Karol SzlazakWarsaw University of Technology · Division of Materials Design
Karol Szlazak
Doctor of Engineering
About
33
Publications
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442
Citations
Citations since 2017
Publications
Publications (33)
![Settings of the 3D printer [28].](publication/358912836/figure/tbl1/AS:1132591524659209@1647042270602/Settings-of-the-3D-printer-28_Q320.jpg)
Poly-ɛ-caprolactone (PCL) is now widely studied in relation to the engineering of bone, cartilage, tendons, and other tissues. Standard histological protocols can destroy the carefully created trabecular and honeycomb-like architecture of PCL scaffolds, and could lead to scaffold fibers swelling, resulting in the displacement or compression of tiss...
This study demonstrates an approach of utilizing high-pressure torsion (HPT) to fabricate a novel hybrid material by the direct bonding of Al and Ti disks at room temperature under a compressive pressure of 6.0 GPa and with increasing numbers of HPT turns up to 50. Detailed structural observations revealed the formation of a multi-layered nanostruc...
The treatment of severe bone loss and resultant large bone gaps is a challenge due to the need to stimulate bone growth using a biomaterial that biodegrades slowly and has mechanical properties similar to the surrounding bone. This work proposes a novel biodegradable nanocomposite to address these needs. The first step of the technology is to prepa...
Composites made of a biodegradable polymer, e.g., polylactic acid (PLA) and hydroxyapatite nanoparticles (HAP NPs) are promising orthopedic materials. There is a particular need for biodegradable hybrid nanocomposites with strong mechanical properties. However, obtaining such composites is challenging, since nanoparticles tend to agglomerate, and i...
There still remains a need for new methods of healing large bone defects, i.e., gaps in bone tissue that are too big to naturally heal. Bone regrowth scaffolds can fill the bone gap and enhance the bone regeneration by providing cells with a support to for new tissue formation. Coating of the scaffolds surface with nanocrystalline hydroxyapatite ma...
Objectives:
To assess the expansion pattern of coronary stents by using different balloon inflation times and pressures.
Background:
The selection of coronary stent size and its proper deployment is crucial in coronary artery interventions, having an impact on the success of the procedure and further therapy.
Methods:
Ten pairs of different st...
The paper presents a novel approach to the production of calcium phosphate coatings of scaffolds. Mineral deposits were formed during incubation of polycaprolactone (PCL) scaffolds with bovine intestinal alkaline phosphatase in sodium glycerophosphate and calcium chloride medium. To modify hydrophobic surface of scaffolds and intensify attachment o...
Tailoring the morphology of macroporous structures remains one of the biggest challenges in material synthesis. Here, we present an innovative approach to fabricate custom macroporous materials with pore size varying throughout the structure by up to an order of magnitude using on‐demand reconfigurable microfluidics. We employ a valve‐based flow‐fo...
Tailoring the morphology of macroporous structures remains one of the biggest challenges in material synthesis. Here, we present an innovative approach to fabricate custom macroporous materials with pore size varying throughout the structure by up to an order of magnitude using on‐demand reconfigurable microfluidics. We employ a valve‐based flow‐fo...
Synthetic polymer biomaterials incorporating cells are a promising technique for treatment of orthopedic injuries. To enhance the integration of biomaterials into the human body, additional functionalization of the scaffold surface should be carried out that would assist one in mimicking the natural cellular environment. In this study, we examined...
Selective Laser Melting (SLM) is a powder-bed-based additive manufacturing method, using a laser beam, which can be used to produce metallic scaffolds for bone regeneration. However, this process also has a few disadvantages. One of its drawbacks is the necessity of post-processing in order to improve the surface finish. Another drawback lies in th...
Nowadays, the assessment of the mechanical competence of tissue engineering scaffolds based on computer simulations is a well-accepted technology. Typically, such simulations are performed by means of the Finite Element (FE) method, with the underlying structural model being created based on micro-computed tomography (microCT). Here, this analysis...
Background:
Material properties of the scaffolds as well as their microstructure are vital in determining in vivo cellular response. Three-dimensional (3D), highly porous scaffolds are used in tissue engineering to provide a suitable microenvironment and to support regeneration of bone. Both pore sizes and their architecture, in particular interco...
Druk 3D jako metoda umożliwiająca wytwarzanie obiektów o skomplikowanej geometrii oraz dużej dokładności odwzorowania kształtu i wymiarów podbija wiele gałęzi przemysłu. Dzieje się tak dzięki coraz bardziej wydajnym urządzeniom do druku 3D oraz rosnącemu spektrum materiałów polimerowych, metalicznych i kompozytowych możliwych do zastosowania w tej...
Purpose: The paper presents the results of microstructure and mechanical properties of composites resulting from a combination of powders of metallic glasses with an epoxy resin (Epidian 100). The study was performed using computed tomography. Design/methodology/approach: The filler used was made of a Fe65Co10Ni3W2B20 amorphous alloy based on, show...
Endodontic therapy depends on complete removing of the pulp tissue, the removal of microorganisms and their degradation products, and on giving the appropriate shape to the root canals with fi nally fi lling them. Canal shaping and mechanical preparation enlarge initial canal space and provide condition for proper rinsing and chemical preparation o...
An optimal method for composites preparation as an input to rapid prototyping fabrication of scaffolds with potential application in osteochondral tissue engineering is still needed. Scaffolds in tissue engineering applications play a role of constructs providing appropriate mechanical support with defined porosity to assist regeneration of tissue....
A novel bone composite scaffolds used in tissue engineering are produced using a 3D rapid prototyping method. To this end, ceramics inclusions are combined with an polymeric matrix. Due to the relatively high strength of commonly used ceramics fillers and biodegradability of polymers, composite scaffolds exhibit different mechanical properties in c...
In this paper, studies are presented that characterize a bulk amorphous Fe61Co10Ti3Y6B20 alloy. Samples were fabricated in two forms: as a rod of 1 mm in diameter and as a tube of 1 mm in the outer diameter. The investigated material was obtained using the injection method, whereby the liquid alloy was injected into a copper mould. Using an X-ray d...
Nowadays, post-surgical or post-accidental bone loss can be substituted by custom-made scaffolds fabricated by additive manufacturing (AM) methods from metallic powders. However, the partially melted powder particles must be removed in a post-process chemical treatment. The aim of this study was to investigate the effect of the chemical polishing w...
Statement of significance:
We present the development of a novel hierarchical scaffold obtained by additivemanufacturing. Structural hierarchy is obtained by changing pore size within the porenetwork characterizing the fabricated scaffolds and proves to be a functional elementin the scaffold to influence adult stem cell differentiation in the chon...
Fused deposition modeling has been used to fabricate three-dimensional (3D) scaffolds for tissue engineering applications, because it allows to tailor their pore network. Despite the proven flexibility in doing so, a limited amount of studies have been performed to evaluate whether specific pore shapes have an influence on cell activity and tissue...
The paper presents the results of experimental investigation on polymer foam with shape memory properties. The research is focused on characterization of the microstructure of the foam and understanding the mechanisms of deformation under static and dynamic loading. To this end, selected experimental techniques have been applied. Dynamic Mechanical...
Background:
The one of the most recent imaging technology is X-ray microtomography which allows non-invasive visualization of structures in 3D. It also offers the opportunity to conduct a comprehensive quantitative analysis of the tested objects such as measuring the shares of the various phases, determining the material density and distribution o...
A progressive bacteria invasion on tooth tissues leads to pulp inflammation, microabscesses of the pulp, destruction and in consequence inflammation of periapical tissues. Therefore the aim of endodontic treatment is three dimensional debridement of a root canal from the vent in pulp chamber to the physiological narrowing. Therefore the aim of the...
Purpose: The purpose of the article was to broaden the knowledge about the behavior of Fibonacci superlattices
as filters electromagnetic waves.
Design/methodology/approach: Simulations of multi-layer systems is usually carried out by using two
complementary methods. The first, matrix method which allows the study of the properties of structures...
Purpose: The influence of the extinction coefficient for transmission, reflectance and absorption in multilayer
binary. Reps cluster was equal to 7 It was built of two types of materials. First was a NaCl equivalent with a
refractive index described by nA=1.544-ik , and as second was GaAs lossless metamaterial equivalent
Design/methodology/approa...
The first stage of this study involved the preparation and seeding of innovative biomaterials with stem cell Scaffolds through a mixture of poly (3-hydroxybutyrate-co-3-hydroksy-valerat) (PHBV), poly (L-lactide-co-glycolide) (PLGA) and tricalcium phosphate (TCP). In the second stage, biomaterials were characterized using a X-ray computed microtomog...
Questions
Question (1)
Hi,
I prepared solvent of PHBV and PLGA in methylene chloride. The resulting slurry was then cast into a Petri dish and dried. The resulting film was used to fabricate composite scaffolds using the rapid prototyping device. Is there any physicochemical data which tell which of two polymers will be on the surface after the 3D printing?
Thanks!
Projects
Projects (3)
The main goal of the project is to develop a novel scaffold-based in vivo tissue engineering approach to regenerate large bone defects (iTE) in oncological patients.
The main goal of the project is to develop a novel scaffold-based in vivo tissue engineering approach to regenerate large bone defects (iTE) in oncological patients.
The research project's objective is to develop advanced X-ray micro and nanotomography methods for investigation and evaluation of tissue engineering products. Especially, it aims to gain more insights on: i) the effects of different CT image acquisition and reconstruction parameters, ii) Four-dimensional tomographic characterization i.e. mechanical loading experiments, acquiring time-resolved CT data, iii) the influence of phase contrast mode on the resulting CT-data and the detectability of detail, iv) how to provide guidelines for micro and nanoCT imaging and in situ testing of biomaterials.
