Karsten Ulrich Kortüm

Karsten Ulrich Kortüm
Ulm University | UULM · Clinic of Ophtalmology

Priv.-Doz. Dr. med.

About

77
Publications
9,627
Reads
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801
Citations
Citations since 2016
65 Research Items
792 Citations
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2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
Additional affiliations
October 2016 - December 2019
Moorfields Eye Hospital NHS Foundation Trust
Position
  • Research Associate
January 2011 - May 2021
Ludwig-Maximilians-University of Munich
Position
  • Medical Doctor
Education
October 2003 - April 2010
University of Wuerzburg
Field of study
  • Humanmedizin

Publications

Publications (77)
Article
Full-text available
Background: An increasing number of patients suffering from diabetes require regular ophthalmological check-ups to diagnose and/or treat potential diabetic retinal disease. Some countries have already implemented systematic fundus assessments including artificial intelligence-based programs in order to detect sight-threatening retinopathy. The aim...
Preprint
Purpose To determine real life quantitative changes in OCT biomarkers in a large set of treatment naive patients undergoing anti-VEGF therapy. For this purpose, we devised a novel deep learning based semantic segmentation algorithm providing, to the best of our knowledge, the first benchmark results for automatic segmentation of 11 OCT features inc...
Article
Purpose: To report on long-term real-life outcomes of anti-vascular endothelial growth factor (anti-VEGF) therapy in neovascular age-related macular degeneration (nAMD) with optimal patient adherence. Methods: For this retrospective monocenter study, we identified 3217 eyes of 2793 patients that received a minimum of three intravitreal anti-VEGF...
Article
Full-text available
Purpose As the number of intravitreal injections (IVI) increases annually, this study aimed to assess the anatomical and functional outcomes following rhegmatogenous retinal detachment (RRD) surgery for IVI-associated RRD (IVARD). Methods All non-vitrectomized eyes developing IVARD since 2007 in two European vitreoretinal centers (Department of Op...
Article
Full-text available
Background Central retinal artery occlusion ((C)RAO) is known to be associated with stroke and/or atrial fibrillation (AF). Nevertheless, patients often present at the ophthalmologist initially and it is unknown how many of these receive an adequate cardiological/neurological work-up (CWU/NWU), including a 24 h-Holter-ECG. Hypothesis Hypothesis of...
Article
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Purpose: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic forced ophthalmologists to adjust their working conditions to ensure patient and staff safety, while still providing effective and timely treatment. This international survey among ophthalmologists was initiated to capture what actions ophthalmologists were taking a...
Article
PurposeNeovascular age-related macular degeneration (nAMD) often affects both eyes. This study compared real-life outcomes of the first affected eye (1st eye) and the last affected eye (2nd eye) after anti-vascular endothelial growth factor (anti-VEGF) treatment.Material and methodsFor this retrospective monocenter study 3217 eyes from 2793 patient...
Article
Full-text available
Purpose Long total waiting times (TWT) experienced by patients during a clinic visit have a significant adverse effect on patient’s satisfaction. Our aim was to use big data simulations of a patient scheduling calendar and its effect on TWT in a general ophthalmology clinic. Based on the simulation, we implemented changes to the calendar and verifi...
Article
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Sensitive and robust outcome measures of retinal function are pivotal for clinical trials in age-related macular degeneration (AMD). A recent development is the implementation of artificial intelligence (AI) to infer results of psychophysical examinations based on findings derived from multimodal imaging. We conducted a review of the current litera...
Article
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Background To study the enlargement rate of primary geographic atrophy (GA) before and after diagnosis of a secondary choroidal neovascularization (CNV) treated with anti-vascular endothelial growth factor (VEGF) therapy. Methods Five hundred twenty-two consecutive eyes with primary GA were screened for the development of a complicating secondary...
Article
Background We introduced a video consultation (VC) during the coronavirus (COVID-19) pandemic in an ophthalmology practice with eight doctors to ensure continuous ophthalmological care, infection prophylaxis and to compensate a decreased number of patient presentations.Objective Evaluation of the most common reasons for patient presentations in the...
Article
Due to their widespread use among the population and their wide range of functions and sensors, smartphones are suitable for data collection for medical purposes. App-supported input masks, patient diaries, and patient information systems, mobile access to the patient file as well as telemedical services will continue to find their way into our fie...
Article
Full-text available
Access to large, annotated samples represents a considerable challenge for training accurate deep-learning models in medical imaging. Although at present transfer learning from pre-trained models can help with cases lacking data, this limits design choices and generally results in the use of unnecessarily large models. Here we propose a self-superv...
Article
Background Results from recent studies show that less intravitreal injections are often performed in everyday practice than in controlled trials, which subsequently leads to worse treatment success. In this study we analyzed the introduction of a more stringent organization of treatment using workflow optimization and new IT systems and analyzed th...
Article
Background Empirical models have been an integral part of everyday clinical practice in ophthalmology since the introduction of the Sanders-Retzlaff-Kraff (SRK) formula. Recent developments in the field of statistical learning (artificial intelligence, AI) now enable an empirical approach to a wide range of ophthalmological questions with an unprec...
Article
Full-text available
The objective of this paper is to evaluate visual acuity (VA) outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) in diabetic macular oedema (DMO). In this retrospective cohort study, electronic medical records for all patients undergoing intravitreal injections in a tertiary referral centre between March 2013 and October 2018 w...
Article
Background We introduced a video consultation (VC) during the coronavirus (COVID-19) pandemic in an ophthalmology practice with eight doctors to ensure continuous ophthalmological care, infection prophylaxis and to compensate a decreased number of patient presentations.Objective Evaluation of the most common reasons for patient presentations in the...
Article
Full-text available
Sub-retinal fluid (SRF) has been discussed as a protective factor against macular atrophy in eyes with neovascular age-related macular degeneration (nAMD).To gauge the impact of SRF on macular atrophy, a database of 310 nAMD eyes was screened for eyes manifesting an SRF-only phenotype under treat & extend anti-VEGF treatment, defined as nAMD expres...
Article
Ophthalmology is subject to constant change. Almost two decades ago the OCT (optical coherence tomography) technology was introduced into ophthalmological practice. Nowadays, artificial intelligence and telemedicine are talked about everywhere. This article gives an overview of the tools currently available in both fields. As an outlook into the ye...
Article
Full-text available
PurposeTo determine the anatomical and functional outcomes of an extended 6-month intravitreal anti-vascular endothelial growth factor (anti-VEGF) upload in choroidal neovascularization (CNV) secondary to chronic central serous chorioretinopathy (CSCR).MethodsA retrospective database analysis was performed applying the following inclusion criteria:...
Article
Full-text available
Purpose: To evaluate the efficacy of dexamethasone implant (DEX) for the treatment of postoperative cystoid macular edema (PCME) in vitrectomized eyes and to investigate visual and morphological OCT predictive factors. Methods: In this retrospective study, eyes with PCME after vitrectomy were treated with at least one DEX injection and were obse...
Article
Full-text available
Purpose To evaluate refractive outcomes for a standard industry calculator using anterior corneal astigmatism or total corneal refractive power. Methods This prospective interventional study evaluated the refractive outcomes of 56 eyes using a standard industry calculator (Zeiss ZCalc) and a digital IOL alignment software. After A-constant optimis...
Article
Full-text available
Purpose: To assess visual and anatomical outcomes of intravitreal aflibercept for clinically significant diabetic macular oedema (DME). Methods: For this retrospective single-center cohort study at a tertiary referral center, we performed a data warehouse query to identify 117 treatment-naive patients (139 eyes) undergoing intravitreal treatment...
Article
Background: In order to supply information for internal and external audit purposes, tumor documentation software supplying structured information from the associated centers' oncology patients exists in many comprehensive cancer centers. However, the documentation data contents of such systems often remain unused and unknown by most of the sites'...
Article
Background Diabetes prevalence is constantly rising, involving the eyes with damage including development of diabetic macular oedema. Since 2012, intravitreal anti-vascular endothelial growth factor medication is available for diabetic macular oedema treatment. Endocrinological studies have shown that fewer women are affected by diabetes. However,...
Article
Full-text available
Access to large, annotated samples represents a considerable challenge for training accurate deep-learning models in medical imaging. While current leading-edge transfer learning from pre-trained models can help with cases lacking data, it limits design choices, and generally results in the use of unnecessarily large models. We propose a novel, sel...
Preprint
Full-text available
PURPOSE: To evaluate visual acuity (VA) outcomes of intravitreal anti-vascular endothelial growth factor (VEGF) in diabetic macular oedema (DMO). METHODS: In this retrospective cohort study, electronic medical records for all patients undergoing intravitreal injections (IVI) in a tertiary referral centre between March 2013 and October 2018 were ana...
Article
Background/Aims Neovascular age-related macular degeneration (nAMD) is frequently bilateral, and previous reports on ‘fellow eyes’ have assumed sequential treatment after a period of treatment of the first eye only. The aim of our study was to analyse baseline characteristics and visual acuity (VA) outcomes of fellow eye involvement with nAMD, spec...
Chapter
Clinicians implicitly incorporate the complementarity of multi-modal data for disease diagnosis. Often a varied order of importance for this heterogeneous data is considered for personalized decisions. Current learning-based methods have achieved better performance with uniform attention to individual information, but a very few have focused on pat...
Preprint
Full-text available
We cast the problem of image denoising as a domain translation problem between high and low noise domains. By modifying the cycleGAN model, we are able to learn a mapping between these domains on unpaired retinal optical coherence tomography images. In quantitative measurements and a qualitative evaluation by ophthalmologists, we show how this appr...
Chapter
We cast the problem of image denoising as a domain translation problem between high and low noise domains. By modifying the cycleGAN model, we are able to learn a mapping between these domains on unpaired retinal optical coherence tomography images. In quantitative measurements and a qualitative evaluation by ophthalmologists, we show how this appr...
Article
Full-text available
Background Hospital Eye Services (HES) in the UK face an increasing number of optometric referrals driven by progress in retinal imaging. The National Health Service (NHS) published a 10-year strategy (NHS Long-Term Plan) to transform services to meet this challenge. In this study, we implemented a cloud-based referral platform to improve communica...
Article
Purpose To evaluate the detection of different lesions of diabetic retinopathy (DR) in scanning laser ophthalmoscopy (SLO) compared to colour fundus photographs within the same retinal field. Methods Scanning laser ophthalmoscopy and colour fundus photographs of 67 eyes taken on the same day of dilated patients with different grades of diabetic re...
Article
Full-text available
Objectives To analyse treatment outcomes and share clinical data from a large, single-centre, well-curated database (8174 eyes/6664 patients with 120 756 single entries) of patients with neovascular age-related macular degeneration (AMD) treated with anti-vascular endothelial growth factor (VEGF). By making our depersonalised raw data openly availa...
Chapter
Geometric deep learning provides a principled and versatile manner for integration of imaging and non-imaging modalities in the medical domain. Graph Convolutional Networks (GCNs) in particular have been explored on a wide variety of problems such as disease prediction, segmentation, and matrix completion by leveraging large, multi-modal datasets....
Article
Purpose: Demographic changes as well as increasing referral rates from national screening services put pressure on available ophthalmologic resources in the United Kingdom. To improve resource allocation, virtual medical retina clinics were introduced in 2016 in Moorfields Eye Hospital, South Division. The scope of this work was to assess clinical...
Preprint
Background/Aims Neovascular age-related macular degeneration (nAMD) is frequently bilateral, and previous reports on ‘fellow eyes’’ have assumed sequential treatment after a period of treatment of the first eye only. The aim of our study was to analyse baseline characteristics and visual acuity (VA) outcomes of fellow eye involvement with nAMD, spe...
Preprint
Multi-modal data comprising imaging (MRI, fMRI, PET, etc.) and non-imaging (clinical test, demographics, etc.) data can be collected together and used for disease prediction. Such diverse data gives complementary information about the patient\'s condition to make an informed diagnosis. A model capable of leveraging the individuality of each multi-m...
Preprint
Geometric deep learning provides a principled and versatile manner for integration of imaging and non-imaging modalities in the medical domain. Graph Convolutional Networks (GCNs) in particular have been explored on a wide variety of problems such as disease prediction , segmentation, and matrix completion by leveraging large, multi-modal datasets....
Preprint
Full-text available
Objectives To analyse treatment outcomes and share clinical data from a large, single-center, well-curated database (8174 eyes / 6664 patients with 120,756 single entries) of patients with neovascular age related macular degeneration (AMD) treated with anti-vascular endothelial growth factor (VEGF). By making our depersonalised raw data openly avai...
Article
Full-text available
Introduction: Treatment decisions for fractures of the orbital floor are based on clinical appearance, ophthalmological examination, and computed tomography (CT) scans. In extensive fractures, decisions are easily made between conservative and surgical treatment. However, objective parameters are rare in inconclusive cases. Materials and methods:...
Article
Full-text available
Purpose: To investigate the long-term efficacy of accelerated corneal collagen cross-linking (CXL) in a large mid-European cohort with progressive keratoconus. Methods: Four hundred thirteen eyes of 316 patients with progressive keratoconus were enrolled and treated with conventional (group A) or accelerated (group B) CXL. Uncorrected distance v...
Article
Full-text available
Background Increasing government legislation and regulations in manufacturing have led to additional documentation regarding the pharmaceutical product requirements of corneal grafts in the European Union. The aim of this project was to develop a software within a hospital information system (HIS) to support the documentation process, to improve th...
Preprint
Structural data from Electronic Health Records as complementary information to imaging data for disease prediction. We incorporate novel weighting layer into the Graph Convolutional Networks, which weights every element of structural data by exploring its relation to the underlying disease. We demonstrate the superiority of our developed technique...
Article
Purpose: To predict, by using machine learning, visual acuity (VA) at 3 and 12 months in patients with neovascular age-related macular degeneration (AMD) after initial upload of 3 anti-vascular endothelial growth factor (VEGF) injections. Design: Database study. Participants: For the 3-month VA forecast, 653 patients (379 female) with 738 eyes...
Article
Full-text available
Purpose To compare two calculators for toric intraocular lens (IOL) calculation and to evaluate the prediction of refractive outcome. Methods Sixty-four eyes of forty-five patients underwent cataract surgery followed by implantation of a toric intraocular lens (Zeiss Torbi 709 M) calculated by a standard industry calculator using front keratometry...
Article
Background The increasing incidence of medical retinal diseases has created capacity issues across UK. In this study, we describe the implementation and outcomes of virtual medical retina clinics (VMRCs) at Moorfields Eye Hospital, South Division, London. It represents a promising solution to ensure that patients are seen and treated in a timely fa...
Article
Full-text available
Background The purpose of this study was to identify differences in clinical corneal findings after standard and accelerated epithelial off cross-linking (CXL) during a long-term follow-up. Methods Two hundred forty-one patients (184 male) were included in this monocentric, retrospective, non-randomized and unmasked study. One hundred forty-eight...
Article
Purpose: To compare the efficacy of a computer-assisted marker system for toric intraocular lenses (IOLs) (Callisto Eye System) with manual marking techniques. Setting: University Eye Hospital Munich, Ludwig-Maximilians-University, Munich, Germany. Design: Prospective case series. Methods: This study included patients having cataract surgery...
Article
Purpose: We assessed differences in compliance and adherence (lateness of patients, visual acuity, reasons for abstaining) between patients with diabetic macular edema (DME) and patients with age-related macular degeneration (AMD), both under anti-vascular endothelial growth factor therapy. Methods: We included 136 patients with DME (36% women,...
Article
Zusammenfassung Hintergrund Die Bedeutung der Analyse von Untersuchungsdaten aus der Behandlungsrealität nimmt stetig zu. Gründe hierfür sind u. a. verbesserte Auswertungsmöglichkeiten durch leistungsfähigere Informatiksysteme. Zudem stehen mehr und mehr Daten digital zur Verfügung. Vor einem Projektstart zur Auswertung von Routinedaten, sind techn...
Article
Purpose: Different modalities of radiation therapy nowadays allow for effective treatment of uveal melanoma combined with the advantage of eye preservation. However, this advantage can secondarily be impaired by radiation-related side effects. After local recurrence, secondary glaucoma (SG) has been described as second most frequent complication l...
Article
Purpose: To develop a near real-time data warehouse (DW) in an academic ophthalmological center to gain scientific use of increasing digital data from electronic medical records (EMR) and diagnostic devices. Design; Database development METHODS: Specific macular clinic user interfaces within the institutional hospital information system were creat...
Article
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Purpose: Our aim was to correlate the overall patient volume and the incidence of several ophthalmological diseases in our emergency department with weather data. Patients and methods: For data analysis, we used our clinical data warehouse and weather data. We investigated the weekly overall patient volume and the average weekly incidence of all...
Article
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Background A specific Electronic Health Record (EHR) for ophthalmology was introduced in an academic center in Germany. As diagnoses coding corresponding to the International Classification of Diseases Version 10 (ICD-10) is mandatory for billing reasons in Germany, we analyzed whether a change occurred in the diversity and number of diagnoses afte...
Article
Background Smart Data means intelligent data accumulation and the evaluation of large data sets. This is particularly important in ophthalmology as more and more data are being created. Increasing knowledge and personalized therapies are expected by combining clinical data from electronic health records (EHR) with measurement data. Objective In thi...
Article
Background The association between cardiovascular events, such as acute coronary syndrome and emotional triggers, such as football world cups is well-known. Significant differences could sometimes be identified depending on the country of origin and design of the study. From an ophthalmological perspective the correlation between pre-existing cardi...