# Karol CapałaSano – Centre for Computational Medicine

Karol Capała

Doctor of Philosophy

## About

35

Publications

1,251

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76

Citations

Citations since 2017

## Publications

Publications (35)

The availability of large data sets is providing an impetus for driving current artificial intelligent developments. There are, however, challenges for developing solutions with small data sets due to practical and cost-effective deployment and the opacity of deep learning models. The Comprehensive Abstraction and Classification Tool for Uncovering...

Stochastic restarting is a strategy of starting anew. Incorporation of the resetting to the random walks can result in the decrease of the mean first passage time, due to the ability to limit unfavorably meandering, sub-optimal trajectories. In the following manuscript we examine how stochastic resetting influences escape dynamics from the $(-\inft...

Knotted proteins, when forced through the pores, can get stuck if the knots in their backbone tighten under force. Alternatively, the knot can slide off the chain, making translocation possible. We construct a simple energy landscape model of this process with a time-periodic potential that mimics the action of a molecular motor. We calculate the t...

Properties of the noise-driven escape kinetics are mainly determined by the stochastic component of the system dynamics. Nevertheless, the escape dynamics is also sensitive to deterministic forces. Here, we are exploring properties of the overdamped drifted escape from finite intervals under the action of symmetric α-stable noises. We show that the...

Stochastic resetting and noise-enhanced stability are two phenomena that can affect the lifetime and relaxation of nonequilibrium states. They can be considered measures of controlling the efficiency of the completion process when a stochastic system has to reach the desired state. Here, we study the interaction of random (Poissonian) resetting and...

Properties of the noise-driven escape kinetics are mainly determined by the stochastic component of the system dynamics. Nevertheless, the escape dynamics is also sensitive to deterministic forces. Here, we are exploring properties of the overdamped drifted escape from finite intervals under the action of symmetric $\alpha$-stable noises. We show t...

Stochastic resetting and noise-enhanced stability are two phenomena which can affect the lifetime and relaxation of nonequilibrium states. They can be considered as measures of controlling the efficiency of the completion process when a stochastic system has to reach a desired state. Here, we study interaction of random (Poissonian) resetting and s...

The escape from a given domain is one of the fundamental problems in statistical physics and the theory of stochastic processes. Here, we explore properties of the escape of an inertial particle driven by Lévy noise from a bounded domain, restricted by two absorbing boundaries. The presence of two absorbing boundaries assures that the escape proces...

The theory of stochastic processes provides theoretical tools which can be efficiently used to explore the properties of noise-induced escape kinetics. Since noise-facilitated escape over the potential barrier resembles free climbing, one can use the first-passage time theory in an analysis of rock climbing. We perform the analysis of the mean firs...

We consider properties of one-dimensional diffusive dichotomous flow and discuss effects of stochastic resonant activation (SRA) in the presence of a statistically independent random resetting mechanism. Resonant activation and stochastic resetting are two similar effects, as both of them can optimize the noise-induced escape. Our studies show comp...

The escape of the randomly accelerated undamped particle from the finite interval under action of stochastic resetting is studied. The motion of such a particle is described by the full Langevin equation and the particle is characterized by the position and velocity. We compare three resetting protocols, which restarts velocity, position, and the w...

Theory of stochastic processes provides theoretical tools which can be efficiently used to explore properties of noise induced escape kinetics. Since noise facilitated escape over the potential barrier resembles free climbing, one can use the first passage time theory in analysis of rock climbing. We perform the analysis of the mean first passage t...

The escape from a given domain is one of the fundamental problems in statistical physics and the theory of stochastic processes. Here, we explore properties of the escape of an inertial particle driven by L\'evy noise from a bounded domain, restricted by two absorbing boundaries.Presence of two absorbing boundaries assures that the escape process c...

We consider properties of one-dimensional diffusive dichotomous flow and discuss effects of resonant activation in the presence of statistically independent random resetting mechanism. Resonant activation and stochastic resetting are two similar effects, as both of them can optimize the noise induced escape. Our studies show completely different or...

The combined action of noise and deterministic force in dynamical systems can induce resonant effects. Here, we demonstrate a minimal, deterministic force-free setup allowing for the occurrence of resonant, noise-induced effects. We show that in the archetypal problem of escape from finite intervals driven by α -stale noise with a periodically modu...

The escape from a potential well is an archetypal problem in the study of stochastic dynamical systems, representing real-world situations from chemical reactions to leaving an established home range in movement ecology. Concurrently, Lévy noise is a well-established approach to model systems characterized by statistical outliers and diverging high...

The noise-driven motion in a bistable potential acts as the archetypal model of various physical phenomena. Here, we contrast properties of the overdamped escape dynamics with the full (underdamped) dynamics. In the weak noise limit, for the overdamped particle driven by nonequilibrium, α-stable noise the ratio of forward to backward transition rat...

Combined action of noise and deterministic force in dynamical systems can induce resonant effects. Here, we demonstrate a minimal, deterministic-force-free, setup allowing for occurrence of resonant, noise induced effects. We show that in the archetypal problem of escape from finite intervals driven by $\alpha$-stale noise with the periodically mod...

The escape from a potential well is an archetypal problem in the study of stochastic dynamical systems, representing real-world situations from chemical reactions to leaving an established home range in movement ecology. Concurrently, L{\'e}vy noise is a well-established approach to model systems characterized by statistical outliers and diverging...

Non-equilibrium stationary states of overdamped anharmonic stochastic oscillators driven by Lévy noise are typically multimodal. The very same situation is recorded for an underdamped Lévy noise-driven motion in single-well potentials with linear friction. Within the current article, we relax the assumption that the friction experienced by a partic...

The noise driven motion in a bistable potential acts as the archetypal model of various physical phenomena. Here, we contrast the overdamped dynamics with the full (underdamped) dynamics. For the overdamped particle driven by a non-equilibrium, $\alpha$-stable noise the ratio of forward and backward transition rates depends only on the width of a p...

Stationary states of overdamped anharmonic stochastic oscillators driven by L\'evy noise are typically multimodal. The very same situation is recorded for an underdamped L\'evy noise driven motion in single-well potentials with linear friction. Within current manuscript we relax the assumption that the friction experienced by a particle is linear....

Stochastic evolution of various dynamic systems and reaction networks is commonly described in terms of noise assisted escape of an overdamped particle from a potential well, as devised by the paradigmatic Langevin equation in which additive Gaussian stochastic force reproduces effects of thermal fluctuations from the reservoir. When implemented fo...

Using numerical methods, we have studied stationary states in the underdamped anharmonic stochastic oscillators driven by Cauchy noise. The shape of stationary states depends on both the potential type and the damping. If the damping is strong enough, for potential wells which in the overdamped regime produce multimodal stationary states, stationar...

Stochastic evolution of various reaction networks is commonly described in terms of noise assisted escape of an overdamped particle from a potential well, as devised by the paradigmatic Langevin equation. When implemented for systems close to equilibrium, the approach correctly explains emergence of Boltzmann distribution for the ensemble of trajec...

Using methods of stochastic dynamics, we have studied stationary states in the underdamped anharmonic stochastic oscillators driven by Cauchy noise. Shape of stationary states depend both on the potential type and the damping. If the damping is strong enough, for potential wells which in the overdamped regime produce multimodal stationary states, s...

A Lévy noise is an efficient description of out-of-equilibrium systems. The presence of Lévy flights results in a plenitude of noise-induced phenomena. Among others, Lévy flights can produce stationary states with more than one modal value in single-well potentials. Here we explore stationary states in special double-well potentials demonstrating t...

Stationary states for a particle moving in a single-well, steeper than parabolic, potential driven by Lévy noise can be bimodal. Here, we explore in details conditions that are required in order to induce multimodal stationary states having more than two modal values. Phenomenological arguments determining necessary conditions for emergence of stat...

A L\'evy noise is an efficient description of out-of-equilibrium systems. The presence of L\'evy flights results in a plenitude of noise-induced phenomena. Among others, L\'evy flights can produce stationary states with more than one modal value in single-well potentials. Here, we explore stationary states in special double-well potentials demonstr...

Stationary states for a particle moving in a single-well, steeper than parabolic, potential driven by L\'evy noise can be bi-modal. Here, we explore in details conditions that are required in order to induce multimodal stationary states of multiplicity larger than two. Phenomenological arguments determining necessary conditions for emergence of sta...

L\'evy walks are continuous time random walks with spatio-temporal coupling of jump lengths and waiting times, often used to model superdiffusive spreading processes such as animals searching for food, tracer motion in weakly chaotic systems, or even the dynamics in quantum systems such as cold atoms. In the simplest version L\'evy walks move with...

Individuals building populations are subject to variability. This variability affects progress of epidemic outbreaks, because individuals tend to be more or less resistant. Individuals also differ with respect to their recovery rate. Here, properties of the SIR model in inhomogeneous populations are studied. It is shown that a small change in model...