Karla Rubio

Karla Rubio
University of Lorraine | UdL · IMopA

Postdoctoral Researcher

About

32
Publications
3,891
Reads
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181
Citations
Introduction
Dr. Karla Rubio obtained her doctoral degree from the Justus-Liebig University, in Giessen, Germany. She is currently working as a postdoctoral researcher at the Max Planck Institute for Heart and Lung Research. Her research interests include in vitro, in vivo and ex vivo models oriented to link molecular RNA mechanisms to human diseases at the translational level, as well as non-canonical activation of transmembrane receptors involved on the resistance of lung cancer to chemotherapy.
Additional affiliations
January 2021 - present
CONCYTEP
Position
  • Head of Department

Publications

Publications (32)
Preprint
Proteoglycans are complex macromolecules formed of glycosaminoglycan chains covalently linked to core proteins through a linker tetrasaccharide common to heparan sulfate proteoglycans (HSPG) and chondroitin sulfate proteoglycans (CSPG). Biosynthesis of a single proteoglycan requires the expression of dozens of genes, which together create the large...
Article
Environmental factors, including pollutants and lifestyle, constitute a significant role in severe, chronic pathologies with an essential societal, economic burden. The measurement of all environmental exposures and assessing their correlation with effects on individual health is defined as the exposome, which interacts with our unique characterist...
Preprint
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is worldwide the main cause of the COVID-19 pandemic. After infection of human pulmonary cells, intracellular viral replication take place in different cellular compartments resulting in the destruction of the host cells and causing severe respiratory diseases. Although cellular traff...
Cover Page
Full-text available
El cáncer representa uno de los más claros ejemplos de la contribución combinada, exponencial, entre factores genéticos, epigenéticos y ambientales. En cuanto al componente genético, suelen estar involucrados varios genes que presentan mutaciones (cambios en la secuencia del ácido desoxirribonucleico, ADN) que por lo general se localizan en diferen...
Book
La información nos da forma, cambia el conocimiento, modifica el significado de las palabras, nos permite corregir errores, nos permite comprender mejor la realidad y, en consecuencia, tomar mejores decisiones. En este libro se compila la información dada a conocer en más de cuatrocientas cincuenta publicaciones seleccionadas por su vigencia, perti...
Article
Hepatectomy is a complex procedure with high morbidity and mortality. Early prediction/prevention of major complications is highly valuable for patient care. Surgical APGAR score (SAS) has been validated to predict post-surgical complications (PCs). We aimed to define a simple complications classification following hepatectomy based on a therapy-or...
Poster
Not only in Mexico, but worldwide, lung cancer is one of the leading cancer subtypes with poor prognosis and high mortality. Recent studies showed that epigenetic mechanisms such as histone neddylation catalyzed by NEDD8-activating enzyme (NAE) contribute to tumorigenic cell transformation. In this sense, inhibition of neddylation appears to be an...
Poster
In the eukaryotic cell nucleus, essential cellular functions take place including DNA replication, transcription, RNA processing, non-coding RNA function, among others. Such mechanisms depend on proper topological genome distribution and appropriate high-order chromatin structure. Moreover, the nuclear space is further compartmentalized into membra...
Article
Lymphoid-specific helicase (LSH) is a member of the SNF2 helicase family of chromatin-remodelling proteins. Dysfunctions or mutations in LSH causes an autosomal recessive disease known as immunodeficiency-centromeric instability-facial anomaly (ICF) syndrome. Interestingly, LSH participates in various aspects of epigenetic regulation, including nuc...
Article
Full-text available
In addition to nucleosomes, chromatin contains non-histone chromatin-associated proteins, of which the high-mobility group proteins are the most abundant. Chromatin-mediated regulation of transcription involves DNA methylation and histone modifications. However, the order of events and the precise function of high-mobility group proteins during tra...
Preprint
Full-text available
In addition to nucleosomes, chromatin also contains non-histone chromatin-associated proteins, of which the high-mobility group (HMG) proteins are the most abundant. Chromatin-mediated regulation of transcription involves DNA methylation and histone modifications. However, the order of events and the precise function of HMG proteins during transcri...
Article
In healing tissue, fibroblasts differentiate to α-smooth muscle actin (SMA)-expressing contractile-myofibroblasts, which pull the wound edges together ensuring proper tissue repair. Uncontrolled expansion of the myofibroblast population may, however, lead to excessive tissue scarring and finally to organ dysfunction. Here, we demonstrate that the l...
Article
Full-text available
Neurodegenerative diseases are among the leading causes of disability and death worldwide. The disease-related socioeconomic burden is expected to increase with the steadily increasing life expectancy. In spite of decades of clinical and basic research, most strategies designed to manage degenerative brain diseases are palliative. This is not surpr...
Article
Full-text available
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and highly lethal lung disease with unknown etiology and poor prognosis. IPF patients die within 2 years after diagnosis mostly due to respiratory failure. Current treatments against IPF aim to ameliorate patient symptoms and to delay disease progression. Unfortunately, therapies target...
Article
The eukaryotic cell nucleus consists of functionally specialized subcompartments. These nuclear subcompartments are biomolecular aggregates built of proteins, transcripts, and specific genome loci. The structure and function of each nuclear subcompartment are defined by the composition and dynamic interaction between these 3 components. The spatio-...
Article
Accumulation of mutations causing aberrant changes in the genome promotes cancer. However, mutations do not occur in every cancer subtype, suggesting additional events that trigger cancer. Chromatin rearrangements initiated by pioneer factors and architectural proteins are key events occurring before cancer-related genes are expressed. Both protein...
Article
Full-text available
The majority of the eukaryotic genome is transcribed into noncoding RNAs (ncRNAs), which are important regulators of different nuclear processes by controlling chromatin structure. However, the full extent of ncRNA function has remained elusive. Here we deciphered the function of the microRNA Mirlet7d as a key regulator of bidirectionally transcrib...

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Projects

Projects (5)
Project
Environmental Epigenetics and Human Diseases
Project
We are looking for contributions to our current Frontiers research topic: https://www.frontiersin.org/research-topics/14773/neurodegenerative-diseases-looking-beyond-the-boundaries-of-the-brain