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Karsten Juhl Jørgensen

Karsten Juhl Jørgensen

Professor

About

179
Publications
20,731
Reads
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5,135
Citations
Introduction
Additional affiliations
August 2004 - October 2015
Independent Researcher
Position
  • Senior Researcher
August 2004 - present
Rigshospitalet
Position
  • Senior Researcher

Publications

Publications (179)
Article
Full-text available
Background Although many people infected with SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) experience no or mild symptoms, some individuals can develop severe illness and may die, particularly older people and those with underlying medical problems. Providing evidence-based interventions to prevent SARS-CoV-2 infection has become mo...
Preprint
Full-text available
Objective: To assess potential dose-response relationships of extended-release methylphenidate for ADHD in adults on efficacy outcomes. Study design and setting: Post-hoc analysis based on a systematic review of extended-release methylphenidate (https://doi.org/10.1002/14651858.CD012857). Using data from clinical trials comparing multiple fixed-dos...
Article
Objectives To assess whether drug regulatory agencies decided on applications for extended-release methylphenidate for use in adult ADHD based on select samples of trials. Study design and setting Case series of publicly available regulatory documents. We matched an index of extended-release methylphenidate trials for adult ADHD with trials appear...
Article
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of interventions in non‐healthcare‐related workplaces to reduce the risk of SARS‐CoV‐2 infection relative to other interventions or no intervention.
Article
Full-text available
Objectives To determine to which degree industry partners in randomised clinical trials own the data and can constrain publication rights of academic investigators. Methods Cohort study of trial protocols, publication agreements and other documents obtained through Freedom of Information requests, for a sample of 42 trials with industry involvemen...
Article
Full-text available
Background Very preterm infants are at high risk of developing chronic lung disease, which requires respiratory support and might have long-term sequelae. As lung inflammation plays an important role in pathogenesis, antileukotrienes have been explored in both clinical and animal studies. We aimed to assess the benefits and harms of antileukotriene...
Article
Full-text available
Background Healthcare professionals are exposed to advertisements for prescription drugs in medical journals. Such advertisements may increase prescriptions of new drugs at the expense of older treatments even when they have no added benefits, are more harmful, and are more expensive. The publication of medical advertisements therefore raises ethic...
Article
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Concern has been raised about whether HPV vaccines might cause serious neurological disorders including postural orthostatic tachycardia syndrome (POTS) and chronic regional pain syndrome (CRPS). The European Medicines Agency (EMA) investigated the issue and declared in 2015 that there is no link between HPV vaccines and serious neurological advers...
Article
Objective: To investigate the association between conflicts of interest and favourable recommendations in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews. Design: Systematic review. Eligibility criteria: Studies that compared the association between conflicts of interest and favourable recommendations of...
Article
Background Treatment and diagnostic recommendations are often made in clinical guidelines, reports from advisory committee meetings, opinion pieces such as editorials, and narrative reviews. Quite often, the authors or members of advisory committees have industry ties or particular specialty interests which may impact on which interventions are rec...
Article
Full-text available
Objective: To investigate if Cochrane reviews that assess screening interventions address their major harms. Study design and setting: A systematic search for Cochrane reviews that assess screening interventions was performed. Two authors independently screened abstracts, assessed full-texts, and extracted data from included reviews. For each revi...
Article
Better intervention strategies for patients with treatment-resistant depression are greatly needed. McIntyre and colleagues1 set out to investigate the effectiveness of intravenous (IV) ketamine through a chart review of 201 such outpatients that all received four IV ketamine infusions over one-to-two weeks. They concluded that IV ketamine was effe...
Article
Background: Handwashing is important to reduce the spread and transmission of infectious disease. Ash, the residue from stoves and fires, is a material used for cleaning hands in settings where soap is not widely available. Objectives: To assess the benefits and harms of hand cleaning with ash compared with hand cleaning using soap or other mate...
Article
To the Editor Based on their randomized clinical trial, Dr Flint and colleagues concluded that continuing sertraline and olanzapine compared with sertraline and placebo reduced the risk of relapse of depression in patients with psychotic depression in remission.¹ We are concerned about limitations in their study design.
Article
Full-text available
Objective To investigate to what extent evidence from previous similar trials or systematic reviews was considered before conducting new trials. Design Cohort study of contemporary protocols for trials with ethical approval. Methods All protocols for randomised trials approved by the five ethical committees in Denmark between January 2012 and Mar...
Article
Background: Screening for malignant melanoma has the potential to reduce morbidity and mortality from the disease through early detection, as prognosis is closely associated with the thickness of the lesion at the time of diagnosis. However, there are also potential harms from screening people without skin lesion concerns, such as overdiagnosis of...
Article
Background: General health checks are common elements of health care in some countries. They aim to detect disease and risk factors for disease with the purpose of reducing morbidity and mortality. Most of the commonly used individual screening tests offered in general health checks have been incompletely studied. Also, screening leads to increase...
Conference Paper
Objectives In October 2016 the French Minister of Health released the report of an independent inquiry into mammography screening, presenting two options for the future: end the national breast screening program, or end the current program and put in place a radically reformed program. Our objective was to critically analyse the report and the proc...
Article
Background: Large reductions in the incidence of abdominal aortic aneurysm (AAA) and AAA-related mortality mean that results from randomised trials of screening for the disorder might be out-dated. The aim of this study was to estimate the effect of AAA screening in Sweden on disease-specific mortality, incidence, and surgery. Methods: Individua...
Article
Full-text available
Article
In October 2016, the French Minister of Health released the report of an independent inquiry into mammography screening. The report presented 2 options: (1) end the national breast screening program, or (2) end the current program and put in place a radically reformed program.
Article
Full-text available
Purpose: To summarise recommendations about 21 selected non-surgical interventions for recent onset (<12 weeks) non-specific neck pain (NP) and cervical radiculopathy (CR) based on two guidelines from the Danish Health Authority. Methods: Two multidisciplinary working groups formulated recommendations based on the GRADE approach. Results: Twel...
Article
Full-text available
A Cochrane systematic review on immediate-release methylphenidate for adults with attention deficit hyperactivity disorder (ADHD) was withdrawn from the Cochrane Library on 26 May 2016 after substantial criticism of its methods and flawed conclusions. Retraction of scientific papers on this basis is unusual but can be necessary. We provide a summar...
Article
Kazan hosted Russia's second International Conference QiQUM 2015 on Cochrane evidence for health policy, which was entirely independent of the pharmaceutical or other health industry, bringing together 259 participants from 11 countries and 13 regions of the Russian Federation. The Conference was greeted and endorsed by world leaders in Evidence-ba...
Article
Full-text available
Background: Effective breast cancer screening should detect early-stage cancer and prevent advanced disease. Objective: To assess the association between screening and the size of detected tumors and to estimate overdiagnosis (detection of tumors that would not become clinically relevant). Design: Cohort study. Setting: Denmark from 1980 to...
Chapter
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This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the effects on morbidity and mortality of screening for malignant melanoma in the general population. © 2016 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
Article
Full-text available
Providing information to enable informed choices about healthcare sounds immediately appealing to most of us. But Minna Johansson and colleagues argue that preventive medicine and expanding disease definitions have changed the ethical premises of informed choice and our good intentions may inadvertently advance overmedicalisation The idea of infor...
Article
Full-text available
Objective: To investigate whether invitations for publicly funded cervical screening provide sufficient information to enable an informed choice about participation. Design: Cross-sectional study using a checklist of 23 information items on benefits and harms from cervical screening and the risks related to cervical cancer. Material: Invitatio...
Article
To the Editor In the systematic review of breast cancer screening, Dr Myers and colleagues1 claimed that our Cochrane review2 showed that breast screening reduces cause-specific mortality by 19%, there was no significant heterogeneity, and our results were similar to those of other reviews. This misrepresents our findings and creates an impression...
Article
Full-text available
Systematically review and analyse the efficacy of CBT versus treatment as usual in adults with ADHD. The literature was systematically searched ending the 28 March 2014. Standardised mean differences (SMD) and 95 % confidence intervals were calculated. CBT was efficacious in reducing symptoms of ADHD (SDM −1.0, 95 % CI −1.5 to −0.5) when evaluated...
Article
Full-text available
The recently updated breast cancer screening guidelines from the American Cancer Society are less aggressive than previous versions and clearer about overdiagnosis. However, a lack of attention was placed on the differences in effect estimates between trials at high and low risk of bias, and the authors failed to quantify the most serious harm.
Article
Full-text available
This article reviews four important screening principles applicable to screening mammography in order to facilitate informed choice. The first principle is that screening may help, hurt, or have no effect. In order to reduce mortality and mastectomy rates, screening must reduce the rate of advanced disease, which likely has not happened. Through ov...
Article
Full-text available
To the Editor: The report from the International Agency for Research on Cancer (IARC) (June 11 issue)(1) does not represent expert consensus. The authors of reports that question breast-cancer screening and were published in major medical journals were not included in the panel. Reductions in breast-cancer-related mortality among young women never...
Article
Full-text available
Purpose: Most guidelines recommend pulmonary rehabilitation (PR) for patients with chronic obstructive pulmonary disease (COPD) and modified Medical Research Council dyspnea scale (mMRC) levels ≥2, but the effectiveness of PR in patients with less advanced disease is not well established. Our aim was to investigate the effects of PR in patients wi...
Article
Full-text available
Resistance training (RT) is thought to be effective in preventing muscle depletion, whereas endurance training (ET) is known to improve exercise capacity and health-related quality of life (HRQoL) in chronic obstructive pulmonary disease (COPD). Our objectives were to assess the efficiency of combining RT with ET compared with ET alone. We identifi...
Article
Endurance training (ET) as part of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD) has been shown to improve exercise capacity and health-related quality of life, but dyspnea limits the exercise intensity. Therefore, resistance training (RT), which may cause less dyspnea, could be an alternative. The purpose o...
Article
Full-text available
Urinary dipsticks are sometimes used for screening asymptomatic people, and for case-finding among inpatients or outpatients who do not have genitourinary symptoms. Abnormalities identified on screening sometimes lead to additional investigations, which may identify serious disease, such as bladder cancer and chronic kidney disease (CKD). Urinary d...
Article
Full-text available
Disease-related undernutrition is a common problem in individuals with COPD. The rationale for nutritional support in pulmonary rehabilitation therefore seems obvious. However there is limited evidence regarding the patient-relevant outcomes i.e. activities of daily living (ADL) or quality of life.Therefore the topic was included in The Danish Heal...
Article
Acute respiratory infections (ARIs) are by far the most common reason for prescribing an antibiotic in primary care, even though the majority of ARIs are of viral or non-severe bacterial aetiology. Unnecessary antibiotic use will, in many cases, not be beneficial to the patients' recovery and expose them to potential side effects. Furthermore, as a...
Article
As our editorial explained, criticism of a clear negative result cannot turn it positive.1 Lauritzen and colleagues say that the trials in our Cochrane review tested outdated screening tests and treatments.2 3 This is not correct—for example, probably all 14 trials measured blood pressure and six trials tested for diabetes. They also say the trials...
Article
Full-text available
Purpose: Favorable outcome after cataract surgery depends on proper control of the inflammatory response induced by cataract surgery. Pseudophakic cystoid macular edema is an important cause of visual decline after uncomplicated cataract surgery. Design: We compared the efficacy of topical steroids with topical nonsteroidal anti-inflammatory dru...
Article
It’s time to let them go We check our cars regularly, so why shouldn’t we also check our bodies so that we can find and treat abnormalities before they cause too much harm? It seems so easy, but the human body is not a car, and, in contrast to a car, it has self healing properties. Actually, the first thing we know about screening is that it will...
Article
Full-text available
Objective To determine, using research on duloxetine for major depressive disorder as an example, if there are inconsistencies between protocols, clinical study reports, and main publicly available sources (journal articles and trial registries), and within clinical study reports themselves, with respect to benefits and major harms. Design Data on...