Karla Holmboe

University of Bristol | UB · School of Experimental Psychology

Knowledge about the functional status of the frontal cortex in infancy is limited. This study investigated the effects of polymorphisms in four dopamine system genes on performance in a task developed to assess such functioning, the Freeze-Frame task, at 9 months of age. Polymorphisms in the catechol-O-methyltransferase (COMT) and the dopamine D4 r...

Executive functions (EFs) are key abilities that allow us to control our thoughts and actions. Research suggests that two EFs, inhibitory control (IC) and working memory (WM), emerge around 9 months. Little is known about IC earlier in infancy and whether basic attentional processes form the “building blocks” of emerging IC. These questions were in...

In the last decade, advances in neuroimaging technologies have given rise to a large number of research studies that investigate the neural underpinnings of executive function (EF). EF has long been associated with the prefrontal cortex (PFC) and involves both a unified, general element, as well as the distinct, separable elements of working memory...

Research into the earliest development of inhibitory control is limited by a lack of suitable tasks. In particular, commonly used inhibitory control tasks frequently have too high language and working memory demands for children under 3 years of age. Furthermore, researchers currently tend to shift to a new set of inhibitory control tasks between i...

Inhibitory control, a core executive function, emerges in infancy and develops rapidly across childhood. Methodological limitations have meant that studies investigating the neural correlates underlying inhibitory control in infancy are rare. Employing functional near-infrared spectroscopy alongside a novel touchscreen task that measures response i...

Past research has focused on infants’ visual preference for the mother’s face, however it is still unknown how these responses change over time and what factors associate with such changes. A longitudinal study (N ~ 60) was conducted to investigate the trajectories of infant visual preference for the mother’s face and how these are related to the d...

This longitudinal study investigated the associations between mother-infant interaction characteristics at 9 months of age with maternal mental health and infant temperament in the first year postpartum, and with child behaviour at 3 years of age. The infants (N = 54, 22 females) mainly had White British ethnic backgrounds (85.7%). Results showed t...

Past research has focused on infants’ visual preference for the mother’s face, however it is still unknown how these responses change over time and what factors associate with such changes. A longitudinal study (N ~ 60) was conducted to investigate the trajectories of infant visual preference for the mother’s face and how these are related to the d...

The COVID‐19 pandemic is an unexpected and major global event, with the potential to have many and varied impacts on child development. However, the implications of the pandemic for maternal depressive symptoms, early childhood temperament dimensions, and their associations, remain largely unknown. To investigate this, questionnaires were completed...

Unlabelled: In their methodological article, "Six solutions for more reliable infant research", Byers-Heinlein, Bergmann and Savalei (2021) present compelling arguments for why developmental researchers should report and consider measures of reliability more frequently in their work. They also provide useful guidance on solutions to this "reliabil...

In a longitudinal study, mothers (N = 50) self-reported on their depressive symptoms (DS) and their child’s behavior during the first year and at 36 months postpartum. Maternal DS during infancy were associated with child conduct problems (CP), suggesting a long-term association between maternal mental health and the development of child behavior....

Inhibitory control (IC) is a core executive function integral to self-regulation and cognitive control, yet is itself multi-componential. Directed global inhibition entails stopping an action on demand. Competitive inhibition is engaged when an alternative response must also be produced. Related, but not an executive function, is temperamentally-dr...

Touchscreen use amongst young children has proliferated in recent years, yet little is known about the association between daily touchscreen exposure and inhibitory control in the first year of life. Previous research has found a negative association between the amount of television viewing and inhibitory control in early childhood, but it is uncle...

Executive functions (EFs) enable us to control our attention and behavior in order to set and work toward goals. Strong EF skills are linked to better academic performance, and greater health, wealth, and happiness in later life. Research into EF development has been hampered by a lack of scalable measures suitable for infancy through to toddlerhoo...

The COVID-19 pandemic is an unexpected and major global event, with the potential to have many and varied impacts on child development. However, the implications of the pandemic for maternal depressive symptoms, early childhood temperament dimensions, and their associations, remain largely unknown. To investigate this, questionnaires were completed...

Inhibitory control, a core executive function, emerges in infancy and develops rapidly across childhood. Methodological limitations have meant that studies investigating the neural correlates underlying inhibitory control in infancy are rare. Employing functional near-infrared spectroscopy alongside a novel touchscreen task that measures response i...

Inhibitory control (IC) is a core executive function integral to self-regulation and cognitive control, yet is itself multi-componential. Directed global inhibition entails stopping an action on demand. Competitive inhibition is engaged when an alternative response must also be produced. Related, but not an executive function, is temperamentally-dr...

Postnatal maternal depression is associated with negative developmental outcomes in infancy and childhood. In a longitudinal study, mothers (N=63) completed questionnaires about their own depressive symptoms and their child’s behaviour at four time-points during the first year postpartum and again at 3 years postpartum. Maternal depressive symptoms...

Cognitive ability is a key factor that contributes to individual differences in life trajectories. Identifying early neural indicators of later cognitive ability may enable us to better elucidate the mechanisms that shape individual differences, eventually aiding identification of infants with an elevated likelihood of less optimal outcomes. A prev...

The Early Executive Functions Questionnaire (EEFQ) is a 31-item parent-report measure which complements temperament measures by targeting cognitive and regulatory capabilities. Exploratory Factor Analysis with 2 samples of 9-to 30-month-olds (n=486; 304) indicates that Inhibitory Control, Flexibility and Working Memory scales load onto a common ‘Co...

Maternal depression is associated with a range of child development outcomes, including difficult temperament. This longitudinal study investigated whether depressive symptoms (DS) that mothers experience after childbirth predict infant negative affect (NA), as well as potential effects of infant NA on maternal DS, across the first year of life. In...

Visual attention is a basic mechanism of information gathering and environment selection and consequently plays a fundamental role in influencing developmental trajectories. Here, we highlight evidence for predictive associations from early visual attention to emotion regulation, executive function, language and broader cognitive ability, mathemati...

Cognitive ability is a key factor that contributes to individual differences in life trajectories. Identifying early neural indicators of later cognitive ability may enable us to better elucidate the mechanisms that shape individual differences, eventually aiding identification of infants with an elevated likelihood of less optimal outcomes. A prev...

Executive Functions (EFs) enable us to control our attention and behaviour, in order to set and work towards goals. EF skills emerge within the first 3 years of life. However, little is known of the stability and consequences of early variation in EF, largely due to an absence of scalable measures that are appropriate for both infants and toddlers....

Research into the earliest development of inhibitory control (IC) is limited by a lack of suitable tasks. The present study (N = 300) validated the new Early Childhood Inhibitory Touchscreen Task (ECITT), in which participants have to overcome a tendency to respond to a frequently rewarded location. Inhibitory performance on the ECITT improved sign...

In the last decade, advances in neuroimaging technologies have given rise to a large number of research studies that investigate the neural underpinnings of executive function (EF). EF has long been associated with the prefrontal cortex (PFC) and involves both a unified, general element, as well as the distinct, separable elements of working memory...

Objective: Maternal depression is associated with a range of effects on child development, including difficult temperament. This study investigated the impact of depressive symptoms (DS) that mothers experience after childbirth on infant negative affect (NA) across the first year of life.Method: In this longitudinal study (N = 65), identical questi...

ABSTRACT (manuscript currently under review). Objective: Maternal depression is associated with a range of effects on child development, including difficult temperament. This study investigated the impact of depressive symptoms (DS) that mothers experience after childbirth on infant negative affect (NA) across the first year of life. Method: In t...

Executive functions (EFs) are key abilities that allow us to control our thoughts and actions. Research suggests that two EFs, inhibitory control (IC) and working memory (WM), emerge around 9 months. Little is known about IC earlier in infancy and whether basic attentional processes form the ‘building blocks’ of emerging IC. These questions were in...

Executive functions (EFs) are key abilities that allow us to control our thoughts and actions. Research suggests that two EFs, inhibitory control (IC) and working memory (WM), emerge around 9 months. Little is known about IC earlier in infancy and whether basic attentional processes form the ‘building blocks’ of emerging IC. These questions were in...

The functional status of the frontal cortex in infancy and early childhood is relatively poorly understood, and not much is known about the relationships between the few tasks developed to assess such functioning. The work presented in this thesis investigated these questions using an individual differences approach. Two cohorts of children were te...

Recently, evidence of poor or atypical motor skills in autism spectrum disorder has led some to argue that motor impairment is a core feature of the condition. The current study uses a longitudinal prospective design to assess the development of motor skills of 20 children at increased risk of developing autism spectrum disorder, who were recruited...

This supplement explains the twin method as a way of estimating genetic and environmental influences on psychological traits.

Objective Disorders on the autism spectrum, as well as autistic traits in the general population, have been found to be both highly stable across age and highly heritable at individual ages. However, little is known about the overlap in genetic and environmental influences on autistic traits across age and the contribution of such influences to tra...

Characteristic features of autism include atypical social perception and social-communication skills, and atypical visual attention, alongside rigid and repetitive thinking and behavior. Debate has focused on whether the later emergence of atypical social skills is a consequence of attention problems early in life, or, conversely, whether early soc...

Atypical attention has been proposed as a marker of the broader autism phenotype. In the present study we investigated this and the related process of inhibitory control at the youngest possible age through the study of infant siblings of children with an autism spectrum disorder (Sibs-ASD). Both attention and inhibition have been related to the fr...

Existing studies of the effect on infant temperament of the 48 base pair variable number of tandem repeats polymorphism in exon 3 of the dopamine D4 receptor gene, DRD4 VNTR, and the serotonin transporter-linked polymorphic region, 5-HTTLPR, have provided contradictory results, and age seems to be an important factor. The present study investigated...

Recent studies of infant siblings of children diagnosed with autism have allowed for a prospective approach to examine the emergence of symptoms and revealed behavioral differences in the broader autism phenotype within the early years. In the current study we focused on a set of functions associated with visual attention, previously reported to be...

Studies of infant siblings of children diagnosed with autism have allowed for a prospective approach to study the emergence of autism in infancy and revealed early behavioral characteristics of the broader autism phenotype. In view of previous findings of atypical eye gaze processing in children and adults with autism, the aim of this study was to...

The current study investigated a new, easily administered, visual inhibition task for infants termed the Freeze-Frame task. In the new task, 9-month-olds were encouraged to inhibit looks to peripheral distractors. This was done by briefly freezing a central animated stimulus when infants looked to the distractors. Half of the trials presented an en...

esearchers in the newly emerg-ing field of developmentalcognitive neuroscience seek tounderstand how postnatalbrain development relates to changesin perceptual, cognitive, and socialabilities in infants and children (1).One of the areas of cognitive develop-ment that has benefited most from adevelopmental cognitive neuroscienceapproach is attention...