Karolina Majewska

Karolina Majewska
Nicolaus Copernicus University | umk · Department of Biotechnology

PhD Student


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Citations since 2016
11 Research Items
4 Citations
Additional affiliations
September 2017 - October 2017
Phytosanitary Diagnostic Laboratory of the Central Laboratory in Toruń
  • trainee
  • - Testing water samples for the presence of Ralstonia solanacearum bacteria (the pathogen of nightshade plants) - media preparation - PCR reaction - FISH reaction - samples accepting
October 2017 - July 2019
Nicolaus Copernicus University
Field of study
  • Biotechnology


Publications (11)
Full-text available
Background: Reports in both animals and plants have recently revealed that a part of protein-coding transcripts might be retained in the nucleus for most of their lifetime. To date, nuclear speckles were the only domain associated with the accumulation of mRNA in animal cells. We previously showed that transcription occurs in a pulsatile manner in...
Full-text available
Our findings provide new insight into the regulatory mechanisms of gene expression based on pre-mRNA retention in the nucleus during the development of generative cells in plants. Gene regulation ensures that the appropriate genes are expressed at the proper time. Nuclear retention of incompletely spliced or mature mRNAs is emerging as a novel, pr...
Full-text available
Recent studies show a crucial role of post-transcriptional processes in the regulation of gene expression. Our research has shown that mRNA retention in the nucleus plays a significant role in such regulation. We studied larch microsporocytes during meiotic prophase, characterized by pulsatile transcriptional activity. After each pulse, the transcr...
Full-text available
Gene regulation ensures that the appropriate genes are expressed at the proper times. Nuclear retention of incompletely spliced or mature mRNAs emerges as a novel, previously underappreciated layer of post-transcriptional gene regulation. Studies on this phenomenon indicated that it exerted significant impact on the regulation of gene expression by...


Cited By


Projects (2)
This project is concentrated on the new role of Cajal bodies (CBs), associated with the accumulation of polyadenylated transcripts. The results of our previous studies on larch microsporocytes have shown that polyadenylated RNA are accumulated in CBs during diplotene. While transcriptional activity is high, microsporocytes synthesize poly (A) RNA in large quantities Significant fraction of these transcripts, however, is not exported into the cytoplasm, and is retained in the nucleus – they accumulate within both the nucleoplasm and the spherical nuclear domains called Cajal bodies. The amount of poly (A) RNA in Cajal bodies gradually increases, and the highest level of retained transcripts in the CBs is observed prior to their massive export into the cytoplasm. In this project we want know the mechanisms of retention polyadenylated transcripts in CBs and know the and processes regulated by these mechanisms.