Karolline Krambeck

• Pharmaceutical Technology PhD
• Invited Professor Adjunt at Polytechnic of Guarda

Introdução: A hipertensão arterial é um problema de saúde pública global, sendo considerada um fator de risco independente, linear e contínuo para o desenvolvimento de doenças cardiovasculares. Objetivo: Analisar a prevalência e os fatores de risco associados à hipertensão arterial sistêmica (HAS) no Distrito Federal, no período de 2014 a 2023. Met...

Monoclonal antibodies (mAbs) have revolutionized the landscape of cancer therapy, offering unprecedented specificity and diverse mechanisms to combat malignant cells. These biologic agents have emerged as a cornerstone in targeted cancer treatment, binding to specific antigens on cancer cells and exerting their therapeutic effects through various m...

Silver nanoparticles (AgNPs) are being proposed as a new pharmaceutical product because of their antimicrobial properties and eco-toxicological profile. AgNPs can be synthesized by physical or chemical methods. However, green synthesis, the so-called biosynthesis in which organic or biological materials are used, is becoming even more popular as it...

The current burden associated to multidrug resistance, and the emerging superbugs, result in a decreased and even loss of antibiotic efficacy, which poses significant challenges in the treatment of infectious diseases. This situation has created a high demand for the discovery of novel antibiotics that are both effective and safe. However, while an...

This analysis explores the principal regulatory concerns linked to nanomedicines and gene vaccines, including the complexities involved and the perspectives on how to navigate them. In the realm of nanomedicines, ensuring the safety of nanomaterials is paramount due to their unique characteristics and potential interactions with biological systems....

The delivery of peptides and proteins usually faces formulation development challenges attributed to the difficulties encountered in their stabilization. Nanoparticles offer an alternative to improve the physicochemical stability of such biomacromolecules, while increasing their bioavailability by overcoming biological absorption barriers. With thi...

The high levels of antibiotic resistance registered worldwide have become a serious health problem, threatening the currently available treatments for a serious of infection diseases. With antibiotics becoming less and less effective, it is becoming increasingly difficult and, in some cases, impossible to treat patients with even common infectious...

Scientific evidence exists about the association between neurological diseases (i.e., Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis, depression, and memory loss) and oxidative damage. The increasing worldwide incidence of such diseases is attracting the attention of researchers to find palliative...

Lactoferrin (Lf) is a glycoprotein belonging to the transferrin family, which can be found in mammalian milk. It was first isolated from bovine milk in the 1930s, and later in the 1960s, it was determined from human milk. This multifunctional protein has the specific ability to bind iron. It plays various biological roles, such as antibacterial, an...

O Livro é composto por trabalhos publicados no I Congresso Brasileiro de Química dos Produtos Naturais, foi um evento que trouxe diferentes áreas importantes e atuais dentro da química dos produtos naturais e também incentivou a troca de experiências entre discentes, docentes e empresários, promovendo o desenvolvimento científico e tecnológico da c...

Pergunta de Pesquisa: As intoxicações por agrotóxicos no estado de Alagoas estão sendo notificadas? Objetivo geral e específico respectivamente: Realizar um levantamento das intoxicações por agrotóxicos no estado de Alagoas no período de 2010 a 2017. Analisar os dados obtidos sobre as intoxicações por agrotóxicos. Hipótese: A falta de notificação d...

Oxidation of lipids and lipoproteins contributes to inflammation processes that promote the development of eye diseases. This is a consequence of metabolism dysregulation; for instance, that of the dysfunctional peroxisomal lipid metabolism. Dysfunction of lipid peroxidation is a critical factor in oxidative stress that causes ROS-induced cell dama...

A Editora Humainze apresenta a I edição do Livro intitulado "Desvendando a Saúde Global no contexto das Ciências da Saúde Única para um Futuro Integrado" composto por capítulos de livro que abordam a área da Saúde Única no modelo inter-multidisciplinar. O livro foi criado a partir da realização do I Congresso Internacional em Ciências da Saúde Únic...

The skin is the largest organ of the human body and has several functions such as barrier against external agents, the maintenance of temperature and homeostatic functions. Skin ageing is a natural process that can be influenced by environmental factors, intrinsic skin factors and lifestyle. UV light plays an important role in skin ageing and can c...

This study aims to design and characterize Nanostructured lipid carriers (NLC) and Nanostructured lipid carrier-based hydrogels with Passiflora edulis seeds oil, a by-product from Madeira Island food industry. NLC were prepared by the ultrasonication technique, using passion fruit seeds oil as a liquid lipid and glyceryl distearate as a solid lipid...

Nanostructured lipid carriers (NLC) have been studied for over 20 years, constituting the second generation of lipid nanoparticles. These nanosystems were introduced to overcome the drawbacks of solid lipid nanoparticles (SLN). Passion fruit seeds oil have a high antioxidant potential and also skin whitening properties. The objectives of this work...

Recently, studies on the by-products from the food industry, such as passion fruit seeds, have significantly increased, as these can have an added value, due to their properties, such as potential antioxidant activity. This study was conducted to determine the presence of piceatannol and resveratrol in various extracts of passion fruit (Passiflora...

It has been reported that the antioxidant activity of the passion fruit seeds oil is comparable to that of ascorbic acid, due to a high content of polyphenols such as stilbenes. The aim of this study was to use the residues from the Madeira Island food industry to produce passion fruit seed extracts by Soxhlet and Ultrasound methods, using acetone...

Passion fruit oil has been used on the skin as a moisturizer, antioxidant, and depigmenting, due to its high content of polyphenols. The objective of this work was to evaluate different methods of preparation of microemulsions containing passion fruit seeds oil. For this, we used sonication and high pressure homogenization (HPH) methods under diffe...

The aims of this study were to compare the effectiveness of Soxhlet and ultrasound extraction methods for obtaining Passiflora edulis seeds oil from Madeira Island and to evaluate its antioxidant capacity. The effects of two different extraction methods (Soxhlet, ultrasound) and four solvents (acetone, isopropanol, ethanol, and hexane) were investi...

The use of nano and microemulsions is increasing every year. This article is a review of the use of these systems in the area of cosmetics, as well as their advantages and disadvantages, citing examples of products already on the market.