t...
Article
This paper reports on a novel high-density CMOS-based silicon microprobe array for intracortical recording applications. In contrast to existing systems, CMOS multiplexing units are integrated directly on the slender, needle-like probe shafts. Single-shaft probes and four-shaft combs have been realized with 188 and 752 electrodes, respectively, wit...
Article
Full-text available
A novel silicon-based microelectrode array with one- and two-dimensional variants was developed in the framework of the EU-funded research project NeuroProbes. The electrode array comprises complementary-metal-oxide-semiconductor based integrated circuitry to implement the concept of electronic depth control which is used to select up to 32 recordi...
Article
Full-text available
This paper reports on silicon-based microprobes, 8 mm long and 250 µm × 250 µm cross-section, comprising four recessed biosensor microelectrodes (50 µm × 150 µm) per probe shank coated with an enzymatic layer for the selective detection of choline at multiple sites in brain tissue. Integrated in the same probe shank are up to two microfluidic chann...
Article
Full-text available
This paper reports on the design, fabrication, assembly and characterization of a three-dimensional silicon-based floating microprobe array for localized drug delivery to be applied in neuroscience research. The microprobe array is composed of a silicon platform into which up to four silicon probe combs with needle-like probe shafts can be inserted...
Article
This paper presents multi-electrode arrays for in vivo neural recording applications incorporating the principle of electronic depth control (EDC), i.e., the electronic selection of recording sites along slender probe shafts independently for multiple channels. Two-dimensional (2D) arrays were realized using a commercial 0.5- μm complementary-metal...
Article
Multi-electrode arrays for in vivo neural recording are presented incorporating the principle of electronic depth control, i.e. an electronic selection of electrode locations along the probe shaft independently for multiple channels. Two-dimensional (2D) arrays are realized using a commercial CMOS process for the electronic circuits combined with p...
Conference Paper
Sensor systems based on piezoresistors have found a wide variety of applications whenever mechanical stress due to external mechanical input is to be determined. Such sensor elements are fabricated using commercial CMOS processes enabling the realization of highly integrated systems with electronics for signal amplification and multiplexing. They c...
Conference Paper
Full-text available
Multi-electrode arrays contain an increasing number of electrodes. The manual selection of good quality signals among hundreds of electrodes becomes impracticable for experimental neuroscientists. This increases the need for an automated selection of electrodes containing good quality signals. To motivate the automated selection, three experimenter...
Article
Full-text available
This paper reports on the design, fabrication and characterization of silicon-based microprobes for simultaneous neural recording and drug delivery. The fabrication technology is based on two-stage deep reactive ion etching combined with silicon wafer bonding and grinding to realize channel structures integrated in needle-like probe shafts. Liquids...
Article
Extracellular recordings from the brain are the basis for the fundamental understanding of the complex interaction of electrical signals in neural information transfer. Going beyond wire electrodes and bundles of electrode wires such as tetrodes, multielectrode arrays based on silicon technologies are receiving growing attention, since they enable...
Article
This paper presents the NeuroSelect software for managing the electronic depth control of cerebral CMOS-based microprobes for extracellular in vivo recordings. These microprobes contain up to 500 electronically switchable electrodes which can be appropriately selected with regard to specific neuron locations in the course of a recording experiment....
Conference Paper
This paper reports on a novel CMOS-based silicon microprobe for high-density intracortical stress mapping. In contrast to existing systems, square p-type field effect transistors (FET) with four source/drain contacts (piezo-FETs) are integrated on the slender, needle-like probe shaft. In total, 345 stress sensors are arranged in five columns (x/y-p...
Article
Full-text available
This work presents a new fabrication technology for silicon-based neural probe devices and their assembly into two-dimensional (2D) as well as three-dimensional (3D) microprobe arrays for neural recording. The fabrication is based on robust double-sided deep reactive ion etching of standard silicon wafers and allows full 3D control of the probe geo...
Conference Paper
This paper reports on a novel CMOS-based high-density silicon microprobe array for intracortical recording applications. In contrast to existing systems, CMOS multiplexing units are integrated on the slender, needle-like probe shaft 160 mum in width. In the present implementation an unequaled number of 188 electrodes (diameter 20 mum, pitch 40 mum)...
Chapter
Full-text available
This paper reports on novel robust microprobe systems for simultaneous neural recording and drug delivery. The systems comprise needle-shaped silicon probes with microfluidic channels and recording electrodes integrated into a robust polyetheretherketone (PEEK) packaging. The microprobes are fabricated using deep reactive ion etching (DRIE) of sili...
Article
We have developed electronic depth control software for managing intracortical microprobes designed by the Neuroprobes consortium for in vivo extracellular recording of neurons. The microprobe arrays contain a large number (up to 8208) of electronically switchable electrodes to enable the precise positioning of each electrode contacts with respect...
Article
Full-text available
This paper summarizes recent advances of the NeuroProbes project, a 4-year Integrated Project funded by the European Commission under the Information Society Technologies (IST) topic of the 6 th Framework Program. NeuroProbes aims at the development of multifunctional probe arrays comprising a 3-dimensional (3D) ar- rangement of recording and stimu...
Article
Full-text available
This paper reports on a novel type of silicon-based microprobes with linear, two and three dimensional (3D) distribution of their recording sites. The microprobes comprise either single shafts, combs with multiple shafts or 3D arrays combining two combs with 9, 36 or 72 recording sites, respectively. The electrical interconnection of the probes is...
Article
As previously shown, Leydig cells in culture dramatically up-regulate the expression of the neural cell adhesion molecule (NCAM) gene and express alternatively spliced forms. Because the family of NCAM adhesion molecules is known to be involved in cell migration and differentiation, we examined the potential involvement of NCAMs in Leydig cell diff...
Article
Full-text available
We have previously described a 30 kDa basic fibroblast growth factor (bFGF)-like protein in rodent testicular homogenates and have shown that pachytene spermatocytes are the sites of predominant immunoreactivity for this bFGF-like protein (Mayerhofer, A., Russell, L.D., Grothe, C., Rudolf, M. and Gratzl, M. (1991) Endocrinology 129, 921–924). We ha...
Article
Full-text available
The neural cell adhesion molecule (NCAM) polypeptides are expressed by numerous tissues during embryonic development, where they are involved in cell-cell interactions. In the adult, NCAM expression is confined to a few cell types, including neurons and peptide-hormone-producing cells. Here we demonstrate that the Leydig cells of the adult rat, mou...
Article
We have previously described a 30 kDa basic fibroblast growth factor (bFGF)-like protein in rodent testicular homogenates and have shown that pachytene spermatocytes are the sites of predominant immunoreactivity for this bFGF-like protein (Mayerhofer, A., Russell, L.D., Grothe, C., Rudolf, M. and Gratzl, M. (1991) Endocrinology 129, 921-924). We ha...
Article
Full-text available
For decades, recordings from the brain have been performed to investigate the activity of individual neurons. However, the complex interactions between electrical and chemical signals with respect to short and long term changes of morphology and information transfer of large cellular networks are still poorly understood. In an ef- fort to provide n...
Conference Paper
We present an optical encoder to report the insertion depth of surgical needles with sub-millimeter resolution. The work pertains to robot-assisted percutaneous needle placement applications. The motivating application is prostate brachytherapy, a procedure to permanently implant radioactive seeds into the prostate to eradicate cancer. Independentl...

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